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Duodenal gastric metaplasia

MedGen UID:
1726972
•Concept ID:
C5421623
•
Cell or Molecular Dysfunction
HPO: HP:0033116

Definition

Foci of gastric-type mucus-secreting cells interspersed between duodenal enterocytes. These foci of gastric epithelial cells contain Periodic acid-Schiff (PAS)-positive neutral mucin and lack a brush border. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDuodenal gastric metaplasia

Professional guidelines

PubMed

Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers.
Hamlet A, Thoreson AC, Nilsson O, Svennerholm AM, Olbe L
Gastroenterology 1999 Feb;116(2):259-68. doi: 10.1016/s0016-5085(99)70121-6. PMID: 9922305

Recent clinical studies

Etiology

McCune Albright Syndrome: Gastrointestinal Polyps and Platelet Dysfunction over 12 Years.
Grob F, Zacharin M
Horm Res Paediatr 2020;93(1):40-45. Epub 2020 May 8 doi: 10.1159/000507442. PMID: 32388508
Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis.
Li XB, Ge ZZ, Chen XY, Liu WZ
Braz J Med Biol Res 2007 Jul;40(7):897-902. doi: 10.1590/s0100-879x2006005000117. PMID: 17653441
Clinical significance of widespread gastric metaplasia in the duodenal bulb.
Veijola L, Sankila A, Rautelin H, Kosunen TU, Sipponen P, Hyvärinen H, Tilvis R, Sarna S, Arkkila PE, Seppälä K
J Clin Gastroenterol 2006 Jul;40(6):510-4. doi: 10.1097/00004836-200607000-00009. PMID: 16825933
Duodenal gastric metaplasia and Helicobacter pylori infection in high and low duodenal ulcer-prevalent areas in India.
Tovey FI, Hobsley M, Kaushik SP, Pandey R, Kurian G, Singh K, Sood A, Jehangir E
J Gastroenterol Hepatol 2004 May;19(5):497-505. doi: 10.1111/j.1440-1746.2003.03320.x. PMID: 15086592
A simple method to demonstrate duodenal gastric metaplasia.
Rubio CA
J Clin Pathol 2002 Jul;55(7):520-3. doi: 10.1136/jcp.55.7.520. PMID: 12101198Free PMC Article

Diagnosis

McCune Albright Syndrome: Gastrointestinal Polyps and Platelet Dysfunction over 12 Years.
Grob F, Zacharin M
Horm Res Paediatr 2020;93(1):40-45. Epub 2020 May 8 doi: 10.1159/000507442. PMID: 32388508
Helicobacter pylori infection and duodenal gastric metaplasia in healthy young adults.
Seo JH, Do HJ, Park CH, Woo HO, Youn HS, Ko GH, Baik SC, Lee WK, Cho MJ, Rhee KH, Lee JH
Korean J Gastroenterol 2013 Apr;61(4):191-5. doi: 10.4166/kjg.2013.61.4.191. PMID: 23624732
Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis.
Li XB, Ge ZZ, Chen XY, Liu WZ
Braz J Med Biol Res 2007 Jul;40(7):897-902. doi: 10.1590/s0100-879x2006005000117. PMID: 17653441
A simple method to demonstrate duodenal gastric metaplasia.
Rubio CA
J Clin Pathol 2002 Jul;55(7):520-3. doi: 10.1136/jcp.55.7.520. PMID: 12101198Free PMC Article
24-hour gastric pH and extent of duodenal gastric metaplasia in Helicobacter pylori-positive patients.
Savarino V, Mela GS, Zentilin P, Lapertosa G, Ceppa P, Vigneri S, Mele MR, Mansi C, Tracci D, Bisso G, Celle G
Gastroenterology 1997 Sep;113(3):741-5. doi: 10.1016/s0016-5085(97)70166-5. PMID: 9287963

Therapy

Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis.
Li XB, Ge ZZ, Chen XY, Liu WZ
Braz J Med Biol Res 2007 Jul;40(7):897-902. doi: 10.1590/s0100-879x2006005000117. PMID: 17653441
Regression of duodenal gastric metaplasia in Helicobacter pylori positive patients with duodenal ulcer disease.
Ciancio G, Nuti M, Orsini B, Iovi F, Ortolani M, Palomba A, Amorosi A, Surrenti E, Ilani SM, Surrenti C
Dig Liver Dis 2002 Jan;34(1):16-21. doi: 10.1016/s1590-8658(02)80054-8. PMID: 11926569
The effect of Helicobacter pylori eradication on duodenal gastric metaplasia.
Uygun A, Kadayifci A, Demiriz M, Erdil A, Gulsen M, Baggi S, Karaeren N, Dagalp K
J Int Med Res 1999 Jul-Aug;27(4):159-66. doi: 10.1177/030006059902700401. PMID: 10599027
Helicobacter pylori and refractory duodenal ulcers: cross-over comparison of continued cimetidine with cimetidine plus antimicrobials.
Boyd HK, Zaterka S, Eisig JN, Chinzon D, Iriya K, Laudanna AA, Boyd EJ
Am J Gastroenterol 1994 Sep;89(9):1505-10. PMID: 8079928
The incidence of gastric metaplasia in patients with duodenal ulcer.
Min YI, Lee BW, Chang YW, Chi HS, Lee JK
Korean J Intern Med 1987 Jan;2(1):93-6. doi: 10.3904/kjim.1987.2.1.93. PMID: 3154823Free PMC Article

Prognosis

McCune Albright Syndrome: Gastrointestinal Polyps and Platelet Dysfunction over 12 Years.
Grob F, Zacharin M
Horm Res Paediatr 2020;93(1):40-45. Epub 2020 May 8 doi: 10.1159/000507442. PMID: 32388508
Duodenal gastric metaplasia and Helicobacter pylori infection in high and low duodenal ulcer-prevalent areas in India.
Tovey FI, Hobsley M, Kaushik SP, Pandey R, Kurian G, Singh K, Sood A, Jehangir E
J Gastroenterol Hepatol 2004 May;19(5):497-505. doi: 10.1111/j.1440-1746.2003.03320.x. PMID: 15086592
Gastric metaplasia: a frequently overlooked feature of duodenal biopsy specimens in untreated celiac disease.
Shaoul R, Marcon MA, Okada Y, Cutz E, Forstner G
J Pediatr Gastroenterol Nutr 2000 Apr;30(4):397-403. doi: 10.1097/00005176-200004000-00009. PMID: 10776950
Helicobacter pylori and refractory duodenal ulcers: cross-over comparison of continued cimetidine with cimetidine plus antimicrobials.
Boyd HK, Zaterka S, Eisig JN, Chinzon D, Iriya K, Laudanna AA, Boyd EJ
Am J Gastroenterol 1994 Sep;89(9):1505-10. PMID: 8079928

Clinical prediction guides

Helicobacter pylori infection and duodenal gastric metaplasia in healthy young adults.
Seo JH, Do HJ, Park CH, Woo HO, Youn HS, Ko GH, Baik SC, Lee WK, Cho MJ, Rhee KH, Lee JH
Korean J Gastroenterol 2013 Apr;61(4):191-5. doi: 10.4166/kjg.2013.61.4.191. PMID: 23624732
Effect of Helicobacter pylori eradication on bulbitis and duodenal gastric metaplasia.
Suriani R, Venturini I, Actis GC, Rocca G, Rizzetto M, Cerutti E, Mazzucco D, Cardesi E, Zeneroli ML
Hepatogastroenterology 2004 Jan-Feb;51(55):176-80. PMID: 15011858
A simple method to demonstrate duodenal gastric metaplasia.
Rubio CA
J Clin Pathol 2002 Jul;55(7):520-3. doi: 10.1136/jcp.55.7.520. PMID: 12101198Free PMC Article
Regression of duodenal gastric metaplasia in Helicobacter pylori positive patients with duodenal ulcer disease.
Ciancio G, Nuti M, Orsini B, Iovi F, Ortolani M, Palomba A, Amorosi A, Surrenti E, Ilani SM, Surrenti C
Dig Liver Dis 2002 Jan;34(1):16-21. doi: 10.1016/s1590-8658(02)80054-8. PMID: 11926569
Duodenal gastric metaplasia, gastric anatomic-functional correlations (parietal cell mass and hydrochloric acid secretion) and Helicobacter pylori. Any differences between chronic autonomous non-specific duodenitis ("non active") and duodenal ulcer?
Testino G, Cornaggia M, Cheli R
Panminerva Med 1997 Dec;39(4):280-3. PMID: 9478067

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