U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased cystatin C level

MedGen UID:
1715248
•Concept ID:
C5397988
•
Finding
HPO: HP:0032997

Definition

A decreased concentration of cystatin C in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased cystatin C level

Professional guidelines

PubMed

Shenkang injection for the treatment of acute kidney injury: a systematic review and meta-analysis.
Liao S, Chen Y, Wang S, Wang C, Ye C
Ren Fail 2024 Dec;46(1):2338566. Epub 2024 Apr 24 doi: 10.1080/0886022X.2024.2338566. PMID: 38655870Free PMC Article
Assessment of vitamin B12 levels and cardiovascular risk factors in metformin- and non-metformin-treated type 2 diabetic patients.
Ilona Nyulas K, Cornelia Tilinca M, Pál S, Fogarasi EM, Croitoru MD, Gabriel Tripon R, Preg Z, Germán-Salló M, Simon-Szabó Z, Nemes-Nagy E
Pak J Pharm Sci 2023 Sep;36(5):1399-1405. PMID: 37869915
Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442

Recent clinical studies

Etiology

Safety analysis of laboratory parameters in paediatric patients with spinal muscular atrophy treated with nusinersen.
Zhu X, Li H, Hu C, Wu M, Zhou S, Wang Y, Li W
BMC Pediatr 2024 Jul 25;24(1):474. doi: 10.1186/s12887-024-04955-0. PMID: 39054521Free PMC Article
Kidney Function and Risk of Renal Cell Carcinoma.
Alcala K, Zahed H, Cortez Cardoso Penha R, Alcala N, Robbins HA, Smith-Byrne K, Martin RM, Muller DC, Brennan P, Johansson M
Cancer Epidemiol Biomarkers Prev 2023 Nov 1;32(11):1644-1650. doi: 10.1158/1055-9965.EPI-23-0558. PMID: 37668600Free PMC Article
Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364

Diagnosis

Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364
Longitudinal patterns of urine biomarkers in infants across gestational ages.
DeFreitas MJ, Seeherunvong W, Katsoufis CP, RamachandraRao S, Duara S, Yasin S, Zilleruelo G, Rodriguez MM, Abitbol CL
Pediatr Nephrol 2016 Jul;31(7):1179-88. Epub 2016 Feb 9 doi: 10.1007/s00467-016-3327-3. PMID: 26862052

Therapy

Prospective validation of an equation based on plasma cystatin C for monitoring the glomerular filtration rate in children treated with cisplatin or ifosfamide for cancer.
Lambert M, Alonso M, Munzer C, Zimoch MC, Malard L, Gambart M, Castex MP, Martins C, Pasquet M, Chatelut E
Cancer Chemother Pharmacol 2024 Apr;93(4):393-395. Epub 2023 Oct 3 doi: 10.1007/s00280-023-04597-6. PMID: 37789166
Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management.
Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R
Biomed Pharmacother 2023 Sep;165:115183. Epub 2023 Jul 22 doi: 10.1016/j.biopha.2023.115183. PMID: 37487442
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article
Bazedoxifene improves renal function and increases renal phosphate excretion in patients with postmenopausal osteoporosis.
Masaki H, Imanishi Y, Naka H, Nagata Y, Kurajoh M, Mori K, Emoto M, Miki T, Inaba M
J Bone Miner Metab 2020 May;38(3):405-411. Epub 2020 Jan 2 doi: 10.1007/s00774-019-01073-1. PMID: 31897746
The use of estimated glomerular filtration rate for dose adjustment of medications in the elderly.
Elinder CG, Bárány P, Heimbürger O
Drugs Aging 2014 Jul;31(7):493-9. doi: 10.1007/s40266-014-0187-z. PMID: 24902935

Prognosis

Caffeine Intake, Plasma Caffeine Level, and Kidney Function: A Mendelian Randomization Study.
Giontella A, de La Harpe R, Cronje HT, Zagkos L, Woolf B, Larsson SC, Gill D
Nutrients 2023 Oct 18;15(20) doi: 10.3390/nu15204422. PMID: 37892497Free PMC Article
Bazedoxifene improves renal function and increases renal phosphate excretion in patients with postmenopausal osteoporosis.
Masaki H, Imanishi Y, Naka H, Nagata Y, Kurajoh M, Mori K, Emoto M, Miki T, Inaba M
J Bone Miner Metab 2020 May;38(3):405-411. Epub 2020 Jan 2 doi: 10.1007/s00774-019-01073-1. PMID: 31897746
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364
Comparison of the nephrotoxic effects of iodixanol versus iohexol in patients with chronic heart failure undergoing coronary angiography or angioplasty.
Song T, Song M, Ge Z, Li Y, Shi P, Sun M
J Interv Cardiol 2017 Jun;30(3):281-285. Epub 2017 Apr 19 doi: 10.1111/joic.12381. PMID: 28421628

Clinical prediction guides

Safety analysis of laboratory parameters in paediatric patients with spinal muscular atrophy treated with nusinersen.
Zhu X, Li H, Hu C, Wu M, Zhou S, Wang Y, Li W
BMC Pediatr 2024 Jul 25;24(1):474. doi: 10.1186/s12887-024-04955-0. PMID: 39054521Free PMC Article
Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.
Li C, Ma Y, Yang C, Hua R, Xie W, Zhang L
JAMA Netw Open 2022 Sep 1;5(9):e2234208. doi: 10.1001/jamanetworkopen.2022.34208. PMID: 36178684Free PMC Article
Hypothyroidism and Kidney Function: A Mendelian Randomization Study.
Ellervik C, Mora S, Ridker PM, Chasman DI
Thyroid 2020 Mar;30(3):365-379. Epub 2020 Feb 14 doi: 10.1089/thy.2019.0167. PMID: 31910748Free PMC Article
Bazedoxifene improves renal function and increases renal phosphate excretion in patients with postmenopausal osteoporosis.
Masaki H, Imanishi Y, Naka H, Nagata Y, Kurajoh M, Mori K, Emoto M, Miki T, Inaba M
J Bone Miner Metab 2020 May;38(3):405-411. Epub 2020 Jan 2 doi: 10.1007/s00774-019-01073-1. PMID: 31897746
Renal dysfunction can be a common complication in patients with myotonic dystrophy 1.
Matsumura T, Saito T, Yonemoto N, Nakamori M, Sugiura T, Nakamori A, Fujimura H, Sakoda S
J Neurol Sci 2016 Sep 15;368:266-71. Epub 2016 Jul 15 doi: 10.1016/j.jns.2016.07.036. PMID: 27538647

Recent systematic reviews

Dexmedetomidine and acute kidney injury after non-cardiac surgery: A meta-analysis with trial sequential analysis.
Zhuang K, Yang HT, Long YQ, Liu H, Ji FH, Peng K
Anaesth Crit Care Pain Med 2024 Jun;43(3):101359. Epub 2024 Feb 21 doi: 10.1016/j.accpm.2024.101359. PMID: 38395357
Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis.
Matuszewski M, Reznikov Y, Pruc M, Peacock FW, Navolokina A, Júarez-Vela R, Jankowski L, Rafique Z, Szarpak L
Int J Environ Res Public Health 2022 Nov 7;19(21) doi: 10.3390/ijerph192114607. PMID: 36361485Free PMC Article
Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.
Dai Y, Quan J, Xiong L, Luo Y, Yi B
Ren Fail 2022 Dec;44(1):862-880. doi: 10.1080/0886022X.2022.2079522. PMID: 35611435Free PMC Article
The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Loomba RS, Villarreal EG, Dhargalkar J, Rausa J, Dorsey V, Farias JS, Flores S
J Clin Pharm Ther 2022 Mar;47(3):287-297. Epub 2021 Sep 12 doi: 10.1111/jcpt.13527. PMID: 34510502
Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis.
Zhu Y, Yang M, Li F, Li M, Xu Z, Yang F, Liu Y, Chen W, Zhang Y, Xu R
Int J Biol Sci 2018;14(9):1041-1053. Epub 2018 Jun 3 doi: 10.7150/ijbs.25711. PMID: 29989057Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...