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Increased urinary orosomucoid

MedGen UID:
1693257
•Concept ID:
C5139306
•
Finding
Synonym: Increased urinary alpha-1-acid glycoprotein
 
HPO: HP:0032377

Definition

An increased concentration in the urine of alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM). AGP is a 41-43-kDa glycoprotein with a pI of 2.8-3.8. AGP is an acute-phase protein that has many activities including, but not limited to, acting as an acute-phase reactant and disease marker, modulating immunity, binding and carrying drugs, maintaining the barrier function of capillary, and mediating the sphingolipid metabolism. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary orosomucoid

Professional guidelines

PubMed

Interleukin-1 receptor antagonist in differential diagnosis of inflammatory bowel diseases.
Propst A, Propst T, Herold M, Vogel W, Judmaier G
Eur J Gastroenterol Hepatol 1995 Nov;7(11):1031-6. doi: 10.1097/00042737-199511000-00004. PMID: 8680901

Recent clinical studies

Etiology

Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up.
Svendstrup M, Christiansen MS, Magid E, Hommel E, Feldt-Rasmussen B
J Diabetes Complications 2013 Nov-Dec;27(6):570-5. Epub 2013 Aug 8 doi: 10.1016/j.jdiacomp.2013.05.008. PMID: 23932410
Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes.
Christiansen MS, Hesse D, Ekbom P, Hesse U, Damm P, Hommel E, Feldt-Rasmussen B, Mathiesen E
Diabetes Res Clin Pract 2010 Jul;89(1):16-21. Epub 2010 Apr 14 doi: 10.1016/j.diabres.2010.03.018. PMID: 20392509
Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes.
Christiansen MS, Iversen K, Larsen CT, Goetze JP, Hommel E, Mølvig J, Pedersen BK, Magid E, Feldt-Rasmussen B
Scand J Clin Lab Invest 2009;69(2):272-81. doi: 10.1080/00365510802531100. PMID: 18972260
Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes.
Christiansen MS, Hommel E, Magid E, Feldt-Rasmussen B
Diabetologia 2002 Jan;45(1):115-20. doi: 10.1007/s125-002-8251-3. PMID: 11845230

Diagnosis

Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up.
Svendstrup M, Christiansen MS, Magid E, Hommel E, Feldt-Rasmussen B
J Diabetes Complications 2013 Nov-Dec;27(6):570-5. Epub 2013 Aug 8 doi: 10.1016/j.jdiacomp.2013.05.008. PMID: 23932410
Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes.
Christiansen MS, Hesse D, Ekbom P, Hesse U, Damm P, Hommel E, Feldt-Rasmussen B, Mathiesen E
Diabetes Res Clin Pract 2010 Jul;89(1):16-21. Epub 2010 Apr 14 doi: 10.1016/j.diabres.2010.03.018. PMID: 20392509
A particle-enhanced turbidimetric immunoassay for quantitative determination of orosomucoid in urine: development, validation and reference values.
Christiansen MS, Blirup-Jensen S, Foged L, Larsen M, Magid E
Clin Chem Lab Med 2004;42(10):1168-77. doi: 10.1515/CCLM.2004.237. PMID: 15552277
Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes.
Christiansen MS, Hommel E, Magid E, Feldt-Rasmussen B
Diabetologia 2002 Jan;45(1):115-20. doi: 10.1007/s125-002-8251-3. PMID: 11845230

Prognosis

Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up.
Svendstrup M, Christiansen MS, Magid E, Hommel E, Feldt-Rasmussen B
J Diabetes Complications 2013 Nov-Dec;27(6):570-5. Epub 2013 Aug 8 doi: 10.1016/j.jdiacomp.2013.05.008. PMID: 23932410
Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes.
Christiansen MS, Hesse D, Ekbom P, Hesse U, Damm P, Hommel E, Feldt-Rasmussen B, Mathiesen E
Diabetes Res Clin Pract 2010 Jul;89(1):16-21. Epub 2010 Apr 14 doi: 10.1016/j.diabres.2010.03.018. PMID: 20392509
Increased urinary orosomucoid excretion is not related to impaired renal function in patients with type 2 diabetes.
Christiansen MS, Hommel E, Friberg L, Mølvig J, Magid E, Feldt-Rasmussen B
J Diabetes Complications 2010 Jan-Feb;24(1):28-36. Epub 2008 Sep 25 doi: 10.1016/j.jdiacomp.2008.08.001. PMID: 18818101
Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes.
Christiansen MS, Iversen K, Larsen CT, Goetze JP, Hommel E, Mølvig J, Pedersen BK, Magid E, Feldt-Rasmussen B
Scand J Clin Lab Invest 2009;69(2):272-81. doi: 10.1080/00365510802531100. PMID: 18972260
Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes.
Christiansen MS, Hommel E, Magid E, Feldt-Rasmussen B
Diabetologia 2002 Jan;45(1):115-20. doi: 10.1007/s125-002-8251-3. PMID: 11845230

Clinical prediction guides

Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up.
Svendstrup M, Christiansen MS, Magid E, Hommel E, Feldt-Rasmussen B
J Diabetes Complications 2013 Nov-Dec;27(6):570-5. Epub 2013 Aug 8 doi: 10.1016/j.jdiacomp.2013.05.008. PMID: 23932410
Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes.
Christiansen MS, Hesse D, Ekbom P, Hesse U, Damm P, Hommel E, Feldt-Rasmussen B, Mathiesen E
Diabetes Res Clin Pract 2010 Jul;89(1):16-21. Epub 2010 Apr 14 doi: 10.1016/j.diabres.2010.03.018. PMID: 20392509
Increased urinary orosomucoid excretion is not related to impaired renal function in patients with type 2 diabetes.
Christiansen MS, Hommel E, Friberg L, Mølvig J, Magid E, Feldt-Rasmussen B
J Diabetes Complications 2010 Jan-Feb;24(1):28-36. Epub 2008 Sep 25 doi: 10.1016/j.jdiacomp.2008.08.001. PMID: 18818101
Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes.
Christiansen MS, Iversen K, Larsen CT, Goetze JP, Hommel E, Mølvig J, Pedersen BK, Magid E, Feldt-Rasmussen B
Scand J Clin Lab Invest 2009;69(2):272-81. doi: 10.1080/00365510802531100. PMID: 18972260
Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes.
Christiansen MS, Hommel E, Magid E, Feldt-Rasmussen B
Diabetologia 2002 Jan;45(1):115-20. doi: 10.1007/s125-002-8251-3. PMID: 11845230

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