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Multinucleation of renal tubular epithelial cells

MedGen UID:
1713716
•Concept ID:
C5397623
•
Cell or Molecular Dysfunction
HPO: HP:0032601

Definition

Tubular epithelial cells with greater than 3 nuclei in a single epithelial cell, often overlapping with each other in a single plane of view. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultinucleation of renal tubular epithelial cells

Recent clinical studies

Etiology

Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro.
Gerges D, Hevesi Z, Schmidt SH, Kapps S, Pajenda S, Geist B, Schmidt A, Wagner L, Winnicki W
PeerJ 2022;10:e14110. Epub 2022 Oct 20 doi: 10.7717/peerj.14110. PMID: 36285332Free PMC Article
Human herpesvirus-6 infection in renal allografts: retrospective immunohistochemical study in Japanese recipients.
Hoshino K, Nishi T, Adachi H, Ito H, Fukuda Y, Dohi K, Kurata T
Transpl Int 1995;8(3):169-73. doi: 10.1007/BF00336532. PMID: 7626174
Myeloma cast nephropathy: immunohistochemical and lectin studies.
Start DA, Silva FG, Davis LD, D'Agati V, Pirani CL
Mod Pathol 1988 Sep;1(5):336-47. PMID: 2467287

Diagnosis

Human herpesvirus-6 infection in renal allografts: retrospective immunohistochemical study in Japanese recipients.
Hoshino K, Nishi T, Adachi H, Ito H, Fukuda Y, Dohi K, Kurata T
Transpl Int 1995;8(3):169-73. doi: 10.1007/BF00336532. PMID: 7626174
Drug-induced hypersensitivity nephritis: lymphocyte stimulation testing and renal biopsy in 10 cases.
Joh K, Aizawa S, Yamaguchi Y, Inomata I, Shibasaki T, Sakai O, Hamaguchi K
Am J Nephrol 1990;10(3):222-30. doi: 10.1159/000168085. PMID: 2382683
The use of hierarchic classification in the image analysis of a complex cell population. Experience with the sediment of voided urine.
Koss LG, Sherman AB, Adams SE
Anal Quant Cytol 1983 Sep;5(3):159-66. PMID: 6651015
The histiocytic origin of the multinucleated giant cells in myeloma kidney.
Factor SM, Winn RM, Biempica L
Hum Pathol 1978 Jan;9(1):114-20. doi: 10.1016/s0046-8177(78)80013-6. PMID: 415962

Therapy

Drug-induced hypersensitivity nephritis: lymphocyte stimulation testing and renal biopsy in 10 cases.
Joh K, Aizawa S, Yamaguchi Y, Inomata I, Shibasaki T, Sakai O, Hamaguchi K
Am J Nephrol 1990;10(3):222-30. doi: 10.1159/000168085. PMID: 2382683
Granulomatous interstitial nephritis after a jejunoileal bypass: an ultrastructural and histochemical study.
Verani R, Nasir M, Foley R
Am J Nephrol 1989;9(1):51-5. doi: 10.1159/000167935. PMID: 2719063

Prognosis

Human herpesvirus-6 infection in renal allografts: retrospective immunohistochemical study in Japanese recipients.
Hoshino K, Nishi T, Adachi H, Ito H, Fukuda Y, Dohi K, Kurata T
Transpl Int 1995;8(3):169-73. doi: 10.1007/BF00336532. PMID: 7626174

Clinical prediction guides

Drug-induced hypersensitivity nephritis: lymphocyte stimulation testing and renal biopsy in 10 cases.
Joh K, Aizawa S, Yamaguchi Y, Inomata I, Shibasaki T, Sakai O, Hamaguchi K
Am J Nephrol 1990;10(3):222-30. doi: 10.1159/000168085. PMID: 2382683
Macrophage origin of the multinucleated cells of myeloma cast nephropathy.
Alpers CE, Magil AB, Gown AM
Am J Clin Pathol 1989 Nov;92(5):662-5. doi: 10.1093/ajcp/92.5.662. PMID: 2479257
The use of hierarchic classification in the image analysis of a complex cell population. Experience with the sediment of voided urine.
Koss LG, Sherman AB, Adams SE
Anal Quant Cytol 1983 Sep;5(3):159-66. PMID: 6651015

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