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Focal aware cognitive seizure

MedGen UID:
1713008
•Concept ID:
C5397691
•
Disease or Syndrome
Synonyms: Focal onset aware cognitive epileptic seizure; Focal onset aware cognitive seizure; Focal-onset aware cognitive epileptic seizure
SNOMED CT: Focal onset aware cognitive epileptic seizure (246536003); Focal-onset aware cognitive epileptic seizure (246536003); Focal aware cognitive seizure (246536003); Focal onset aware cognitive seizure (246536003)
 
HPO: HP:0032681

Definition

A focal aware cognitive seizure during which awareness is retained throughout the seizure. [from HPO]

Professional guidelines

PubMed

Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4-12 years: a real-world study.
Zeng Q, Xia X, Jiang L, Chen J, Liu Y, Hu Y
J Neurol 2024 Jul;271(7):4566-4576. Epub 2024 May 8 doi: 10.1007/s00415-024-12416-y. PMID: 38717610
Diagnosis, treatment, and follow-up of patients with cerebral amyloid angiopathy-related inflammation.
Cancelloni V, Rufa A, Battisti C, De Stefano N, Mastrocinque E, Garosi G, Venezia D, Chiarotti I, Cerase A
Neurol Sci 2022 Nov;43(11):6381-6387. Epub 2022 Aug 5 doi: 10.1007/s10072-022-06299-y. PMID: 35930182Free PMC Article
Clinical characteristics and treatment experience of individuals with SCN8A developmental and epileptic encephalopathy (SCN8A-DEE): Findings from an online caregiver survey.
Cutts A, Savoie H, Hammer MF, Schreiber J, Grayson C, Luzon C, Butterfield N, Pimstone SN, Aycardi E, Harden C, Yonan C, Jen E, Nguyen T, Carmack T, Haubenberger D
Seizure 2022 Apr;97:50-57. Epub 2022 Mar 10 doi: 10.1016/j.seizure.2022.03.008. PMID: 35325842

Recent clinical studies

Etiology

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Epilepsy and EEG Abnormalities in Children with Autism Spectrum Disorders.
Sharma V, Saini AG, Malhi P, Singhi P
Indian J Pediatr 2022 Oct;89(10):975-982. Epub 2021 Nov 29 doi: 10.1007/s12098-021-03928-w. PMID: 34843062
Social cognition and psychopathology in childhood and adolescence.
Besag FMC, Vasey MJ
Epilepsy Behav 2019 Nov;100(Pt B):106210. Epub 2019 Jun 10 doi: 10.1016/j.yebeh.2019.03.015. PMID: 31196824
Neurostimulation to improve level of consciousness in patients with epilepsy.
Gummadavelli A, Kundishora AJ, Willie JT, Andrews JP, Gerrard JL, Spencer DD, Blumenfeld H
Neurosurg Focus 2015 Jun;38(6):E10. doi: 10.3171/2015.3.FOCUS1535. PMID: 26030698Free PMC Article
Consciousness of seizures and consciousness during seizures: are they related?
Detyniecki K, Blumenfeld H
Epilepsy Behav 2014 Jan;30:6-9. Epub 2013 Oct 12 doi: 10.1016/j.yebeh.2013.09.018. PMID: 24126026Free PMC Article

Diagnosis

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
A systematic review of adults with Dravet syndrome.
Selvarajah A, Zulfiqar-Ali Q, Marques P, Rong M, Andrade DM
Seizure 2021 Apr;87:39-45. Epub 2021 Feb 22 doi: 10.1016/j.seizure.2021.02.025. PMID: 33677403
Social cognition and psychopathology in childhood and adolescence.
Besag FMC, Vasey MJ
Epilepsy Behav 2019 Nov;100(Pt B):106210. Epub 2019 Jun 10 doi: 10.1016/j.yebeh.2019.03.015. PMID: 31196824
Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM
Epilepsia 2017 Apr;58(4):522-530. Epub 2017 Mar 8 doi: 10.1111/epi.13670. PMID: 28276060

Therapy

Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4-12 years: a real-world study.
Zeng Q, Xia X, Jiang L, Chen J, Liu Y, Hu Y
J Neurol 2024 Jul;271(7):4566-4576. Epub 2024 May 8 doi: 10.1007/s00415-024-12416-y. PMID: 38717610
Prescribing electroconvulsive therapy for depression: Not as simple as it used to be.
Gill S, Hussain S, Purushothaman S, Sarma S, Weiss A, Chamoli S, Fasnacht M, Gandhi A, Fitzgerald PB, Simpson B, Loo CK
Aust N Z J Psychiatry 2023 Sep;57(9):1202-1207. Epub 2023 Jun 23 doi: 10.1177/00048674231183368. PMID: 37353902
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Utility of the electroencephalogram in attention deficit hyperactivity disorder.
Millichap JG, Millichap JJ, Stack CV
Clin EEG Neurosci 2011 Jul;42(3):180-4. doi: 10.1177/155005941104200307. PMID: 21870470

Prognosis

Diagnosis, treatment, and follow-up of patients with cerebral amyloid angiopathy-related inflammation.
Cancelloni V, Rufa A, Battisti C, De Stefano N, Mastrocinque E, Garosi G, Venezia D, Chiarotti I, Cerase A
Neurol Sci 2022 Nov;43(11):6381-6387. Epub 2022 Aug 5 doi: 10.1007/s10072-022-06299-y. PMID: 35930182Free PMC Article
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Epilepsy and EEG Abnormalities in Children with Autism Spectrum Disorders.
Sharma V, Saini AG, Malhi P, Singhi P
Indian J Pediatr 2022 Oct;89(10):975-982. Epub 2021 Nov 29 doi: 10.1007/s12098-021-03928-w. PMID: 34843062
Methylprednisolone pulse therapy in 31 patients with refractory epilepsy: A single-center retrospective analysis.
Kimizu T, Takahashi Y, Oboshi T, Horino A, Omatsu H, Koike T, Yoshitomi S, Yamaguchi T, Otani H, Ikeda H, Imai K, Shigematsu H
Epilepsy Behav 2020 Aug;109:107116. Epub 2020 May 6 doi: 10.1016/j.yebeh.2020.107116. PMID: 32388139
Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659

Clinical prediction guides

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation.
Scholly J, Gras A, Guye M, Bilger M, Valenti Hirsch MP, Hirsch E, Timofeev A, Vidailhet P, Bénar CG, Bartolomei F
Brain Topogr 2022 Nov;35(5-6):627-635. Epub 2022 Sep 7 doi: 10.1007/s10548-022-00913-0. PMID: 36071370
Epilepsy and EEG Abnormalities in Children with Autism Spectrum Disorders.
Sharma V, Saini AG, Malhi P, Singhi P
Indian J Pediatr 2022 Oct;89(10):975-982. Epub 2021 Nov 29 doi: 10.1007/s12098-021-03928-w. PMID: 34843062
Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
How to establish causality in epilepsy surgery.
Asano E, Brown EC, Juhász C
Brain Dev 2013 Sep;35(8):706-20. Epub 2013 May 15 doi: 10.1016/j.braindev.2013.04.004. PMID: 23684007Free PMC Article

Recent systematic reviews

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
A systematic review of adults with Dravet syndrome.
Selvarajah A, Zulfiqar-Ali Q, Marques P, Rong M, Andrade DM
Seizure 2021 Apr;87:39-45. Epub 2021 Feb 22 doi: 10.1016/j.seizure.2021.02.025. PMID: 33677403
Remacemide for drug-resistant localization related epilepsy.
Leach JP, Marson AG, Hutton JL
Cochrane Database Syst Rev 2002;(4):CD001900. doi: 10.1002/14651858.CD001900. PMID: 12519561

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