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Abnormal renal tubular epithelial morphology

MedGen UID:
1717573
•Concept ID:
C5397621
•
Anatomical Abnormality
HPO: HP:0032599

Definition

Any structural anomaly of the renal tubular epithelial cells (RTEC), a layer of cells in the outer layer of the renal tubule. These cells play a role in the absorption of substances such as glucose and amino from the primary urine. [from HPO]

Professional guidelines

PubMed

Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease.
Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA
Curr Opin Nephrol Hypertens 2004 Jul;13(4):417-22. doi: 10.1097/01.mnh.0000133974.24935.fe. PMID: 15199292

Recent clinical studies

Etiology

Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis.
Zheng M, Jiang Q, You J, Gao B, Cui W, Yao W, Su F, Sun X, La L
Eur J Pharmacol 2024 Dec 5;984:176999. Epub 2024 Sep 28 doi: 10.1016/j.ejphar.2024.176999. PMID: 39349116
Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway.
Cheng R, Wang X, Huang L, Lu Z, Wu A, Guo S, Li C, Mao W, Xie Y, Xu P, Tian R
Chem Biol Interact 2024 May 25;395:111016. Epub 2024 Apr 24 doi: 10.1016/j.cbi.2024.111016. PMID: 38670420
Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors.
Guo W, Li H, Li Y, Kong W
Biomed Pharmacother 2023 Sep;165:115025. Epub 2023 Jun 28 doi: 10.1016/j.biopha.2023.115025. PMID: 37385209
Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease.
Rajani R, Pastor-Soler NM, Hallows KR
Curr Opin Nephrol Hypertens 2017 Sep;26(5):375-383. doi: 10.1097/MNH.0000000000000349. PMID: 28614117
Pathophysiology of ischaemic acute kidney injury.
Kanagasundaram NS
Ann Clin Biochem 2015 Mar;52(Pt 2):193-205. Epub 2014 Oct 7 doi: 10.1177/0004563214556820. PMID: 25293591

Diagnosis

Drug-induced Fanconi syndrome in patients with kidney allograft transplantation.
Tang Z, Li T, Dai H, Feng C, Xie X, Peng F, Lan G, Yu S, Wang Y, Fang C, Nie M, Yuan X, Tang X, Jiang X, Zhu X, Fan Y, Peng J, Sun S, Zhong M, Zhang H, Peng L
Front Immunol 2022;13:979983. Epub 2022 Aug 19 doi: 10.3389/fimmu.2022.979983. PMID: 36059468Free PMC Article
Mechanistic insights into hyperuricemia-associated renal abnormalities with special emphasis on epithelial-to-mesenchymal transition: Pathologic implications and putative pharmacologic targets.
Balakumar P, Alqahtani A, Khan NA, Mahadevan N, Dhanaraj SA
Pharmacol Res 2020 Nov;161:105209. Epub 2020 Sep 23 doi: 10.1016/j.phrs.2020.105209. PMID: 32979505
Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury.
Wang WG, Sun WX, Gao BS, Lian X, Zhou HL
Curr Protein Pept Sci 2017;18(12):1224-1231. doi: 10.2174/1389203717666160915162238. PMID: 27634440
2004 WHO classification of the renal tumors of the adults.
Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z
Eur Urol 2006 May;49(5):798-805. Epub 2006 Jan 17 doi: 10.1016/j.eururo.2005.11.035. PMID: 16442207
History of the cerebrohepatorenal syndrome of Zellweger and other peroxisomal disorders.
Zellweger H, Maertens P, Superneau D, Wertelecki W
South Med J 1988 Mar;81(3):357-64. doi: 10.1097/00007611-198803000-00017. PMID: 2450404

Therapy

Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis.
Zheng M, Jiang Q, You J, Gao B, Cui W, Yao W, Su F, Sun X, La L
Eur J Pharmacol 2024 Dec 5;984:176999. Epub 2024 Sep 28 doi: 10.1016/j.ejphar.2024.176999. PMID: 39349116
Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway.
Cheng R, Wang X, Huang L, Lu Z, Wu A, Guo S, Li C, Mao W, Xie Y, Xu P, Tian R
Chem Biol Interact 2024 May 25;395:111016. Epub 2024 Apr 24 doi: 10.1016/j.cbi.2024.111016. PMID: 38670420
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Lu J, Li XQ, Chen PP, Zhang JX, Li L, Wang GH, Liu XQ, Jiang CM, Ma KL
Acta Pharmacol Sin 2024 Feb;45(2):366-377. Epub 2023 Sep 28 doi: 10.1038/s41401-023-01160-0. PMID: 37770579Free PMC Article
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis.
Wang B, Yang LN, Yang LT, Liang Y, Guo F, Fu P, Ma L
Acta Pharmacol Sin 2024 Jan;45(1):150-165. Epub 2023 Sep 11 doi: 10.1038/s41401-023-01156-w. PMID: 37696989Free PMC Article
Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors.
Guo W, Li H, Li Y, Kong W
Biomed Pharmacother 2023 Sep;165:115025. Epub 2023 Jun 28 doi: 10.1016/j.biopha.2023.115025. PMID: 37385209

Prognosis

Drug-induced Fanconi syndrome in patients with kidney allograft transplantation.
Tang Z, Li T, Dai H, Feng C, Xie X, Peng F, Lan G, Yu S, Wang Y, Fang C, Nie M, Yuan X, Tang X, Jiang X, Zhu X, Fan Y, Peng J, Sun S, Zhong M, Zhang H, Peng L
Front Immunol 2022;13:979983. Epub 2022 Aug 19 doi: 10.3389/fimmu.2022.979983. PMID: 36059468Free PMC Article
Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.
Caza T, Wijewardena C, Al-Rabadi L, Perl A
Transl Res 2022 Jul;245:55-81. Epub 2022 Mar 12 doi: 10.1016/j.trsl.2022.03.004. PMID: 35288362Free PMC Article
Mechanistic insights into hyperuricemia-associated renal abnormalities with special emphasis on epithelial-to-mesenchymal transition: Pathologic implications and putative pharmacologic targets.
Balakumar P, Alqahtani A, Khan NA, Mahadevan N, Dhanaraj SA
Pharmacol Res 2020 Nov;161:105209. Epub 2020 Sep 23 doi: 10.1016/j.phrs.2020.105209. PMID: 32979505
Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury.
Wang WG, Sun WX, Gao BS, Lian X, Zhou HL
Curr Protein Pept Sci 2017;18(12):1224-1231. doi: 10.2174/1389203717666160915162238. PMID: 27634440
Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis.
Anders HJ, Ryu M
Kidney Int 2011 Nov;80(9):915-925. Epub 2011 Aug 3 doi: 10.1038/ki.2011.217. PMID: 21814171

Clinical prediction guides

Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.
Caza T, Wijewardena C, Al-Rabadi L, Perl A
Transl Res 2022 Jul;245:55-81. Epub 2022 Mar 12 doi: 10.1016/j.trsl.2022.03.004. PMID: 35288362Free PMC Article
Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway.
Wen Y, Chen J, Liu L, Guo G, Zeng Y, Zhang Y, Zeng Z, Wang Z, Peng X, Liang J
J Recept Signal Transduct Res 2020 Apr;40(2):141-147. Epub 2020 Jan 31 doi: 10.1080/10799893.2020.1719518. PMID: 32000560
New insights into the role of HNF-1β in kidney (patho)physiology.
Ferrè S, Igarashi P
Pediatr Nephrol 2019 Aug;34(8):1325-1335. Epub 2018 Jul 1 doi: 10.1007/s00467-018-3990-7. PMID: 29961928Free PMC Article
Cell Proliferation and Apoptosis in ADPKD.
Lee EJ
Adv Exp Med Biol 2016;933:25-34. doi: 10.1007/978-981-10-2041-4_3. PMID: 27730432
Pathophysiology of ischaemic acute kidney injury.
Kanagasundaram NS
Ann Clin Biochem 2015 Mar;52(Pt 2):193-205. Epub 2014 Oct 7 doi: 10.1177/0004563214556820. PMID: 25293591

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