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Focal aware autonomic seizure

MedGen UID:
1713511
Concept ID:
C5397750
Disease or Syndrome
Synonyms: Focal autonomic seizures without altered responsiveness; Focal onset aware autonomic epileptic seizure; Focal onset aware autonomic seizure; Focal-onset aware autonomic epileptic seizure; Localised autonomic seizures without altered responsiveness; Localized autonomic seizures without altered responsiveness; Partial autonomic seizures without altered responsiveness
SNOMED CT: Focal onset aware autonomic epileptic seizure (7454002); Focal-onset aware autonomic epileptic seizure (7454002); Focal aware autonomic seizure (7454002); Focal onset aware autonomic seizure (7454002)
 
HPO: HP:0032740

Definition

A focal aware autonomic seizure has an initial manifestation pertaining to autonomic nervous system function, which may be objective (for example, pupillary dilation) or subjective (for example, nausea). As a type of focal aware seizure, awareness is retained throughout. [from HPO]

Professional guidelines

PubMed

Cheval M, Houot M, Chastan N, Szurhaj W, Marchal C, Catenoix H, Valton L, Gavaret M, Herlin B, Biraben A, Lagarde S, Mazzola L, Minotti L, Maillard L, Dupont S
J Neurol 2023 May;270(5):2715-2723. Epub 2023 Feb 10 doi: 10.1007/s00415-023-11603-7. PMID: 36763175
Sathyaprabha TN, Koot LAM, Hermans BHM, Adoor M, Sinha S, Kramer BW, Raju TR, Satishchandra P, Delhaas T
Clin Drug Investig 2018 Sep;38(9):845-851. doi: 10.1007/s40261-018-0677-6. PMID: 30047104Free PMC Article

Recent clinical studies

Etiology

Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Ucar HK, Arhan E, Aydin K, Hirfanoglu T, Serdaroglu A
Eur Rev Med Pharmacol Sci 2022 Apr;26(7):2343-2352. doi: 10.26355/eurrev_202204_28463. PMID: 35442488
Pelliccia V, Avanzini P, Rizzi M, Caruana F, Tassi L, Francione S, Gozzo F, Mariani V, d'Orio P, Castana L, Mai R, Terzaghi M, Nobili L, Sartori I
Neurology 2022 May 31;98(22):e2211-e2223. Epub 2022 Feb 21 doi: 10.1212/WNL.0000000000200145. PMID: 35190463
Mielke H, Meissner S, Wagner K, Joos A, Schulze-Bonhage A
Epilepsia 2020 Jul;61(7):1365-1375. Epub 2020 Jun 9 doi: 10.1111/epi.16550. PMID: 32515852
Steriade C, Moosa ANV, Hantus S, Prayson RA, Alexopoulos A, Rae-Grant A
Seizure 2018 Aug;60:198-204. Epub 2018 Jun 28 doi: 10.1016/j.seizure.2018.06.021. PMID: 30031297

Diagnosis

Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Ucar HK, Arhan E, Aydin K, Hirfanoglu T, Serdaroglu A
Eur Rev Med Pharmacol Sci 2022 Apr;26(7):2343-2352. doi: 10.26355/eurrev_202204_28463. PMID: 35442488
Mielke H, Meissner S, Wagner K, Joos A, Schulze-Bonhage A
Epilepsia 2020 Jul;61(7):1365-1375. Epub 2020 Jun 9 doi: 10.1111/epi.16550. PMID: 32515852
Graziosi A, Pellegrino N, Di Stefano V, Raucci U, Luchetti A, Parisi P
Epilepsy Behav 2019 Sep;98(Pt A):124-128. Epub 2019 Jul 29 doi: 10.1016/j.yebeh.2019.07.016. PMID: 31369969
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM
Epilepsia 2017 Apr;58(4):522-530. Epub 2017 Mar 8 doi: 10.1111/epi.13670. PMID: 28276060

Therapy

Jeppesen J, Fuglsang-Frederiksen A, Johansen P, Christensen J, Wüstenhagen S, Tankisi H, Qerama E, Beniczky S
Epilepsia 2020 Nov;61 Suppl 1:S41-S46. Epub 2020 May 7 doi: 10.1111/epi.16511. PMID: 32378197
Natera-de Benito D, Muchart J, Itzep D, Ortez C, González-Quereda L, Gallano P, Ramirez A, Aparicio J, Domínguez-Carral J, Carrera-García L, Expósito-Escudero J, Pardo Cardozo N, Cuadras D, Codina A, Jou C, Jimenez-Mallebrera C, Palau F, Colomer J, Arzimanoglou A, Nascimento A, San Antonio-Arce V
Epilepsia 2020 May;61(5):971-983. Epub 2020 Apr 8 doi: 10.1111/epi.16493. PMID: 32266982
Steriade C, Moosa ANV, Hantus S, Prayson RA, Alexopoulos A, Rae-Grant A
Seizure 2018 Aug;60:198-204. Epub 2018 Jun 28 doi: 10.1016/j.seizure.2018.06.021. PMID: 30031297
Myers KA, Mandelstam SA, Ramantani G, Rushing EJ, de Vries BB, Koolen DA, Scheffer IE
Epilepsia 2017 Jun;58(6):1085-1094. Epub 2017 Apr 25 doi: 10.1111/epi.13746. PMID: 28440867
Wei DY, Kao J, Wu TY, Pereira JA, Anderson NE, Alan Barber P
J Clin Neurosci 2015 Jul;22(7):1201-2. Epub 2015 Mar 13 doi: 10.1016/j.jocn.2014.12.012. PMID: 25778383

Prognosis

Cheval M, Houot M, Chastan N, Szurhaj W, Marchal C, Catenoix H, Valton L, Gavaret M, Herlin B, Biraben A, Lagarde S, Mazzola L, Minotti L, Maillard L, Dupont S
J Neurol 2023 May;270(5):2715-2723. Epub 2023 Feb 10 doi: 10.1007/s00415-023-11603-7. PMID: 36763175
Vieluf S, Amengual-Gual M, Zhang B, El Atrache R, Ufongene C, Jackson MC, Branch S, Reinsberger C, Loddenkemper T
Epilepsia 2021 Apr;62(4):960-972. Epub 2021 Feb 23 doi: 10.1111/epi.16843. PMID: 33619751
Natera-de Benito D, Muchart J, Itzep D, Ortez C, González-Quereda L, Gallano P, Ramirez A, Aparicio J, Domínguez-Carral J, Carrera-García L, Expósito-Escudero J, Pardo Cardozo N, Cuadras D, Codina A, Jou C, Jimenez-Mallebrera C, Palau F, Colomer J, Arzimanoglou A, Nascimento A, San Antonio-Arce V
Epilepsia 2020 May;61(5):971-983. Epub 2020 Apr 8 doi: 10.1111/epi.16493. PMID: 32266982
Steriade C, Moosa ANV, Hantus S, Prayson RA, Alexopoulos A, Rae-Grant A
Seizure 2018 Aug;60:198-204. Epub 2018 Jun 28 doi: 10.1016/j.seizure.2018.06.021. PMID: 30031297
Pischik E, Kauppinen R
Cell Mol Biol (Noisy-le-grand) 2009 Feb 16;55(1):72-83. PMID: 19268005

Clinical prediction guides

Shibata T, Kondo M, Fukushima Y, Akiyama M, Akiyama T, Morooka T, Baba K, Ohtsuki S, Tsukahara H, Kasahara S, Kobayashi K
Pediatr Neurol 2023 Oct;147:28-35. Epub 2023 Jul 13 doi: 10.1016/j.pediatrneurol.2023.07.004. PMID: 37542972
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Cheval M, Houot M, Chastan N, Szurhaj W, Marchal C, Catenoix H, Valton L, Gavaret M, Herlin B, Biraben A, Lagarde S, Mazzola L, Minotti L, Maillard L, Dupont S
J Neurol 2023 May;270(5):2715-2723. Epub 2023 Feb 10 doi: 10.1007/s00415-023-11603-7. PMID: 36763175
Vieluf S, Amengual-Gual M, Zhang B, El Atrache R, Ufongene C, Jackson MC, Branch S, Reinsberger C, Loddenkemper T
Epilepsia 2021 Apr;62(4):960-972. Epub 2021 Feb 23 doi: 10.1111/epi.16843. PMID: 33619751
Natera-de Benito D, Muchart J, Itzep D, Ortez C, González-Quereda L, Gallano P, Ramirez A, Aparicio J, Domínguez-Carral J, Carrera-García L, Expósito-Escudero J, Pardo Cardozo N, Cuadras D, Codina A, Jou C, Jimenez-Mallebrera C, Palau F, Colomer J, Arzimanoglou A, Nascimento A, San Antonio-Arce V
Epilepsia 2020 May;61(5):971-983. Epub 2020 Apr 8 doi: 10.1111/epi.16493. PMID: 32266982

Recent systematic reviews

Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208

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