U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Unresectable Digestive System Neuroendocrine Neoplasm

MedGen UID:
1711756
•Concept ID:
C5237196
•
Neoplastic Process

Definition

A digestive system neuroendocrine neoplasm that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Management of Locally Advanced and Unresectable Small Bowel Neuroendocrine Tumours.
Koea J; Commonwealth Neuroendocrine Tumour Research Collaborative (CommNETs) Surgical Section
World J Surg 2021 Jan;45(1):219-224. Epub 2020 Aug 28 doi: 10.1007/s00268-020-05740-7. PMID: 32860138
Radioembolization in the treatment of unresectable liver tumors: experience across a range of primary cancers.
Coldwell D, Sangro B, Salem R, Wasan H, Kennedy A
Am J Clin Oncol 2012 Apr;35(2):167-77. doi: 10.1097/COC.0b013e3181f47923. PMID: 21127414

Recent clinical studies

Etiology

Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis.
Wu X, Li B, Hong T, Liu W, He X, Zheng C
Cancer Med 2023 May;12(10):11344-11350. Epub 2023 Mar 23 doi: 10.1002/cam4.5846. PMID: 36952352Free PMC Article
Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Antiproliferative Systemic Therapies for Metastatic Small Bowel Neuroendocrine Tumours.
Dawod M, Gordoa TA, Cives M, De Mestier L, Crona J, Spada F, Oberg K, Pavel M, Lamarca A
Curr Treat Options Oncol 2021 Jun 29;22(8):73. doi: 10.1007/s11864-021-00863-y. PMID: 34185197
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
New treatment strategies in advanced neuroendocrine tumours.
Walter T, Brixi-Benmansour H, Lombard-Bohas C, Cadiot G
Dig Liver Dis 2012 Feb;44(2):95-105. Epub 2011 Oct 7 doi: 10.1016/j.dld.2011.08.022. PMID: 21983252

Diagnosis

Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis.
Wu X, Li B, Hong T, Liu W, He X, Zheng C
Cancer Med 2023 May;12(10):11344-11350. Epub 2023 Mar 23 doi: 10.1002/cam4.5846. PMID: 36952352Free PMC Article
Adult pancreatoblastoma: Current concepts in pathology.
Omiyale AO
World J Gastroenterol 2021 Jul 14;27(26):4172-4181. doi: 10.3748/wjg.v27.i26.4172. PMID: 34326617Free PMC Article
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Transplantation and Debulking Procedures for Neuroendocrine Tumors.
Frilling A, Al-Nahhas A, Clift AK
Front Horm Res 2015;44:164-76. Epub 2015 Aug 14 doi: 10.1159/000382145. PMID: 26303711
New treatment strategies in advanced neuroendocrine tumours.
Walter T, Brixi-Benmansour H, Lombard-Bohas C, Cadiot G
Dig Liver Dis 2012 Feb;44(2):95-105. Epub 2011 Oct 7 doi: 10.1016/j.dld.2011.08.022. PMID: 21983252

Therapy

Updates and Expert Opinions on Liver Transplantation for Gastrointestinal Malignancies.
Shannon AH, Ruff SM, Schenk AD, Washburn K, Pawlik TM
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071290. PMID: 37512101Free PMC Article
Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Antiproliferative Systemic Therapies for Metastatic Small Bowel Neuroendocrine Tumours.
Dawod M, Gordoa TA, Cives M, De Mestier L, Crona J, Spada F, Oberg K, Pavel M, Lamarca A
Curr Treat Options Oncol 2021 Jun 29;22(8):73. doi: 10.1007/s11864-021-00863-y. PMID: 34185197
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Neuroendocrine tumors. Peptide receptor radionuclide therapy.
Forrer F, Valkema R, Kwekkeboom DJ, de Jong M, Krenning EP
Best Pract Res Clin Endocrinol Metab 2007 Mar;21(1):111-29. doi: 10.1016/j.beem.2007.01.007. PMID: 17382268

Prognosis

The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis.
Wu X, Li B, Hong T, Liu W, He X, Zheng C
Cancer Med 2023 May;12(10):11344-11350. Epub 2023 Mar 23 doi: 10.1002/cam4.5846. PMID: 36952352Free PMC Article
Relevant prognostic factors in patients with stage IV small intestine neuroendocrine neoplasms.
Maurer E, Heinzel-Gutenbrunner M, Rinke A, Rütz J, Holzer K, Figiel J, Luster M, Bartsch DK
J Neuroendocrinol 2022 Jan;34(1):e13076. Epub 2021 Dec 28 doi: 10.1111/jne.13076. PMID: 34964186
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Transplantation and Debulking Procedures for Neuroendocrine Tumors.
Frilling A, Al-Nahhas A, Clift AK
Front Horm Res 2015;44:164-76. Epub 2015 Aug 14 doi: 10.1159/000382145. PMID: 26303711

Clinical prediction guides

The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
The potential of somatostatin receptor 2 as a novel therapeutic target in salivary gland malignant tumors.
Meirovitz A, Shouchane-Blum K, Maly A, Bersudski E, Hirshoren N, Abrams R, Popovtzer A, Orevi M, Weinberger J
J Cancer Res Clin Oncol 2021 May;147(5):1335-1340. Epub 2021 Feb 17 doi: 10.1007/s00432-021-03538-1. PMID: 33598797
Severe gastrointestinal toxicity of MEK inhibitors.
Mourad N, Lourenço N, Delyon J, Eftekhari P, Bertheau P, Allayous C, Ballon A, Pagès C, Allez M, Lebbé C, Baroudjian B; PATIO group
Melanoma Res 2019 Oct;29(5):556-559. doi: 10.1097/CMR.0000000000000618. PMID: 31095035
Phase 1b study of pasireotide, everolimus, and selective internal radioembolization therapy for unresectable neuroendocrine tumors with hepatic metastases.
Kim HS, Shaib WL, Zhang C, Nagaraju GP, Wu C, Alese OB, Chen Z, Brutcher E, Renfroe M, El-Rayes BF
Cancer 2018 May 1;124(9):1992-2000. Epub 2018 Feb 16 doi: 10.1002/cncr.31192. PMID: 29451701
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Recent systematic reviews

Everolimus, lutetium-177 DOTATATE and sunitinib for advanced, unresectable or metastatic neuroendocrine tumours with disease progression: a systematic review and cost-effectiveness analysis.
Mujica-Mota R, Varley-Campbell J, Tikhonova I, Cooper C, Griffin E, Haasova M, Peters J, Lucherini S, Talens-Bou J, Long L, Sherriff D, Napier M, Ramage J, Hoyle M
Health Technol Assess 2018 Sep;22(49):1-326. doi: 10.3310/hta22490. PMID: 30209002Free PMC Article
Role of palliative resection of the primary tumour in advanced pancreatic and small intestinal neuroendocrine tumours: A systematic review and meta-analysis.
Almond LM, Hodson J, Ford SJ, Gourevitch D, Roberts KJ, Shah T, Isaac J, Desai A
Eur J Surg Oncol 2017 Oct;43(10):1808-1815. Epub 2017 May 25 doi: 10.1016/j.ejso.2017.05.016. PMID: 28583792

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...