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Abnormal cystatin C level

MedGen UID:
1712733
•Concept ID:
C5397987
•
Finding
HPO: HP:0032996

Definition

Any deviation from the normal concentration of cystatin C in serum or plasma. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cystatin C level

Recent clinical studies

Etiology

Safety analysis of laboratory parameters in paediatric patients with spinal muscular atrophy treated with nusinersen.
Zhu X, Li H, Hu C, Wu M, Zhou S, Wang Y, Li W
BMC Pediatr 2024 Jul 25;24(1):474. doi: 10.1186/s12887-024-04955-0. PMID: 39054521Free PMC Article
The association between blood pressure variability and renal damage in patients with primary aldosteronism.
Wu S, Li S, Huang J, Yu J, Wei C, Wei L, Zhu S, Chen S, Chen M, Li J
J Clin Hypertens (Greenwich) 2024 Jul;26(7):765-771. Epub 2024 Apr 30 doi: 10.1111/jch.14824. PMID: 38689511Free PMC Article
Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: Putative consequences in mucopolysaccharidosis.
Denamur S, Chazeirat T, Maszota-Zieleniak M, Vivès RR, Saidi A, Zhang F, Linhardt RJ, Labarthe F, Samsonov SA, Lalmanach G, Lecaille F
Carbohydr Polym 2022 Oct 1;293:119734. Epub 2022 Jun 18 doi: 10.1016/j.carbpol.2022.119734. PMID: 35798429
Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.
Lee JH, Lee AJ, Dang LH, Pang D, Kisselev S, Krinsky-McHale SJ, Zigman WB, Luchsinger JA, Silverman W, Tycko B, Clark LN, Schupf N
Neurobiol Aging 2017 Aug;56:150-158. Epub 2017 May 3 doi: 10.1016/j.neurobiolaging.2017.04.018. PMID: 28554490Free PMC Article
A common RET variant is associated with reduced newborn kidney size and function.
Zhang Z, Quinlan J, Hoy W, Hughson MD, Lemire M, Hudson T, Hueber PA, Benjamin A, Roy A, Pascuet E, Goodyer M, Raju C, Houghton F, Bertram J, Goodyer P
J Am Soc Nephrol 2008 Oct;19(10):2027-34. doi: 10.1681/ASN.2007101098. PMID: 18820179Free PMC Article

Diagnosis

The association between blood pressure variability and renal damage in patients with primary aldosteronism.
Wu S, Li S, Huang J, Yu J, Wei C, Wei L, Zhu S, Chen S, Chen M, Li J
J Clin Hypertens (Greenwich) 2024 Jul;26(7):765-771. Epub 2024 Apr 30 doi: 10.1111/jch.14824. PMID: 38689511Free PMC Article
Comparing Cystatin C- and Creatinine-Estimated Glomerular Filtration Rates in Patients With Thoracic Versus Sacral Motor Levels of Spina Bifida.
Morrow AK, Zabel TA, Dodson J, Korth SA
Am J Phys Med Rehabil 2022 Feb 1;101(2):139-144. doi: 10.1097/PHM.0000000000001756. PMID: 35026776
Correlation among cystatin C, homocysteine and arteriosclerosis indexes in patients with chronic kidney disease.
Chen T, Li Y, Wang J, Wang J
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Dec 28;46(12):1338-1345. doi: 10.11817/j.issn.1672-7347.2021.210059. PMID: 35232902Free PMC Article
How to use… serum creatinine, cystatin C and GFR.
Pasala S, Carmody JB
Arch Dis Child Educ Pract Ed 2017 Feb;102(1):37-43. Epub 2016 Sep 19 doi: 10.1136/archdischild-2016-311062. PMID: 27647862
Serum immunoglobulin free light chain measurements and heavy chain isotype usage provide insight into disease biology in patients with POEMS syndrome.
Stankowski-Drengler T, Gertz MA, Katzmann JA, Lacy MQ, Kumar S, Leung N, Hayman SR, Buadi F, Kyle RA, Rajkumar SV, Dispenzieri A
Am J Hematol 2010 Jun;85(6):431-4. doi: 10.1002/ajh.21707. PMID: 20513121Free PMC Article

Therapy

Comparison of the Predictive Performance Between Cystatin C and Serum Creatinine by Vancomycin via a Population Pharmacokinetic Models: A Prospective Study in a Chinese Population.
Zhang R, Chen M, Liu TT, Lu JJ, Lv CL
Eur J Drug Metab Pharmacokinet 2020 Feb;45(1):135-149. doi: 10.1007/s13318-019-00578-4. PMID: 31541402
Urinary fibrinogen is elevated in hospitalized patients undergoing angiography.
Du T, Dong H, Li C, Yan S, Li H
Vascular 2019 Feb;27(1):33-37. Epub 2018 Sep 10 doi: 10.1177/1708538118797877. PMID: 30200827
Hereditary spherocytosis in a patient undergoing coronary artery bypass grafting with cardiopulmonary bypass--a case report.
Spegar J, Riha H, Kotulak T, Vanek T
Perfusion 2015 Jan;30(1):77-81. Epub 2014 Apr 8 doi: 10.1177/0267659114529323. PMID: 24714521
Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery.
Seitz S, Rauh M, Gloeckler M, Cesnjevar R, Dittrich S, Koch AM
Swiss Med Wkly 2013;143:w13744. Epub 2013 Jan 17 doi: 10.4414/smw.2013.13744. PMID: 23348800
Derivation and validation of cystatin C-based prediction equations for GFR in children.
Zappitelli M, Parvex P, Joseph L, Paradis G, Grey V, Lau S, Bell L
Am J Kidney Dis 2006 Aug;48(2):221-30. doi: 10.1053/j.ajkd.2006.04.085. PMID: 16860187

Prognosis

Association Between Dietary Quality and Serum Cystatin C in Kidney Transplant Recipients Based on Chinese Diet Balance Index 2016 (DBI-16).
Zhang H, Shi K, Yuan L, Guan X, Yin H, Zhao W, Zhou X, Chu A
Ann Transplant 2023 Feb 28;28:e939149. doi: 10.12659/AOT.939149. PMID: 36851833Free PMC Article
Comparison of the Predictive Performance Between Cystatin C and Serum Creatinine by Vancomycin via a Population Pharmacokinetic Models: A Prospective Study in a Chinese Population.
Zhang R, Chen M, Liu TT, Lu JJ, Lv CL
Eur J Drug Metab Pharmacokinet 2020 Feb;45(1):135-149. doi: 10.1007/s13318-019-00578-4. PMID: 31541402
Cystatin C and long term risk of community-acquired sepsis: a population-based cohort study.
Powell TC, Donnelly JP, Gutiérrez OM, Griffin RL, Safford MM, Wang HE
BMC Nephrol 2015 Apr 23;16:61. doi: 10.1186/s12882-015-0055-z. PMID: 25903849Free PMC Article
Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery.
Seitz S, Rauh M, Gloeckler M, Cesnjevar R, Dittrich S, Koch AM
Swiss Med Wkly 2013;143:w13744. Epub 2013 Jan 17 doi: 10.4414/smw.2013.13744. PMID: 23348800
Renal failure--measuring the glomerular filtration rate.
Thomas C, Thomas L
Dtsch Arztebl Int 2009 Dec;106(51-52):849-54. Epub 2009 Dec 18 doi: 10.3238/arztebl.2009.0849. PMID: 20062583Free PMC Article

Clinical prediction guides

Safety analysis of laboratory parameters in paediatric patients with spinal muscular atrophy treated with nusinersen.
Zhu X, Li H, Hu C, Wu M, Zhou S, Wang Y, Li W
BMC Pediatr 2024 Jul 25;24(1):474. doi: 10.1186/s12887-024-04955-0. PMID: 39054521Free PMC Article
The association between blood pressure variability and renal damage in patients with primary aldosteronism.
Wu S, Li S, Huang J, Yu J, Wei C, Wei L, Zhu S, Chen S, Chen M, Li J
J Clin Hypertens (Greenwich) 2024 Jul;26(7):765-771. Epub 2024 Apr 30 doi: 10.1111/jch.14824. PMID: 38689511Free PMC Article
Dominant CST3 variants cause adult onset leukodystrophy without amyloid angiopathy.
Bergner CG, Breur M, Soto-Bernardini MC, Schäfer L, Lier J, Le Duc D, Bundalian L, Schubert S, Brenner D, Kreuz FR, Schulte B, Waisfisz Q, Bugiani M, Köhler W, Sticht H, Abou Jamra R, van der Knaap MS
Brain 2024 Oct 3;147(10):3562-3572. doi: 10.1093/brain/awae085. PMID: 38489591
Serum immunoglobulin free light chain measurements and heavy chain isotype usage provide insight into disease biology in patients with POEMS syndrome.
Stankowski-Drengler T, Gertz MA, Katzmann JA, Lacy MQ, Kumar S, Leung N, Hayman SR, Buadi F, Kyle RA, Rajkumar SV, Dispenzieri A
Am J Hematol 2010 Jun;85(6):431-4. doi: 10.1002/ajh.21707. PMID: 20513121Free PMC Article
Renal failure--measuring the glomerular filtration rate.
Thomas C, Thomas L
Dtsch Arztebl Int 2009 Dec;106(51-52):849-54. Epub 2009 Dec 18 doi: 10.3238/arztebl.2009.0849. PMID: 20062583Free PMC Article

Recent systematic reviews

Review shows that lipid disorders are associated with endothelial but not renal dysfunction in children.
Kosmeri C, Siomou E, Vlahos AP, Milionis H
Acta Paediatr 2019 Jan;108(1):19-27. Epub 2018 Aug 22 doi: 10.1111/apa.14529. PMID: 30066344

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