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Localized Pancreatic Adenocarcinoma

MedGen UID:
1710378
•Concept ID:
C5239334
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the pancreas and has not spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Pancreatic Adenocarcinoma

Professional guidelines

PubMed

FOLFIRINOX as Initial Treatment for Localized Pancreatic Adenocarcinoma: A Retrospective Analysis by the Trans-Atlantic Pancreatic Surgery Consortium.
Janssen QP, van Dam JL, Doppenberg D, Prakash LR, van Eijck CHJ, Jarnagin WR, O' Reilly EM, Paniccia A, Besselink MG, Katz MHG, Tzeng CD, Wei AC, Zureikat AH, Groot Koerkamp B; Trans-Atlantic Pancreatic Surgery (TAPS) Consortium
J Natl Cancer Inst 2022 May 9;114(5):695-703. doi: 10.1093/jnci/djac018. PMID: 35157075Free PMC Article
Neoadjuvant Treatment for Patients With Localized Pancreatic Adenocarcinoma: Are We There Yet?
da Costa WL Jr, Tran Cao HS, Massarweh NN
JAMA Oncol 2020 Aug 1;6(8):1163-1164. doi: 10.1001/jamaoncol.2020.0562. PMID: 32463451
Multidisciplinary management of resectable adenocarcinoma of the pancreatic head.
Yamamoto M, Imagawa DK, Katz MH
Expert Rev Anticancer Ther 2008 Oct;8(10):1611-21. doi: 10.1586/14737140.8.10.1611. PMID: 18925853

Recent clinical studies

Therapy

Pathological Complete Response in Patients With Resected Pancreatic Adenocarcinoma After Preoperative Chemotherapy.
Stoop TF, Oba A, Wu YHA, Beaty LE, Colborn KL, Janssen BV, Al-Musawi MH, Franco SR, Sugawara T, Franklin O, Jain A, Saiura A, Sauvanet A, Coppola A, Javed AA, Groot Koerkamp B, Miller BN, Mack CE, Hashimoto D, Caputo D, Kleive D, Sereni E, Belfiori G, Ichida H, van Dam JL, Dembinski J, Akahoshi K, Roberts KJ, Tanaka K, Labori KJ, Falconi M, House MG, Sugimoto M, Tanabe M, Gotohda N, Krohn PS, Burkhart RA, Thakkar RG, Pande R, Dokmak S, Hirano S, Burgdorf SK, Crippa S, van Roessel S, Satoi S, White SA, Hackert T, Nguyen TK, Yamamoto T, Nakamura T, Bachu V, Burns WR, Inoue Y, Takahashi Y, Ushida Y, Aslami ZV, Verbeke CS, Fariña A, He J, Wilmink JW, Messersmith W, Verheij J, Kaplan J, Schulick RD, Besselink MG, Del Chiaro M
JAMA Netw Open 2024 Jun 3;7(6):e2417625. doi: 10.1001/jamanetworkopen.2024.17625. PMID: 38888920Free PMC Article
A safety study of intraoperative radiation therapy following stereotactic body radiation therapy and multi-agent chemotherapy in the treatment of localized pancreatic adenocarcinoma: study protocol of a phase I trial.
Reddy AV, Hill CS, Zheng L, He J, Narang AK
Radiat Oncol 2022 Oct 28;17(1):173. doi: 10.1186/s13014-022-02145-9. PMID: 36307845Free PMC Article
Combined multiagent chemotherapy and radiotherapy is associated with prolonged overall survival in patients with non-operatively managed stage II-III pancreatic adenocarcinoma.
Sugumar K, Hue JJ, Hardacre JM, Ammori JB, Rothermel LD, Dorth J, Saltzman J, Mohamed A, Selfridge JE, Bajor D, Winter JM, Ocuin LM
HPB (Oxford) 2022 Apr;24(4):433-442. Epub 2021 Aug 18 doi: 10.1016/j.hpb.2021.08.938. PMID: 34465529
The Multidisciplinary Approach to Localized Pancreatic Adenocarcinoma.
Parekh HD, Starr J, George TJ Jr
Curr Treat Options Oncol 2017 Nov 16;18(12):73. doi: 10.1007/s11864-017-0515-8. PMID: 29143898
What is the optimal treatment of localized pancreatic adenocarcinoma?
Duffy A, O'Reilly EM
Oncology (Williston Park) 2008 Oct;22(11):1283-91; discussion 1294, 1296-8. PMID: 18980025

Prognosis

Neoadjuvant chemotherapy for pancreatic cancer: Quality over quantity.
Thalji SZ, Aldakkak M, Christians KK, Clarke CN, George B, Kamgar M, Erickson BA, Hall WA, Chisholm P, Kulkarni N, Doucette S, Evans DB, Tsai S
J Surg Oncol 2023 Jul;128(1):41-50. Epub 2023 Apr 11 doi: 10.1002/jso.27265. PMID: 36960919
A safety study of intraoperative radiation therapy following stereotactic body radiation therapy and multi-agent chemotherapy in the treatment of localized pancreatic adenocarcinoma: study protocol of a phase I trial.
Reddy AV, Hill CS, Zheng L, He J, Narang AK
Radiat Oncol 2022 Oct 28;17(1):173. doi: 10.1186/s13014-022-02145-9. PMID: 36307845Free PMC Article
Clinical significance and predictors of complete or near-complete histological response to preoperative chemoradiotherapy in patients with localized pancreatic ductal adenocarcinoma.
Murata Y, Mizuno S, Kishiwada M, Uchida K, Noguchi D, Gyoten K, Hayasaki A, Fujii T, Iizawa Y, Tanemura A, Kuriyama N, Sakurai H, Isaji S
Pancreatology 2021 Dec;21(8):1482-1490. Epub 2021 Aug 24 doi: 10.1016/j.pan.2021.08.011. PMID: 34452821
The Multidisciplinary Approach to Localized Pancreatic Adenocarcinoma.
Parekh HD, Starr J, George TJ Jr
Curr Treat Options Oncol 2017 Nov 16;18(12):73. doi: 10.1007/s11864-017-0515-8. PMID: 29143898
What is the optimal treatment of localized pancreatic adenocarcinoma?
Duffy A, O'Reilly EM
Oncology (Williston Park) 2008 Oct;22(11):1283-91; discussion 1294, 1296-8. PMID: 18980025

Clinical prediction guides

Pathological Complete Response in Patients With Resected Pancreatic Adenocarcinoma After Preoperative Chemotherapy.
Stoop TF, Oba A, Wu YHA, Beaty LE, Colborn KL, Janssen BV, Al-Musawi MH, Franco SR, Sugawara T, Franklin O, Jain A, Saiura A, Sauvanet A, Coppola A, Javed AA, Groot Koerkamp B, Miller BN, Mack CE, Hashimoto D, Caputo D, Kleive D, Sereni E, Belfiori G, Ichida H, van Dam JL, Dembinski J, Akahoshi K, Roberts KJ, Tanaka K, Labori KJ, Falconi M, House MG, Sugimoto M, Tanabe M, Gotohda N, Krohn PS, Burkhart RA, Thakkar RG, Pande R, Dokmak S, Hirano S, Burgdorf SK, Crippa S, van Roessel S, Satoi S, White SA, Hackert T, Nguyen TK, Yamamoto T, Nakamura T, Bachu V, Burns WR, Inoue Y, Takahashi Y, Ushida Y, Aslami ZV, Verbeke CS, Fariña A, He J, Wilmink JW, Messersmith W, Verheij J, Kaplan J, Schulick RD, Besselink MG, Del Chiaro M
JAMA Netw Open 2024 Jun 3;7(6):e2417625. doi: 10.1001/jamanetworkopen.2024.17625. PMID: 38888920Free PMC Article
Delays to surgery following chemoradiotherapy lead to poorer oncologic outcomes in patients with localized pancreatic adenocarcinoma.
Cienfuegos JA, Martí-Cruchaga P, Zozaya G, Hernández Lizoain JL, Martínez Regueira F, Pardo F, Rodríguez J, Arbea Moreno L, Rotellar F
Rev Esp Enferm Dig 2023 Aug;115(8):428-434. doi: 10.17235/reed.2022.9256/2022. PMID: 36412484
Downstaging of Pancreatic Adenocarcinoma With Either Neoadjuvant Chemotherapy or Chemoradiotherapy Improves Survival.
O'Shea AE, Bohan PMK, Carpenter EL, McCarthy PM, Adams AM, Chick RC, Bader JO, Krell RW, Peoples GE, Clifton GT, Nelson DW, Vreeland TJ
Ann Surg Oncol 2022 Sep;29(9):6015-6028. Epub 2022 May 18 doi: 10.1245/s10434-022-11800-0. PMID: 35583691
Clinical significance and predictors of complete or near-complete histological response to preoperative chemoradiotherapy in patients with localized pancreatic ductal adenocarcinoma.
Murata Y, Mizuno S, Kishiwada M, Uchida K, Noguchi D, Gyoten K, Hayasaki A, Fujii T, Iizawa Y, Tanemura A, Kuriyama N, Sakurai H, Isaji S
Pancreatology 2021 Dec;21(8):1482-1490. Epub 2021 Aug 24 doi: 10.1016/j.pan.2021.08.011. PMID: 34452821
The Multidisciplinary Approach to Localized Pancreatic Adenocarcinoma.
Parekh HD, Starr J, George TJ Jr
Curr Treat Options Oncol 2017 Nov 16;18(12):73. doi: 10.1007/s11864-017-0515-8. PMID: 29143898

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