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Elevated fecal pH

MedGen UID:
1703251
•Concept ID:
C5139651
•
Finding
Synonyms: Elevated faecal pH; Stool pH high
 
HPO: HP:0032489

Definition

Abnormally high fecal pH, i.e., abnormal alkalinity of feces. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated fecal pH

Conditions with this feature

Congenital secretory sodium diarrhea 8
MedGen UID:
1783137
•Concept ID:
C5441928
•
Disease or Syndrome
Any secretory diarrhea in which the cause of the disease is a mutation in the SLC9A3 gene.
See: Condition Record
Congenital secretory sodium diarrhea 8

Professional guidelines

PubMed

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis.
Wang F, Liu X, Huang F, Zhou Y, Wang X, Song Z, Wang S, Wang X, Shi D, Ruan G, Ji X, Zhang E, Tan Z, Ye Y, Wang C, Zhu J, Wang W
Elife 2024 Mar 15;12 doi: 10.7554/eLife.89045. PMID: 38488837Free PMC Article
Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis.
Martinez-Gili L, Pechlivanis A, McDonald JAK, Begum S, Badrock J, Dyson JK, Jones R, Hirschfield G, Ryder SD, Sandford R, Rushbrook S, Thorburn D, Taylor-Robinson SD, Crossey MME, Marchesi JR, Mells G, Holmes E, Jones D
Gut Microbes 2023 Jan-Dec;15(1):2208501. doi: 10.1080/19490976.2023.2208501. PMID: 37191344Free PMC Article
AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Ulcerative Colitis.
Singh S, Ananthakrishnan AN, Nguyen NH, Cohen BL, Velayos FS, Weiss JM, Sultan S, Siddique SM, Adler J, Chachu KA; AGA Clinical Guidelines Committee. Electronic address: clinicalpractice@gastro.org
Gastroenterology 2023 Mar;164(3):344-372. doi: 10.1053/j.gastro.2022.12.007. PMID: 36822736

Recent clinical studies

Etiology

Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial changes in healthy adults: a randomized controlled trial.
Shin JH, Kim CS, Cha J, Kim S, Lee S, Chae S, Chun WY, Shin DM
J Nutr Biochem 2022 Jan;99:108854. Epub 2021 Sep 14 doi: 10.1016/j.jnutbio.2021.108854. PMID: 34530112
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
Yang J, Wei H, Zhou Y, Szeto CH, Li C, Lin Y, Coker OO, Lau HCH, Chan AWH, Sung JJY, Yu J
Gastroenterology 2022 Jan;162(1):135-149.e2. Epub 2021 Aug 27 doi: 10.1053/j.gastro.2021.08.041. PMID: 34461052
Multidimensional Impact of Mediterranean Diet on IBD Patients.
Chicco F, Magrì S, Cingolani A, Paduano D, Pesenti M, Zara F, Tumbarello F, Urru E, Melis A, Casula L, Fantini MC, Usai P
Inflamm Bowel Dis 2021 Jan 1;27(1):1-9. doi: 10.1093/ibd/izaa097. PMID: 32440680Free PMC Article
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Niméus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G
Nat Med 2019 Apr;25(4):679-689. Epub 2019 Apr 1 doi: 10.1038/s41591-019-0406-6. PMID: 30936547Free PMC Article

Diagnosis

AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Ulcerative Colitis.
Singh S, Ananthakrishnan AN, Nguyen NH, Cohen BL, Velayos FS, Weiss JM, Sultan S, Siddique SM, Adler J, Chachu KA; AGA Clinical Guidelines Committee. Electronic address: clinicalpractice@gastro.org
Gastroenterology 2023 Mar;164(3):344-372. doi: 10.1053/j.gastro.2022.12.007. PMID: 36822736
Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts.
Liu NN, Jiao N, Tan JC, Wang Z, Wu D, Wang AJ, Chen J, Tao L, Zhou C, Fang W, Cheong IH, Pan W, Liao W, Kozlakidis Z, Heeschen C, Moore GG, Zhu L, Chen X, Zhang G, Zhu R, Wang H
Nat Microbiol 2022 Feb;7(2):238-250. Epub 2022 Jan 27 doi: 10.1038/s41564-021-01030-7. PMID: 35087227Free PMC Article
Identification of microbial markers across populations in early detection of colorectal cancer.
Wu Y, Jiao N, Zhu R, Zhang Y, Wu D, Wang AJ, Fang S, Tao L, Li Y, Cheng S, He X, Lan P, Tian C, Liu NN, Zhu L
Nat Commun 2021 May 24;12(1):3063. doi: 10.1038/s41467-021-23265-y. PMID: 34031391Free PMC Article
Anatomy, Physiology and Pathophysiology of Haemorrhoids.
Pata F, Sgró A, Ferrara F, Vigorita V, Gallo G, Pellino G
Rev Recent Clin Trials 2021;16(1):75-80. doi: 10.2174/1574887115666200406115150. PMID: 32250229
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.
Yachida S, Mizutani S, Shiroma H, Shiba S, Nakajima T, Sakamoto T, Watanabe H, Masuda K, Nishimoto Y, Kubo M, Hosoda F, Rokutan H, Matsumoto M, Takamaru H, Yamada M, Matsuda T, Iwasaki M, Yamaji T, Yachida T, Soga T, Kurokawa K, Toyoda A, Ogura Y, Hayashi T, Hatakeyama M, Nakagama H, Saito Y, Fukuda S, Shibata T, Yamada T
Nat Med 2019 Jun;25(6):968-976. Epub 2019 Jun 6 doi: 10.1038/s41591-019-0458-7. PMID: 31171880

Therapy

AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Ulcerative Colitis.
Singh S, Ananthakrishnan AN, Nguyen NH, Cohen BL, Velayos FS, Weiss JM, Sultan S, Siddique SM, Adler J, Chachu KA; AGA Clinical Guidelines Committee. Electronic address: clinicalpractice@gastro.org
Gastroenterology 2023 Mar;164(3):344-372. doi: 10.1053/j.gastro.2022.12.007. PMID: 36822736
Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial changes in healthy adults: a randomized controlled trial.
Shin JH, Kim CS, Cha J, Kim S, Lee S, Chae S, Chun WY, Shin DM
J Nutr Biochem 2022 Jan;99:108854. Epub 2021 Sep 14 doi: 10.1016/j.jnutbio.2021.108854. PMID: 34530112
Multidimensional Impact of Mediterranean Diet on IBD Patients.
Chicco F, Magrì S, Cingolani A, Paduano D, Pesenti M, Zara F, Tumbarello F, Urru E, Melis A, Casula L, Fantini MC, Usai P
Inflamm Bowel Dis 2021 Jan 1;27(1):1-9. doi: 10.1093/ibd/izaa097. PMID: 32440680Free PMC Article
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes.
Ding N, Zhang X, Zhang XD, Jing J, Liu SS, Mu YP, Peng LL, Yan YJ, Xiao GM, Bi XY, Chen H, Li FH, Yao B, Zhao AZ
Gut 2020 Sep;69(9):1608-1619. Epub 2020 Jan 2 doi: 10.1136/gutjnl-2019-319127. PMID: 31900292Free PMC Article

Prognosis

A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation.
Chen J, Liu X, Zou Y, Gong J, Ge Z, Lin X, Zhang W, Huang H, Zhao J, Saw PE, Lu Y, Hu H, Song E
Proc Natl Acad Sci U S A 2024 May 14;121(20):e2306776121. Epub 2024 May 6 doi: 10.1073/pnas.2306776121. PMID: 38709933Free PMC Article
Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-κB-IL6-STAT3 axis.
Zhong W, Wu K, Long Z, Zhou X, Zhong C, Wang S, Lai H, Guo Y, Lv D, Lu J, Mao X
Microbiome 2022 Jun 16;10(1):94. doi: 10.1186/s40168-022-01289-w. PMID: 35710492Free PMC Article
Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts.
Liu NN, Jiao N, Tan JC, Wang Z, Wu D, Wang AJ, Chen J, Tao L, Zhou C, Fang W, Cheong IH, Pan W, Liao W, Kozlakidis Z, Heeschen C, Moore GG, Zhu L, Chen X, Zhang G, Zhu R, Wang H
Nat Microbiol 2022 Feb;7(2):238-250. Epub 2022 Jan 27 doi: 10.1038/s41564-021-01030-7. PMID: 35087227Free PMC Article
Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives.
Vallianou N, Christodoulatos GS, Karampela I, Tsilingiris D, Magkos F, Stratigou T, Kounatidis D, Dalamaga M
Biomolecules 2021 Dec 31;12(1) doi: 10.3390/biom12010056. PMID: 35053205Free PMC Article
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Niméus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G
Nat Med 2019 Apr;25(4):679-689. Epub 2019 Apr 1 doi: 10.1038/s41591-019-0406-6. PMID: 30936547Free PMC Article

Clinical prediction guides

Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial changes in healthy adults: a randomized controlled trial.
Shin JH, Kim CS, Cha J, Kim S, Lee S, Chae S, Chun WY, Shin DM
J Nutr Biochem 2022 Jan;99:108854. Epub 2021 Sep 14 doi: 10.1016/j.jnutbio.2021.108854. PMID: 34530112
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
Yang J, Wei H, Zhou Y, Szeto CH, Li C, Lin Y, Coker OO, Lau HCH, Chan AWH, Sung JJY, Yu J
Gastroenterology 2022 Jan;162(1):135-149.e2. Epub 2021 Aug 27 doi: 10.1053/j.gastro.2021.08.041. PMID: 34461052
Multidimensional Impact of Mediterranean Diet on IBD Patients.
Chicco F, Magrì S, Cingolani A, Paduano D, Pesenti M, Zara F, Tumbarello F, Urru E, Melis A, Casula L, Fantini MC, Usai P
Inflamm Bowel Dis 2021 Jan 1;27(1):1-9. doi: 10.1093/ibd/izaa097. PMID: 32440680Free PMC Article
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Niméus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G
Nat Med 2019 Apr;25(4):679-689. Epub 2019 Apr 1 doi: 10.1038/s41591-019-0406-6. PMID: 30936547Free PMC Article
Gut microbiota dysbiosis contributes to the development of hypertension.
Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, Zhang W, Weldon R, Auguste K, Yang L, Liu X, Chen L, Yang X, Zhu B, Cai J
Microbiome 2017 Feb 1;5(1):14. doi: 10.1186/s40168-016-0222-x. PMID: 28143587Free PMC Article

Recent systematic reviews

Factors Associated With Response to Rescue Therapy in Acute Severe Ulcerative Colitis.
Li Wai Suen CFD, Seah D, Choy MC, De Cruz P
Inflamm Bowel Dis 2024 Aug 1;30(8):1389-1405. doi: 10.1093/ibd/izad183. PMID: 37725044
Fecal microbiota transplantation in obesity metabolism: A meta analysis and systematic review.
Zecheng L, Donghai L, Runchuan G, Yuan Q, Qi J, Yijia Z, Shuaman R, Xiaoqi L, Yi W, Ni M, Yijin Q, Liang P, Jun W
Diabetes Res Clin Pract 2023 Aug;202:110803. Epub 2023 Jun 24 doi: 10.1016/j.diabres.2023.110803. PMID: 37356723
Graduate Student Literature Review: A scoping review on the impact of consumption of dairy products on phosphatidylcholine and lysophosphatidylcholine in circulation and the liver in human studies and animal models.
Yuzbashian E, Moftah S, Chan CB
J Dairy Sci 2023 Jan;106(1):24-38. Epub 2022 Nov 16 doi: 10.3168/jds.2022-21938. PMID: 36400621
Calprotectin levels in necrotizing enterocolitis: a systematic review of the literature.
Pergialiotis V, Konstantopoulos P, Karampetsou N, Koutaki D, Gkioka E, Perrea DN, Papantoniou N
Inflamm Res 2016 Nov;65(11):847-852. Epub 2016 Jun 21 doi: 10.1007/s00011-016-0963-9. PMID: 27328832
Association between mode of delivery and pelvic floor dysfunction.
Rørtveit G, Hannestad YS
Tidsskr Nor Laegeforen 2014 Oct 14;134(19):1848-52. doi: 10.4045/tidsskr.13.0860. PMID: 25314985

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