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Renal interstitial granulomas

MedGen UID:
1710690
Concept ID:
C5397658
Pathologic Function
Synonym: Renal interstitial granulomata
 
HPO: HP:0032641

Definition

Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present. [from HPO]

Professional guidelines

PubMed

Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154
Hilderson I, Van Laecke S, Wauters A, Donck J
Nephrol Dial Transplant 2014 Oct;29(10):1841-7. Epub 2013 Nov 13 doi: 10.1093/ndt/gft442. PMID: 24235078

Recent clinical studies

Etiology

Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Majeed NK, Acosta AM, Kajdacsy-Balla A, Setty S, Aardsma NA
Pathol Res Pract 2017 Nov;213(11):1431-1434. Epub 2017 Jul 23 doi: 10.1016/j.prp.2017.07.021. PMID: 28780082
Bijol V, Mendez GP, Nosé V, Rennke HG
Int J Surg Pathol 2006 Jan;14(1):57-63. doi: 10.1177/106689690601400110. PMID: 16501836
Sharma OP
Curr Opin Pulm Med 2000 Sep;6(5):442-7. doi: 10.1097/00063198-200009000-00010. PMID: 10958237

Diagnosis

Mocanu A, Bogos RA, Trandafir LM, Cojocaru E, Ioniuc I, Alecsa M, Lupu VV, Miron L, Lazaruc TI, Lupu A, Miron IC, Starcea IM
Int J Mol Sci 2023 Apr 15;24(8) doi: 10.3390/ijms24087327. PMID: 37108489Free PMC Article
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Zhang Y, Ahmed H, Haririan A, Ugarte R, Papadimitriou JC, Drachenberg CB
Transpl Infect Dis 2018 Oct;20(5):e12939. Epub 2018 Jun 22 doi: 10.1111/tid.12939. PMID: 29863293
Tatsukawa H, Nagano S, Umeno Y, Oribe M
Intern Med 2003 Sep;42(9):893-6. doi: 10.2169/internalmedicine.42.893. PMID: 14518684
Sharma OP
Curr Opin Pulm Med 2000 Sep;6(5):442-7. doi: 10.1097/00063198-200009000-00010. PMID: 10958237

Therapy

Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Anupama BK, Sampat P, Gambhir HS
J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211001659. doi: 10.1177/23247096211001659. PMID: 33733898Free PMC Article
Alangari FS, Binsalih SA, Heijani B, Aloudah N
Saudi J Kidney Dis Transpl 2020 Jul-Aug;31(4):856-859. doi: 10.4103/1319-2442.292321. PMID: 32801248
Zhang Y, Ahmed H, Haririan A, Ugarte R, Papadimitriou JC, Drachenberg CB
Transpl Infect Dis 2018 Oct;20(5):e12939. Epub 2018 Jun 22 doi: 10.1111/tid.12939. PMID: 29863293
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154

Prognosis

Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Zhang Y, Ahmed H, Haririan A, Ugarte R, Papadimitriou JC, Drachenberg CB
Transpl Infect Dis 2018 Oct;20(5):e12939. Epub 2018 Jun 22 doi: 10.1111/tid.12939. PMID: 29863293
Sharma OP
Curr Opin Pulm Med 2000 Sep;6(5):442-7. doi: 10.1097/00063198-200009000-00010. PMID: 10958237

Clinical prediction guides

Maiti J, Mathew GG, Jayaprakash V, Sreedhar S
Indian J Pharmacol 2024 Jul 1;56(4):290-292. Epub 2024 Sep 10 doi: 10.4103/ijp.ijp_19_24. PMID: 39250627Free PMC Article
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Aurore AC, Couderc T, Dueymes JM, Deligny C, Lecuit M, Molinié V, Ferlicot S
Am J Kidney Dis 2021 Dec;78(6):902-906. Epub 2021 Jun 16 doi: 10.1053/j.ajkd.2021.04.012. PMID: 34144105
Eguchi E, Shimazu K, Nishiguchi K, Yorifuji S, Tanaka A, Kuwahara T
Clin Exp Nephrol 2012 Feb;16(1):168-72. Epub 2011 Sep 23 doi: 10.1007/s10157-011-0531-0. PMID: 21947692Free PMC Article
Andrassy K
Nephrologie 1992;13(6):279-81. PMID: 1299788

Recent systematic reviews

Wang C, Liu H, Zhang T, Xu H, Shen J, Feng J, Sun L
Clin Chim Acta 2019 Feb;489:68-74. Epub 2018 Nov 7 doi: 10.1016/j.cca.2018.11.014. PMID: 30414436

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