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Increased urinary neutrophil gelatinase-associated lipocalin

MedGen UID:
1694915
•Concept ID:
C5208041
•
Finding
Synonym: Increased urinary NGAL
 
HPO: HP:0020130

Definition

An increased concentration of neutrophil gelatinase-associated lipocalin in the urine (there is no generally accepted threshold, but some studies choose a threshold of above 150 nanogram per milliliter). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary neutrophil gelatinase-associated lipocalin

Professional guidelines

PubMed

Assessment of urinary NGAL for differential diagnosis and progression of diabetic kidney disease.
Duan S, Chen J, Wu L, Nie G, Sun L, Zhang C, Huang Z, Xing C, Zhang B, Yuan Y
J Diabetes Complications 2020 Oct;34(10):107665. Epub 2020 Jun 26 doi: 10.1016/j.jdiacomp.2020.107665. PMID: 32653382
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
The clinical utility of urinary neutrophil gelatinase-associated lipocalin in the neonatal ICU.
Parravicini E
Curr Opin Pediatr 2010 Apr;22(2):146-50. doi: 10.1097/MOP.0b013e3283369e78. PMID: 20061951

Recent clinical studies

Etiology

Increased urinary neutrophil gelatinase-associated lipocalin in very-low-birth-weight infants with oliguria and normal serum creatinine.
Shin SY, Ha JY, Lee SL, Lee WM, Park JH
Pediatr Nephrol 2017 Jun;32(6):1059-1065. Epub 2017 Jan 12 doi: 10.1007/s00467-016-3572-5. PMID: 28083702
Urinary Neutrophil Gelatinase-Associated Lipocalin Predicts Renal Injury Following Extracorporeal Membrane Oxygenation.
Zwiers AJ, Cransberg K, de Rijke YB, van Rosmalen J, Tibboel D, de Wildt SN
Pediatr Crit Care Med 2015 Sep;16(7):663-70. doi: 10.1097/PCC.0000000000000476. PMID: 26121099
Lack of renal protection of ultrafiltration during cardiac surgery: a randomized clinical trial.
Foroughi M, Argani H, Hassntash SA, Hekmat M, Majidi M, Beheshti M, Mehdizadeh B, Yekani B
J Cardiovasc Surg (Torino) 2014 Jun;55(3):407-13. Epub 2013 Nov 5 PMID: 24189519

Diagnosis

Increased urinary neutrophil gelatinase-associated lipocalin in very-low-birth-weight infants with oliguria and normal serum creatinine.
Shin SY, Ha JY, Lee SL, Lee WM, Park JH
Pediatr Nephrol 2017 Jun;32(6):1059-1065. Epub 2017 Jan 12 doi: 10.1007/s00467-016-3572-5. PMID: 28083702
Urinary Neutrophil Gelatinase-Associated Lipocalin Predicts Renal Injury Following Extracorporeal Membrane Oxygenation.
Zwiers AJ, Cransberg K, de Rijke YB, van Rosmalen J, Tibboel D, de Wildt SN
Pediatr Crit Care Med 2015 Sep;16(7):663-70. doi: 10.1097/PCC.0000000000000476. PMID: 26121099
Lack of renal protection of ultrafiltration during cardiac surgery: a randomized clinical trial.
Foroughi M, Argani H, Hassntash SA, Hekmat M, Majidi M, Beheshti M, Mehdizadeh B, Yekani B
J Cardiovasc Surg (Torino) 2014 Jun;55(3):407-13. Epub 2013 Nov 5 PMID: 24189519

Therapy

Urinary Neutrophil Gelatinase-Associated Lipocalin Predicts Renal Injury Following Extracorporeal Membrane Oxygenation.
Zwiers AJ, Cransberg K, de Rijke YB, van Rosmalen J, Tibboel D, de Wildt SN
Pediatr Crit Care Med 2015 Sep;16(7):663-70. doi: 10.1097/PCC.0000000000000476. PMID: 26121099
Lack of renal protection of ultrafiltration during cardiac surgery: a randomized clinical trial.
Foroughi M, Argani H, Hassntash SA, Hekmat M, Majidi M, Beheshti M, Mehdizadeh B, Yekani B
J Cardiovasc Surg (Torino) 2014 Jun;55(3):407-13. Epub 2013 Nov 5 PMID: 24189519

Prognosis

Urinary Neutrophil Gelatinase-Associated Lipocalin Predicts Renal Injury Following Extracorporeal Membrane Oxygenation.
Zwiers AJ, Cransberg K, de Rijke YB, van Rosmalen J, Tibboel D, de Wildt SN
Pediatr Crit Care Med 2015 Sep;16(7):663-70. doi: 10.1097/PCC.0000000000000476. PMID: 26121099
Lack of renal protection of ultrafiltration during cardiac surgery: a randomized clinical trial.
Foroughi M, Argani H, Hassntash SA, Hekmat M, Majidi M, Beheshti M, Mehdizadeh B, Yekani B
J Cardiovasc Surg (Torino) 2014 Jun;55(3):407-13. Epub 2013 Nov 5 PMID: 24189519

Clinical prediction guides

Increased urinary neutrophil gelatinase-associated lipocalin in very-low-birth-weight infants with oliguria and normal serum creatinine.
Shin SY, Ha JY, Lee SL, Lee WM, Park JH
Pediatr Nephrol 2017 Jun;32(6):1059-1065. Epub 2017 Jan 12 doi: 10.1007/s00467-016-3572-5. PMID: 28083702
Urinary Neutrophil Gelatinase-Associated Lipocalin Predicts Renal Injury Following Extracorporeal Membrane Oxygenation.
Zwiers AJ, Cransberg K, de Rijke YB, van Rosmalen J, Tibboel D, de Wildt SN
Pediatr Crit Care Med 2015 Sep;16(7):663-70. doi: 10.1097/PCC.0000000000000476. PMID: 26121099
Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia.
Decavele AS, Dhondt L, De Buyzere ML, Delanghe JR
Clin Chem Lab Med 2011 Jun;49(6):999-1003. Epub 2011 Mar 11 doi: 10.1515/CCLM.2011.156. PMID: 21391867

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