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Localized Pancreatic Adenocarcinoma

MedGen UID:
1710378
•Concept ID:
C5239334
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the pancreas and has not spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Pancreatic Adenocarcinoma

Professional guidelines

PubMed

Neoadjuvant Treatment for Patients With Localized Pancreatic Adenocarcinoma: Are We There Yet?
da Costa WL Jr, Tran Cao HS, Massarweh NN
JAMA Oncol 2020 Aug 1;6(8):1163-1164. doi: 10.1001/jamaoncol.2020.0562. PMID: 32463451
Multidisciplinary management of resectable adenocarcinoma of the pancreatic head.
Yamamoto M, Imagawa DK, Katz MH
Expert Rev Anticancer Ther 2008 Oct;8(10):1611-21. doi: 10.1586/14737140.8.10.1611. PMID: 18925853
Guidelines for the surgical management of pancreatic adenocarcinoma.
Ujiki MB, Talamonti MS
Semin Oncol 2007 Aug;34(4):311-20. doi: 10.1053/j.seminoncol.2007.05.004. PMID: 17674959

Recent clinical studies

Etiology

A safety study of intraoperative radiation therapy following stereotactic body radiation therapy and multi-agent chemotherapy in the treatment of localized pancreatic adenocarcinoma: study protocol of a phase I trial.
Reddy AV, Hill CS, Zheng L, He J, Narang AK
Radiat Oncol 2022 Oct 28;17(1):173. doi: 10.1186/s13014-022-02145-9. PMID: 36307845Free PMC Article
FOLFIRINOX as Initial Treatment for Localized Pancreatic Adenocarcinoma: A Retrospective Analysis by the Trans-Atlantic Pancreatic Surgery Consortium.
Janssen QP, van Dam JL, Doppenberg D, Prakash LR, van Eijck CHJ, Jarnagin WR, O' Reilly EM, Paniccia A, Besselink MG, Katz MHG, Tzeng CD, Wei AC, Zureikat AH, Groot Koerkamp B; Trans-Atlantic Pancreatic Surgery (TAPS) Consortium
J Natl Cancer Inst 2022 May 9;114(5):695-703. doi: 10.1093/jnci/djac018. PMID: 35157075Free PMC Article
Clinical significance and predictors of complete or near-complete histological response to preoperative chemoradiotherapy in patients with localized pancreatic ductal adenocarcinoma.
Murata Y, Mizuno S, Kishiwada M, Uchida K, Noguchi D, Gyoten K, Hayasaki A, Fujii T, Iizawa Y, Tanemura A, Kuriyama N, Sakurai H, Isaji S
Pancreatology 2021 Dec;21(8):1482-1490. Epub 2021 Aug 24 doi: 10.1016/j.pan.2021.08.011. PMID: 34452821
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
Perri G, Prakash L, Qiao W, Varadhachary GR, Wolff R, Fogelman D, Overman M, Pant S, Javle M, Koay EJ, Herman J, Kim M, Ikoma N, Tzeng CW, Lee JE, Katz MHG
JAMA Surg 2020 Sep 1;155(9):832-839. doi: 10.1001/jamasurg.2020.2286. PMID: 32667641Free PMC Article
Multidisciplinary management of resectable adenocarcinoma of the pancreatic head.
Yamamoto M, Imagawa DK, Katz MH
Expert Rev Anticancer Ther 2008 Oct;8(10):1611-21. doi: 10.1586/14737140.8.10.1611. PMID: 18925853

Diagnosis

FOLFIRINOX as Initial Treatment for Localized Pancreatic Adenocarcinoma: A Retrospective Analysis by the Trans-Atlantic Pancreatic Surgery Consortium.
Janssen QP, van Dam JL, Doppenberg D, Prakash LR, van Eijck CHJ, Jarnagin WR, O' Reilly EM, Paniccia A, Besselink MG, Katz MHG, Tzeng CD, Wei AC, Zureikat AH, Groot Koerkamp B; Trans-Atlantic Pancreatic Surgery (TAPS) Consortium
J Natl Cancer Inst 2022 May 9;114(5):695-703. doi: 10.1093/jnci/djac018. PMID: 35157075Free PMC Article
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
Perri G, Prakash L, Qiao W, Varadhachary GR, Wolff R, Fogelman D, Overman M, Pant S, Javle M, Koay EJ, Herman J, Kim M, Ikoma N, Tzeng CW, Lee JE, Katz MHG
JAMA Surg 2020 Sep 1;155(9):832-839. doi: 10.1001/jamasurg.2020.2286. PMID: 32667641Free PMC Article
Surgery for Localized Pancreatic Cancer: The Trend Is Not Improving.
Strohl MP, Raigani S, Ammori JB, Hardacre JM, Kim JA
Pancreas 2016 May-Jun;45(5):687-93. doi: 10.1097/MPA.0000000000000511. PMID: 26491905
An update on surgical staging of patients with pancreatic cancer.
Winner M, Allendorf JD, Saif MW
JOP 2012 Mar 10;13(2):143-6. PMID: 22406586
Multidisciplinary management of resectable adenocarcinoma of the pancreatic head.
Yamamoto M, Imagawa DK, Katz MH
Expert Rev Anticancer Ther 2008 Oct;8(10):1611-21. doi: 10.1586/14737140.8.10.1611. PMID: 18925853

Therapy

A safety study of intraoperative radiation therapy following stereotactic body radiation therapy and multi-agent chemotherapy in the treatment of localized pancreatic adenocarcinoma: study protocol of a phase I trial.
Reddy AV, Hill CS, Zheng L, He J, Narang AK
Radiat Oncol 2022 Oct 28;17(1):173. doi: 10.1186/s13014-022-02145-9. PMID: 36307845Free PMC Article
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
Perri G, Prakash L, Qiao W, Varadhachary GR, Wolff R, Fogelman D, Overman M, Pant S, Javle M, Koay EJ, Herman J, Kim M, Ikoma N, Tzeng CW, Lee JE, Katz MHG
JAMA Surg 2020 Sep 1;155(9):832-839. doi: 10.1001/jamasurg.2020.2286. PMID: 32667641Free PMC Article
The Multidisciplinary Approach to Localized Pancreatic Adenocarcinoma.
Parekh HD, Starr J, George TJ Jr
Curr Treat Options Oncol 2017 Nov 16;18(12):73. doi: 10.1007/s11864-017-0515-8. PMID: 29143898
What is the optimal treatment of localized pancreatic adenocarcinoma?
Duffy A, O'Reilly EM
Oncology (Williston Park) 2008 Oct;22(11):1283-91; discussion 1294, 1296-8. PMID: 18980025
Guidelines for the surgical management of pancreatic adenocarcinoma.
Ujiki MB, Talamonti MS
Semin Oncol 2007 Aug;34(4):311-20. doi: 10.1053/j.seminoncol.2007.05.004. PMID: 17674959

Prognosis

A safety study of intraoperative radiation therapy following stereotactic body radiation therapy and multi-agent chemotherapy in the treatment of localized pancreatic adenocarcinoma: study protocol of a phase I trial.
Reddy AV, Hill CS, Zheng L, He J, Narang AK
Radiat Oncol 2022 Oct 28;17(1):173. doi: 10.1186/s13014-022-02145-9. PMID: 36307845Free PMC Article
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
Perri G, Prakash L, Qiao W, Varadhachary GR, Wolff R, Fogelman D, Overman M, Pant S, Javle M, Koay EJ, Herman J, Kim M, Ikoma N, Tzeng CW, Lee JE, Katz MHG
JAMA Surg 2020 Sep 1;155(9):832-839. doi: 10.1001/jamasurg.2020.2286. PMID: 32667641Free PMC Article
The Multidisciplinary Approach to Localized Pancreatic Adenocarcinoma.
Parekh HD, Starr J, George TJ Jr
Curr Treat Options Oncol 2017 Nov 16;18(12):73. doi: 10.1007/s11864-017-0515-8. PMID: 29143898
What is the optimal treatment of localized pancreatic adenocarcinoma?
Duffy A, O'Reilly EM
Oncology (Williston Park) 2008 Oct;22(11):1283-91; discussion 1294, 1296-8. PMID: 18980025
Guidelines for the surgical management of pancreatic adenocarcinoma.
Ujiki MB, Talamonti MS
Semin Oncol 2007 Aug;34(4):311-20. doi: 10.1053/j.seminoncol.2007.05.004. PMID: 17674959

Clinical prediction guides

Downstaging of Pancreatic Adenocarcinoma With Either Neoadjuvant Chemotherapy or Chemoradiotherapy Improves Survival.
O'Shea AE, Bohan PMK, Carpenter EL, McCarthy PM, Adams AM, Chick RC, Bader JO, Krell RW, Peoples GE, Clifton GT, Nelson DW, Vreeland TJ
Ann Surg Oncol 2022 Sep;29(9):6015-6028. Epub 2022 May 18 doi: 10.1245/s10434-022-11800-0. PMID: 35583691
Clinical significance and predictors of complete or near-complete histological response to preoperative chemoradiotherapy in patients with localized pancreatic ductal adenocarcinoma.
Murata Y, Mizuno S, Kishiwada M, Uchida K, Noguchi D, Gyoten K, Hayasaki A, Fujii T, Iizawa Y, Tanemura A, Kuriyama N, Sakurai H, Isaji S
Pancreatology 2021 Dec;21(8):1482-1490. Epub 2021 Aug 24 doi: 10.1016/j.pan.2021.08.011. PMID: 34452821
Predictors of early recurrence following neoadjuvant chemotherapy and surgical resection for localized pancreatic adenocarcinoma.
Narayanan S, AlMasri S, Zenati M, Nassour I, Chopra A, Rieser C, Smith K, Oyefusi V, Daum T, Bahary N, Bartlett D, Lee K, Zureikat A, Paniccia A
J Surg Oncol 2021 Sep;124(3):308-316. Epub 2021 Apr 24 doi: 10.1002/jso.26510. PMID: 33893740Free PMC Article
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
Perri G, Prakash L, Qiao W, Varadhachary GR, Wolff R, Fogelman D, Overman M, Pant S, Javle M, Koay EJ, Herman J, Kim M, Ikoma N, Tzeng CW, Lee JE, Katz MHG
JAMA Surg 2020 Sep 1;155(9):832-839. doi: 10.1001/jamasurg.2020.2286. PMID: 32667641Free PMC Article
The Multidisciplinary Approach to Localized Pancreatic Adenocarcinoma.
Parekh HD, Starr J, George TJ Jr
Curr Treat Options Oncol 2017 Nov 16;18(12):73. doi: 10.1007/s11864-017-0515-8. PMID: 29143898

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