U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased circulating total IgG

MedGen UID:
1692727
Concept ID:
C5139151
Finding
HPO: HP:0032132

Definition

A reduction beneath the normal level of total immunoglobulin G (IgG) in the blood. [from HPO]

Conditions with this feature

Immunodeficiency, common variable, 7
MedGen UID:
762276
Concept ID:
C3542922
Disease or Syndrome
Immunodeficiency 47
MedGen UID:
934786
Concept ID:
C4310819
Disease or Syndrome
Immunodeficiency-47 (IMD47) is an X-linked recessive complex syndrome characterized by liver dysfunction, recurrent bacterial infections, hypogammaglobulinemia, and defective glycosylation of serum proteins. Some patients also have neurologic abnormalities (summary by Jansen et al., 2016).
Immunodeficiency 70
MedGen UID:
1740270
Concept ID:
C5436501
Disease or Syndrome
Immunodeficiency-70 (IMD70) is an autosomal dominant immunologic disorder characterized by severe cutaneous warts on the hands, feet, and face, suggesting increased susceptibility to human papillomavirus (HPV) infection. Affected individuals may also have recurrent bacterial infections, such as sinusitis, as well as feature of autoinflammation, such as colitis, celiac disease, and retinal vasculitis. Laboratory studies show decreased CD4+ T cells and decreased CD19+ B cells; hypogammaglobulinemia has also been observed (summary by Thaventhiran et al., 2020).
Immunodeficiency 82 with systemic inflammation
MedGen UID:
1781752
Concept ID:
C5543581
Disease or Syndrome
Immunodeficiency-82 with systemic inflammation (IMD82) is a complex autosomal dominant immunologic disorder characterized by recurrent infections with various organisms, as well as noninfectious inflammation manifest as lymphocytic organ infiltration with gastritis, colitis, and lung, liver, CNS, or skin disease. One of the more common features is inflammation of the stomach and bowel. Most patients develop symptoms in infancy or early childhood; the severity is variable. There may be accompanying fever, elevated white blood cell count, decreased B cells, hypogammaglobulinemia, increased C-reactive protein (CRP; 123260), and a generalized hyperinflammatory state. Immunologic workup shows variable B- and T-cell abnormalities such as skewed subgroups. Patients have a propensity for the development of lymphoma, usually in adulthood. At the molecular level, the disorder results from a gain-of-function mutation that leads to constitutive and enhanced activation of the intracellular inflammatory signaling pathway. Treatment with SYK inhibitors rescued human cell abnormalities and resulted in clinical improvement in mice (Wang et al., 2021).

Professional guidelines

PubMed

Ren J, Bai Y, Hao L, Dong Y, Pi Z, Jia L
J Biomed Mater Res A 2011 Sep 15;98(4):589-95. Epub 2011 Jun 30 doi: 10.1002/jbm.a.33139. PMID: 21721115
El-On J
Acta Trop 2003 Feb;85(2):243-52. doi: 10.1016/s0001-706x(02)00217-6. PMID: 12606103
Fox RI, Chan E, Benton L, Fong S, Friedlaender M, Howell FV
Am J Med 1988 Oct 14;85(4A):62-7. doi: 10.1016/0002-9343(88)90365-8. PMID: 3177432

Recent clinical studies

Etiology

Rød BE, Wergeland S, Bjørnevik K, Holmøy T, Ulvestad E, Njølstad G, Myhr KM, Torkildsen Ø
Mult Scler Relat Disord 2023 Nov;79:105037. Epub 2023 Sep 30 doi: 10.1016/j.msard.2023.105037. PMID: 37804765
Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530
Petrović T, Vijay A, Vučković F, Trbojević-Akmačić I, Ollivere BJ, Marjanović D, Bego T, Prnjavorac B, Đerek L, Markotić A, Lukšić I, Jurin I, Valdes AM, Hadžibegović I, Lauc G
EBioMedicine 2022 Jul;81:104101. Epub 2022 Jun 27 doi: 10.1016/j.ebiom.2022.104101. PMID: 35773089Free PMC Article
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Whelan R, St Clair D, Mustard CJ, Hallford P, Wei J
Schizophr Bull 2018 Oct 17;44(6):1341-1349. doi: 10.1093/schbul/sbx175. PMID: 29373732Free PMC Article

Diagnosis

Rød BE, Wergeland S, Bjørnevik K, Holmøy T, Ulvestad E, Njølstad G, Myhr KM, Torkildsen Ø
Mult Scler Relat Disord 2023 Nov;79:105037. Epub 2023 Sep 30 doi: 10.1016/j.msard.2023.105037. PMID: 37804765
Abou-Elalla AA, Yacoub MF, Abdelfattah W, Abdelhameed AM, Khereba BS, Hanna MOF
Blood Coagul Fibrinolysis 2023 Jul 1;34(5):281-288. Epub 2023 May 11 doi: 10.1097/MBC.0000000000001223. PMID: 37395214
Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A
Oxid Med Cell Longev 2022;2022:7850659. Epub 2022 Aug 1 doi: 10.1155/2022/7850659. PMID: 35958018Free PMC Article
Wang P, Liu S, Wang Z, Zhao H, Zhang X
J Int Med Res 2020 Aug;48(8):300060520948750. doi: 10.1177/0300060520948750. PMID: 32811267Free PMC Article
Whelan R, St Clair D, Mustard CJ, Hallford P, Wei J
Schizophr Bull 2018 Oct 17;44(6):1341-1349. doi: 10.1093/schbul/sbx175. PMID: 29373732Free PMC Article

Therapy

Rød BE, Wergeland S, Bjørnevik K, Holmøy T, Ulvestad E, Njølstad G, Myhr KM, Torkildsen Ø
Mult Scler Relat Disord 2023 Nov;79:105037. Epub 2023 Sep 30 doi: 10.1016/j.msard.2023.105037. PMID: 37804765
Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A
Oxid Med Cell Longev 2022;2022:7850659. Epub 2022 Aug 1 doi: 10.1155/2022/7850659. PMID: 35958018Free PMC Article
Shin JS, Subhan MO, Cambridge G, Guo Y, de Groot R, Scully M, Thomas M
Blood Adv 2022 Jun 28;6(12):3792-3802. doi: 10.1182/bloodadvances.2022007025. PMID: 35507753Free PMC Article
El-On J
Acta Trop 2003 Feb;85(2):243-52. doi: 10.1016/s0001-706x(02)00217-6. PMID: 12606103
Regan JF, Lyonnais C, Campbell K, Smith LV, Buelow R; US Thymoglobulin Multi-Center Study Group
Transpl Immunol 2001 Oct;9(1):29-36. doi: 10.1016/s0966-3274(01)00048-x. PMID: 11680569

Prognosis

Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530
Fraussen J, Beckers L, van Laake-Geelen CCM, Depreitere B, Deckers J, Cornips EMJ, Peuskens D, Somers V
Front Immunol 2022;13:873315. Epub 2022 Jun 28 doi: 10.3389/fimmu.2022.873315. PMID: 35837411Free PMC Article
Petrović T, Vijay A, Vučković F, Trbojević-Akmačić I, Ollivere BJ, Marjanović D, Bego T, Prnjavorac B, Đerek L, Markotić A, Lukšić I, Jurin I, Valdes AM, Hadžibegović I, Lauc G
EBioMedicine 2022 Jul;81:104101. Epub 2022 Jun 27 doi: 10.1016/j.ebiom.2022.104101. PMID: 35773089Free PMC Article
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
El-On J
Acta Trop 2003 Feb;85(2):243-52. doi: 10.1016/s0001-706x(02)00217-6. PMID: 12606103

Clinical prediction guides

Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530
Petrović T, Vijay A, Vučković F, Trbojević-Akmačić I, Ollivere BJ, Marjanović D, Bego T, Prnjavorac B, Đerek L, Markotić A, Lukšić I, Jurin I, Valdes AM, Hadžibegović I, Lauc G
EBioMedicine 2022 Jul;81:104101. Epub 2022 Jun 27 doi: 10.1016/j.ebiom.2022.104101. PMID: 35773089Free PMC Article
Goyins KA, Yu JJ, Papp SB, Beddard R, Murthy AK, Chambers JP, Arulanandam BP
Exp Biol Med (Maywood) 2022 Jun;247(12):1055-1060. Epub 2022 Apr 2 doi: 10.1177/15353702221084966. PMID: 35369776Free PMC Article
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Nieman DC, Nehlsen-Cannarella SL
Sports Med 1991 Mar;11(3):183-201. doi: 10.2165/00007256-199111030-00003. PMID: 2047622

Recent systematic reviews

Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A
Oxid Med Cell Longev 2022;2022:7850659. Epub 2022 Aug 1 doi: 10.1155/2022/7850659. PMID: 35958018Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...