Pain in muscle.

Repeated infections of the urinary tract.

The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks.

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the throat.

An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.

Abnormal increased size of the spleen.

Decreased levels of immunoglobulin A (IgA).

Increased susceptibility to infections.

The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci.

A reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.

Level of isohemagglutinin reduced below expected concentration. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person).

A lasting absence of immunoglobulin G4 (IgG4) in the blood, whereby at most trace quantities of IgG4 can be measured.

A lasting limited decrease of immunoglobulin G1 (IgG1) in the blood.

Body temperature elevated above the normal range.