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Neuroendocrine Carcinoma of Unknown Primary

MedGen UID:
1720013
Concept ID:
C5235863
Neoplastic Process

Definition

A neuroendocrine carcinoma that has metastasized from an unknown primary site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine Carcinoma of Unknown Primary

Professional guidelines

PubMed

Hadoux J, Walter T, Kanaan C, Hescot S, Hautefeuille V, Perrier M, Tauveron I, Laboureau S, Do Cao C, Petorin C, Blanchet O, Faron M, Leteurtre E, Rousselet MC, Joubert Zakeyh J, Marchal A, Chatelain D, Beaulaton C, Hervieu V, Lombard-Bohas C, Ducreux M, Scoazec JY, Baudin E; Groupe d’Etude des Tumeurs Endocrines (GTE); ENDOCAN-RENATEN network
Endocr Relat Cancer 2022 Oct 1;29(10):569-580. Epub 2022 Aug 17 doi: 10.1530/ERC-22-0102. PMID: 35920609
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Tarantola TI, Vallow LA, Halyard MY, Weenig RH, Warschaw KE, Weaver AL, Roenigk RK, Brewer JD, Otley CC
J Am Acad Dermatol 2013 Mar;68(3):433-40. Epub 2012 Nov 19 doi: 10.1016/j.jaad.2012.07.035. PMID: 23182060

Recent clinical studies

Etiology

Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Broida SE, Chen XT, Baum CL, Brewer JD, Block MS, Jakub JW, Pockaj BA, Foote RL, Markovic SN, Hieken TJ, Houdek MT
J Surg Oncol 2022 Nov;126(6):1080-1086. Epub 2022 Jul 9 doi: 10.1002/jso.27010. PMID: 35809230
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Tarantola TI, Vallow LA, Halyard MY, Weenig RH, Warschaw KE, Weaver AL, Roenigk RK, Brewer JD, Otley CC
J Am Acad Dermatol 2013 Mar;68(3):433-40. Epub 2012 Nov 19 doi: 10.1016/j.jaad.2012.07.035. PMID: 23182060

Diagnosis

Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL
Endocr Pathol 2022 Mar;33(1):115-154. Epub 2022 Mar 16 doi: 10.1007/s12022-022-09708-2. PMID: 35294740
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Kennel T, Garrel R, Costes V, Boisselier P, Crampette L, Favier V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jun;136(3):185-192. Epub 2019 Apr 17 doi: 10.1016/j.anorl.2019.04.002. PMID: 31005456
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Therapy

Hadoux J, Walter T, Kanaan C, Hescot S, Hautefeuille V, Perrier M, Tauveron I, Laboureau S, Do Cao C, Petorin C, Blanchet O, Faron M, Leteurtre E, Rousselet MC, Joubert Zakeyh J, Marchal A, Chatelain D, Beaulaton C, Hervieu V, Lombard-Bohas C, Ducreux M, Scoazec JY, Baudin E; Groupe d’Etude des Tumeurs Endocrines (GTE); ENDOCAN-RENATEN network
Endocr Relat Cancer 2022 Oct 1;29(10):569-580. Epub 2022 Aug 17 doi: 10.1530/ERC-22-0102. PMID: 35920609
Matrood S, Apostolidis L, Schrader J, Krug S, Lahner H, Ramaswamy A, Librizzi D, Kender Z, Kröcher A, Kreutzfeldt S, Gress TM, Rinke A
Front Endocrinol (Lausanne) 2021;12:709256. Epub 2021 Oct 6 doi: 10.3389/fendo.2021.709256. PMID: 34690926Free PMC Article
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Tao L, Chen Y, Shi X, Yu G, Yin W, Huang Y
Virchows Arch 2020 Oct;477(4):573-579. Epub 2020 Apr 23 doi: 10.1007/s00428-020-02815-7. PMID: 32328798
Sporn JR, Greenberg BR
Am J Med 1990 Jan;88(1):49-55. doi: 10.1016/0002-9343(90)90127-y. PMID: 2403756

Prognosis

Broida SE, Chen XT, Baum CL, Brewer JD, Block MS, Jakub JW, Pockaj BA, Foote RL, Markovic SN, Hieken TJ, Houdek MT
J Surg Oncol 2022 Nov;126(6):1080-1086. Epub 2022 Jul 9 doi: 10.1002/jso.27010. PMID: 35809230
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Clinical prediction guides

Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Spigel DR, Hainsworth JD, Greco FA
Semin Oncol 2009 Feb;36(1):52-9. doi: 10.1053/j.seminoncol.2008.10.003. PMID: 19179188

Recent systematic reviews

Ostojewska J, Wieczorek I, Pachciński O, Zdziennicki W, Burdan F
Folia Med Cracov 2023 Apr 30;63(1):19-37. doi: 10.24425/fmc.2023.145427. PMID: 37406274
Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Shinogi T, Nagase K, Inoue T, Sato K, Onita A, Takamori A, Narisawa Y
J Dermatol 2021 Jul;48(7):1027-1034. Epub 2021 Apr 13 doi: 10.1111/1346-8138.15875. PMID: 33847013
Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055
Stoyianni A, Pentheroudakis G, Pavlidis N
Cancer Treat Rev 2011 Aug;37(5):358-65. Epub 2011 Apr 9 doi: 10.1016/j.ctrv.2011.03.002. PMID: 21481536

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