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Acute Myeloid Leukemia with Trisomy 8

MedGen UID:
1696774
•Concept ID:
C5206816
•
Neoplastic Process

Definition

An acute myeloid leukemia with trisomy 8. Trisomy 8 is one of the most frequent occurring cytogenetic abnormalities in acute myeloid leukemia. It is grouped as intermediate risk in cytogenetic classifications of acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myeloid Leukemia with Trisomy 8

Professional guidelines

PubMed

Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients.
Xiong T, Xia L, Song Q
J Clin Lab Anal 2023 Feb;37(3):e24835. Epub 2023 Jan 16 doi: 10.1002/jcla.24835. PMID: 36644997Free PMC Article
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004.
Rasche M, von Neuhoff C, Dworzak M, Bourquin JP, Bradtke J, Göhring G, Escherich G, Fleischhack G, Graf N, Gruhn B, Haas OA, Klingebiel T, Kremens B, Lehrnbecher T, von Stackelberg A, Tchinda J, Zemanova Z, Thiede C, von Neuhoff N, Zimmermann M, Creutzig U, Reinhardt D
Leukemia 2017 Dec;31(12):2807-2814. Epub 2017 Apr 25 doi: 10.1038/leu.2017.121. PMID: 28443606Free PMC Article
Chronic myelogenous leukemia in the lymphoid blastic phase: characteristics, treatment response, and prognosis.
Derderian PM, Kantarjian HM, Talpaz M, O'Brien S, Cork A, Estey E, Pierce S, Keating M
Am J Med 1993 Jan;94(1):69-74. PMID: 8420302

Recent clinical studies

Etiology

Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.
Duployez N, Vasseur L, Kim R, Largeaud L, Passet M, L'Haridon A, Lemaire P, Fenwarth L, Geffroy S, Helevaut N, Celli-Lebras K, Adès L, Lebon D, Berthon C, Marceau-Renaut A, Cheok M, Lambert J, Récher C, Raffoux E, Micol JB, Pigneux A, Gardin C, Delabesse E, Soulier J, Hunault M, Dombret H, Itzykson R, Clappier E, Preudhomme C
Leukemia 2023 Jun;37(6):1245-1253. Epub 2023 Apr 21 doi: 10.1038/s41375-023-01906-z. PMID: 37085611Free PMC Article
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Genetic abnormalities and pathophysiology of MDS.
Hosono N
Int J Clin Oncol 2019 Aug;24(8):885-892. Epub 2019 May 15 doi: 10.1007/s10147-019-01462-6. PMID: 31093808
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Diagnosis

UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.
Duployez N, Vasseur L, Kim R, Largeaud L, Passet M, L'Haridon A, Lemaire P, Fenwarth L, Geffroy S, Helevaut N, Celli-Lebras K, Adès L, Lebon D, Berthon C, Marceau-Renaut A, Cheok M, Lambert J, Récher C, Raffoux E, Micol JB, Pigneux A, Gardin C, Delabesse E, Soulier J, Hunault M, Dombret H, Itzykson R, Clappier E, Preudhomme C
Leukemia 2023 Jun;37(6):1245-1253. Epub 2023 Apr 21 doi: 10.1038/s41375-023-01906-z. PMID: 37085611Free PMC Article
Autoimmune and inflammatory manifestations associated with acute myeloid leukemia with Trisomy 8-Case series and review of the literature.
Buchrits S, Kozlovoski D, Gafter-Gvili A, Raanani P, Hayman L, Revyako I, Bernstine H, Wolach O, Shimony S
Eur J Haematol 2022 Mar;108(3):199-203. Epub 2021 Dec 21 doi: 10.1111/ejh.13725. PMID: 34748235
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Therapy

Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
Long-term outcomes of aplastic anemia with cytogenetic abnormalities at diagnosis.
Li J, Liu X, Zhao X, Yang W, Zhang L, Jing L, Zhou K, Ye L, Li Y, Li Y, Peng G, Song L, Fan H, Hu X, Li X, Zhang F
Eur J Haematol 2023 Apr;110(4):379-385. Epub 2023 Jan 7 doi: 10.1111/ejh.13913. PMID: 36533899
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Relapse and cytogenetic evolution in myeloid neoplasms.
Ertz-Archambault N, Kelemen K
Panminerva Med 2017 Dec;59(4):308-319. doi: 10.23736/S0031-0808.17.03380-8. PMID: 29144072
Therapy reduction in patients with Down syndrome and myeloid leukemia: the international ML-DS 2006 trial.
Uffmann M, Rasche M, Zimmermann M, von Neuhoff C, Creutzig U, Dworzak M, Scheffers L, Hasle H, Zwaan CM, Reinhardt D, Klusmann JH
Blood 2017 Jun 22;129(25):3314-3321. Epub 2017 Apr 11 doi: 10.1182/blood-2017-01-765057. PMID: 28400376

Prognosis

Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.
Duployez N, Vasseur L, Kim R, Largeaud L, Passet M, L'Haridon A, Lemaire P, Fenwarth L, Geffroy S, Helevaut N, Celli-Lebras K, Adès L, Lebon D, Berthon C, Marceau-Renaut A, Cheok M, Lambert J, Récher C, Raffoux E, Micol JB, Pigneux A, Gardin C, Delabesse E, Soulier J, Hunault M, Dombret H, Itzykson R, Clappier E, Preudhomme C
Leukemia 2023 Jun;37(6):1245-1253. Epub 2023 Apr 21 doi: 10.1038/s41375-023-01906-z. PMID: 37085611Free PMC Article
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Relapse and cytogenetic evolution in myeloid neoplasms.
Ertz-Archambault N, Kelemen K
Panminerva Med 2017 Dec;59(4):308-319. doi: 10.23736/S0031-0808.17.03380-8. PMID: 29144072
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Clinical prediction guides

Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
ASXL1 mutations in AML are associated with specific clinical and cytogenetic characteristics.
Kakosaiou K, Panitsas F, Daraki A, Pagoni M, Apostolou P, Ioannidou A, Vlachadami I, Marinakis T, Giatra C, Vasilatou D, Sambani C, Pappa V, Manola KN
Leuk Lymphoma 2018 Oct;59(10):2439-2446. Epub 2018 Feb 7 doi: 10.1080/10428194.2018.1433298. PMID: 29411666
Relapse and cytogenetic evolution in myeloid neoplasms.
Ertz-Archambault N, Kelemen K
Panminerva Med 2017 Dec;59(4):308-319. doi: 10.23736/S0031-0808.17.03380-8. PMID: 29144072
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease.
Shihadeh F, Reed V, Faderl S, Medeiros LJ, Mazloom A, Hadziahmetovic M, Kantarjian H, Allen P, Ballas L, Pierce S, Dabaja B
Cancer 2012 Jan 1;118(1):112-7. Epub 2011 Jun 20 doi: 10.1002/cncr.26253. PMID: 21692072

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