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Neonatal seizure with electrographic correlate

MedGen UID:
1719965
•Concept ID:
C5397814
•
Disease or Syndrome
HPO: HP:0032808

Definition

Neonatal seizure is a seizure type that occurs in neonatal period and is characterized by an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end. This event can be associated or not with a clinical manifestation. [from HPO]

Professional guidelines

PubMed

Therapeutic Hypothermia in Transport Permits Earlier Treatment Regardless of Transfer Distance.
Leon RL, Krause KE, Sides RS, Koch MB, Trautman MS, Mietzsch U
Am J Perinatol 2022 Apr;39(6):633-639. Epub 2020 Oct 14 doi: 10.1055/s-0040-1718372. PMID: 33053593
Variability in Preferred Management of Electrographic Seizures in Neonatal Hypoxic Ischemic Encephalopathy.
McNally MA, Hartman AL
Pediatr Neurol 2017 Dec;77:37-41. Epub 2017 Jun 15 doi: 10.1016/j.pediatrneurol.2017.06.006. PMID: 28982530

Recent clinical studies

Etiology

Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Pavel AM, O'Toole JM, Proietti J, Livingstone V, Mitra S, Marnane WP, Finder M, Dempsey EM, Murray DM, Boylan GB; ANSeR Consortium
Epilepsia 2023 Feb;64(2):456-468. Epub 2022 Dec 20 doi: 10.1111/epi.17468. PMID: 36398397Free PMC Article
The duration of successive epileptic seizures is monotonically correlated in neonates.
Pisani F, Statello R, Pedrazzi G, Miragoli M, Piccolo B, Turco EC
Neurophysiol Clin 2022 Nov;52(6):472-481. Epub 2022 Nov 10 doi: 10.1016/j.neucli.2022.10.004. PMID: 36372645
Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
El Atrache R, Tamilia E, Amengual-Gual M, Mohammadpour Touserkani F, Yang Y, Wang X, Ufongene C, Sheehan T, Cantley S, Jackson M, Zhang B, Papadelis C, Sarkis RA, Loddenkemper T
Epilepsy Behav 2021 Sep;122:108228. Epub 2021 Aug 10 doi: 10.1016/j.yebeh.2021.108228. PMID: 34388667
Neonatal presentation of genetic epilepsies: Early differentiation from acute provoked seizures.
Cornet MC, Morabito V, Lederer D, Glass HC, Ferrao Santos S, Numis AL, Ferriero DM, Sands TT, Cilio MR
Epilepsia 2021 Aug;62(8):1907-1920. Epub 2021 Jun 21 doi: 10.1111/epi.16957. PMID: 34153113
The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.
Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM
Epilepsia 2021 Mar;62(3):615-628. Epub 2021 Feb 1 doi: 10.1111/epi.16815. PMID: 33522601

Diagnosis

Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Pavel AM, O'Toole JM, Proietti J, Livingstone V, Mitra S, Marnane WP, Finder M, Dempsey EM, Murray DM, Boylan GB; ANSeR Consortium
Epilepsia 2023 Feb;64(2):456-468. Epub 2022 Dec 20 doi: 10.1111/epi.17468. PMID: 36398397Free PMC Article
Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
El Atrache R, Tamilia E, Amengual-Gual M, Mohammadpour Touserkani F, Yang Y, Wang X, Ufongene C, Sheehan T, Cantley S, Jackson M, Zhang B, Papadelis C, Sarkis RA, Loddenkemper T
Epilepsy Behav 2021 Sep;122:108228. Epub 2021 Aug 10 doi: 10.1016/j.yebeh.2021.108228. PMID: 34388667
Neonatal presentation of genetic epilepsies: Early differentiation from acute provoked seizures.
Cornet MC, Morabito V, Lederer D, Glass HC, Ferrao Santos S, Numis AL, Ferriero DM, Sands TT, Cilio MR
Epilepsia 2021 Aug;62(8):1907-1920. Epub 2021 Jun 21 doi: 10.1111/epi.16957. PMID: 34153113
The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.
Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM
Epilepsia 2021 Mar;62(3):615-628. Epub 2021 Feb 1 doi: 10.1111/epi.16815. PMID: 33522601
Monitoring of seizures in the newborn.
Shah DK, Boylan GB, Rennie JM
Arch Dis Child Fetal Neonatal Ed 2012 Jan;97(1):F65-9. Epub 2010 Aug 5 doi: 10.1136/adc.2009.169508. PMID: 20688863

Therapy

Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Pavel AM, O'Toole JM, Proietti J, Livingstone V, Mitra S, Marnane WP, Finder M, Dempsey EM, Murray DM, Boylan GB; ANSeR Consortium
Epilepsia 2023 Feb;64(2):456-468. Epub 2022 Dec 20 doi: 10.1111/epi.17468. PMID: 36398397Free PMC Article
Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study.
Basti C, Maranella E, Cimini N, Catalucci A, Ciccarelli S, Del Torto M, Di Luca L, Di Natale C, Mareri A, Nardi V, Pannone V, Di Fabio S
Seizure 2020 Dec;83:154-159. Epub 2020 Oct 29 doi: 10.1016/j.seizure.2020.10.021. PMID: 33160202
Phenobarbital for Neonatal Seizures: Response Rate and Predictors of Refractoriness.
Spagnoli C, Seri S, Pavlidis E, Mazzotta S, Pelosi A, Pisani F
Neuropediatrics 2016 Oct;47(5):318-26. Epub 2016 Jul 26 doi: 10.1055/s-0036-1586214. PMID: 27458678
Monitoring of seizures in the newborn.
Shah DK, Boylan GB, Rennie JM
Arch Dis Child Fetal Neonatal Ed 2012 Jan;97(1):F65-9. Epub 2010 Aug 5 doi: 10.1136/adc.2009.169508. PMID: 20688863
Electrographic seizures in neonates correlate with poor neurodevelopmental outcome.
McBride MC, Laroia N, Guillet R
Neurology 2000 Aug 22;55(4):506-13. doi: 10.1212/wnl.55.4.506. PMID: 10953181

Prognosis

Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Pavel AM, O'Toole JM, Proietti J, Livingstone V, Mitra S, Marnane WP, Finder M, Dempsey EM, Murray DM, Boylan GB; ANSeR Consortium
Epilepsia 2023 Feb;64(2):456-468. Epub 2022 Dec 20 doi: 10.1111/epi.17468. PMID: 36398397Free PMC Article
The duration of successive epileptic seizures is monotonically correlated in neonates.
Pisani F, Statello R, Pedrazzi G, Miragoli M, Piccolo B, Turco EC
Neurophysiol Clin 2022 Nov;52(6):472-481. Epub 2022 Nov 10 doi: 10.1016/j.neucli.2022.10.004. PMID: 36372645
Neonatal presentation of genetic epilepsies: Early differentiation from acute provoked seizures.
Cornet MC, Morabito V, Lederer D, Glass HC, Ferrao Santos S, Numis AL, Ferriero DM, Sands TT, Cilio MR
Epilepsia 2021 Aug;62(8):1907-1920. Epub 2021 Jun 21 doi: 10.1111/epi.16957. PMID: 34153113
Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study.
Basti C, Maranella E, Cimini N, Catalucci A, Ciccarelli S, Del Torto M, Di Luca L, Di Natale C, Mareri A, Nardi V, Pannone V, Di Fabio S
Seizure 2020 Dec;83:154-159. Epub 2020 Oct 29 doi: 10.1016/j.seizure.2020.10.021. PMID: 33160202
Controversies regarding neonatal seizure recognition.
Scher MS
Epileptic Disord 2002 Jun;4(2):139-58. PMID: 12105077

Clinical prediction guides

Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Pavel AM, O'Toole JM, Proietti J, Livingstone V, Mitra S, Marnane WP, Finder M, Dempsey EM, Murray DM, Boylan GB; ANSeR Consortium
Epilepsia 2023 Feb;64(2):456-468. Epub 2022 Dec 20 doi: 10.1111/epi.17468. PMID: 36398397Free PMC Article
The duration of successive epileptic seizures is monotonically correlated in neonates.
Pisani F, Statello R, Pedrazzi G, Miragoli M, Piccolo B, Turco EC
Neurophysiol Clin 2022 Nov;52(6):472-481. Epub 2022 Nov 10 doi: 10.1016/j.neucli.2022.10.004. PMID: 36372645
Electrographic pattern recognition: A simple tool to predict clinical outcome in children with lissencephaly.
Jauhari P, Farmania R, Chakrabarty B, Kumar A, Gulati S
Seizure 2020 Dec;83:175-180. Epub 2020 Oct 31 doi: 10.1016/j.seizure.2020.10.020. PMID: 33161247
Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study.
Basti C, Maranella E, Cimini N, Catalucci A, Ciccarelli S, Del Torto M, Di Luca L, Di Natale C, Mareri A, Nardi V, Pannone V, Di Fabio S
Seizure 2020 Dec;83:154-159. Epub 2020 Oct 29 doi: 10.1016/j.seizure.2020.10.021. PMID: 33160202
Controversies regarding neonatal seizure recognition.
Scher MS
Epileptic Disord 2002 Jun;4(2):139-58. PMID: 12105077

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