U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neuroendocrine Carcinoma of Unknown Primary

MedGen UID:
1720013
Concept ID:
C5235863
Neoplastic Process

Definition

A neuroendocrine carcinoma that has metastasized from an unknown primary site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine Carcinoma of Unknown Primary

Professional guidelines

PubMed

Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Hadoux J, Walter T, Kanaan C, Hescot S, Hautefeuille V, Perrier M, Tauveron I, Laboureau S, Do Cao C, Petorin C, Blanchet O, Faron M, Leteurtre E, Rousselet MC, Joubert Zakeyh J, Marchal A, Chatelain D, Beaulaton C, Hervieu V, Lombard-Bohas C, Ducreux M, Scoazec JY, Baudin E; Groupe d’Etude des Tumeurs Endocrines (GTE); ENDOCAN-RENATEN network
Endocr Relat Cancer 2022 Oct 1;29(10):569-580. Epub 2022 Aug 17 doi: 10.1530/ERC-22-0102. PMID: 35920609
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Recent clinical studies

Etiology

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Broida SE, Chen XT, Baum CL, Brewer JD, Block MS, Jakub JW, Pockaj BA, Foote RL, Markovic SN, Hieken TJ, Houdek MT
J Surg Oncol 2022 Nov;126(6):1080-1086. Epub 2022 Jul 9 doi: 10.1002/jso.27010. PMID: 35809230
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, Shapiro DD, Perelli L, Srinivasan S, Carbone F, Pilié PG, Karki M, Seervai RNH, Vokshi BH, Lopez-Terrada D, Cheng EH, Tang X, Lu W, Wistuba II, Thompson TC, Davidson I, Giuliani V, Schlacher K, Carugo A, Heffernan TP, Sharma P, Karam JA, Wood CG, Walker CL, Genovese G, Tannir NM
Cancer Cell 2020 May 11;37(5):720-734.e13. Epub 2020 Apr 30 doi: 10.1016/j.ccell.2020.04.002. PMID: 32359397Free PMC Article
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Diagnosis

Broida SE, Chen XT, Baum CL, Brewer JD, Block MS, Jakub JW, Pockaj BA, Foote RL, Markovic SN, Hieken TJ, Houdek MT
J Surg Oncol 2022 Nov;126(6):1080-1086. Epub 2022 Jul 9 doi: 10.1002/jso.27010. PMID: 35809230
Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL
Endocr Pathol 2022 Mar;33(1):115-154. Epub 2022 Mar 16 doi: 10.1007/s12022-022-09708-2. PMID: 35294740
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Kennel T, Garrel R, Costes V, Boisselier P, Crampette L, Favier V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jun;136(3):185-192. Epub 2019 Apr 17 doi: 10.1016/j.anorl.2019.04.002. PMID: 31005456

Therapy

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Hadoux J, Walter T, Kanaan C, Hescot S, Hautefeuille V, Perrier M, Tauveron I, Laboureau S, Do Cao C, Petorin C, Blanchet O, Faron M, Leteurtre E, Rousselet MC, Joubert Zakeyh J, Marchal A, Chatelain D, Beaulaton C, Hervieu V, Lombard-Bohas C, Ducreux M, Scoazec JY, Baudin E; Groupe d’Etude des Tumeurs Endocrines (GTE); ENDOCAN-RENATEN network
Endocr Relat Cancer 2022 Oct 1;29(10):569-580. Epub 2022 Aug 17 doi: 10.1530/ERC-22-0102. PMID: 35920609
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Gerard L, Garcia J, Gauthier A, Lopez J, Durand A, Hervieu V, Lemelin A, Chardon L, Landel V, Gibert B, Lombard-Bohas C, Payen L, Walter T
Neuroendocrinology 2021;111(10):951-964. Epub 2020 Oct 23 doi: 10.1159/000512502. PMID: 33099543

Prognosis

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Broida SE, Chen XT, Baum CL, Brewer JD, Block MS, Jakub JW, Pockaj BA, Foote RL, Markovic SN, Hieken TJ, Houdek MT
J Surg Oncol 2022 Nov;126(6):1080-1086. Epub 2022 Jul 9 doi: 10.1002/jso.27010. PMID: 35809230
Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, Shapiro DD, Perelli L, Srinivasan S, Carbone F, Pilié PG, Karki M, Seervai RNH, Vokshi BH, Lopez-Terrada D, Cheng EH, Tang X, Lu W, Wistuba II, Thompson TC, Davidson I, Giuliani V, Schlacher K, Carugo A, Heffernan TP, Sharma P, Karam JA, Wood CG, Walker CL, Genovese G, Tannir NM
Cancer Cell 2020 May 11;37(5):720-734.e13. Epub 2020 Apr 30 doi: 10.1016/j.ccell.2020.04.002. PMID: 32359397Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972

Clinical prediction guides

Ren M, Cai X, Jia L, Bai Q, Zhu X, Hu X, Wang Q, Luo Z, Zhou X
BMC Cancer 2023 Dec 1;23(1):1175. doi: 10.1186/s12885-023-11563-1. PMID: 38041048Free PMC Article
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Recent systematic reviews

Ostojewska J, Wieczorek I, Pachciński O, Zdziennicki W, Burdan F
Folia Med Cracov 2023 Apr 30;63(1):19-37. doi: 10.24425/fmc.2023.145427. PMID: 37406274
Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Shinogi T, Nagase K, Inoue T, Sato K, Onita A, Takamori A, Narisawa Y
J Dermatol 2021 Jul;48(7):1027-1034. Epub 2021 Apr 13 doi: 10.1111/1346-8138.15875. PMID: 33847013
Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055
Stoyianni A, Pentheroudakis G, Pavlidis N
Cancer Treat Rev 2011 Aug;37(5):358-65. Epub 2011 Apr 9 doi: 10.1016/j.ctrv.2011.03.002. PMID: 21481536

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...