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Increased circulating ethanolamine concentration

MedGen UID:
1702410
•Concept ID:
C5139635
•
Finding
Synonym: High ethanolamine levels in the blood
 
HPO: HP:0500250

Definition

Abnormally increased levels of ethanolamine in circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating ethanolamine concentration

Professional guidelines

PubMed

Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants.
Romero-Sanchiz P, Nogueira-Arjona R, Pastor A, Araos P, Serrano A, Boronat A, Garcia-Marchena N, Mayoral F, Bordallo A, Alen F, Suárez J, de la Torre R, Pavón FJ, Rodríguez de Fonseca F
Neuropharmacology 2019 May 1;149:212-220. Epub 2019 Feb 26 doi: 10.1016/j.neuropharm.2019.02.026. PMID: 30822499
Altered stress hormone response following acute exercise during prostate cancer treatment.
Hanson ED, Sakkal S, Evans WS, Violet JA, Battaglini CL, McConell GK, Hayes A
Scand J Med Sci Sports 2018 Aug;28(8):1925-1933. Epub 2018 May 8 doi: 10.1111/sms.13199. PMID: 29668082
PEGylated liposomes of anastrozole for long-term treatment of breast cancer: in vitro and in vivo evaluation.
Shavi GV, Sreenivasa Reddy M, Raghavendra R, Nayak UY, Kumar AR, Deshpande PB, Udupa N, Behl G, Dave V, Kushwaha K
J Liposome Res 2016;26(1):28-46. Epub 2015 Apr 8 doi: 10.3109/08982104.2015.1029493. PMID: 25853340

Recent clinical studies

Etiology

Association of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis.
Yang Q, Han H, Sun Z, Liu L, Zheng X, Meng Z, Tao N, Liu J
Eur J Clin Invest 2023 Oct;53(10):e14041. Epub 2023 Jun 15 doi: 10.1111/eci.14041. PMID: 37318151
Characteristics of circulatory failure after out-of-hospital cardiac arrest: a prospective cohort study.
Langeland H, Bergum D, Løberg M, Bjørnstad K, Skaug TR, Nordseth T, Klepstad P, Skjærvold NK
Open Heart 2022 Jan;9(1) doi: 10.1136/openhrt-2021-001890. PMID: 35046124Free PMC Article
Circulating choline pathway nutrients and depression after ischemic stroke.
Miao M, Du J, Che B, Guo Y, Zhang J, Ju Z, Xu T, Zhong X, Zhang Y, Zhong C
Eur J Neurol 2022 Feb;29(2):459-468. Epub 2021 Oct 17 doi: 10.1111/ene.15133. PMID: 34611955
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
Zhong C, Lu Z, Che B, Qian S, Zheng X, Wang A, Bu X, Zhang J, Ju Z, Xu T, Zhang Y
Stroke 2021 Mar;52(3):887-895. Epub 2021 Jan 20 doi: 10.1161/STROKEAHA.120.031903. PMID: 33467878
Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances.
Ortega E, García JJ, Bote ME, Martín-Cordero L, Escalante Y, Saavedra JM, Northoff H, Giraldo E
Exerc Immunol Rev 2009;15:42-65. PMID: 19957871

Diagnosis

Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
Zhong C, Lu Z, Che B, Qian S, Zheng X, Wang A, Bu X, Zhang J, Ju Z, Xu T, Zhang Y
Stroke 2021 Mar;52(3):887-895. Epub 2021 Jan 20 doi: 10.1161/STROKEAHA.120.031903. PMID: 33467878
B-type natriuretic peptide increases cortisol and catecholamine concentrations in healthy subjects.
Grimm G, Resl M, Heinisch BB, Hülsmann M, Luger A, Clodi M, Vila G
J Appl Physiol (1985) 2017 May 1;122(5):1249-1254. Epub 2016 Dec 22 doi: 10.1152/japplphysiol.00360.2016. PMID: 28008098
Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances.
Ortega E, García JJ, Bote ME, Martín-Cordero L, Escalante Y, Saavedra JM, Northoff H, Giraldo E
Exerc Immunol Rev 2009;15:42-65. PMID: 19957871
Oral absorption and concentration-effect relationship of tyramine with and without cimoxatone, a type-A specific inhibitor of monoamine oxidase.
Dollery CT, Brown MJ, Davies DS, Lewis PJ, Strolin-Benedetti M
Clin Pharmacol Ther 1983 Nov;34(5):651-62. doi: 10.1038/clpt.1983.228. PMID: 6627826
Somatostatin--physiological and pathophysiological aspects.
Schusdziarra V
Scand J Gastroenterol Suppl 1983;82:69-84. PMID: 6138852

Therapy

Association of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis.
Yang Q, Han H, Sun Z, Liu L, Zheng X, Meng Z, Tao N, Liu J
Eur J Clin Invest 2023 Oct;53(10):e14041. Epub 2023 Jun 15 doi: 10.1111/eci.14041. PMID: 37318151
Characteristics of circulatory failure after out-of-hospital cardiac arrest: a prospective cohort study.
Langeland H, Bergum D, Løberg M, Bjørnstad K, Skaug TR, Nordseth T, Klepstad P, Skjærvold NK
Open Heart 2022 Jan;9(1) doi: 10.1136/openhrt-2021-001890. PMID: 35046124Free PMC Article
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
Zhong C, Lu Z, Che B, Qian S, Zheng X, Wang A, Bu X, Zhang J, Ju Z, Xu T, Zhang Y
Stroke 2021 Mar;52(3):887-895. Epub 2021 Jan 20 doi: 10.1161/STROKEAHA.120.031903. PMID: 33467878
Carbohydrate metabolism in cardiovascular disease.
Opie LH, Stubbs WA
Clin Endocrinol Metab 1976 Nov;5(3):703-29. doi: 10.1016/s0300-595x(76)80047-3. PMID: 797485
Pathophysiology and therapy of the shock of myocardial infarction.
Haddy FJ
Ann Intern Med 1970 Nov;73(5):809-27. doi: 10.7326/0003-4819-73-5-809. PMID: 4920288

Prognosis

Characteristics of circulatory failure after out-of-hospital cardiac arrest: a prospective cohort study.
Langeland H, Bergum D, Løberg M, Bjørnstad K, Skaug TR, Nordseth T, Klepstad P, Skjærvold NK
Open Heart 2022 Jan;9(1) doi: 10.1136/openhrt-2021-001890. PMID: 35046124Free PMC Article
Trimethylamine oxide: a potential target for heart failure therapy.
Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
Zhong C, Lu Z, Che B, Qian S, Zheng X, Wang A, Bu X, Zhang J, Ju Z, Xu T, Zhang Y
Stroke 2021 Mar;52(3):887-895. Epub 2021 Jan 20 doi: 10.1161/STROKEAHA.120.031903. PMID: 33467878
B-type natriuretic peptide increases cortisol and catecholamine concentrations in healthy subjects.
Grimm G, Resl M, Heinisch BB, Hülsmann M, Luger A, Clodi M, Vila G
J Appl Physiol (1985) 2017 May 1;122(5):1249-1254. Epub 2016 Dec 22 doi: 10.1152/japplphysiol.00360.2016. PMID: 28008098
Short-term responses of the kidney to high altitude in mountain climbers.
Goldfarb-Rumyantzev AS, Alper SL
Nephrol Dial Transplant 2014 Mar;29(3):497-506. Epub 2013 Mar 22 doi: 10.1093/ndt/gft051. PMID: 23525530Free PMC Article

Clinical prediction guides

Association of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis.
Yang Q, Han H, Sun Z, Liu L, Zheng X, Meng Z, Tao N, Liu J
Eur J Clin Invest 2023 Oct;53(10):e14041. Epub 2023 Jun 15 doi: 10.1111/eci.14041. PMID: 37318151
Characteristics of circulatory failure after out-of-hospital cardiac arrest: a prospective cohort study.
Langeland H, Bergum D, Løberg M, Bjørnstad K, Skaug TR, Nordseth T, Klepstad P, Skjærvold NK
Open Heart 2022 Jan;9(1) doi: 10.1136/openhrt-2021-001890. PMID: 35046124Free PMC Article
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
Zhong C, Lu Z, Che B, Qian S, Zheng X, Wang A, Bu X, Zhang J, Ju Z, Xu T, Zhang Y
Stroke 2021 Mar;52(3):887-895. Epub 2021 Jan 20 doi: 10.1161/STROKEAHA.120.031903. PMID: 33467878
B-type natriuretic peptide increases cortisol and catecholamine concentrations in healthy subjects.
Grimm G, Resl M, Heinisch BB, Hülsmann M, Luger A, Clodi M, Vila G
J Appl Physiol (1985) 2017 May 1;122(5):1249-1254. Epub 2016 Dec 22 doi: 10.1152/japplphysiol.00360.2016. PMID: 28008098
Short-term responses of the kidney to high altitude in mountain climbers.
Goldfarb-Rumyantzev AS, Alper SL
Nephrol Dial Transplant 2014 Mar;29(3):497-506. Epub 2013 Mar 22 doi: 10.1093/ndt/gft051. PMID: 23525530Free PMC Article

Recent systematic reviews

Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review.
Haunhorst S, Bloch W, Ringleb M, Fennen L, Wagner H, Gabriel HHW, Puta C
Exerc Immunol Rev 2022;28:36-52. PMID: 35452397

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