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Severe albuminuria

MedGen UID:
1726965
Concept ID:
C5421583
Finding
Synonym: Heavy albuminuria
 
HPO: HP:0033066

Definition

The presence of severely increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio greater than 300 mg/gm (greater than 34 mg/mmol). [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Zhang J, Healy HG, Venuthurupalli SK, Tan KS, Wang Z, Cameron A, Hoy WE
BMC Nephrol 2019 Sep 4;20(1):348. doi: 10.1186/s12882-019-1532-6. PMID: 31484506Free PMC Article
Vassalotti JA, Centor R, Turner BJ, Greer RC, Choi M, Sequist TD; National Kidney Foundation Kidney Disease Outcomes Quality Initiative
Am J Med 2016 Feb;129(2):153-162.e7. Epub 2015 Sep 25 doi: 10.1016/j.amjmed.2015.08.025. PMID: 26391748
Iwakura Y, Morimoto R, Kudo M, Ono Y, Takase K, Seiji K, Arai Y, Nakamura Y, Sasano H, Ito S, Satoh F
J Clin Endocrinol Metab 2014 May;99(5):1593-8. Epub 2013 Nov 27 doi: 10.1210/jc.2013-2180. PMID: 24285678

Recent clinical studies

Etiology

Vestergaard AHS, Jensen SK, Heide-Jørgensen U, Frederiksen LE, Birn H, Jarbøl DE, Søndergaard J, Persson F, Thomsen RW, Christiansen CF
Nephrol Dial Transplant 2024 Jun 28;39(7):1150-1158. doi: 10.1093/ndt/gfad271. PMID: 38168720Free PMC Article
Kim H, Hyun YY, Joo YS, Yun HR, Kim Y, Jung JY, Jeong JC, Kim J, Park JT, Yoo TH, Kang SW, Oh KH, Han SH
Nephrol Dial Transplant 2024 Feb 28;39(3):473-482. doi: 10.1093/ndt/gfad195. PMID: 37723608Free PMC Article
Writing Group for the CKD Prognosis Consortium, Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, Surapaneni A, Alencar de Pinho N, Anderson A, Appel LJ, Ärnlöv J, Azizi F, Bansal N, Bell S, Bilo HJG, Brunskill NJ, Carrero JJ, Chadban S, Chalmers J, Chen J, Ciemins E, Cirillo M, Ebert N, Evans M, Ferreiro A, Fu EL, Fukagawa M, Green JA, Gutierrez OM, Herrington WG, Hwang SJ, Inker LA, Iseki K, Jafar T, Jassal SK, Jha V, Kadota A, Katz R, Köttgen A, Konta T, Kronenberg F, Lee BJ, Lees J, Levin A, Looker HC, Major R, Melzer Cohen C, Mieno M, Miyazaki M, Moranne O, Muraki I, Naimark D, Nitsch D, Oh W, Pena M, Purnell TS, Sabanayagam C, Satoh M, Sawhney S, Schaeffner E, Schöttker B, Shen JI, Shlipak MG, Sinha S, Stengel B, Sumida K, Tonelli M, Valdivielso JM, van Zuilen AD, Visseren FLJ, Wang AY, Wen CP, Wheeler DC, Yatsuya H, Yamagata K, Yang JW, Young A, Zhang H, Zhang L, Levey AS, Gansevoort RT
JAMA 2023 Oct 3;330(13):1266-1277. doi: 10.1001/jama.2023.17002. PMID: 37787795Free PMC Article
Jansson Sigfrids F, Groop PH, Harjutsalo V
Lancet Diabetes Endocrinol 2022 Jul;10(7):489-498. Epub 2022 Apr 27 doi: 10.1016/S2213-8587(22)00099-7. PMID: 35489369
Vassalotti JA, Centor R, Turner BJ, Greer RC, Choi M, Sequist TD; National Kidney Foundation Kidney Disease Outcomes Quality Initiative
Am J Med 2016 Feb;129(2):153-162.e7. Epub 2015 Sep 25 doi: 10.1016/j.amjmed.2015.08.025. PMID: 26391748

Diagnosis

Vestergaard AHS, Jensen SK, Heide-Jørgensen U, Frederiksen LE, Birn H, Jarbøl DE, Søndergaard J, Persson F, Thomsen RW, Christiansen CF
Nephrol Dial Transplant 2024 Jun 28;39(7):1150-1158. doi: 10.1093/ndt/gfad271. PMID: 38168720Free PMC Article
Kim H, Hyun YY, Joo YS, Yun HR, Kim Y, Jung JY, Jeong JC, Kim J, Park JT, Yoo TH, Kang SW, Oh KH, Han SH
Nephrol Dial Transplant 2024 Feb 28;39(3):473-482. doi: 10.1093/ndt/gfad195. PMID: 37723608Free PMC Article
Writing Group for the CKD Prognosis Consortium, Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, Surapaneni A, Alencar de Pinho N, Anderson A, Appel LJ, Ärnlöv J, Azizi F, Bansal N, Bell S, Bilo HJG, Brunskill NJ, Carrero JJ, Chadban S, Chalmers J, Chen J, Ciemins E, Cirillo M, Ebert N, Evans M, Ferreiro A, Fu EL, Fukagawa M, Green JA, Gutierrez OM, Herrington WG, Hwang SJ, Inker LA, Iseki K, Jafar T, Jassal SK, Jha V, Kadota A, Katz R, Köttgen A, Konta T, Kronenberg F, Lee BJ, Lees J, Levin A, Looker HC, Major R, Melzer Cohen C, Mieno M, Miyazaki M, Moranne O, Muraki I, Naimark D, Nitsch D, Oh W, Pena M, Purnell TS, Sabanayagam C, Satoh M, Sawhney S, Schaeffner E, Schöttker B, Shen JI, Shlipak MG, Sinha S, Stengel B, Sumida K, Tonelli M, Valdivielso JM, van Zuilen AD, Visseren FLJ, Wang AY, Wen CP, Wheeler DC, Yatsuya H, Yamagata K, Yang JW, Young A, Zhang H, Zhang L, Levey AS, Gansevoort RT
JAMA 2023 Oct 3;330(13):1266-1277. doi: 10.1001/jama.2023.17002. PMID: 37787795Free PMC Article
Jansson Sigfrids F, Groop PH, Harjutsalo V
Lancet Diabetes Endocrinol 2022 Jul;10(7):489-498. Epub 2022 Apr 27 doi: 10.1016/S2213-8587(22)00099-7. PMID: 35489369
Vassalotti JA, Centor R, Turner BJ, Greer RC, Choi M, Sequist TD; National Kidney Foundation Kidney Disease Outcomes Quality Initiative
Am J Med 2016 Feb;129(2):153-162.e7. Epub 2015 Sep 25 doi: 10.1016/j.amjmed.2015.08.025. PMID: 26391748

Therapy

Blum MF, Surapaneni A, Chang A, Inker LA, Chen TK, Appel LJ, Shin JI, Grams ME
J Gen Intern Med 2024 Aug;39(10):1880-1886. Epub 2024 Apr 19 doi: 10.1007/s11606-024-08762-2. PMID: 38639831Free PMC Article
Writing Group for the CKD Prognosis Consortium, Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, Surapaneni A, Alencar de Pinho N, Anderson A, Appel LJ, Ärnlöv J, Azizi F, Bansal N, Bell S, Bilo HJG, Brunskill NJ, Carrero JJ, Chadban S, Chalmers J, Chen J, Ciemins E, Cirillo M, Ebert N, Evans M, Ferreiro A, Fu EL, Fukagawa M, Green JA, Gutierrez OM, Herrington WG, Hwang SJ, Inker LA, Iseki K, Jafar T, Jassal SK, Jha V, Kadota A, Katz R, Köttgen A, Konta T, Kronenberg F, Lee BJ, Lees J, Levin A, Looker HC, Major R, Melzer Cohen C, Mieno M, Miyazaki M, Moranne O, Muraki I, Naimark D, Nitsch D, Oh W, Pena M, Purnell TS, Sabanayagam C, Satoh M, Sawhney S, Schaeffner E, Schöttker B, Shen JI, Shlipak MG, Sinha S, Stengel B, Sumida K, Tonelli M, Valdivielso JM, van Zuilen AD, Visseren FLJ, Wang AY, Wen CP, Wheeler DC, Yatsuya H, Yamagata K, Yang JW, Young A, Zhang H, Zhang L, Levey AS, Gansevoort RT
JAMA 2023 Oct 3;330(13):1266-1277. doi: 10.1001/jama.2023.17002. PMID: 37787795Free PMC Article
Shah N, Perkovic V, Kotwal S
Expert Rev Clin Pharmacol 2022 Jul;15(7):827-842. Epub 2022 Aug 22 doi: 10.1080/17512433.2022.2108402. PMID: 35912871
Jansson Sigfrids F, Groop PH, Harjutsalo V
Lancet Diabetes Endocrinol 2022 Jul;10(7):489-498. Epub 2022 Apr 27 doi: 10.1016/S2213-8587(22)00099-7. PMID: 35489369
Cativo EH, Lopez PD, Cativo DP, Atlas SA, Rosendorff C
Am J Med 2021 Jan;134(1):104-113.e3. Epub 2020 Jul 6 doi: 10.1016/j.amjmed.2020.05.039. PMID: 32645341

Prognosis

Haukka JK, Antikainen AA, Valo E, Syreeni A, Dahlström EH, Lin BM, Franceschini N, Krolewski AS, Harjutsalo V, Groop PH, Sandholm N; FinnDiane Study Group
Diabetologia 2024 Nov;67(11):2494-2506. Epub 2024 Aug 6 doi: 10.1007/s00125-024-06241-1. PMID: 39103720Free PMC Article
Kim H, Hyun YY, Joo YS, Yun HR, Kim Y, Jung JY, Jeong JC, Kim J, Park JT, Yoo TH, Kang SW, Oh KH, Han SH
Nephrol Dial Transplant 2024 Feb 28;39(3):473-482. doi: 10.1093/ndt/gfad195. PMID: 37723608Free PMC Article
Writing Group for the CKD Prognosis Consortium, Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, Surapaneni A, Alencar de Pinho N, Anderson A, Appel LJ, Ärnlöv J, Azizi F, Bansal N, Bell S, Bilo HJG, Brunskill NJ, Carrero JJ, Chadban S, Chalmers J, Chen J, Ciemins E, Cirillo M, Ebert N, Evans M, Ferreiro A, Fu EL, Fukagawa M, Green JA, Gutierrez OM, Herrington WG, Hwang SJ, Inker LA, Iseki K, Jafar T, Jassal SK, Jha V, Kadota A, Katz R, Köttgen A, Konta T, Kronenberg F, Lee BJ, Lees J, Levin A, Looker HC, Major R, Melzer Cohen C, Mieno M, Miyazaki M, Moranne O, Muraki I, Naimark D, Nitsch D, Oh W, Pena M, Purnell TS, Sabanayagam C, Satoh M, Sawhney S, Schaeffner E, Schöttker B, Shen JI, Shlipak MG, Sinha S, Stengel B, Sumida K, Tonelli M, Valdivielso JM, van Zuilen AD, Visseren FLJ, Wang AY, Wen CP, Wheeler DC, Yatsuya H, Yamagata K, Yang JW, Young A, Zhang H, Zhang L, Levey AS, Gansevoort RT
JAMA 2023 Oct 3;330(13):1266-1277. doi: 10.1001/jama.2023.17002. PMID: 37787795Free PMC Article
Vazquez L, Vazquez Arreola E, Hanson RL, Sinha M
Diabetes Care 2023 Sep 1;46(9):1659-1667. doi: 10.2337/dc23-0343. PMID: 37433116Free PMC Article
Jansson Sigfrids F, Groop PH, Harjutsalo V
Lancet Diabetes Endocrinol 2022 Jul;10(7):489-498. Epub 2022 Apr 27 doi: 10.1016/S2213-8587(22)00099-7. PMID: 35489369

Clinical prediction guides

Haukka JK, Antikainen AA, Valo E, Syreeni A, Dahlström EH, Lin BM, Franceschini N, Krolewski AS, Harjutsalo V, Groop PH, Sandholm N; FinnDiane Study Group
Diabetologia 2024 Nov;67(11):2494-2506. Epub 2024 Aug 6 doi: 10.1007/s00125-024-06241-1. PMID: 39103720Free PMC Article
Kim H, Hyun YY, Joo YS, Yun HR, Kim Y, Jung JY, Jeong JC, Kim J, Park JT, Yoo TH, Kang SW, Oh KH, Han SH
Nephrol Dial Transplant 2024 Feb 28;39(3):473-482. doi: 10.1093/ndt/gfad195. PMID: 37723608Free PMC Article
Vazquez L, Vazquez Arreola E, Hanson RL, Sinha M
Diabetes Care 2023 Sep 1;46(9):1659-1667. doi: 10.2337/dc23-0343. PMID: 37433116Free PMC Article
Jansson Sigfrids F, Groop PH, Harjutsalo V
Lancet Diabetes Endocrinol 2022 Jul;10(7):489-498. Epub 2022 Apr 27 doi: 10.1016/S2213-8587(22)00099-7. PMID: 35489369
Luther T, Bülow-Anderberg S, Larsson A, Rubertsson S, Lipcsey M, Frithiof R, Hultström M
Acta Anaesthesiol Scand 2021 Mar;65(3):364-372. Epub 2020 Nov 28 doi: 10.1111/aas.13746. PMID: 33190222Free PMC Article

Recent systematic reviews

Luo Q, Cai Y, Zhao Q, Tian L, Liu Y, Liu WJ
Ren Fail 2022 Dec;44(1):806-814. doi: 10.1080/0886022X.2022.2068443. PMID: 35856157Free PMC Article
Monticone S, Sconfienza E, D'Ascenzo F, Buffolo F, Satoh F, Sechi LA, Veglio F, Mulatero P
J Hypertens 2020 Jan;38(1):3-12. doi: 10.1097/HJH.0000000000002216. PMID: 31385870

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