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FUS Gene Translocation

MedGen UID:
1711771
•Concept ID:
C5238920
•
Cell or Molecular Dysfunction
Synonyms: FUS RNA Binding Protein Gene Translocation; FUS Translocation; FUS1 Gene Translocation; Fused In Sarcoma Gene Translocation; Fusion Gene In Myxoid Liposarcoma Gene Translocation; TLS Gene Translocation; Translocated In Liposarcoma Gene Translocation

Definition

A cytogenetic abnormality that refers to any translocation involving the FUS gene. [from NCI]

Professional guidelines

PubMed

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovée JV
Mol Cancer 2010 Sep 23;9:257. doi: 10.1186/1476-4598-9-257. PMID: 20863376Free PMC Article
SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.
Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noël L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V
J Med Genet 2010 Aug;47(8):554-60. Epub 2010 Jun 24 doi: 10.1136/jmg.2010.077180. PMID: 20577002
The role of genetic testing in soft tissue sarcoma.
Antonescu CR
Histopathology 2006 Jan;48(1):13-21. doi: 10.1111/j.1365-2559.2005.02285.x. PMID: 16359533

Recent clinical studies

Etiology

Rapidly developing intrathoracic low-grade fibromyxoid sarcoma: A case report.
Narukami E, Anayama T, Yamamoto M, Bunno Y, Miyazaki R, Okada H, Iguchi M
Thorac Cancer 2023 Aug;14(23):2314-2319. Epub 2023 Jul 3 doi: 10.1111/1759-7714.15020. PMID: 37401119Free PMC Article

Diagnosis

Rapidly developing intrathoracic low-grade fibromyxoid sarcoma: A case report.
Narukami E, Anayama T, Yamamoto M, Bunno Y, Miyazaki R, Okada H, Iguchi M
Thorac Cancer 2023 Aug;14(23):2314-2319. Epub 2023 Jul 3 doi: 10.1111/1759-7714.15020. PMID: 37401119Free PMC Article
Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology.
Chen G, Folpe AL, Colby TV, Sittampalam K, Patey M, Chen MG, Chan JK
Mod Pathol 2011 Dec;24(12):1560-70. Epub 2011 Aug 5 doi: 10.1038/modpathol.2011.126. PMID: 21822206

Supplemental Content

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