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Decreased circulating corticosterone level

MedGen UID:
1696313
•Concept ID:
C5139296
•
Finding
HPO: HP:0032363

Definition

An abnormally reduced concentration of corticosterone in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating corticosterone level

Recent clinical studies

Etiology

Sex and disease severity-based analysis of steroid hormones in ME/CFS.
Pipper C, Bliem L, León LE, Mennickent D, Bodner C, Guzmán-Gutiérrez E, Stingl M, Untersmayr E, Wagner B, Bertinat R, Sepúlveda N, Westermeier F
J Endocrinol Invest 2024 Sep;47(9):2235-2248. Epub 2024 May 10 doi: 10.1007/s40618-024-02334-1. PMID: 38724880Free PMC Article
Impact of age, body weight and metabolic risk factors on steroid reference intervals in men.
Mezzullo M, Di Dalmazi G, Fazzini A, Baccini M, Repaci A, Gambineri A, Vicennati V, Pelusi C, Pagotto U, Fanelli F
Eur J Endocrinol 2020 May;182(5):459-471. doi: 10.1530/EJE-19-0928. PMID: 32130202
Acute Statin Administration Reduces Levels of Steroid Hormone Precursors.
London E, Tatsi C, Soldin SJ, Wassif CA, Backlund P, Ng D, Biesecker LG, Stratakis CA
Horm Metab Res 2020 Oct;52(10):742-746. Epub 2020 Feb 10 doi: 10.1055/a-1099-9556. PMID: 32040961Free PMC Article
Resetting the Stress System with a Mifepristone Challenge.
Dalm S, Karssen AM, Meijer OC, Belanoff JK, de Kloet ER
Cell Mol Neurobiol 2019 May;39(4):503-522. Epub 2018 Sep 1 doi: 10.1007/s10571-018-0614-5. PMID: 30173378Free PMC Article
Stress and cocaine addiction.
Goeders NE
J Pharmacol Exp Ther 2002 Jun;301(3):785-9. doi: 10.1124/jpet.301.3.785. PMID: 12023504

Diagnosis

Impact of age, body weight and metabolic risk factors on steroid reference intervals in men.
Mezzullo M, Di Dalmazi G, Fazzini A, Baccini M, Repaci A, Gambineri A, Vicennati V, Pelusi C, Pagotto U, Fanelli F
Eur J Endocrinol 2020 May;182(5):459-471. doi: 10.1530/EJE-19-0928. PMID: 32130202
Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex.
Pronko SP, Saba LM, Hoffman PL, Tabakoff B
J Pharmacol Exp Ther 2010 Jul;334(1):44-52. Epub 2010 Apr 2 doi: 10.1124/jpet.110.166793. PMID: 20363852Free PMC Article
Stress and cocaine addiction.
Goeders NE
J Pharmacol Exp Ther 2002 Jun;301(3):785-9. doi: 10.1124/jpet.301.3.785. PMID: 12023504
The HPA axis and cocaine reinforcement.
Goeders NE
Psychoneuroendocrinology 2002 Jan-Feb;27(1-2):13-33. doi: 10.1016/s0306-4530(01)00034-8. PMID: 11750768
Regulation of pituitary ACTH secretion during chronic stress.
Aguilera G
Front Neuroendocrinol 1994 Dec;15(4):321-50. doi: 10.1006/frne.1994.1013. PMID: 7895891

Therapy

Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production.
Xu J, Shao X, Zeng H, Wang C, Li J, Peng X, Zhuo Y, Hua L, Meng F, Han X
Int J Mol Sci 2023 Oct 5;24(19) doi: 10.3390/ijms241914922. PMID: 37834368Free PMC Article
Cigarette smoke-induced pulmonary impairment is associated with social recognition memory impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus.
De Luca SN, Chan SMH, Dobric A, Wang H, Seow HJ, Brassington K, Mou K, Alateeq R, Akhtar A, Bozinovski S, Vlahos R
Brain Behav Immun 2023 Mar;109:292-307. Epub 2023 Feb 10 doi: 10.1016/j.bbi.2023.02.005. PMID: 36775074
Ferulic acid inhibits catamenial epilepsy through modulation of female hormones.
Dhillon HK, Singh T, Goel RK
Metab Brain Dis 2022 Dec;37(8):2827-2838. Epub 2022 Aug 6 doi: 10.1007/s11011-022-01054-w. PMID: 35932441
Stress and cocaine addiction.
Goeders NE
J Pharmacol Exp Ther 2002 Jun;301(3):785-9. doi: 10.1124/jpet.301.3.785. PMID: 12023504
The effects of steroids upon the gastrointestinal tract.
Black HE
Toxicol Pathol 1988;16(2):213-22. doi: 10.1177/019262338801600214. PMID: 3055231

Prognosis

Increased lead and glucocorticoid concentrations reduce reproductive success in house sparrows along an urban gradient.
White JH, Heppner JJ, Ouyang JQ
Ecol Appl 2022 Dec;32(8):e2688. Epub 2022 Jul 27 doi: 10.1002/eap.2688. PMID: 35754197Free PMC Article
Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways.
Preston E, Cooney GJ, Wilks D, Baran K, Zhang L, Kraegen EW, Sainsbury A
Neuropeptides 2011 Dec;45(6):407-15. Epub 2011 Aug 20 doi: 10.1016/j.npep.2011.07.009. PMID: 21862125
Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium.
Elabida B, Edwards A, Salhi A, Azroyan A, Fodstad H, Meneton P, Doucet A, Bloch-Faure M, Crambert G
Kidney Int 2011 Aug;80(3):256-62. Epub 2011 Feb 16 doi: 10.1038/ki.2011.15. PMID: 21326170
Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex.
Pronko SP, Saba LM, Hoffman PL, Tabakoff B
J Pharmacol Exp Ther 2010 Jul;334(1):44-52. Epub 2010 Apr 2 doi: 10.1124/jpet.110.166793. PMID: 20363852Free PMC Article
11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects.
Edwards CR, Benediktsson R, Lindsay RS, Seckl JR
Steroids 1996 Apr;61(4):263-9. doi: 10.1016/0039-128x(96)00033-5. PMID: 8733012

Clinical prediction guides

Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function.
De Bruyn L, Téblick A, Van Oudenhove T, Vander Perre S, Derese I, Pauwels L, Derde S, De Vlieger G, Van den Berghe G, Langouche L
Crit Care 2024 Sep 5;28(1):295. doi: 10.1186/s13054-024-05079-8. PMID: 39238038Free PMC Article
Increased lead and glucocorticoid concentrations reduce reproductive success in house sparrows along an urban gradient.
White JH, Heppner JJ, Ouyang JQ
Ecol Appl 2022 Dec;32(8):e2688. Epub 2022 Jul 27 doi: 10.1002/eap.2688. PMID: 35754197Free PMC Article
Acute Statin Administration Reduces Levels of Steroid Hormone Precursors.
London E, Tatsi C, Soldin SJ, Wassif CA, Backlund P, Ng D, Biesecker LG, Stratakis CA
Horm Metab Res 2020 Oct;52(10):742-746. Epub 2020 Feb 10 doi: 10.1055/a-1099-9556. PMID: 32040961Free PMC Article
Physiological and behavioral responses to observing a sibling experience a direct stressor in prairie voles.
Wardwell J, Watanasriyakul WT, Normann MC, Akinbo OI, McNeal N, Ciosek S, Cox M, Holzapfel N, Sujet S, Grippo AJ
Stress 2020 Jul;23(4):444-456. Epub 2020 Feb 17 doi: 10.1080/10253890.2020.1724950. PMID: 32008380Free PMC Article
The effects of steroids upon the gastrointestinal tract.
Black HE
Toxicol Pathol 1988;16(2):213-22. doi: 10.1177/019262338801600214. PMID: 3055231

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