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Resectable Lung Non-Small Cell Carcinoma

MedGen UID:
1718964
•Concept ID:
C5237442
•
Neoplastic Process

Definition

Lung non-small cell carcinoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Lung Non-Small Cell Carcinoma

Professional guidelines

PubMed

Radiation therapy in the management of medically inoperable carcinoma of the lung: results and implications for future treatment strategies.
Dosoretz DE, Katin MJ, Blitzer PH, Rubenstein JH, Salenius S, Rashid M, Dosani RA, Mestas G, Siegel AD, Chadha TT
Int J Radiat Oncol Biol Phys 1992;24(1):3-9. doi: 10.1016/0360-3016(92)91013-d. PMID: 1324899

Recent clinical studies

Etiology

Safety and effectiveness of neoadjuvant PD-1 inhibitor (toripalimab) plus chemotherapy in stage II-III NSCLC (LungMate 002): an open-label, single-arm, phase 2 trial.
Zhu X, Sun L, Song N, He W, Xie B, Hu J, Zhang J, Yang J, Dai J, Bian D, Xia H, Sun F, Xiong A, Luo J, Zhang L, Yu H, Liu M, Liu H, Wang H, Zhang H, Chen C, Wu C, Duan L, Zhu Y, Zhang P, Jiang G
BMC Med 2022 Dec 30;20(1):493. doi: 10.1186/s12916-022-02696-4. PMID: 36581917Free PMC Article
Moving Immunotherapy Into Early-Stage Lung Cancer.
Linehan A, Forde PM
Cancer J 2020 Nov/Dec;26(6):543-547. doi: 10.1097/PPO.0000000000000493. PMID: 33298726
Adjuvant Therapy of Resected Non-small Cell Lung Cancer: can We Move Forward?
Buffoni L, Vavalà T, Novello S
Curr Treat Options Oncol 2016 Oct;17(10):54. doi: 10.1007/s11864-016-0429-x. PMID: 27523606
Non-small cell lung cancer: when to offer sublobar resection.
Sihoe AD, Van Schil P
Lung Cancer 2014 Nov;86(2):115-20. Epub 2014 Sep 16 doi: 10.1016/j.lungcan.2014.09.004. PMID: 25249427
Treatment of stage I and II non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC
Chest 2013 May;143(5 Suppl):e278S-e313S. doi: 10.1378/chest.12-2359. PMID: 23649443

Diagnosis

Non-small cell lung cancer in China.
Chen P, Liu Y, Wen Y, Zhou C
Cancer Commun (Lond) 2022 Oct;42(10):937-970. Epub 2022 Sep 8 doi: 10.1002/cac2.12359. PMID: 36075878Free PMC Article
Advances in systemic therapy for non-small cell lung cancer.
Miller M, Hanna N
BMJ 2021 Nov 9;375:n2363. doi: 10.1136/bmj.n2363. PMID: 34753715
Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review.
Tandberg DJ, Tong BC, Ackerson BG, Kelsey CR
Cancer 2018 Feb 15;124(4):667-678. Epub 2017 Dec 19 doi: 10.1002/cncr.31196. PMID: 29266226
Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer.
De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M
Eur J Cardiothorac Surg 2014 May;45(5):787-98. Epub 2014 Feb 26 doi: 10.1093/ejcts/ezu028. PMID: 24578407
Treatment of stage I and II non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC
Chest 2013 May;143(5 Suppl):e278S-e313S. doi: 10.1378/chest.12-2359. PMID: 23649443

Therapy

Preoperative and Postoperative Systemic Therapy for Operable Non-Small-Cell Lung Cancer.
Chaft JE, Shyr Y, Sepesi B, Forde PM
J Clin Oncol 2022 Feb 20;40(6):546-555. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01589. PMID: 34985966Free PMC Article
Major breakthroughs in lung cancer adjuvant treatment: Looking beyond the horizon.
Passiglia F, Bertaglia V, Reale ML, Delcuratolo MD, Tabbò F, Olmetto E, Capelletto E, Bironzo P, Novello S
Cancer Treat Rev 2021 Dec;101:102308. Epub 2021 Oct 18 doi: 10.1016/j.ctrv.2021.102308. PMID: 34757306
Evolution of systemic therapy for stages I-III non-metastatic non-small-cell lung cancer.
Chaft JE, Rimner A, Weder W, Azzoli CG, Kris MG, Cascone T
Nat Rev Clin Oncol 2021 Sep;18(9):547-557. Epub 2021 Apr 28 doi: 10.1038/s41571-021-00501-4. PMID: 33911215Free PMC Article
Treatment of Non-small Cell Lung Cancer with EGFR-mutations.
Yoneda K, Imanishi N, Ichiki Y, Tanaka F
J UOEH 2019;41(2):153-163. doi: 10.7888/juoeh.41.153. PMID: 31292359
Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data.
NSCLC Meta-analysis Collaborative Group
Lancet 2014 May 3;383(9928):1561-71. Epub 2014 Feb 25 doi: 10.1016/S0140-6736(13)62159-5. PMID: 24576776Free PMC Article

Prognosis

The current treatment landscape in the UK for stage III NSCLC.
Evison M; AstraZeneca UK Limited
Br J Cancer 2020 Dec;123(Suppl 1):3-9. doi: 10.1038/s41416-020-01069-z. PMID: 33293670Free PMC Article
Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery: a review.
Aokage K, Yoshida J, Hishida T, Tsuboi M, Saji H, Okada M, Suzuki K, Watanabe S, Asamura H
Jpn J Clin Oncol 2017 Jan;47(1):7-11. Epub 2016 Oct 20 doi: 10.1093/jjco/hyw148. PMID: 27765813
Resectable non-small cell lung cancer Adjuvant chemotherapy: slightly longer survival.
Prescrire Int 2016 Dec;25(177):299-301. PMID: 30758927
Chemotherapy for non-small-cell lung carcinoma: from a blanket approach to individual therapy.
Reungwetwattana T, Eadens MJ, Molina JR
Semin Respir Crit Care Med 2011 Feb;32(1):78-93. Epub 2011 Apr 15 doi: 10.1055/s-0031-1272872. PMID: 21500127
Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group.
Ginsberg RJ, Rubinstein LV
Ann Thorac Surg 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. PMID: 7677489

Clinical prediction guides

Safety and effectiveness of neoadjuvant PD-1 inhibitor (toripalimab) plus chemotherapy in stage II-III NSCLC (LungMate 002): an open-label, single-arm, phase 2 trial.
Zhu X, Sun L, Song N, He W, Xie B, Hu J, Zhang J, Yang J, Dai J, Bian D, Xia H, Sun F, Xiong A, Luo J, Zhang L, Yu H, Liu M, Liu H, Wang H, Zhang H, Chen C, Wu C, Duan L, Zhu Y, Zhang P, Jiang G
BMC Med 2022 Dec 30;20(1):493. doi: 10.1186/s12916-022-02696-4. PMID: 36581917Free PMC Article
Treatment Sequencing in Resectable Lung Cancer: The Good and the Bad of Adjuvant Versus Neoadjuvant Therapy.
Provencio M, Calvo V, Romero A, Spicer JD, Cruz-Bermúdez A
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-18. doi: 10.1200/EDBK_358995. PMID: 35561296
Segment Location and Ground Glass Opacity Ratio Reliably Predict Node-Negative Status in Lung Cancer.
Zhang Y, Fu F, Wen Z, Deng L, Wang S, Li Y, Chen H
Ann Thorac Surg 2020 Apr;109(4):1061-1068. Epub 2019 Dec 18 doi: 10.1016/j.athoracsur.2019.10.072. PMID: 31863756
Adjuvant Therapy of Resected Non-small Cell Lung Cancer: can We Move Forward?
Buffoni L, Vavalà T, Novello S
Curr Treat Options Oncol 2016 Oct;17(10):54. doi: 10.1007/s11864-016-0429-x. PMID: 27523606
Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer.
De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M
Eur J Cardiothorac Surg 2014 May;45(5):787-98. Epub 2014 Feb 26 doi: 10.1093/ejcts/ezu028. PMID: 24578407

Recent systematic reviews

Neoadjuvant immunotherapy for advanced, resectable non-small cell lung cancer: A systematic review and meta-analysis.
Wu Y, Verma V, Gay CM, Chen Y, Liang F, Lin Q, Wang J, Zhang W, Hui Z, Zhao M, Wang J, Chang JY
Cancer 2023 Jul 1;129(13):1969-1985. Epub 2023 Mar 30 doi: 10.1002/cncr.34755. PMID: 36994945
Preoperative exercise training for people with non-small cell lung cancer.
Granger C, Cavalheri V
Cochrane Database Syst Rev 2022 Sep 28;9(9):CD012020. doi: 10.1002/14651858.CD012020.pub3. PMID: 36170564Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data.
NSCLC Meta-analysis Collaborative Group
Lancet 2014 May 3;383(9928):1561-71. Epub 2014 Feb 25 doi: 10.1016/S0140-6736(13)62159-5. PMID: 24576776Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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