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BRD3 Gene Translocation

MedGen UID:
1711012
•Concept ID:
C5236060
•
Cell or Molecular Dysfunction
Synonyms: BRD3 Translocation; Bromodomain Containing 3 Gene Translocation; Bromodomain-Containing 3 Gene Translocation; ORFX Gene Translocation; RING3-Like Gene Translocation; RING3L Gene Translocation

Definition

A cytogenetic abnormality that refers to a translocation involving the BRD3 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBRD3 Gene Translocation

Professional guidelines

PubMed

NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment.
French CA
Pathol Int 2018 Nov;68(11):583-595. Epub 2018 Oct 26 doi: 10.1111/pin.12727. PMID: 30362654
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T
Nature 2011 Oct 2;478(7370):529-33. doi: 10.1038/nature10509. PMID: 21964340Free PMC Article

Recent clinical studies

Etiology

Transcription-facilitating histone chaperons interact with genomic and synthetic G4 structures.
Pavlova II, Tsvetkov VB, Isaakova EA, Severov VV, Khomyakova EA, Lacis IA, Lazarev VN, Lagarkova MA, Pozmogova GE, Varizhuk AM
Int J Biol Macromol 2020 Oct 1;160:1144-1157. Epub 2020 May 23 doi: 10.1016/j.ijbiomac.2020.05.173. PMID: 32454109
Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients.
Bishop JA, French CA, Ali SZ
Cancer Cytopathol 2016 Dec;124(12):901-908. Epub 2016 Jul 11 doi: 10.1002/cncy.21761. PMID: 27400194
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC
Oncogene 2008 Apr 3;27(15):2237-42. Epub 2007 Oct 15 doi: 10.1038/sj.onc.1210852. PMID: 17934517

Diagnosis

NUTM1-fusion positive malignant neoplasms of the genitourinary tract: A report of six cases highlighting involvement of unusual anatomic locations and histologic heterogeneity.
Xu B, Chen JF, Sarungbam J, Tickoo S, Dickson BC, Reuter VE, Antonescu CR
Genes Chromosomes Cancer 2022 Sep;61(9):542-550. Epub 2022 Apr 27 doi: 10.1002/gcc.23046. PMID: 35430756Free PMC Article
NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment.
French CA
Pathol Int 2018 Nov;68(11):583-595. Epub 2018 Oct 26 doi: 10.1111/pin.12727. PMID: 30362654
Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients.
Bishop JA, French CA, Ali SZ
Cancer Cytopathol 2016 Dec;124(12):901-908. Epub 2016 Jul 11 doi: 10.1002/cncy.21761. PMID: 27400194
NSD3-NUT-expressing midline carcinoma of the lung: first characterization of primary cancer tissue.
Suzuki S, Kurabe N, Ohnishi I, Yasuda K, Aoshima Y, Naito M, Tanioka F, Sugimura H
Pathol Res Pract 2015 May;211(5):404-8. Epub 2014 Nov 13 doi: 10.1016/j.prp.2014.10.013. PMID: 25466466
Demystified molecular pathology of NUT midline carcinomas.
French CA
J Clin Pathol 2010 Jun;63(6):492-6. Epub 2008 Jun 13 doi: 10.1136/jcp.2007.052902. PMID: 18552174

Therapy

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T
Nature 2011 Oct 2;478(7370):529-33. doi: 10.1038/nature10509. PMID: 21964340Free PMC Article

Prognosis

Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients.
Bishop JA, French CA, Ali SZ
Cancer Cytopathol 2016 Dec;124(12):901-908. Epub 2016 Jul 11 doi: 10.1002/cncy.21761. PMID: 27400194
NUT rearrangement is uncommon in human thymic epithelial tumors.
Petrini P, French CA, Rajan A, Cameron MJ, Jaffe ES, Zucali PA, Xie J, Wang Y, Giaccone G
J Thorac Oncol 2012 Apr;7(4):744-50. doi: 10.1097/JTO.0b013e3182460f8f. PMID: 22425924Free PMC Article
NUT midline carcinoma in a newborn with multiorgan disseminated tumor and a 2-year-old with a pancreatic/hepatic primary.
Shehata BM, Steelman CK, Abramowsky CR, Olson TA, French CA, Saxe DF, Ricketts RR, Katzenstein HM
Pediatr Dev Pathol 2010 Nov-Dec;13(6):481-5. Epub 2009 Dec 17 doi: 10.2350/09-10-0727-CR.1. PMID: 20017639

Clinical prediction guides

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.
Hensel T, Giorgi C, Schmidt O, Calzada-Wack J, Neff F, Buch T, Niggli FK, Schäfer BW, Burdach S, Richter GH
Oncotarget 2016 Jan 12;7(2):1451-63. doi: 10.18632/oncotarget.6385. PMID: 26623725Free PMC Article

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