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NTRK3 Gene Amplification

MedGen UID:
1714405
•Concept ID:
C5238271
•
Cell or Molecular Dysfunction
Synonyms: Neurotrophic Receptor Tyrosine Kinase 3 Gene Amplification; Neurotrophic Tyrosine Kinase Receptor 3 Gene Amplification; Neurotrophic Tyrosine Kinase Receptor Type 3 Gene Amplification; Neurotrophic Tyrosine Kinase, Receptor, Type 3 Gene Amplification; NTRK3 Amplification; TRKC Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the NTRK3 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNTRK3 Gene Amplification

Professional guidelines

PubMed

The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical Trials.
Suh JH, Johnson A, Albacker L, Wang K, Chmielecki J, Frampton G, Gay L, Elvin JA, Vergilio JA, Ali S, Miller VA, Stephens PJ, Ross JS
Oncologist 2016 Jun;21(6):684-91. Epub 2016 May 5 doi: 10.1634/theoncologist.2016-0030. PMID: 27151654Free PMC Article

Recent clinical studies

Etiology

Genomic Signature of Driver Genes Identified by Target Next-Generation Sequencing in Chinese Non-Small Cell Lung Cancer.
Wen S, Dai L, Wang L, Wang W, Wu D, Wang K, He Z, Wang A, Chen H, Zhang P, Dong X, Dong YA, Wang K, Yao M, Wang M
Oncologist 2019 Nov;24(11):e1070-e1081. Epub 2019 Mar 22 doi: 10.1634/theoncologist.2018-0572. PMID: 30902917Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Copy number variations of neurotrophic tyrosine receptor kinase 3 (NTRK3) may predict prognosis of ovarian cancer.
Ge L, Li N, Liu M, Xu NZ, Wang MR, Wu LY
Medicine (Baltimore) 2017 Jul;96(30):e7621. doi: 10.1097/MD.0000000000007621. PMID: 28746220Free PMC Article
Identification of NTRK3 Fusions in Childhood Melanocytic Neoplasms.
Wang L, Busam KJ, Benayed R, Cimera R, Wang J, Denley R, Rao M, Aryeequaye R, Mullaney K, Cao L, Ladanyi M, Hameed M
J Mol Diagn 2017 May;19(3):387-396. doi: 10.1016/j.jmoldx.2016.11.005. PMID: 28433076Free PMC Article
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.
Hechtman JF, Zehir A, Yaeger R, Wang L, Middha S, Zheng T, Hyman DM, Solit D, Arcila ME, Borsu L, Shia J, Vakiani E, Saltz L, Ladanyi M
Mol Cancer Res 2016 Mar;14(3):296-301. Epub 2015 Dec 11 doi: 10.1158/1541-7786.MCR-15-0392-T. PMID: 26660078Free PMC Article

Diagnosis

Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.
Gianno F, Giovannoni I, Cafferata B, Diomedi-Camassei F, Minasi S, Barresi S, Buttarelli FR, Alesi V, Cardoni A, Antonelli M, Puggioni C, Colafati GS, Carai A, Vinci M, Mastronuzzi A, Miele E, Alaggio R, Giangaspero F, Rossi S
Pathologica 2022 Dec;114(6):422-435. doi: 10.32074/1591-951X-830. PMID: 36534421Free PMC Article
Problematic breast tumors reassessed in light of novel molecular data.
Pareja F, Weigelt B, Reis-Filho JS
Mod Pathol 2021 Jan;34(Suppl 1):38-47. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00693-7. PMID: 33024304Free PMC Article
The histologic spectrum of soft tissue spindle cell tumors with NTRK3 gene rearrangements.
Suurmeijer AJ, Dickson BC, Swanson D, Zhang L, Sung YS, Huang HY, Fletcher CD, Antonescu CR
Genes Chromosomes Cancer 2019 Nov;58(11):739-746. Epub 2019 Jun 4 doi: 10.1002/gcc.22767. PMID: 31112350Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma.
Wang Y, Miller S, Roulston D, Bixby D, Shao L
J Mol Diagn 2016 Jul;18(4):595-603. Epub 2016 May 6 doi: 10.1016/j.jmoldx.2016.03.004. PMID: 27161658

Therapy

Copy number variations of neurotrophic tyrosine receptor kinase 3 (NTRK3) may predict prognosis of ovarian cancer.
Ge L, Li N, Liu M, Xu NZ, Wang MR, Wu LY
Medicine (Baltimore) 2017 Jul;96(30):e7621. doi: 10.1097/MD.0000000000007621. PMID: 28746220Free PMC Article
Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical Trials.
Suh JH, Johnson A, Albacker L, Wang K, Chmielecki J, Frampton G, Gay L, Elvin JA, Vergilio JA, Ali S, Miller VA, Stephens PJ, Ross JS
Oncologist 2016 Jun;21(6):684-91. Epub 2016 May 5 doi: 10.1634/theoncologist.2016-0030. PMID: 27151654Free PMC Article
Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia.
Kralik JM, Kranewitter W, Boesmueller H, Marschon R, Tschurtschenthaler G, Rumpold H, Wiesinger K, Erdel M, Petzer AL, Webersinke G
Diagn Pathol 2011 Mar 15;6:19. doi: 10.1186/1746-1596-6-19. PMID: 21401966Free PMC Article
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization.
Lambros MB, Simpson PT, Jones C, Natrajan R, Westbury C, Steele D, Savage K, Mackay A, Schmitt FC, Ashworth A, Reis-Filho JS
Lab Invest 2006 Apr;86(4):398-408. doi: 10.1038/labinvest.3700390. PMID: 16446704

Prognosis

NTRK gene aberrations in triple-negative breast cancer: detection challenges using IHC, FISH, RT-PCR, and NGS.
Zito Marino F, Buono S, Montella M, Giannatiempo R, Messina F, Casaretta G, Arpino G, Vita G, Fiorentino F, Insabato L, Sgambato A, Orditura M, Franco R, Accardo M
J Pathol Clin Res 2023 Sep;9(5):367-377. Epub 2023 May 4 doi: 10.1002/cjp2.324. PMID: 37143440Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Copy number variations of neurotrophic tyrosine receptor kinase 3 (NTRK3) may predict prognosis of ovarian cancer.
Ge L, Li N, Liu M, Xu NZ, Wang MR, Wu LY
Medicine (Baltimore) 2017 Jul;96(30):e7621. doi: 10.1097/MD.0000000000007621. PMID: 28746220Free PMC Article
Identification of NTRK3 Fusions in Childhood Melanocytic Neoplasms.
Wang L, Busam KJ, Benayed R, Cimera R, Wang J, Denley R, Rao M, Aryeequaye R, Mullaney K, Cao L, Ladanyi M, Hameed M
J Mol Diagn 2017 May;19(3):387-396. doi: 10.1016/j.jmoldx.2016.11.005. PMID: 28433076Free PMC Article
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.
Hechtman JF, Zehir A, Yaeger R, Wang L, Middha S, Zheng T, Hyman DM, Solit D, Arcila ME, Borsu L, Shia J, Vakiani E, Saltz L, Ladanyi M
Mol Cancer Res 2016 Mar;14(3):296-301. Epub 2015 Dec 11 doi: 10.1158/1541-7786.MCR-15-0392-T. PMID: 26660078Free PMC Article

Clinical prediction guides

NTRK gene aberrations in triple-negative breast cancer: detection challenges using IHC, FISH, RT-PCR, and NGS.
Zito Marino F, Buono S, Montella M, Giannatiempo R, Messina F, Casaretta G, Arpino G, Vita G, Fiorentino F, Insabato L, Sgambato A, Orditura M, Franco R, Accardo M
J Pathol Clin Res 2023 Sep;9(5):367-377. Epub 2023 May 4 doi: 10.1002/cjp2.324. PMID: 37143440Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Identification of NTRK3 Fusions in Childhood Melanocytic Neoplasms.
Wang L, Busam KJ, Benayed R, Cimera R, Wang J, Denley R, Rao M, Aryeequaye R, Mullaney K, Cao L, Ladanyi M, Hameed M
J Mol Diagn 2017 May;19(3):387-396. doi: 10.1016/j.jmoldx.2016.11.005. PMID: 28433076Free PMC Article
Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma.
Wang Y, Miller S, Roulston D, Bixby D, Shao L
J Mol Diagn 2016 Jul;18(4):595-603. Epub 2016 May 6 doi: 10.1016/j.jmoldx.2016.03.004. PMID: 27161658
Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression.
Mosse YP, Diskin SJ, Wasserman N, Rinaldi K, Attiyeh EF, Cole K, Jagannathan J, Bhambhani K, Winter C, Maris JM
Genes Chromosomes Cancer 2007 Oct;46(10):936-49. doi: 10.1002/gcc.20477. PMID: 17647283

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