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BRD4 Gene Translocation

MedGen UID:
1719821
Concept ID:
C5236058
Cell or Molecular Dysfunction
Synonyms: BRD4 Translocation; Bromodomain Containing 4 Gene Translocation; Bromodomain-Containing 4 Gene Translocation; CAP Gene Translocation; Chromosome-Associated Protein Gene Translocation; HUNK1 Gene Translocation; HUNKI Gene Translocation; MCAP Gene Translocation

Definition

A cytogenetic abnormality that refers to a translocation involving the BRD4 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBRD4 Gene Translocation

Professional guidelines

PubMed

French CA
Pathol Int 2018 Nov;68(11):583-595. Epub 2018 Oct 26 doi: 10.1111/pin.12727. PMID: 30362654
Wang X, Zhang Y, Nilsson CL, Berven FS, Andrén PE, Carlsohn E, Horvatovich P, Malm J, Fuentes M, Végvári Á, Welinder C, Fehniger TE, Rezeli M, Edula G, Hober S, Nishimura T, Marko-Varga G
Cancer Metastasis Rev 2015 Jun;34(2):217-26. doi: 10.1007/s10555-015-9556-2. PMID: 25982285

Recent clinical studies

Etiology

Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gürtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G
Nat Metab 2021 May;3(5):651-664. Epub 2021 May 10 doi: 10.1038/s42255-021-00386-8. PMID: 33972798Free PMC Article
Khan I, Eklund EE, Gartel AL
Mol Cancer Ther 2021 Feb;20(2):229-237. Epub 2020 Nov 6 doi: 10.1158/1535-7163.MCT-20-0115. PMID: 33158995Free PMC Article
Jiang Y, Zhu L, Zhang T, Lu H, Wang C, Xue B, Xu X, Liu Y, Cai Z, Sang W, Hua Y, Ma J
Biochim Biophys Acta Mol Basis Dis 2017 Dec;1863(12):3001-3015. Epub 2017 Aug 24 doi: 10.1016/j.bbadis.2017.08.009. PMID: 28844955
Evans AG, French CA, Cameron MJ, Fletcher CD, Jackman DM, Lathan CS, Sholl LM
Am J Surg Pathol 2012 Aug;36(8):1222-7. doi: 10.1097/PAS.0b013e318258f03b. PMID: 22790861Free PMC Article
Stelow EB, Bellizzi AM, Taneja K, Mills SE, Legallo RD, Kutok JL, Aster JC, French CA
Am J Surg Pathol 2008 Jun;32(6):828-34. doi: 10.1097/PAS.0b013e31815a3900. PMID: 18391746

Diagnosis

Rose AJ, Fleming MM, Francis JC, Ning J, Patrikeev A, Chauhan R, Harrington KJ, Swain A
J Pathol 2024 Jan;262(1):37-49. Epub 2023 Oct 4 doi: 10.1002/path.6209. PMID: 37792636
Chatzopoulos K, Boland JM
Virchows Arch 2021 Jan;478(1):21-30. Epub 2021 Jan 6 doi: 10.1007/s00428-020-03011-3. PMID: 33409598
French CA
Pathol Int 2018 Nov;68(11):583-595. Epub 2018 Oct 26 doi: 10.1111/pin.12727. PMID: 30362654
Hellquist H, French CA, Bishop JA, Coca-Pelaz A, Propst EJ, Paiva Correia A, Ngan BY, Grant R, Cipriani NA, Vokes D, Henrique R, Pardal F, Vizcaino JR, Rinaldo A, Ferlito A
Histopathology 2017 May;70(6):861-868. Epub 2017 Feb 21 doi: 10.1111/his.13143. PMID: 27926786Free PMC Article
French CA
J Clin Pathol 2010 Jun;63(6):492-6. Epub 2008 Jun 13 doi: 10.1136/jcp.2007.052902. PMID: 18552174

Therapy

Lee S, Hu Y, Loo SK, Tan Y, Bhargava R, Lewis MT, Wang XS
Proc Natl Acad Sci U S A 2020 May 5;117(18):9912-9921. Epub 2020 Apr 22 doi: 10.1073/pnas.1921333117. PMID: 32321829Free PMC Article
Liu J, Duan Z, Guo W, Zeng L, Wu Y, Chen Y, Tai F, Wang Y, Lin Y, Zhang Q, He Y, Deng J, Stewart RL, Wang C, Lin PC, Ghaffari S, Evers BM, Liu S, Zhou MM, Zhou BP, Shi J
Nat Commun 2018 Dec 5;9(1):5200. doi: 10.1038/s41467-018-07258-y. PMID: 30518851Free PMC Article
Xu X, Saw PE, Tao W, Li Y, Ji X, Yu M, Mahmoudi M, Rasmussen J, Ayyash D, Zhou Y, Farokhzad OC, Shi J
Nano Lett 2017 Jul 12;17(7):4427-4435. Epub 2017 Jun 26 doi: 10.1021/acs.nanolett.7b01571. PMID: 28636389Free PMC Article
Shim JM, Lee JS, Russell KE, Wiegman CH, Barnes PJ, Fear D, Adcock IM, Durham AL
Epigenomics 2017 Apr;9(4):393-406. Epub 2017 Mar 21 doi: 10.2217/epi-2016-0147. PMID: 28322577Free PMC Article
Zhang Y, Chen A, Yan XM, Huang G
Int J Hematol 2012 Oct;96(4):428-37. Epub 2012 Sep 29 doi: 10.1007/s12185-012-1180-0. PMID: 23054645

Prognosis

Larkin R, Hermsen MA, London NR Jr
Curr Oncol Rep 2023 Apr;25(4):269-278. Epub 2023 Feb 8 doi: 10.1007/s11912-023-01364-x. PMID: 36753024Free PMC Article
Khan I, Eklund EE, Gartel AL
Mol Cancer Ther 2021 Feb;20(2):229-237. Epub 2020 Nov 6 doi: 10.1158/1535-7163.MCT-20-0115. PMID: 33158995Free PMC Article
Wang LT, Liu KY, Jeng WY, Chiang CM, Chai CY, Chiou SS, Huang MS, Yokoyama KK, Wang SN, Huang SK, Hsu SH
EMBO Rep 2020 Feb 5;21(2):e48795. Epub 2020 Jan 7 doi: 10.15252/embr.201948795. PMID: 31908141Free PMC Article
Ke L, Zhou H, Wang C, Xiong G, Xiang Y, Ling Y, Khabir A, Tsao GS, Zeng Y, Zeng M, Busson P, Kieff E, Guo X, Zhao B
Proc Natl Acad Sci U S A 2017 Sep 5;114(36):9683-9688. Epub 2017 Aug 22 doi: 10.1073/pnas.1705236114. PMID: 28831010Free PMC Article
Zhang Y, Chen A, Yan XM, Huang G
Int J Hematol 2012 Oct;96(4):428-37. Epub 2012 Sep 29 doi: 10.1007/s12185-012-1180-0. PMID: 23054645

Clinical prediction guides

Gibson WJ, Sadagopan A, Shoba VM, Choudhary A, Meyerson M, Schreiber SL
J Am Chem Soc 2023 Dec 6;145(48):26028-26037. Epub 2023 Nov 22 doi: 10.1021/jacs.3c06179. PMID: 37992275Free PMC Article
Dave J, Jagana V, Janostiak R, Bisserier M
J Transl Med 2023 Jul 17;21(1):477. doi: 10.1186/s12967-023-04339-5. PMID: 37461108Free PMC Article
Owen I, Yee D, Wyne H, Perdikari TM, Johnson V, Smyth J, Kortum R, Fawzi NL, Shewmaker F
J Cell Sci 2021 Sep 1;134(17) Epub 2021 Sep 3 doi: 10.1242/jcs.258578. PMID: 34357401Free PMC Article
Henry KE, Dilling TR, Abdel-Atti D, Edwards KJ, Evans MJ, Lewis JS
J Nucl Med 2018 Jan;59(1):51-57. Epub 2017 Aug 28 doi: 10.2967/jnumed.117.192286. PMID: 28848040Free PMC Article
Tian B, Zhao Y, Sun H, Zhang Y, Yang J, Brasier AR
Am J Physiol Lung Cell Mol Physiol 2016 Dec 1;311(6):L1183-L1201. Epub 2016 Oct 28 doi: 10.1152/ajplung.00224.2016. PMID: 27793799Free PMC Article

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