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FGFR4 Gene Amplification

MedGen UID:
1717256
Concept ID:
C5238311
Cell or Molecular Dysfunction
Synonyms: CD334 Gene Amplification; FGFR-4 Gene Amplification; FGFR4 Amplification; Fibroblast Growth Factor Receptor 4 Gene Amplification; JKT2 Gene Amplification; TKF Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the FGFR4 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFGFR4 Gene Amplification

Professional guidelines

PubMed

Arnold MA, Barr FG
Expert Rev Mol Diagn 2017 Feb;17(2):189-194. Epub 2017 Jan 6 doi: 10.1080/14737159.2017.1275965. PMID: 28058850Free PMC Article

Recent clinical studies

Etiology

Katarzyna S
J Cancer Res Ther 2023 Jan-Mar;19(2):355-358. doi: 10.4103/jcrt.jcrt_1516_21. PMID: 37006072
Moes-Sosnowska J, Skupinska M, Lechowicz U, Szczepulska-Wojcik E, Skronska P, Rozy A, Stepniewska A, Langfort R, Rudzinski P, Orlowski T, Popiel D, Stanczak A, Wieczorek M, Chorostowska-Wynimko J
Int J Mol Sci 2022 Sep 10;23(18) doi: 10.3390/ijms231810506. PMID: 36142417Free PMC Article
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Arnold MA, Barr FG
Expert Rev Mol Diagn 2017 Feb;17(2):189-194. Epub 2017 Jan 6 doi: 10.1080/14737159.2017.1275965. PMID: 28058850Free PMC Article
Jain VK, Turner NC
Breast Cancer Res 2012 Jun 19;14(3):208. doi: 10.1186/bcr3139. PMID: 22731805Free PMC Article

Diagnosis

Katarzyna S
J Cancer Res Ther 2023 Jan-Mar;19(2):355-358. doi: 10.4103/jcrt.jcrt_1516_21. PMID: 37006072
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Arnold MA, Barr FG
Expert Rev Mol Diagn 2017 Feb;17(2):189-194. Epub 2017 Jan 6 doi: 10.1080/14737159.2017.1275965. PMID: 28058850Free PMC Article
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Therapy

Lang L, Teng Y
Cells 2019 Jan 9;8(1) doi: 10.3390/cells8010031. PMID: 30634399Free PMC Article
Koole K, van Kempen PM, van Bockel LW, Smets T, van der Klooster Z, Dutman AC, Peeters T, Koole R, van Diest P, van Es RJ, Willems SM
Pathobiology 2015;82(6):280-9. Epub 2015 Nov 10 doi: 10.1159/000439536. PMID: 26551585
André F, Cortés J
Breast Cancer Res Treat 2015 Feb;150(1):1-8. Epub 2015 Feb 13 doi: 10.1007/s10549-015-3301-y. PMID: 25677745Free PMC Article
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246
Kelleher FC, O'Sullivan H, Smyth E, McDermott R, Viterbo A
Carcinogenesis 2013 Oct;34(10):2198-205. Epub 2013 Jul 23 doi: 10.1093/carcin/bgt254. PMID: 23880303

Prognosis

Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Garcia-Recio S, Thennavan A, East MP, Parker JS, Cejalvo JM, Garay JP, Hollern DP, He X, Mott KR, Galván P, Fan C, Selitsky SR, Coffey AR, Marron D, Brasó-Maristany F, Burgués O, Albanell J, Rojo F, Lluch A, de Dueñas EM, Rosen JM, Johnson GL, Carey LA, Prat A, Perou CM
J Clin Invest 2020 Sep 1;130(9):4871-4887. doi: 10.1172/JCI130323. PMID: 32573490Free PMC Article
Arnold MA, Barr FG
Expert Rev Mol Diagn 2017 Feb;17(2):189-194. Epub 2017 Jan 6 doi: 10.1080/14737159.2017.1275965. PMID: 28058850Free PMC Article
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574
André F, Cortés J
Breast Cancer Res Treat 2015 Feb;150(1):1-8. Epub 2015 Feb 13 doi: 10.1007/s10549-015-3301-y. PMID: 25677745Free PMC Article

Clinical prediction guides

Repetto M, Crimini E, Giugliano F, Morganti S, Belli C, Curigliano G
Expert Rev Clin Pharmacol 2021 Oct;14(10):1233-1252. doi: 10.1080/17512433.2021.1947246. PMID: 34591728
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Garcia-Recio S, Thennavan A, East MP, Parker JS, Cejalvo JM, Garay JP, Hollern DP, He X, Mott KR, Galván P, Fan C, Selitsky SR, Coffey AR, Marron D, Brasó-Maristany F, Burgués O, Albanell J, Rojo F, Lluch A, de Dueñas EM, Rosen JM, Johnson GL, Carey LA, Prat A, Perou CM
J Clin Invest 2020 Sep 1;130(9):4871-4887. doi: 10.1172/JCI130323. PMID: 32573490Free PMC Article
Arnold MA, Barr FG
Expert Rev Mol Diagn 2017 Feb;17(2):189-194. Epub 2017 Jan 6 doi: 10.1080/14737159.2017.1275965. PMID: 28058850Free PMC Article
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574

Recent systematic reviews

Ipenburg NA, Koole K, Liem KS, van Kempen PM, Koole R, van Diest PJ, van Es RJ, Willems SM
Target Oncol 2016 Feb;11(1):17-27. doi: 10.1007/s11523-015-0374-9. PMID: 26115874Free PMC Article

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