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Abnormal circulating enzyme concentration

MedGen UID:
869169
•Concept ID:
C4023591
•
Finding
Synonym: Abnormality of circulating enzyme level
 
HPO: HP:0011021

Definition

The concentration or activity of an enzyme in the blood circulation is outside of the limits of the normal range. [from HPO]

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview.
Kirkegaard I, Uldbjerg N, Oxvig C
Acta Obstet Gynecol Scand 2010 Sep;89(9):1118-25. doi: 10.3109/00016349.2010.505639. PMID: 20804336
Congenital blood coagulation factor XIII deficiency and perinatal management.
Ichinose A, Asahina T, Kobayashi T
Curr Drug Targets 2005 Aug;6(5):541-9. doi: 10.2174/1389450054545953. PMID: 16026274

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
The role of sulfated steroid hormones in reproductive processes.
Geyer J, Bakhaus K, Bernhardt R, Blaschka C, Dezhkam Y, Fietz D, Grosser G, Hartmann K, Hartmann MF, Neunzig J, Papadopoulos D, Sánchez-Guijo A, Scheiner-Bobis G, Schuler G, Shihan M, Wrenzycki C, Wudy SA, Bergmann M
J Steroid Biochem Mol Biol 2017 Sep;172:207-221. Epub 2016 Jul 5 doi: 10.1016/j.jsbmb.2016.07.002. PMID: 27392637
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol.
Poirier S, Mayer G
Drug Des Devel Ther 2013;7:1135-48. Epub 2013 Oct 4 doi: 10.2147/DDDT.S36984. PMID: 24115837Free PMC Article
Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
Obeid R, Holzgreve W, Pietrzik K
J Perinat Med 2013 Sep 1;41(5):469-83. doi: 10.1515/jpm-2012-0256. PMID: 23482308
Role of bile acid measurement in pregnancy.
Walker IA, Nelson-Piercy C, Williamson C
Ann Clin Biochem 2002 Mar;39(Pt 2):105-13. doi: 10.1258/0004563021901856. PMID: 11928758

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Prenatal sonographic features of fetuses in trisomy 13 pregnancies. IV.
Chen CP
Taiwan J Obstet Gynecol 2010 Mar;49(1):3-12. doi: 10.1016/S1028-4559(10)60002-2. PMID: 20466286
The pharmacology of letrozole.
Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS
J Steroid Biochem Mol Biol 2003 Oct;87(1):35-45. doi: 10.1016/s0960-0760(03)00384-4. PMID: 14630089
Normotensive primary aldosteronism.
Shiroto H, Ando H, Ebitani I, Hara M, Numazawa K, Kawamura S, Sasaki H
Am J Med 1980 Oct;69(4):603-6. doi: 10.1016/0002-9343(80)90474-x. PMID: 6999899

Therapy

Abnormal glucose metabolism and galactose-deficient immunoglobulin A1 (IgA1) synthesis: a possible mechanism of IgA nephropathy.
Lai L, Liu T, Yan M, Shang D, Qian J, Hao C, Xue J
Discov Med 2019 Jul;28(151):39-45. PMID: 31465724
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
Obeid R, Holzgreve W, Pietrzik K
J Perinat Med 2013 Sep 1;41(5):469-83. doi: 10.1515/jpm-2012-0256. PMID: 23482308
Obstructive nephropathy.
Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173
Catecholamine levels and treatment in chronic heart failure.
Anker SD
Eur Heart J 1998 Jun;19 Suppl F:F56-61. PMID: 9651737

Prognosis

Lower levels of α-Klotho in serum are associated with decreased lung function in individuals with interstitial lung abnormalities.
Buendia-Roldan I, Machuca N, Mejía M, Maldonado M, Pardo A, Selman M
Sci Rep 2019 Jul 25;9(1):10801. doi: 10.1038/s41598-019-47199-0. PMID: 31346213Free PMC Article
The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy.
Chambers AE, Mills WE, Mercadé I, Crovetto F, Crispi F, Bodi LR, Pugia M, Mira A, Lasalvia L, Banerjee S, Casals E, Gratacos E
BMC Pregnancy Childbirth 2014 Jun 6;14:197. doi: 10.1186/1471-2393-14-197. PMID: 24906955Free PMC Article
Circulating levels of HER-2/neu oncoprotein in breast cancer.
Molina R, Escudero JM, Muñoz M, Augé JM, Filella X
Clin Chem Lab Med 2012 Jan 4;50(1):5-21. doi: 10.1515/cclm.2011.822. PMID: 22505536
Catecholamine levels and treatment in chronic heart failure.
Anker SD
Eur Heart J 1998 Jun;19 Suppl F:F56-61. PMID: 9651737
Renal impairment in chronic cigarette smokers.
Gambaro G, Verlato F, Budakovic A, Casara D, Saladini G, Del Prete D, Bertaglia G, Masiero M, Checchetto S, Baggio B
J Am Soc Nephrol 1998 Apr;9(4):562-7. doi: 10.1681/ASN.V94562. PMID: 9555657

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.
Blass BE, Iyer P, Abou-Gharbia M, Childers WE, Gordon JC, Ramanjulu M, Morton G, Arumugam P, Boruwa J, Ellingboe J, Mitra S, Nimmareddy RR, Paliwal S, Rajasekhar J, Shivakumar S, Srivastava P, Tangirala RS, Venkataramanaiah K, Yanamandra M
Bioorg Med Chem Lett 2016 Dec 1;26(23):5825-5829. Epub 2016 Oct 10 doi: 10.1016/j.bmcl.2016.10.016. PMID: 27789139
Catecholamine levels and treatment in chronic heart failure.
Anker SD
Eur Heart J 1998 Jun;19 Suppl F:F56-61. PMID: 9651737
Epidemiological evidence associating dietary calcium and calcium metabolism with blood pressure.
McCarron DA, Morris CD
Am J Nephrol 1986;6 Suppl 1:3-9. doi: 10.1159/000167206. PMID: 2950755
Pathogenetic aspects of hypertension in Cushing's syndrome.
Tenschert W, Baumgart P, Greminger P, Vetter W, Vetter H
Cardiology 1985;72 Suppl 1:84-90. doi: 10.1159/000173950. PMID: 3902234

Recent systematic reviews

Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.
Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
Hum Reprod Update 2013 May-Jun;19(3):268-88. Epub 2013 Jan 9 doi: 10.1093/humupd/dms059. PMID: 23303572

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