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Abnormal circulating corticosterone level

MedGen UID:
868637
•Concept ID:
C4023037
•
Finding
Synonym: Abnormality of circulating corticosterone level
 
HPO: HP:0012112

Definition

An abnormality of the concentration of corticosterone in the blood. [from HPO]

Professional guidelines

PubMed

Steroid metabolism gene variants and their genotype-phenotype correlations in Chinese early-onset hypertension patients.
Qin F, Liu K, Zhang C, Sun X, Zhang Y, Wu Y, Ma W, Wang W, Wu X, Qin Y, Zou Y, Zhou X, Jiang X, Wu H, Hui R, Wang J, Zhang H, Song L
Hypertens Res 2019 Oct;42(10):1536-1543. Epub 2019 Aug 6 doi: 10.1038/s41440-019-0306-7. PMID: 31388123

Recent clinical studies

Diagnosis

Steroid metabolism gene variants and their genotype-phenotype correlations in Chinese early-onset hypertension patients.
Qin F, Liu K, Zhang C, Sun X, Zhang Y, Wu Y, Ma W, Wang W, Wu X, Qin Y, Zou Y, Zhou X, Jiang X, Wu H, Hui R, Wang J, Zhang H, Song L
Hypertens Res 2019 Oct;42(10):1536-1543. Epub 2019 Aug 6 doi: 10.1038/s41440-019-0306-7. PMID: 31388123
Ashwagandha root in the treatment of non-classical adrenal hyperplasia.
Kalani A, Bahtiyar G, Sacerdote A
BMJ Case Rep 2012 Sep 17;2012 doi: 10.1136/bcr-2012-006989. PMID: 22987912Free PMC Article
The role of 11β-hydroxysteroid dehydrogenase type 2 in human hypertension.
Ferrari P
Biochim Biophys Acta 2010 Dec;1802(12):1178-87. Epub 2009 Nov 10 doi: 10.1016/j.bbadis.2009.10.017. PMID: 19909806
Hypertension due to 17alpha-hydroxylase deficiency.
Wang C, Yeung RT, Coghlan JP, Oddie CJ, Scoggins BA, Stockigt JR
Aust N Z J Med 1978 Jun;8(3):295-9. doi: 10.1111/j.1445-5994.1978.tb04528.x. PMID: 308800

Therapy

Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production.
Xu J, Shao X, Zeng H, Wang C, Li J, Peng X, Zhuo Y, Hua L, Meng F, Han X
Int J Mol Sci 2023 Oct 5;24(19) doi: 10.3390/ijms241914922. PMID: 37834368Free PMC Article
Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease.
Dufour BD, McBride JL
Exp Neurol 2016 Sep;283(Pt A):308-17. Epub 2016 Jul 2 doi: 10.1016/j.expneurol.2016.06.028. PMID: 27381424Free PMC Article
The effects of steroids upon the gastrointestinal tract.
Black HE
Toxicol Pathol 1988;16(2):213-22. doi: 10.1177/019262338801600214. PMID: 3055231
Anaphylactic shock after synthetic adrenocorticotropin-(1-18) in a patient with isolated adrenocorticotropin and beta-lipotropin deficiency.
Hashimoto K, Takahara J, Takaya Y, Yunoki S, Ofuji T
J Clin Endocrinol Metab 1980 Nov;51(5):1175-9. doi: 10.1210/jcem-51-5-1175. PMID: 6252232

Prognosis

Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease.
Dufour BD, McBride JL
Exp Neurol 2016 Sep;283(Pt A):308-17. Epub 2016 Jul 2 doi: 10.1016/j.expneurol.2016.06.028. PMID: 27381424Free PMC Article

Clinical prediction guides

Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice.
Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H
Diabetes 2015 Jun;64(6):2194-206. Epub 2014 Dec 31 doi: 10.2337/db14-1192. PMID: 25552599
The effects of steroids upon the gastrointestinal tract.
Black HE
Toxicol Pathol 1988;16(2):213-22. doi: 10.1177/019262338801600214. PMID: 3055231

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