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Hand apraxia

MedGen UID:
1715739
•Concept ID:
C5397612
•
Finding
Synonym: Lack of purposeful hand use
 
HPO: HP:0032588

Definition

Inability to perform purposeful (learned) movements with the hand upon command, even though the command is understood and there is a willingness to perform the movement. Hand apraxia includes the inability to grasp, pick up, and hold large and small objects. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHand apraxia

Professional guidelines

PubMed

The Differential Diagnosis and Treatment of Atypical Parkinsonism.
Levin J, Kurz A, Arzberger T, Giese A, Höglinger GU
Dtsch Arztebl Int 2016 Feb 5;113(5):61-9. doi: 10.3238/arztebl.2016.0061. PMID: 26900156Free PMC Article
Botulinum toxin in the treatment of tremors, dystonias, sialorrhea and other symptoms associated with Parkinson's disease.
Sheffield JK, Jankovic J
Expert Rev Neurother 2007 Jun;7(6):637-47. doi: 10.1586/14737175.7.6.637. PMID: 17563247
Diagnostic criteria for Rett syndrome. The Rett Syndrome Diagnostic Criteria Work Group.
Ann Neurol 1988 Apr;23(4):425-8. doi: 10.1002/ana.410230432. PMID: 2454607

Recent clinical studies

Etiology

Fingolimod in children with Rett syndrome: the FINGORETT study.
Naegelin Y, Kuhle J, Schädelin S, Datta AN, Magon S, Amann M, Barro C, Ramelli GP, Heesom K, Barde YA, Weber P, Kappos L
Orphanet J Rare Dis 2021 Jan 6;16(1):19. doi: 10.1186/s13023-020-01655-7. PMID: 33407685Free PMC Article
Assessment of the praxis circuit in glioma surgery to reduce the incidence of postoperative and long-term apraxia: a new intraoperative test.
Rossi M, Fornia L, Puglisi G, Leonetti A, Zuccon G, Fava E, Milani D, Casarotti A, Riva M, Pessina F, Cerri G, Bello L
J Neurosurg 2019 Jan 1;130(1):17-27. Epub 2018 Feb 23 doi: 10.3171/2017.7.JNS17357. PMID: 29473778
Folinic acid supplementation in Rett syndrome patients does not influence the course of the disease: a randomized study.
Hagebeuk EE, Duran M, Koelman JH, Abeling NG, Vyth A, Poll-The BT
J Child Neurol 2012 Mar;27(3):304-9. Epub 2011 Aug 24 doi: 10.1177/0883073811417184. PMID: 21868372
Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy.
Borroni B, Alberici A, Agosti C, Cosseddu M, Padovani A
Int Psychogeriatr 2009 Jun;21(3):463-8. Epub 2009 Mar 27 doi: 10.1017/S1041610209008862. PMID: 19323870
Pantomime to visual presentation of objects: left hand dyspraxia in patients with complete callosotomy.
Lausberg H, Cruz RF, Kita S, Zaidel E, Ptito A
Brain 2003 Feb;126(Pt 2):343-60. doi: 10.1093/brain/awg042. PMID: 12538402

Diagnosis

Fingolimod in children with Rett syndrome: the FINGORETT study.
Naegelin Y, Kuhle J, Schädelin S, Datta AN, Magon S, Amann M, Barro C, Ramelli GP, Heesom K, Barde YA, Weber P, Kappos L
Orphanet J Rare Dis 2021 Jan 6;16(1):19. doi: 10.1186/s13023-020-01655-7. PMID: 33407685Free PMC Article
Assessment of the praxis circuit in glioma surgery to reduce the incidence of postoperative and long-term apraxia: a new intraoperative test.
Rossi M, Fornia L, Puglisi G, Leonetti A, Zuccon G, Fava E, Milani D, Casarotti A, Riva M, Pessina F, Cerri G, Bello L
J Neurosurg 2019 Jan 1;130(1):17-27. Epub 2018 Feb 23 doi: 10.3171/2017.7.JNS17357. PMID: 29473778
Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy.
Borroni B, Alberici A, Agosti C, Cosseddu M, Padovani A
Int Psychogeriatr 2009 Jun;21(3):463-8. Epub 2009 Mar 27 doi: 10.1017/S1041610209008862. PMID: 19323870
Key clinical features to identify girls with CDKL5 mutations.
Bahi-Buisson N, Nectoux J, Rosas-Vargas H, Milh M, Boddaert N, Girard B, Cances C, Ville D, Afenjar A, Rio M, Héron D, N'guyen Morel MA, Arzimanoglou A, Philippe C, Jonveaux P, Chelly J, Bienvenu T
Brain 2008 Oct;131(Pt 10):2647-61. Epub 2008 Sep 12 doi: 10.1093/brain/awn197. PMID: 18790821
The hand apraxia scale.
Burd L, Cook J, Randall T
Percept Mot Skills 1990 Feb;70(1):219-24. doi: 10.2466/pms.1990.70.1.219. PMID: 2326119

Therapy

Fingolimod in children with Rett syndrome: the FINGORETT study.
Naegelin Y, Kuhle J, Schädelin S, Datta AN, Magon S, Amann M, Barro C, Ramelli GP, Heesom K, Barde YA, Weber P, Kappos L
Orphanet J Rare Dis 2021 Jan 6;16(1):19. doi: 10.1186/s13023-020-01655-7. PMID: 33407685Free PMC Article
Callosal warning syndrome.
Nandhagopal R, Al-Asmi A, Johnston WJ, Jacob PC, Arunodaya GR
J Neurol Sci 2012 Mar 15;314(1-2):178-80. Epub 2011 Nov 8 doi: 10.1016/j.jns.2011.10.007. PMID: 22075046
Folinic acid supplementation in Rett syndrome patients does not influence the course of the disease: a randomized study.
Hagebeuk EE, Duran M, Koelman JH, Abeling NG, Vyth A, Poll-The BT
J Child Neurol 2012 Mar;27(3):304-9. Epub 2011 Aug 24 doi: 10.1177/0883073811417184. PMID: 21868372
Rett syndrome: randomized controlled trial of L-carnitine.
Ellaway C, Williams K, Leonard H, Higgins G, Wilcken B, Christodoulou J
J Child Neurol 1999 Mar;14(3):162-7. doi: 10.1177/088307389901400306. PMID: 10190267

Prognosis

Assessment of the praxis circuit in glioma surgery to reduce the incidence of postoperative and long-term apraxia: a new intraoperative test.
Rossi M, Fornia L, Puglisi G, Leonetti A, Zuccon G, Fava E, Milani D, Casarotti A, Riva M, Pessina F, Cerri G, Bello L
J Neurosurg 2019 Jan 1;130(1):17-27. Epub 2018 Feb 23 doi: 10.3171/2017.7.JNS17357. PMID: 29473778
Left leg apraxia after anterior cerebral artery territory infarction: functional analysis using single-photon emission computed tomography.
Ito I, Ito K, Shindo N
Eur Neurol 2013;69(4):252-6. Epub 2013 Feb 16 doi: 10.1159/000342222. PMID: 23428982
Folinic acid supplementation in Rett syndrome patients does not influence the course of the disease: a randomized study.
Hagebeuk EE, Duran M, Koelman JH, Abeling NG, Vyth A, Poll-The BT
J Child Neurol 2012 Mar;27(3):304-9. Epub 2011 Aug 24 doi: 10.1177/0883073811417184. PMID: 21868372
Rett syndrome: randomized controlled trial of L-carnitine.
Ellaway C, Williams K, Leonard H, Higgins G, Wilcken B, Christodoulou J
J Child Neurol 1999 Mar;14(3):162-7. doi: 10.1177/088307389901400306. PMID: 10190267

Clinical prediction guides

Fingolimod in children with Rett syndrome: the FINGORETT study.
Naegelin Y, Kuhle J, Schädelin S, Datta AN, Magon S, Amann M, Barro C, Ramelli GP, Heesom K, Barde YA, Weber P, Kappos L
Orphanet J Rare Dis 2021 Jan 6;16(1):19. doi: 10.1186/s13023-020-01655-7. PMID: 33407685Free PMC Article
Folinic acid supplementation in Rett syndrome patients does not influence the course of the disease: a randomized study.
Hagebeuk EE, Duran M, Koelman JH, Abeling NG, Vyth A, Poll-The BT
J Child Neurol 2012 Mar;27(3):304-9. Epub 2011 Aug 24 doi: 10.1177/0883073811417184. PMID: 21868372
Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy.
Borroni B, Alberici A, Agosti C, Cosseddu M, Padovani A
Int Psychogeriatr 2009 Jun;21(3):463-8. Epub 2009 Mar 27 doi: 10.1017/S1041610209008862. PMID: 19323870
Key clinical features to identify girls with CDKL5 mutations.
Bahi-Buisson N, Nectoux J, Rosas-Vargas H, Milh M, Boddaert N, Girard B, Cances C, Ville D, Afenjar A, Rio M, Héron D, N'guyen Morel MA, Arzimanoglou A, Philippe C, Jonveaux P, Chelly J, Bienvenu T
Brain 2008 Oct;131(Pt 10):2647-61. Epub 2008 Sep 12 doi: 10.1093/brain/awn197. PMID: 18790821
Rett syndrome: randomized controlled trial of L-carnitine.
Ellaway C, Williams K, Leonard H, Higgins G, Wilcken B, Christodoulou J
J Child Neurol 1999 Mar;14(3):162-7. doi: 10.1177/088307389901400306. PMID: 10190267

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