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Dedifferentiated Lesion

MedGen UID:
1696699
•Concept ID:
C5203962
•
Finding

Definition

A lesion composed of cells that have undergone transformation to less mature forms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDedifferentiated Lesion

Professional guidelines

PubMed

Treatment of De-Differentiated Liposarcoma in the Era of Immunotherapy.
Zhou MY, Bui NQ, Charville GW, Ganjoo KN, Pan M
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119571. PMID: 37298520Free PMC Article
Differential diagnosis of T2 hypointense masses in musculoskeletal MRI.
Finkelstein D, Foremny G, Singer A, Clifford P, Pretell-Mazzini J, Kerr DA, Subhawong TK
Skeletal Radiol 2021 Oct;50(10):1981-1994. Epub 2021 Mar 2 doi: 10.1007/s00256-021-03711-0. PMID: 33651128
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Recent clinical studies

Etiology

Chondrosarcoma.
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.
Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T
Nat Med 2019 Aug;25(8):1280-1289. Epub 2019 Jul 29 doi: 10.1038/s41591-019-0512-5. PMID: 31359001Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Diagnosis

Chordoma.
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Autologous Minced Cartilage Implantation for Treatment of Chondral and Osteochondral Lesions in the Knee Joint: An Overview.
Salzmann GM, Ossendorff R, Gilat R, Cole BJ
Cartilage 2021 Dec;13(1_suppl):1124S-1136S. Epub 2020 Jul 25 doi: 10.1177/1947603520942952. PMID: 32715735Free PMC Article
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article

Therapy

Research progress on flat epithelium of the inner ear.
He L, Guo JY, Liu K, Wang GP, Gong SS
Physiol Res 2020 Nov 16;69(5):775-785. Epub 2020 Sep 9 doi: 10.33549/physiolres.934447. PMID: 32901490Free PMC Article
Dedifferentiated gastrointestinal stromal tumor: Recent advances.
Karakas C, Christensen P, Baek D, Jung M, Ro JY
Ann Diagn Pathol 2019 Apr;39:118-124. Epub 2018 Dec 18 doi: 10.1016/j.anndiagpath.2018.12.005. PMID: 30661742
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer.
Tesselaar MH, Smit JW, Nagarajah J, Netea-Maier RT, Plantinga TS
J Mol Endocrinol 2017 Nov;59(4):R141-R154. Epub 2017 Sep 20 doi: 10.1530/JME-17-0134. PMID: 28931558
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Prognosis

Retroperitoneal and Mesenteric Liposarcomas.
Siew CCH, Apte SS, Baia M, Gyorki DE, Ford S, van Houdt WJ
Surg Oncol Clin N Am 2022 Jul;31(3):399-417. doi: 10.1016/j.soc.2022.03.005. PMID: 35715141
Chordoma.
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Chondrosarcoma.
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article

Clinical prediction guides

Differential diagnosis of T2 hypointense masses in musculoskeletal MRI.
Finkelstein D, Foremny G, Singer A, Clifford P, Pretell-Mazzini J, Kerr DA, Subhawong TK
Skeletal Radiol 2021 Oct;50(10):1981-1994. Epub 2021 Mar 2 doi: 10.1007/s00256-021-03711-0. PMID: 33651128
Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases.
Cao L, Wu Y, Han SM, Sun T, Yu BH, Gao F, Wu WJ, Gao BL
BMC Musculoskelet Disord 2021 Feb 15;22(1):189. doi: 10.1186/s12891-021-04053-7. PMID: 33588810Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Immunohistochemical Biomarkers in Thyroid Pathology.
Baloch Z, Mete O, Asa SL
Endocr Pathol 2018 Jun;29(2):91-112. doi: 10.1007/s12022-018-9532-9. PMID: 29744727
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371

Recent systematic reviews

How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration-A Systemic Review.
Borger A, Stadlmayr S, Haertinger M, Semmler L, Supper P, Millesi F, Radtke C
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073440. PMID: 35408800Free PMC Article
Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion: A case report and systematic literature review.
Xu L, Zhang M, Xu M
Medicine (Baltimore) 2019 May;98(20):e15482. doi: 10.1097/MD.0000000000015482. PMID: 31096446Free PMC Article
Intralesional vs. extralesional procedures for low-grade central chondrosarcoma: a systematic review of the literature.
Zoccali C, Baldi J, Attala D, Rossi B, Anelli V, Annovazzi A, Ferraresi V
Arch Orthop Trauma Surg 2018 Jul;138(7):929-937. Epub 2018 Apr 10 doi: 10.1007/s00402-018-2930-0. PMID: 29633075

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