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Renal tubular epithelial cell detachment

MedGen UID:
1708990
•Concept ID:
C5397617
•
Cell or Molecular Dysfunction
HPO: HP:0032595

Definition

Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal tubular epithelial cell detachment

Recent clinical studies

Etiology

Time-dependent changes in kidney histopathology in ethylene glycol poisoning.
Bokor J, Danics K, Keller E, Szollosi Z
Med Sci Law 2018 Oct;58(4):257-260. Epub 2018 Aug 19 doi: 10.1177/0025802418795352. PMID: 30124101
Renal tubular epithelial cells injury induced by mannitol and its potential mechanism.
Shi J, Qian J, Li H, Luo H, Luo W, Lin Z
Ren Fail 2018 Nov;40(1):85-91. doi: 10.1080/0886022X.2017.1419973. PMID: 29299951Free PMC Article
Severe reversible acute renal failure in idiopathic nephrotic syndrome.
Stellato T, Cappelleri A, Farina M, Pisano L, Scanziani R, Meroni M, Banfi G, Imbasciati E, Stella A
J Nephrol 2010 Nov-Dec;23(6):717-24. PMID: 20301082
Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis.
Yang L, Li X, Wang H
Nephrol Dial Transplant 2007 Feb;22(2):445-56. Epub 2006 Nov 23 doi: 10.1093/ndt/gfl556. PMID: 17124284
Myeloma cast nephropathy: immunohistochemical and lectin studies.
Start DA, Silva FG, Davis LD, D'Agati V, Pirani CL
Mod Pathol 1988 Sep;1(5):336-47. PMID: 2467287

Diagnosis

A case of acute kidney injury due to native kidney BK polyomavirus-associated nephropathy in a human T-lymphotropic virus type 1 carrier.
Takae K, Ueno Y, Shojima M, Nagae H, Nakano T, Takata S, Katafuchi R, Masutani K, Nakano T, Kuroki Y
BMC Nephrol 2023 Oct 31;24(1):323. doi: 10.1186/s12882-023-03373-1. PMID: 37907886Free PMC Article
Time-dependent changes in kidney histopathology in ethylene glycol poisoning.
Bokor J, Danics K, Keller E, Szollosi Z
Med Sci Law 2018 Oct;58(4):257-260. Epub 2018 Aug 19 doi: 10.1177/0025802418795352. PMID: 30124101
Severe reversible acute renal failure in idiopathic nephrotic syndrome.
Stellato T, Cappelleri A, Farina M, Pisano L, Scanziani R, Meroni M, Banfi G, Imbasciati E, Stella A
J Nephrol 2010 Nov-Dec;23(6):717-24. PMID: 20301082
Cellular response to injury in membranous nephropathy.
Nangaku M, Shankland SJ, Couser WG
J Am Soc Nephrol 2005 May;16(5):1195-204. Epub 2005 Mar 30 doi: 10.1681/ASN.2004121098. PMID: 15800119

Therapy

A case of acute kidney injury due to native kidney BK polyomavirus-associated nephropathy in a human T-lymphotropic virus type 1 carrier.
Takae K, Ueno Y, Shojima M, Nagae H, Nakano T, Takata S, Katafuchi R, Masutani K, Nakano T, Kuroki Y
BMC Nephrol 2023 Oct 31;24(1):323. doi: 10.1186/s12882-023-03373-1. PMID: 37907886Free PMC Article
Time-dependent changes in kidney histopathology in ethylene glycol poisoning.
Bokor J, Danics K, Keller E, Szollosi Z
Med Sci Law 2018 Oct;58(4):257-260. Epub 2018 Aug 19 doi: 10.1177/0025802418795352. PMID: 30124101
Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathy.
Lin CY, Lin TY, Lee MC, Chen SC, Chang JS
PLoS One 2013;8(2):e56731. Epub 2013 Feb 28 doi: 10.1371/journal.pone.0056731. PMID: 23468876Free PMC Article
Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis.
Yang L, Li X, Wang H
Nephrol Dial Transplant 2007 Feb;22(2):445-56. Epub 2006 Nov 23 doi: 10.1093/ndt/gfl556. PMID: 17124284
Posttransplantation relapse of FSGS is characterized by glomerular epithelial cell transdifferentiation.
Bariéty J, Bruneval P, Hill G, Irinopoulou T, Mandet C, Meyrier A
J Am Soc Nephrol 2001 Feb;12(2):261-274. doi: 10.1681/ASN.V122261. PMID: 11158216

Prognosis

Peritubular capillary rarefaction: a new therapeutic target in chronic kidney disease.
Kida Y, Tchao BN, Yamaguchi I
Pediatr Nephrol 2014 Mar;29(3):333-42. Epub 2013 Mar 10 doi: 10.1007/s00467-013-2430-y. PMID: 23475077Free PMC Article
Severe reversible acute renal failure in idiopathic nephrotic syndrome.
Stellato T, Cappelleri A, Farina M, Pisano L, Scanziani R, Meroni M, Banfi G, Imbasciati E, Stella A
J Nephrol 2010 Nov-Dec;23(6):717-24. PMID: 20301082
Cellular and molecular biology of membranous nephropathy.
Couser WG, Nangaku M
J Nephrol 2006 Nov-Dec;19(6):699-705. PMID: 17173240
Histologic, ultrastructural, and immunomicroscopic findings in 96 one hour human renal allograft biopsy specimens. Immunologic and clinical significance.
Valenzuela R, Hamway SA, Deodhar SD, Braun WE, Banowsky LH, Magnusson MO, Osborne DG
Hum Pathol 1980 Mar;11(2):187-95. doi: 10.1016/s0046-8177(80)80143-2. PMID: 6995267

Clinical prediction guides

Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury.
Shin NS, Marlier A, Xu L, Lam T, Cantley LG, Guo JK
Am J Physiol Renal Physiol 2022 Mar 1;322(3):F322-F334. Epub 2022 Jan 31 doi: 10.1152/ajprenal.00284.2021. PMID: 35100823Free PMC Article
Renal tubular epithelial cells injury induced by mannitol and its potential mechanism.
Shi J, Qian J, Li H, Luo H, Luo W, Lin Z
Ren Fail 2018 Nov;40(1):85-91. doi: 10.1080/0886022X.2017.1419973. PMID: 29299951Free PMC Article
Peritubular capillary rarefaction: a new therapeutic target in chronic kidney disease.
Kida Y, Tchao BN, Yamaguchi I
Pediatr Nephrol 2014 Mar;29(3):333-42. Epub 2013 Mar 10 doi: 10.1007/s00467-013-2430-y. PMID: 23475077Free PMC Article
Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathy.
Lin CY, Lin TY, Lee MC, Chen SC, Chang JS
PLoS One 2013;8(2):e56731. Epub 2013 Feb 28 doi: 10.1371/journal.pone.0056731. PMID: 23468876Free PMC Article
Cellular and molecular biology of membranous nephropathy.
Couser WG, Nangaku M
J Nephrol 2006 Nov-Dec;19(6):699-705. PMID: 17173240

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