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Liver Large Cell Neuroendocrine Carcinoma

MedGen UID:
1720998
Concept ID:
C2111730
Neoplastic Process
Synonym: Hepatic Large Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Liu DJ, Fu XL, Liu W, Zheng LY, Zhang JF, Huo YM, Li J, Hua R, Liu Q, Sun YW
World J Gastroenterol 2017 Jan 21;23(3):516-524. doi: 10.3748/wjg.v23.i3.516. PMID: 28210088Free PMC Article
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Alshammari TF, Hakami RA, Alali MN, AlShammari S, Zayed MA, AlSohaibani MO, Bin Traiki T
Am J Case Rep 2019 Jun 28;20:920-925. doi: 10.12659/AJCR.916288. PMID: 31249283Free PMC Article
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Rudin CM, Pietanza MC, Bauer TM, Ready N, Morgensztern D, Glisson BS, Byers LA, Johnson ML, Burris HA 3rd, Robert F, Han TH, Bheddah S, Theiss N, Watson S, Mathur D, Vennapusa B, Zayed H, Lally S, Strickland DK, Govindan R, Dylla SJ, Peng SL, Spigel DR; SCRX16-001 investigators
Lancet Oncol 2017 Jan;18(1):42-51. Epub 2016 Dec 5 doi: 10.1016/S1470-2045(16)30565-4. PMID: 27932068Free PMC Article
Tsaras G, Owusu-Ansah A, Boateng FO, Amoateng-Adjepong Y
Am J Med 2009 Jun;122(6):507-12. Epub 2009 Apr 24 doi: 10.1016/j.amjmed.2008.12.020. PMID: 19393983

Diagnosis

Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Ren X, Jiang H, Sun K, Qin X, Qu Y, Xia T, Chen Y
Diagn Pathol 2022 Jun 17;17(1):51. doi: 10.1186/s13000-022-01231-6. PMID: 35715834Free PMC Article
Bellizzi AM
Adv Anat Pathol 2020 May;27(3):114-163. doi: 10.1097/PAP.0000000000000256. PMID: 32205473Free PMC Article
Alshammari TF, Hakami RA, Alali MN, AlShammari S, Zayed MA, AlSohaibani MO, Bin Traiki T
Am J Case Rep 2019 Jun 28;20:920-925. doi: 10.12659/AJCR.916288. PMID: 31249283Free PMC Article
Araki T, Sholl LM, Hatabu H, Nishino M
Clin Radiol 2018 May;73(5):479-484. Epub 2018 Jan 6 doi: 10.1016/j.crad.2017.11.025. PMID: 29310810

Therapy

Rudin CM, Pietanza MC, Bauer TM, Ready N, Morgensztern D, Glisson BS, Byers LA, Johnson ML, Burris HA 3rd, Robert F, Han TH, Bheddah S, Theiss N, Watson S, Mathur D, Vennapusa B, Zayed H, Lally S, Strickland DK, Govindan R, Dylla SJ, Peng SL, Spigel DR; SCRX16-001 investigators
Lancet Oncol 2017 Jan;18(1):42-51. Epub 2016 Dec 5 doi: 10.1016/S1470-2045(16)30565-4. PMID: 27932068Free PMC Article
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Cornella H, Alsinet C, Sayols S, Zhang Z, Hao K, Cabellos L, Hoshida Y, Villanueva A, Thung S, Ward SC, Rodriguez-Carunchio L, Vila-Casadesús M, Imbeaud S, Lachenmayer A, Quaglia A, Nagorney DM, Minguez B, Carrilho F, Roberts LR, Waxman S, Mazzaferro V, Schwartz M, Esteller M, Heaton ND, Zucman-Rossi J, Llovet JM
Gastroenterology 2015 Apr;148(4):806-18.e10. Epub 2014 Dec 31 doi: 10.1053/j.gastro.2014.12.028. PMID: 25557953Free PMC Article
Kon T, Wada R, Suzuki R, Nakayama Y, Ebina Y, Yagihashi S
JOP 2012 Mar 10;13(2):226-30. PMID: 22406608
Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti M, De Rosa G, Colao A, Contegiacomo A
J Endocrinol Invest 2005 Apr;28(4):371-8. doi: 10.1007/BF03347206. PMID: 15966513

Prognosis

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Rudin CM, Pietanza MC, Bauer TM, Ready N, Morgensztern D, Glisson BS, Byers LA, Johnson ML, Burris HA 3rd, Robert F, Han TH, Bheddah S, Theiss N, Watson S, Mathur D, Vennapusa B, Zayed H, Lally S, Strickland DK, Govindan R, Dylla SJ, Peng SL, Spigel DR; SCRX16-001 investigators
Lancet Oncol 2017 Jan;18(1):42-51. Epub 2016 Dec 5 doi: 10.1016/S1470-2045(16)30565-4. PMID: 27932068Free PMC Article
Vora M, Lacour RA, Black DR, Turbat-Herrera EA, Gu X
Arch Gynecol Obstet 2016 Mar;293(3):659-65. Epub 2015 Aug 26 doi: 10.1007/s00404-015-3865-0. PMID: 26306985
Cornella H, Alsinet C, Sayols S, Zhang Z, Hao K, Cabellos L, Hoshida Y, Villanueva A, Thung S, Ward SC, Rodriguez-Carunchio L, Vila-Casadesús M, Imbeaud S, Lachenmayer A, Quaglia A, Nagorney DM, Minguez B, Carrilho F, Roberts LR, Waxman S, Mazzaferro V, Schwartz M, Esteller M, Heaton ND, Zucman-Rossi J, Llovet JM
Gastroenterology 2015 Apr;148(4):806-18.e10. Epub 2014 Dec 31 doi: 10.1053/j.gastro.2014.12.028. PMID: 25557953Free PMC Article

Clinical prediction guides

Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Chen C, Hu H, Zheng Z, Yang Y, Chen W, Qiao X, Li P, Zhang S
Cancer Med 2022 Dec;11(24):4935-4945. Epub 2022 May 21 doi: 10.1002/cam4.4829. PMID: 35596661Free PMC Article
Ishida S, Akita M, Fujikura K, Komatsu M, Sawada R, Matsumoto H, Saegusa J, Itoh T, Kakeji Y, Zen Y
Hum Pathol 2021 Apr;110:1-10. Epub 2021 Jan 21 doi: 10.1016/j.humpath.2020.12.008. PMID: 33359239
Papa A, Rossi L, Verrico M, Di Cristofano C, Moretti V, Strudel M, Zoratto F, Minozzi M, Tomao S
Clin Respir J 2017 Sep;11(5):574-578. Epub 2015 Oct 20 doi: 10.1111/crj.12385. PMID: 26365150
Cornella H, Alsinet C, Sayols S, Zhang Z, Hao K, Cabellos L, Hoshida Y, Villanueva A, Thung S, Ward SC, Rodriguez-Carunchio L, Vila-Casadesús M, Imbeaud S, Lachenmayer A, Quaglia A, Nagorney DM, Minguez B, Carrilho F, Roberts LR, Waxman S, Mazzaferro V, Schwartz M, Esteller M, Heaton ND, Zucman-Rossi J, Llovet JM
Gastroenterology 2015 Apr;148(4):806-18.e10. Epub 2014 Dec 31 doi: 10.1053/j.gastro.2014.12.028. PMID: 25557953Free PMC Article

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