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Decreased cystatin C level

MedGen UID:
1715248
•Concept ID:
C5397988
•
Finding
HPO: HP:0032997

Definition

A decreased concentration of cystatin C in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased cystatin C level

Professional guidelines

PubMed

Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Clinical utility of serum cystatin C in predicting coronary artery disease in patients without chronic kidney disease.
Dandana A, Gammoudi I, Chalghoum A, Chahed H, Addad F, Ferchichi S, Miled A
J Clin Lab Anal 2014 May;28(3):191-7. Epub 2014 Jan 29 doi: 10.1002/jcla.21665. PMID: 24478035Free PMC Article
The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease.
Maetzler W, Schmid B, Synofzik M, Schulte C, Riester K, Huber H, Brockmann K, Gasser T, Berg D, Melms A
J Alzheimers Dis 2010;19(3):937-42. doi: 10.3233/JAD-2010-1289. PMID: 20157249

Recent clinical studies

Etiology

Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Creatinine-cystatin C ratio and mortality in cancer patients: a retrospective cohort study.
Jung CY, Kim HW, Han SH, Yoo TH, Kang SW, Park JT
J Cachexia Sarcopenia Muscle 2022 Aug;13(4):2064-2072. Epub 2022 Apr 27 doi: 10.1002/jcsm.13006. PMID: 35478277Free PMC Article
Renoprotective Effect of Intraoperative Dexmedetomidine in Renal Transplantation.
Liu Z, Jin Y, Feng C, Liu G, Wang Y, Zhao X, Liu G
Comput Math Methods Med 2022;2022:9275406. Epub 2022 Feb 15 doi: 10.1155/2022/9275406. PMID: 35211189Free PMC Article
The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Loomba RS, Villarreal EG, Dhargalkar J, Rausa J, Dorsey V, Farias JS, Flores S
J Clin Pharm Ther 2022 Mar;47(3):287-297. Epub 2021 Sep 12 doi: 10.1111/jcpt.13527. PMID: 34510502
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364

Diagnosis

Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Creatinine-cystatin C ratio and mortality in cancer patients: a retrospective cohort study.
Jung CY, Kim HW, Han SH, Yoo TH, Kang SW, Park JT
J Cachexia Sarcopenia Muscle 2022 Aug;13(4):2064-2072. Epub 2022 Apr 27 doi: 10.1002/jcsm.13006. PMID: 35478277Free PMC Article
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364
How to use… serum creatinine, cystatin C and GFR.
Pasala S, Carmody JB
Arch Dis Child Educ Pract Ed 2017 Feb;102(1):37-43. Epub 2016 Sep 19 doi: 10.1136/archdischild-2016-311062. PMID: 27647862

Therapy

Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
Renoprotective Effect of Intraoperative Dexmedetomidine in Renal Transplantation.
Liu Z, Jin Y, Feng C, Liu G, Wang Y, Zhao X, Liu G
Comput Math Methods Med 2022;2022:9275406. Epub 2022 Feb 15 doi: 10.1155/2022/9275406. PMID: 35211189Free PMC Article
The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Loomba RS, Villarreal EG, Dhargalkar J, Rausa J, Dorsey V, Farias JS, Flores S
J Clin Pharm Ther 2022 Mar;47(3):287-297. Epub 2021 Sep 12 doi: 10.1111/jcpt.13527. PMID: 34510502
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article

Prognosis

Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis.
Matuszewski M, Reznikov Y, Pruc M, Peacock FW, Navolokina A, Júarez-Vela R, Jankowski L, Rafique Z, Szarpak L
Int J Environ Res Public Health 2022 Nov 7;19(21) doi: 10.3390/ijerph192114607. PMID: 36361485Free PMC Article
Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure and Mortality by Black vs Non-Black Race.
Gutiérrez OM, Sang Y, Grams ME, Ballew SH, Surapaneni A, Matsushita K, Go AS, Shlipak MG, Inker LA, Eneanya ND, Crews DC, Powe NR, Levey AS, Coresh J; Chronic Kidney Disease Prognosis Consortium
JAMA 2022 Jun 21;327(23):2306-2316. doi: 10.1001/jama.2022.8801. PMID: 35667006Free PMC Article
Renoprotective Effect of Intraoperative Dexmedetomidine in Renal Transplantation.
Liu Z, Jin Y, Feng C, Liu G, Wang Y, Zhao X, Liu G
Comput Math Methods Med 2022;2022:9275406. Epub 2022 Feb 15 doi: 10.1155/2022/9275406. PMID: 35211189Free PMC Article
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364

Clinical prediction guides

Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure and Mortality by Black vs Non-Black Race.
Gutiérrez OM, Sang Y, Grams ME, Ballew SH, Surapaneni A, Matsushita K, Go AS, Shlipak MG, Inker LA, Eneanya ND, Crews DC, Powe NR, Levey AS, Coresh J; Chronic Kidney Disease Prognosis Consortium
JAMA 2022 Jun 21;327(23):2306-2316. doi: 10.1001/jama.2022.8801. PMID: 35667006Free PMC Article
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
Renoprotective Effect of Intraoperative Dexmedetomidine in Renal Transplantation.
Liu Z, Jin Y, Feng C, Liu G, Wang Y, Zhao X, Liu G
Comput Math Methods Med 2022;2022:9275406. Epub 2022 Feb 15 doi: 10.1155/2022/9275406. PMID: 35211189Free PMC Article
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article

Recent systematic reviews

Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis.
Matuszewski M, Reznikov Y, Pruc M, Peacock FW, Navolokina A, Júarez-Vela R, Jankowski L, Rafique Z, Szarpak L
Int J Environ Res Public Health 2022 Nov 7;19(21) doi: 10.3390/ijerph192114607. PMID: 36361485Free PMC Article
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Loomba RS, Villarreal EG, Dhargalkar J, Rausa J, Dorsey V, Farias JS, Flores S
J Clin Pharm Ther 2022 Mar;47(3):287-297. Epub 2021 Sep 12 doi: 10.1111/jcpt.13527. PMID: 34510502
The value of serum cystatin C in early evaluation of renal insufficiency in patients undergoing chemotherapy: a systematic review and meta-analysis.
He L, Li J, Zhan J, Yi F, Fan X, Wei Y, Zhang W
Cancer Chemother Pharmacol 2019 Mar;83(3):561-571. Epub 2019 Jan 4 doi: 10.1007/s00280-018-3762-x. PMID: 30610366
Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis.
Zhu Y, Yang M, Li F, Li M, Xu Z, Yang F, Liu Y, Chen W, Zhang Y, Xu R
Int J Biol Sci 2018;14(9):1041-1053. Epub 2018 Jun 3 doi: 10.7150/ijbs.25711. PMID: 29989057Free PMC Article

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