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Decreased cystatin C level

MedGen UID:
1715248
•Concept ID:
C5397988
•
Finding
HPO: HP:0032997

Definition

A decreased concentration of cystatin C in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased cystatin C level

Professional guidelines

PubMed

Assessment of vitamin B12 levels and cardiovascular risk factors in metformin- and non-metformin-treated type 2 diabetic patients.
Ilona Nyulas K, Cornelia Tilinca M, Pál S, Fogarasi EM, Croitoru MD, Gabriel Tripon R, Preg Z, Germán-Salló M, Simon-Szabó Z, Nemes-Nagy E
Pak J Pharm Sci 2023 Sep;36(5):1399-1405. PMID: 37869915
Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Clinical utility of serum cystatin C in predicting coronary artery disease in patients without chronic kidney disease.
Dandana A, Gammoudi I, Chalghoum A, Chahed H, Addad F, Ferchichi S, Miled A
J Clin Lab Anal 2014 May;28(3):191-7. Epub 2014 Jan 29 doi: 10.1002/jcla.21665. PMID: 24478035Free PMC Article

Recent clinical studies

Etiology

Caffeine Intake, Plasma Caffeine Level, and Kidney Function: A Mendelian Randomization Study.
Giontella A, de La Harpe R, Cronje HT, Zagkos L, Woolf B, Larsson SC, Gill D
Nutrients 2023 Oct 18;15(20) doi: 10.3390/nu15204422. PMID: 37892497Free PMC Article
Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Risk for Chronic Kidney Disease Progression After Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort Study.
Muiru AN, Hsu JY, Zhang X, Appel LJ, Chen J, Cohen DL, Drawz PE, Freedman BI, Go AS, He J, Horwitz EJ, Hsu RK, Lash JP, Liu KD, McCoy IE, Porter A, Rao P, Ricardo AC, Rincon-Choles H, Sondheimer J, Taliercio J, Unruh M, Hsu CY; CRIC Study Investigators
Ann Intern Med 2023 Jul;176(7):961-968. Epub 2023 Jul 11 doi: 10.7326/M22-3617. PMID: 37429030Free PMC Article
Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364

Diagnosis

Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364

Therapy

Caffeine Intake, Plasma Caffeine Level, and Kidney Function: A Mendelian Randomization Study.
Giontella A, de La Harpe R, Cronje HT, Zagkos L, Woolf B, Larsson SC, Gill D
Nutrients 2023 Oct 18;15(20) doi: 10.3390/nu15204422. PMID: 37892497Free PMC Article
Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article

Prognosis

Sarcopenia, adiposity and large discordance between cystatin C and creatinine-based estimated glomerular filtration rate in patients with cancer.
Hanna PE, Ouyang T, Tahir I, Katz-Agranov N, Wang Q, Mantz L, Strohbehn I, Moreno D, Harden D, Dinulos JE, Cosar D, Seethapathy H, Gainor JF, Shah SJ, Gupta S, Leaf DE, Fintelmann FJ, Sise ME
J Cachexia Sarcopenia Muscle 2024 Jun;15(3):1187-1198. Epub 2024 Apr 22 doi: 10.1002/jcsm.13469. PMID: 38646842Free PMC Article
Caffeine Intake, Plasma Caffeine Level, and Kidney Function: A Mendelian Randomization Study.
Giontella A, de La Harpe R, Cronje HT, Zagkos L, Woolf B, Larsson SC, Gill D
Nutrients 2023 Oct 18;15(20) doi: 10.3390/nu15204422. PMID: 37892497Free PMC Article
Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis.
Matuszewski M, Reznikov Y, Pruc M, Peacock FW, Navolokina A, Júarez-Vela R, Jankowski L, Rafique Z, Szarpak L
Int J Environ Res Public Health 2022 Nov 7;19(21) doi: 10.3390/ijerph192114607. PMID: 36361485Free PMC Article
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364

Clinical prediction guides

Caffeine Intake, Plasma Caffeine Level, and Kidney Function: A Mendelian Randomization Study.
Giontella A, de La Harpe R, Cronje HT, Zagkos L, Woolf B, Larsson SC, Gill D
Nutrients 2023 Oct 18;15(20) doi: 10.3390/nu15204422. PMID: 37892497Free PMC Article
Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
Gestational and Age-Specific Cystatin C Reference Intervals for Newborns.
Tong C, Liu Y, Wu Y, Li Q, Wu Y, Wang L, Chen Y
Am J Perinatol 2022 Nov;39(15):1654-1658. Epub 2021 Feb 23 doi: 10.1055/s-0041-1724000. PMID: 33621984
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article

Recent systematic reviews

Dexmedetomidine and acute kidney injury after non-cardiac surgery: A meta-analysis with trial sequential analysis.
Zhuang K, Yang HT, Long YQ, Liu H, Ji FH, Peng K
Anaesth Crit Care Pain Med 2024 Jun;43(3):101359. Epub 2024 Feb 21 doi: 10.1016/j.accpm.2024.101359. PMID: 38395357
Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis.
Matuszewski M, Reznikov Y, Pruc M, Peacock FW, Navolokina A, Júarez-Vela R, Jankowski L, Rafique Z, Szarpak L
Int J Environ Res Public Health 2022 Nov 7;19(21) doi: 10.3390/ijerph192114607. PMID: 36361485Free PMC Article
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Loomba RS, Villarreal EG, Dhargalkar J, Rausa J, Dorsey V, Farias JS, Flores S
J Clin Pharm Ther 2022 Mar;47(3):287-297. Epub 2021 Sep 12 doi: 10.1111/jcpt.13527. PMID: 34510502
Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis.
Zhu Y, Yang M, Li F, Li M, Xu Z, Yang F, Liu Y, Chen W, Zhang Y, Xu R
Int J Biol Sci 2018;14(9):1041-1053. Epub 2018 Jun 3 doi: 10.7150/ijbs.25711. PMID: 29989057Free PMC Article

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