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Tubulointerstitial viral infiltration

MedGen UID:
1711798
•Concept ID:
C5397653
•
Finding
Synonym: Renal tubulointerstitial viral inclusions
 
HPO: HP:0032636

Definition

Infiltration of viruses into renal tubulointerstitial tissues as demonstrated on renal biopsy by viral inclusions which can be seen on routine stains or with immunohistochemistry. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTubulointerstitial viral infiltration

Recent clinical studies

Etiology

Levels of donor-derived cell-free DNA and chemokines in BK polyomavirus-associated nephropathy.
Mayer KA, Omic H, Weseslindtner L, Doberer K, Reindl-Schwaighofer R, Viard T, Tillgren A, Haindl S, Casas S, Eskandary F, Heinzel A, Kozakowski N, Kikić Ž, Böhmig GA, Eder M
Clin Transplant 2022 Nov;36(11):e14785. Epub 2022 Aug 5 doi: 10.1111/ctr.14785. PMID: 35894263Free PMC Article
A multicentre study of 95 biopsy-proven cases of renal disease in primary Sjögren's syndrome.
Jasiek M, Karras A, Le Guern V, Krastinova E, Mesbah R, Faguer S, Jourde-Chiche N, Fauchais AL, Chiche L, Dernis E, Moulis G, Fraison JB, Lazaro E, Jullien P, Hachulla E, Le Quellec A, Rémy P, Hummel A, Costedoat-Chalumeau N, Ronco P, Vanhille P, Meas-Yedid V, Cordonnier C, Ferlicot S, Daniel L, Seror R, Mariette X, Thervet E, François H, Terrier B
Rheumatology (Oxford) 2017 Mar 1;56(3):362-370. doi: 10.1093/rheumatology/kew376. PMID: 27940588
Renal involvement in primary Sjögren syndrome.
François H, Mariette X
Nat Rev Nephrol 2016 Feb;12(2):82-93. Epub 2015 Nov 16 doi: 10.1038/nrneph.2015.174. PMID: 26568188
A 20-year history of childhood HIV-associated nephropathy.
Ray PE, Xu L, Rakusan T, Liu XH
Pediatr Nephrol 2004 Oct;19(10):1075-92. Epub 2004 Aug 5 doi: 10.1007/s00467-004-1558-1. PMID: 15300477
Hepatitis C virus-associated tubulointerstitial injury.
Kasuno K, Ono T, Matsumori A, Nogaki F, Kusano H, Watanabe H, Yodoi J, Muso E
Am J Kidney Dis 2003 Apr;41(4):767-75. doi: 10.1016/s0272-6386(03)00024-6. PMID: 12666063

Diagnosis

A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results.
Cha RH, Yang SH, Moon KC, Joh JS, Lee JY, Shin HS, Kim DK, Kim YS
J Korean Med Sci 2016 Apr;31(4):635-40. Epub 2016 Mar 10 doi: 10.3346/jkms.2016.31.4.635. PMID: 27051251Free PMC Article
Renal involvement in primary Sjögren syndrome.
François H, Mariette X
Nat Rev Nephrol 2016 Feb;12(2):82-93. Epub 2015 Nov 16 doi: 10.1038/nrneph.2015.174. PMID: 26568188
BK virus-associated nephropathy with hydronephrosis in a patient with AIDS: a case report and literature review.
Jung SW, Sung JY, Park SJ, Jeong KH
Clin Nephrol 2016 Mar;85(3):173-8. doi: 10.5414/CN108482. PMID: 26249547
The case of BK virus infection in which it was difficult to differentiate from acute rejection.
Ito Y, Nishi S, Imai N, Yoshita K, Saito K, Nakagawa Y, Takahashi K, Narita I
Clin Transplant 2011 Jul;25 Suppl 23:44-8. doi: 10.1111/j.1399-0012.2011.01481.x. PMID: 21623914
Hemophagocytic syndrome in a patient with acute tubulointerstitial nephritis secondary to hepatitis A virus infection.
Cho E, Cha I, Yoon K, Yang HN, Kim HW, Kim MG, Jo SK, Cho WY, Kim HK
J Korean Med Sci 2010 Oct;25(10):1529-31. Epub 2010 Sep 17 doi: 10.3346/jkms.2010.25.10.1529. PMID: 20890439Free PMC Article

Therapy

Levels of donor-derived cell-free DNA and chemokines in BK polyomavirus-associated nephropathy.
Mayer KA, Omic H, Weseslindtner L, Doberer K, Reindl-Schwaighofer R, Viard T, Tillgren A, Haindl S, Casas S, Eskandary F, Heinzel A, Kozakowski N, Kikić Ž, Böhmig GA, Eder M
Clin Transplant 2022 Nov;36(11):e14785. Epub 2022 Aug 5 doi: 10.1111/ctr.14785. PMID: 35894263Free PMC Article
The case of BK virus infection in which it was difficult to differentiate from acute rejection.
Ito Y, Nishi S, Imai N, Yoshita K, Saito K, Nakagawa Y, Takahashi K, Narita I
Clin Transplant 2011 Jul;25 Suppl 23:44-8. doi: 10.1111/j.1399-0012.2011.01481.x. PMID: 21623914
JC virus-associated nephropathy in a renal transplant recipient and comparative analysis of previous cases.
Kantarci G, Eren Z, Demirağ A, Dogan I, Cakalagaoglu F, Yilmaz G
Transpl Infect Dis 2011 Feb;13(1):89-92. Epub 2010 Sep 6 doi: 10.1111/j.1399-3062.2010.00567.x. PMID: 21299772
Hepatitis C virus-associated tubulointerstitial injury.
Kasuno K, Ono T, Matsumori A, Nogaki F, Kusano H, Watanabe H, Yodoi J, Muso E
Am J Kidney Dis 2003 Apr;41(4):767-75. doi: 10.1016/s0272-6386(03)00024-6. PMID: 12666063
The 3-week sulphasalazine syndrome strikes again.
Lau G, Kwan C, Chong SM
Forensic Sci Int 2001 Nov 1;122(2-3):79-84. doi: 10.1016/s0379-0738(01)00476-5. PMID: 11672959

Prognosis

Cytokine signatures of end organ injury in COVID-19.
Gómez-Escobar LG, Hoffman KL, Choi JJ, Borczuk A, Salvatore S, Alvarez-Mulett SL, Galvan MD, Zhao Z, Racine-Brzostek SE, Yang HS, Stout-Delgado HW, Choi ME, Choi AMK, Cho SJ, Schenck EJ
Sci Rep 2021 Jun 15;11(1):12606. doi: 10.1038/s41598-021-91859-z. PMID: 34131192Free PMC Article
Renal involvement in primary Sjögren syndrome.
François H, Mariette X
Nat Rev Nephrol 2016 Feb;12(2):82-93. Epub 2015 Nov 16 doi: 10.1038/nrneph.2015.174. PMID: 26568188
BK virus-associated nephropathy with hydronephrosis in a patient with AIDS: a case report and literature review.
Jung SW, Sung JY, Park SJ, Jeong KH
Clin Nephrol 2016 Mar;85(3):173-8. doi: 10.5414/CN108482. PMID: 26249547
Hepatitis C virus-associated tubulointerstitial injury.
Kasuno K, Ono T, Matsumori A, Nogaki F, Kusano H, Watanabe H, Yodoi J, Muso E
Am J Kidney Dis 2003 Apr;41(4):767-75. doi: 10.1016/s0272-6386(03)00024-6. PMID: 12666063
Epstein-Barr virus genome-positive tubulointerstitial nephritis associated with Kawasaki disease-like coronary aneurysms.
Muso E, Fujiwara H, Yoshida H, Hosokawa R, Yashiro M, Hongo Y, Matumiya T, Yamabe H, Kikuta H, Hironaka T
Clin Nephrol 1993 Jul;40(1):7-15. PMID: 8395370

Clinical prediction guides

Cytokine signatures of end organ injury in COVID-19.
Gómez-Escobar LG, Hoffman KL, Choi JJ, Borczuk A, Salvatore S, Alvarez-Mulett SL, Galvan MD, Zhao Z, Racine-Brzostek SE, Yang HS, Stout-Delgado HW, Choi ME, Choi AMK, Cho SJ, Schenck EJ
Sci Rep 2021 Jun 15;11(1):12606. doi: 10.1038/s41598-021-91859-z. PMID: 34131192Free PMC Article
A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results.
Cha RH, Yang SH, Moon KC, Joh JS, Lee JY, Shin HS, Kim DK, Kim YS
J Korean Med Sci 2016 Apr;31(4):635-40. Epub 2016 Mar 10 doi: 10.3346/jkms.2016.31.4.635. PMID: 27051251Free PMC Article
A case of adult-onset tubulointerstitial nephritis and uveitis ("TINU syndrome") associated with sacroileitis and Epstein-Barr virus infection with good spontaneous outcome.
Cigni A, Soro G, Faedda R, Caucci F, Amadori F, Manca A, Tanda F, Satta AE
Am J Kidney Dis 2003 Sep;42(3):E4-10. doi: 10.1016/s0272-6386(03)00795-9. PMID: 12955704
Hepatitis C virus-associated tubulointerstitial injury.
Kasuno K, Ono T, Matsumori A, Nogaki F, Kusano H, Watanabe H, Yodoi J, Muso E
Am J Kidney Dis 2003 Apr;41(4):767-75. doi: 10.1016/s0272-6386(03)00024-6. PMID: 12666063
Rhesus macaques infected with macrophage-tropic simian immunodeficiency virus (SIVmacR71/17E) exhibit extensive focal segmental and global glomerulosclerosis.
Stephens EB, Tian C, Li Z, Narayan O, Gattone VH 2nd
J Virol 1998 Nov;72(11):8820-32. doi: 10.1128/JVI.72.11.8820-8832.1998. PMID: 9765427Free PMC Article

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