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Digestive System Large Cell Neuroendocrine Carcinoma

MedGen UID:
1655081
Concept ID:
C4743662
Neoplastic Process
Synonym: Gastrointestinal System Large Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system. It is characterized by the presence of malignant large cells. [from NCI]

Professional guidelines

PubMed

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Mascitti M, Luconi E, Togni L, Rubini C
Pathologica 2019 Jun;111(2):70-75. doi: 10.32074/1591-951X-13-19. PMID: 31388199
Scoazec JY
Ann Endocrinol (Paris) 2019 Jun;80(3):163-165. Epub 2019 Apr 11 doi: 10.1016/j.ando.2019.04.011. PMID: 31064659
Yao JC
Best Pract Res Clin Endocrinol Metab 2007 Mar;21(1):163-72. doi: 10.1016/j.beem.2007.01.006. PMID: 17382271

Diagnosis

Decraene F, Van De Mierop F
Acta Gastroenterol Belg 2022 Oct-Dec;85(4):640-642. Epub 2022 Jun 21 doi: 10.51821/85.4.9429. PMID: 35770290
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Yu R
Pancreas 2020 Jul;49(6):733-736. doi: 10.1097/MPA.0000000000001562. PMID: 32590616
Law J, Zhornitskiy A, Tabibian JH
Gastroenterology 2020 Apr;158(5):e7-e9. Epub 2019 Nov 15 doi: 10.1053/j.gastro.2019.10.045. PMID: 31738916
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article

Therapy

Law J, Zhornitskiy A, Tabibian JH
Gastroenterology 2020 Apr;158(5):e7-e9. Epub 2019 Nov 15 doi: 10.1053/j.gastro.2019.10.045. PMID: 31738916
Boubacar E, Atsame-Ebang G, Rabiou S, Fatimazahra A, Mazti A, Sidibé IS, Tahiri L, Hammas N, Yassine O, Mohamed S, Laila C, Hinde EF
J Med Case Rep 2017 Jun 12;11(1):155. doi: 10.1186/s13256-017-1331-2. PMID: 28602157Free PMC Article
Papa A, Rossi L, Verrico M, Di Cristofano C, Moretti V, Strudel M, Zoratto F, Minozzi M, Tomao S
Clin Respir J 2017 Sep;11(5):574-578. Epub 2015 Oct 20 doi: 10.1111/crj.12385. PMID: 26365150
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Rindi G, Wiedenmann B
Nat Rev Endocrinol 2011 Aug 2;8(1):54-64. doi: 10.1038/nrendo.2011.120. PMID: 21808296

Prognosis

Wu H, Yu Z, Liu Y, Guo L, Teng L, Guo L, Liang L, Wang J, Gao J, Li R, Yang L, Nie X, Su D, Liang Z
Cancer Commun (Lond) 2022 Dec;42(12):1367-1386. Epub 2022 Oct 20 doi: 10.1002/cac2.12372. PMID: 36264285Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Law J, Zhornitskiy A, Tabibian JH
Gastroenterology 2020 Apr;158(5):e7-e9. Epub 2019 Nov 15 doi: 10.1053/j.gastro.2019.10.045. PMID: 31738916
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article

Clinical prediction guides

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Ishida S, Akita M, Fujikura K, Komatsu M, Sawada R, Matsumoto H, Saegusa J, Itoh T, Kakeji Y, Zen Y
Hum Pathol 2021 Apr;110:1-10. Epub 2021 Jan 21 doi: 10.1016/j.humpath.2020.12.008. PMID: 33359239
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article
Inzani F, Petrone G, Fadda G, Rindi G
Rev Endocr Metab Disord 2017 Dec;18(4):381-391. doi: 10.1007/s11154-017-9428-x. PMID: 28871510

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