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Increased circulating creatine kinase BB isoform

MedGen UID:
1696135
•Concept ID:
C5139212
•
Finding
Synonym: Increased circulating CK BB isoform
 
HPO: HP:0032233

Definition

An increased concentration of the BB isoform of creatine kinase in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating creatine kinase BB isoform

Recent clinical studies

Etiology

Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction.
Peterzan MA, Clarke WT, Lygate CA, Lake HA, Lau JYC, Miller JJ, Johnson E, Rayner JJ, Hundertmark MJ, Sayeed R, Petrou M, Krasopoulos G, Srivastava V, Neubauer S, Rodgers CT, Rider OJ
Circulation 2020 Jun 16;141(24):1971-1985. Epub 2020 May 22 doi: 10.1161/CIRCULATIONAHA.119.043450. PMID: 32438845Free PMC Article
Brain protection via cerebral retrograde perfusion during aortic arch aneurysm repair.
Safi HJ, Brien HW, Winter JN, Thomas AC, Maulsby RL, Doerr HK, Svensson LG
Ann Thorac Surg 1993 Aug;56(2):270-6. doi: 10.1016/0003-4975(93)91158-j. PMID: 8347008
No flow or low flow? A study of the ischemic marker creatine kinase BB after deep hypothermic procedures.
Rossi R, van der Linden J, Ekroth R, Scallan M, Thompson RJ, Lincoln C
J Thorac Cardiovasc Surg 1989 Aug;98(2):193-9. PMID: 2502690
Detection of cerebral injury after total circulatory arrest and profound hypothermia by estimation of specific creatine kinase isoenzyme levels using monoclonal antibody techniques.
Rossi R, Ekroth R, Lincoln C, Jackson AP, Thompson RJ, Scallan M, Tsang V
Am J Cardiol 1986 Dec 1;58(13):1236-41. doi: 10.1016/0002-9149(86)90389-9. PMID: 3788813
Observed activities of serum creatine kinase: total and B subunit activity and other enzymes in young persons abusing solvents.
Spooner RJ, Birrell RC, McLelland AS, Baird JA, Sourindhrin I
J Clin Pathol 1984 Apr;37(4):455-9. doi: 10.1136/jcp.37.4.455. PMID: 6142904Free PMC Article

Diagnosis

Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction.
Peterzan MA, Clarke WT, Lygate CA, Lake HA, Lau JYC, Miller JJ, Johnson E, Rayner JJ, Hundertmark MJ, Sayeed R, Petrou M, Krasopoulos G, Srivastava V, Neubauer S, Rodgers CT, Rider OJ
Circulation 2020 Jun 16;141(24):1971-1985. Epub 2020 May 22 doi: 10.1161/CIRCULATIONAHA.119.043450. PMID: 32438845Free PMC Article
Creatine kinase brain isoenzyme (BB-CK) presence in serum distinguishes osteopetroses among the sclerosing bone disorders.
Whyte MP, Chines A, Silva DP Jr, Landt Y, Ladenson JH
J Bone Miner Res 1996 Oct;11(10):1438-43. doi: 10.1002/jbmr.5650111010. PMID: 8889843
Detection of cerebral injury after total circulatory arrest and profound hypothermia by estimation of specific creatine kinase isoenzyme levels using monoclonal antibody techniques.
Rossi R, Ekroth R, Lincoln C, Jackson AP, Thompson RJ, Scallan M, Tsang V
Am J Cardiol 1986 Dec 1;58(13):1236-41. doi: 10.1016/0002-9149(86)90389-9. PMID: 3788813
Elevated CK-MB and CK-BB in serum and tumor homogenate of a patient with lung cancer.
Lee BI, Bach PM, Horton JD, Hickey TM, Davis WA
Clin Cardiol 1985 Apr;8(4):233-6. doi: 10.1002/clc.4960080409. PMID: 2985311
Creatine kinase BB: a new tumor-associated marker.
Silverman LM, Dermer GB, Zweig MH, Van Steirteghem AC, Tökés ZA
Clin Chem 1979 Aug;25(8):1432-5. PMID: 455680

Therapy

No flow or low flow? A study of the ischemic marker creatine kinase BB after deep hypothermic procedures.
Rossi R, van der Linden J, Ekroth R, Scallan M, Thompson RJ, Lincoln C
J Thorac Cardiovasc Surg 1989 Aug;98(2):193-9. PMID: 2502690
Detection of cerebral injury after total circulatory arrest and profound hypothermia by estimation of specific creatine kinase isoenzyme levels using monoclonal antibody techniques.
Rossi R, Ekroth R, Lincoln C, Jackson AP, Thompson RJ, Scallan M, Tsang V
Am J Cardiol 1986 Dec 1;58(13):1236-41. doi: 10.1016/0002-9149(86)90389-9. PMID: 3788813

Prognosis

Effects of acidosis on the activity of creatine phosphokinase and its isoenzymes in the serum of newborn infants.
Warburton D, Singer DB, Oh W
Pediatrics 1981 Aug;68(2):195-7. PMID: 7267225
Creatine kinase BB: a new tumor-associated marker.
Silverman LM, Dermer GB, Zweig MH, Van Steirteghem AC, Tökés ZA
Clin Chem 1979 Aug;25(8):1432-5. PMID: 455680

Clinical prediction guides

Observed activities of serum creatine kinase: total and B subunit activity and other enzymes in young persons abusing solvents.
Spooner RJ, Birrell RC, McLelland AS, Baird JA, Sourindhrin I
J Clin Pathol 1984 Apr;37(4):455-9. doi: 10.1136/jcp.37.4.455. PMID: 6142904Free PMC Article
Circulating CK-MB and CK-BB isoenzyme after gastrointestinal surgery.
Tsung SH
J Clin Pathol 1982 Feb;35(2):200-3. doi: 10.1136/jcp.35.2.200. PMID: 7068911Free PMC Article
Effects of acidosis on the activity of creatine phosphokinase and its isoenzymes in the serum of newborn infants.
Warburton D, Singer DB, Oh W
Pediatrics 1981 Aug;68(2):195-7. PMID: 7267225
Creatine kinase BB: a new tumor-associated marker.
Silverman LM, Dermer GB, Zweig MH, Van Steirteghem AC, Tökés ZA
Clin Chem 1979 Aug;25(8):1432-5. PMID: 455680

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