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Abnormal cystatin C level

MedGen UID:
1712733
•Concept ID:
C5397987
•
Finding
HPO: HP:0032996

Definition

Any deviation from the normal concentration of cystatin C in serum or plasma. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cystatin C level

Recent clinical studies

Etiology

Correlation between serum cystatin C and lipid level in patients with chronic heart failure.
Ni F, Xiang Y
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Jan 28;48(1):34-39. doi: 10.11817/j.issn.1672-7347.2023.220025. PMID: 36935175Free PMC Article
The study of serum C-reactive protein, Serum cystatin C, and carbohydrate antigen 125 in patients with acute ischemic stroke.
Lin X, Yu C, Ding H, Ma X, Guo F, Chen D, Fan Y
Cell Mol Biol (Noisy-le-grand) 2022 May 31;68(5):89-95. doi: 10.14715/cmb/2022.68.5.12. PMID: 36029510
Comparing Cystatin C- and Creatinine-Estimated Glomerular Filtration Rates in Patients With Thoracic Versus Sacral Motor Levels of Spina Bifida.
Morrow AK, Zabel TA, Dodson J, Korth SA
Am J Phys Med Rehabil 2022 Feb 1;101(2):139-144. doi: 10.1097/PHM.0000000000001756. PMID: 35026776
Correlation among cystatin C, homocysteine and arteriosclerosis indexes in patients with chronic kidney disease.
Chen T, Li Y, Wang J, Wang J
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Dec 28;46(12):1338-1345. doi: 10.11817/j.issn.1672-7347.2021.210059. PMID: 35232902Free PMC Article
Serum sFlt-1, cystatin C and cathepsin B are potential severity markers in preeclampsia: a pilot study.
Park YS, Kim Y, Kim HY, Ahn KH, Cho GJ, Hong SC, Oh MJ, Kim HJ
Arch Gynecol Obstet 2020 Apr;301(4):955-962. Epub 2020 Mar 5 doi: 10.1007/s00404-020-05478-6. PMID: 32140809

Diagnosis

Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus.
Dejenie TA, Abebe EC, Mengstie MA, Seid MA, Gebeyehu NA, Adella GA, Kassie GA, Gebrekidan AY, Gesese MM, Tegegne KD, Anley DT, Feleke SF, Zemene MA, Dessie AM, Moges N, Kebede YS, Bantie B, Adugna DG
Front Endocrinol (Lausanne) 2023;14:1124367. Epub 2023 Apr 4 doi: 10.3389/fendo.2023.1124367. PMID: 37082121Free PMC Article
Correlation between serum cystatin C and lipid level in patients with chronic heart failure.
Ni F, Xiang Y
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Jan 28;48(1):34-39. doi: 10.11817/j.issn.1672-7347.2023.220025. PMID: 36935175Free PMC Article
High serum cystatin C levels in juvenile myelomonocytic leukemia patients without abnormal kidney function.
Shimabukuro W, Hamada S, Oshiro T, Nakada S, Hyakuna N, Nakanishi K
Pediatr Nephrol 2022 Jul;37(7):1687-1691. Epub 2022 Jan 20 doi: 10.1007/s00467-021-05418-9. PMID: 35059855
How to use… serum creatinine, cystatin C and GFR.
Pasala S, Carmody JB
Arch Dis Child Educ Pract Ed 2017 Feb;102(1):37-43. Epub 2016 Sep 19 doi: 10.1136/archdischild-2016-311062. PMID: 27647862
Anorexia nervosa and the kidney.
Bouquegneau A, Dubois BE, Krzesinski JM, Delanaye P
Am J Kidney Dis 2012 Aug;60(2):299-307. Epub 2012 May 19 doi: 10.1053/j.ajkd.2012.03.019. PMID: 22609034

Therapy

The relationship between dietary inflammatory index (DII) and early renal injury in population with/without hypertension: analysis of the National health and nutrition examination survey 2001-2002.
Huang J, Li H, Yang X, Qian C, Wei Y, Sun M
Ren Fail 2024 Dec;46(1):2294155. Epub 2024 Jan 4 doi: 10.1080/0886022X.2023.2294155. PMID: 38178375Free PMC Article
Comparison of the Predictive Performance Between Cystatin C and Serum Creatinine by Vancomycin via a Population Pharmacokinetic Models: A Prospective Study in a Chinese Population.
Zhang R, Chen M, Liu TT, Lu JJ, Lv CL
Eur J Drug Metab Pharmacokinet 2020 Feb;45(1):135-149. doi: 10.1007/s13318-019-00578-4. PMID: 31541402
Urinary fibrinogen is elevated in hospitalized patients undergoing angiography.
Du T, Dong H, Li C, Yan S, Li H
Vascular 2019 Feb;27(1):33-37. Epub 2018 Sep 10 doi: 10.1177/1708538118797877. PMID: 30200827
Renal dysfunction is rare in Fukuyama congenital muscular dystrophy.
Ishigaki K, Kato I, Murakami T, Sato T, Shichiji M, Ishiguro K, Ishizuka K, Funatsuka M, Saito K, Osawa M, Nagata S
Brain Dev 2019 Jan;41(1):43-49. Epub 2018 Aug 1 doi: 10.1016/j.braindev.2018.07.012. PMID: 30077507
Derivation and validation of cystatin C-based prediction equations for GFR in children.
Zappitelli M, Parvex P, Joseph L, Paradis G, Grey V, Lau S, Bell L
Am J Kidney Dis 2006 Aug;48(2):221-30. doi: 10.1053/j.ajkd.2006.04.085. PMID: 16860187

Prognosis

Association Between Dietary Quality and Serum Cystatin C in Kidney Transplant Recipients Based on Chinese Diet Balance Index 2016 (DBI-16).
Zhang H, Shi K, Yuan L, Guan X, Yin H, Zhao W, Zhou X, Chu A
Ann Transplant 2023 Feb 28;28:e939149. doi: 10.12659/AOT.939149. PMID: 36851833Free PMC Article
Comparison of the Predictive Performance Between Cystatin C and Serum Creatinine by Vancomycin via a Population Pharmacokinetic Models: A Prospective Study in a Chinese Population.
Zhang R, Chen M, Liu TT, Lu JJ, Lv CL
Eur J Drug Metab Pharmacokinet 2020 Feb;45(1):135-149. doi: 10.1007/s13318-019-00578-4. PMID: 31541402
Urinary fibrinogen is elevated in hospitalized patients undergoing angiography.
Du T, Dong H, Li C, Yan S, Li H
Vascular 2019 Feb;27(1):33-37. Epub 2018 Sep 10 doi: 10.1177/1708538118797877. PMID: 30200827
Cystatin C and long term risk of community-acquired sepsis: a population-based cohort study.
Powell TC, Donnelly JP, Gutiérrez OM, Griffin RL, Safford MM, Wang HE
BMC Nephrol 2015 Apr 23;16:61. doi: 10.1186/s12882-015-0055-z. PMID: 25903849Free PMC Article
Renal failure--measuring the glomerular filtration rate.
Thomas C, Thomas L
Dtsch Arztebl Int 2009 Dec;106(51-52):849-54. Epub 2009 Dec 18 doi: 10.3238/arztebl.2009.0849. PMID: 20062583Free PMC Article

Clinical prediction guides

The relationship between dietary inflammatory index (DII) and early renal injury in population with/without hypertension: analysis of the National health and nutrition examination survey 2001-2002.
Huang J, Li H, Yang X, Qian C, Wei Y, Sun M
Ren Fail 2024 Dec;46(1):2294155. Epub 2024 Jan 4 doi: 10.1080/0886022X.2023.2294155. PMID: 38178375Free PMC Article
Association Between Dietary Quality and Serum Cystatin C in Kidney Transplant Recipients Based on Chinese Diet Balance Index 2016 (DBI-16).
Zhang H, Shi K, Yuan L, Guan X, Yin H, Zhao W, Zhou X, Chu A
Ann Transplant 2023 Feb 28;28:e939149. doi: 10.12659/AOT.939149. PMID: 36851833Free PMC Article
Role of serum cystatin C in the prediction of acute kidney injury following pediatric cardiac surgeries: A single center experience.
Zakaria M, Hassan T, Refaat A, Fathy M, Hashem MIA, Khalifa N, Ali AA, Elhewala A, Ramadan A, Nafea A
Medicine (Baltimore) 2022 Dec 9;101(49):e31938. doi: 10.1097/MD.0000000000031938. PMID: 36626503Free PMC Article
Cystatin C and long term risk of community-acquired sepsis: a population-based cohort study.
Powell TC, Donnelly JP, Gutiérrez OM, Griffin RL, Safford MM, Wang HE
BMC Nephrol 2015 Apr 23;16:61. doi: 10.1186/s12882-015-0055-z. PMID: 25903849Free PMC Article
Renal failure--measuring the glomerular filtration rate.
Thomas C, Thomas L
Dtsch Arztebl Int 2009 Dec;106(51-52):849-54. Epub 2009 Dec 18 doi: 10.3238/arztebl.2009.0849. PMID: 20062583Free PMC Article

Recent systematic reviews

Review shows that lipid disorders are associated with endothelial but not renal dysfunction in children.
Kosmeri C, Siomou E, Vlahos AP, Milionis H
Acta Paediatr 2019 Jan;108(1):19-27. Epub 2018 Aug 22 doi: 10.1111/apa.14529. PMID: 30066344

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