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Increased proportion of plasmablasts

MedGen UID:
1693971
Concept ID:
C5139148
Finding
HPO: HP:0032128

Definition

An elevation above the normal proportion of plasmablasts in circulation relative to total number of B cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of plasmablasts

Professional guidelines

PubMed

Schrezenmeier E, Rincon-Arevalo H, Jens A, Stefanski AL, Hammett C, Osmanodja B, Koch N, Zukunft B, Beck J, Oellerich M, Proß V, Stahl C, Choi M, Bachmann F, Liefeldt L, Glander P, Schütz E, Bornemann-Kolatzki K, López Del Moral C, Schrezenmeier H, Ludwig C, Jahrsdörfer B, Eckardt KU, Lachmann N, Kotsch K, Dörner T, Halleck F, Sattler A, Budde K
JCI Insight 2022 May 9;7(9) doi: 10.1172/jci.insight.157836. PMID: 35349490Free PMC Article
Jiao L, Xiang Y, Li S, Zhang F, Ruan X, Guo S
J Neuroimmunol 2020 Aug 15;345:577280. Epub 2020 Jun 5 doi: 10.1016/j.jneuroim.2020.577280. PMID: 32563125

Recent clinical studies

Etiology

Kopitar AN, Repas J, Janžič L, Bizjak M, Vesel TT, Emeršič N, Avramovič MZ, Ihan A, Avčin T, Pavlin M
Front Immunol 2023;14:1157702. Epub 2023 Apr 20 doi: 10.3389/fimmu.2023.1157702. PMID: 37153551Free PMC Article
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article
Oniszczuk J, Beldi-Ferchiou A, Audureau E, Azzaoui I, Molinier-Frenkel V, Frontera V, Karras A, Moktefi A, Pillebout E, Zaidan M, El Karoui K, Delfau-Larue MH, Hénique C, Ollero M, Sahali D, Mahévas M, Audard V
Nephrol Dial Transplant 2021 Mar 29;36(4):609-617. doi: 10.1093/ndt/gfaa279. PMID: 33241414
Jiao L, Xiang Y, Li S, Zhang F, Ruan X, Guo S
J Neuroimmunol 2020 Aug 15;345:577280. Epub 2020 Jun 5 doi: 10.1016/j.jneuroim.2020.577280. PMID: 32563125

Diagnosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Testera-Montes A, Palomares F, Jurado-Escobar R, Fernandez-Santamaria R, Ariza A, Verge J, Salas M, Campo P, Mayorga C, Torres MJ, Rondon C, Eguiluz-Gracia I
Allergy 2022 Sep;77(9):2712-2724. Epub 2022 Apr 8 doi: 10.1111/all.15292. PMID: 35340036
Liu J, Qu Z, Chen H, Sun W, Jiang Y
Int Immunopharmacol 2021 Sep;98:107839. Epub 2021 Jun 8 doi: 10.1016/j.intimp.2021.107839. PMID: 34111735
Oniszczuk J, Beldi-Ferchiou A, Audureau E, Azzaoui I, Molinier-Frenkel V, Frontera V, Karras A, Moktefi A, Pillebout E, Zaidan M, El Karoui K, Delfau-Larue MH, Hénique C, Ollero M, Sahali D, Mahévas M, Audard V
Nephrol Dial Transplant 2021 Mar 29;36(4):609-617. doi: 10.1093/ndt/gfaa279. PMID: 33241414
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article

Therapy

Raqib R, Akhtar E, Ahsanul Haq M, Ahmed S, Haque F, Chowdhury MAH, Shahriar MH, Begum BA, Eunus M, Sarwar G, Parvez F, Sharker Y, Ahsan H, Yunus M
Environ Int 2023 Sep;179:108137. Epub 2023 Aug 9 doi: 10.1016/j.envint.2023.108137. PMID: 37579572
Merrill JT, Guthridge J, Smith M, June J, Koumpouras F, Machua W, Askanase A, Khosroshahi A, Sheikh SZ, Rathi G, Burington B, Foster P, Matijevic M, Arora S, Wang X, Gao M, Wax S, James JA, Zack DJ
Arthritis Rheumatol 2023 Dec;75(12):2185-2194. doi: 10.1002/art.42652. PMID: 37459248
Lin C, DiCioccio RA, Haykal T, McManigle WC, Li Z, Anand SM, Poe JC, Bracken SJ, Jia W, Alyea EP 3rd, Cardones AR, Choi T, Gasparetto C, Grunwald MR, Hennig T, Kang Y, Long GD, Lopez R, Martin M, Minor KK, Quinones VLP, Sung AD, Wiggins K, Chao NJ, Horwitz ME, Rizzieri DA, Sarantopoulos S
Transplant Cell Ther 2023 Mar;29(3):179.e1-179.e10. Epub 2022 Dec 25 doi: 10.1016/j.jtct.2022.12.015. PMID: 36577483Free PMC Article
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article

Prognosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Kopitar AN, Repas J, Janžič L, Bizjak M, Vesel TT, Emeršič N, Avramovič MZ, Ihan A, Avčin T, Pavlin M
Front Immunol 2023;14:1157702. Epub 2023 Apr 20 doi: 10.3389/fimmu.2023.1157702. PMID: 37153551Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Jiao L, Xiang Y, Li S, Zhang F, Ruan X, Guo S
J Neuroimmunol 2020 Aug 15;345:577280. Epub 2020 Jun 5 doi: 10.1016/j.jneuroim.2020.577280. PMID: 32563125

Clinical prediction guides

Lu C, Li S, Qing P, Zhang Q, Ji X, Tang Z, Chen C, Wu T, Hu Y, Zhao Y, Zhang X, He Q, Fox DA, Tan C, Luo Y, Liu Y
JCI Insight 2023 Sep 8;8(17) doi: 10.1172/jci.insight.167602. PMID: 37561593Free PMC Article
Shimojima Y, Kishida D, Ichikawa T, Takamatsu R, Nomura S, Sekijima Y
Clin Exp Immunol 2023 Jul 5;213(1):125-137. doi: 10.1093/cei/uxad024. PMID: 36794867Free PMC Article
Lin C, DiCioccio RA, Haykal T, McManigle WC, Li Z, Anand SM, Poe JC, Bracken SJ, Jia W, Alyea EP 3rd, Cardones AR, Choi T, Gasparetto C, Grunwald MR, Hennig T, Kang Y, Long GD, Lopez R, Martin M, Minor KK, Quinones VLP, Sung AD, Wiggins K, Chao NJ, Horwitz ME, Rizzieri DA, Sarantopoulos S
Transplant Cell Ther 2023 Mar;29(3):179.e1-179.e10. Epub 2022 Dec 25 doi: 10.1016/j.jtct.2022.12.015. PMID: 36577483Free PMC Article
Bao W, Xie M, Ye Y
Cell Immunol 2022 Jul;377:104533. Epub 2022 May 6 doi: 10.1016/j.cellimm.2022.104533. PMID: 35594728
Testera-Montes A, Palomares F, Jurado-Escobar R, Fernandez-Santamaria R, Ariza A, Verge J, Salas M, Campo P, Mayorga C, Torres MJ, Rondon C, Eguiluz-Gracia I
Allergy 2022 Sep;77(9):2712-2724. Epub 2022 Apr 8 doi: 10.1111/all.15292. PMID: 35340036

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