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Increased circulating ethanolamine concentration

MedGen UID:
1702410
•Concept ID:
C5139635
•
Finding
Synonym: High ethanolamine levels in the blood
 
HPO: HP:0500250

Definition

Abnormally increased levels of ethanolamine in circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating ethanolamine concentration

Professional guidelines

PubMed

Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants.
Romero-Sanchiz P, Nogueira-Arjona R, Pastor A, Araos P, Serrano A, Boronat A, Garcia-Marchena N, Mayoral F, Bordallo A, Alen F, Suárez J, de la Torre R, Pavón FJ, Rodríguez de Fonseca F
Neuropharmacology 2019 May 1;149:212-220. Epub 2019 Feb 26 doi: 10.1016/j.neuropharm.2019.02.026. PMID: 30822499
Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis.
Menhaji-Klotz E, Hesp KD, Londregan AT, Kalgutkar AS, Piotrowski DW, Boehm M, Song K, Ryder T, Beaumont K, Jones RM, Atkinson K, Brown JA, Litchfield J, Xiao J, Canterbury DP, Burford K, Thuma BA, Limberakis C, Jiao W, Bagley SW, Agarwal S, Crowell D, Pazdziorko S, Ward J, Price DA, Clerin V
J Med Chem 2018 Apr 26;61(8):3685-3696. Epub 2018 Apr 17 doi: 10.1021/acs.jmedchem.8b00190. PMID: 29627981
PEGylated liposomes of anastrozole for long-term treatment of breast cancer: in vitro and in vivo evaluation.
Shavi GV, Sreenivasa Reddy M, Raghavendra R, Nayak UY, Kumar AR, Deshpande PB, Udupa N, Behl G, Dave V, Kushwaha K
J Liposome Res 2016;26(1):28-46. Epub 2015 Apr 8 doi: 10.3109/08982104.2015.1029493. PMID: 25853340

Recent clinical studies

Etiology

Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review.
Haunhorst S, Bloch W, Ringleb M, Fennen L, Wagner H, Gabriel HHW, Puta C
Exerc Immunol Rev 2022;28:36-52. PMID: 35452397
Endotracheal Administered Epinephrine Is Effective in Return of Spontaneous Circulation Within a Pediatric Swine Hypovolemic Cardiac Arrest Model.
Yauger YJ, Beaumont DM, Brady K, Schauer SG, O'Sullivan J, Hensler JG, Johnson D
Pediatr Emerg Care 2022 Jan 1;38(1):e187-e192. doi: 10.1097/PEC.0000000000002208. PMID: 32701868
Adrenaline-induced mobilization of T cells in HIV-infected patients.
Søndergaard SR, Cozzi Lepri A, Ullum H, Wiis J, Hermann CK, Laursen SB, Qvist J, Gerstoft J, Skinhøj P, Pedersen BK
Clin Exp Immunol 2000 Jan;119(1):115-22. doi: 10.1046/j.1365-2249.2000.01102.x. PMID: 10606972Free PMC Article
Epinephrine impairs splanchnic perfusion in septic shock.
Meier-Hellmann A, Reinhart K, Bredle DL, Specht M, Spies CD, Hannemann L
Crit Care Med 1997 Mar;25(3):399-404. doi: 10.1097/00003246-199703000-00005. PMID: 9118653
Circulating catecholamine and potassium concentrations early in acute myocardial infarction: effect of intervention with timolol.
Nordrehaug JE, Johannessen KA, von der Lippe G, Myking OL
Am Heart J 1985 Nov;110(5):944-8. doi: 10.1016/0002-8703(85)90189-9. PMID: 4061268

Diagnosis

Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review.
Haunhorst S, Bloch W, Ringleb M, Fennen L, Wagner H, Gabriel HHW, Puta C
Exerc Immunol Rev 2022;28:36-52. PMID: 35452397
Seasonal variation in plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma.
Pamporaki C, Bursztyn M, Reimann M, Ziemssen T, Bornstein SR, Sweep FC, Timmers H, Lenders JW, Eisenhofer G
Eur J Endocrinol 2014 Mar;170(3):349-57. Epub 2014 Feb 4 doi: 10.1530/EJE-13-0673. PMID: 24497497
Induction of tissue plasminogen activator secretion from rat heart microvascular cells by fM 1,25(OH)(2)D(3).
Puri S, Bansal DD, Uskoković MR, MacGregor RR
Am J Physiol Endocrinol Metab 2000 Feb;278(2):E293-301. doi: 10.1152/ajpendo.2000.278.2.E293. PMID: 10662714
Pregnancy: increased effect of verapamil in human uterine arteries.
Suresh MS, Nelson SH, Nelson TE, Steinsland OS
Eur J Pharmacol 1985 Jun 19;112(3):387-91. doi: 10.1016/0014-2999(85)90785-x. PMID: 4018141
Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation.
Svedmyr K, Mellstrand T, Svedmyr N
Allergy 1982 Feb;37(2):111-7. doi: 10.1111/j.1398-9995.1982.tb01884.x. PMID: 7137520

Therapy

Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial.
Kim N, Parolin B, Renshaw D, Deb SK, Zariwala MG
Nutrients 2024 Feb 8;16(4) doi: 10.3390/nu16040489. PMID: 38398813Free PMC Article
Use of phosphatide precursors to promote synaptogenesis.
Wurtman RJ, Cansev M, Sakamoto T, Ulus IH
Annu Rev Nutr 2009;29:59-87. doi: 10.1146/annurev-nutr-080508-141059. PMID: 19400698
Mobilization of bone marrow cells by leukocytapheresis in patients with ulcerative colitis.
Mitsuyama K, Andoh A, Masuda J, Yamasaki H, Kuwaki K, Takedatsu H, Seki R, Nishida H, Tsuruta O, Sata M
Ther Apher Dial 2008 Aug;12(4):271-7. doi: 10.1111/j.1744-9987.2008.00587.x. PMID: 18789113
Adrenaline-induced mobilization of T cells in HIV-infected patients.
Søndergaard SR, Cozzi Lepri A, Ullum H, Wiis J, Hermann CK, Laursen SB, Qvist J, Gerstoft J, Skinhøj P, Pedersen BK
Clin Exp Immunol 2000 Jan;119(1):115-22. doi: 10.1046/j.1365-2249.2000.01102.x. PMID: 10606972Free PMC Article
Splanchnic vasoconstriction in heat-stressed men: role of renin-angiotensin system.
Escourrou P, Freund PR, Rowell LB, Johnson DG
J Appl Physiol Respir Environ Exerc Physiol 1982 Jun;52(6):1438-43. doi: 10.1152/jappl.1982.52.6.1438. PMID: 7050057

Prognosis

Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial.
Kim N, Parolin B, Renshaw D, Deb SK, Zariwala MG
Nutrients 2024 Feb 8;16(4) doi: 10.3390/nu16040489. PMID: 38398813Free PMC Article
Changes in gene transcription underlying the aberrant citrate and choline metabolism in human prostate cancer samples.
Bertilsson H, Tessem MB, Flatberg A, Viset T, Gribbestad I, Angelsen A, Halgunset J
Clin Cancer Res 2012 Jun 15;18(12):3261-9. Epub 2012 Apr 17 doi: 10.1158/1078-0432.CCR-11-2929. PMID: 22510345
The analysis of plasma kinetics and beta-receptor binding and -blocking activity of timolol following its small intravenous dose.
Kaila T, Karhuvaara S, Huupponen R, Iisalo E
Int J Clin Pharmacol Ther Toxicol 1993 Jul;31(7):351-7. PMID: 8103764
Adrenergic mechanisms in congestive heart failure.
Andersson KE
Acta Med Scand Suppl 1986;707:37-44. PMID: 2874691
Low plasma ionized calcium and response to calcium therapy in critically ill man.
Drop LJ, Laver MB
Anesthesiology 1975 Sep;43(3):300-6. doi: 10.1097/00000542-197509000-00005. PMID: 240298

Clinical prediction guides

The biodistribution and pharmacokinetic evaluation of choline-bound gold nanoparticles in a human prostate tumor xenograft model.
Razzak R, Zhou J, Yang X, Pervez N, Bédard EL, Moore RB, Shaw A, Amanie J, Roa WH
Clin Invest Med 2013 Jun 1;36(3):E133-42. doi: 10.25011/cim.v36i3.19724. PMID: 23739667
In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects.
Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH
J Pharmacol Exp Ther 2002 Apr;301(1):229-33. doi: 10.1124/jpet.301.1.229. PMID: 11907178
Antibodies as drug carriers. II. For proteins.
Rehlaender BN, Cho MJ
Pharm Res 2001 Jun;18(6):753-60. doi: 10.1023/a:1011024126247. PMID: 11474778
Direct vascular effects of furosemide in humans.
Pickkers P, Dormans TP, Russel FG, Hughes AD, Thien T, Schaper N, Smits P
Circulation 1997 Sep 16;96(6):1847-52. doi: 10.1161/01.cir.96.6.1847. PMID: 9323071
Normal levels of norepinephrine in short term hypothyroidism.
Wahi RS, Chansouria JP, Udupa KN
J Clin Endocrinol Metab 1980 Oct;51(4):934-5. doi: 10.1210/jcem-51-4-934. PMID: 7419674

Recent systematic reviews

Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review.
Haunhorst S, Bloch W, Ringleb M, Fennen L, Wagner H, Gabriel HHW, Puta C
Exerc Immunol Rev 2022;28:36-52. PMID: 35452397

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