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Chronic decreased circulating IgG3

MedGen UID:
1727000
•Concept ID:
C5421703
•
Finding
Synonym: Chronic decreased IgG3 in blood
 
HPO: HP:0041072

Definition

A lasting decrease of immunoglobulin G3 (IgG3) in the blood. [from HPO]

Professional guidelines

PubMed

IgG4 antibodies to the recombinant filarial antigen Wb-Bhp-1 decrease dramatically following treatment of lymphatic filariasis.
Greene SE, Huang Y, Curtis KC, King CL, Fischer PU, Weil GJ
PLoS Negl Trop Dis 2023 Jun;17(6):e0011364. Epub 2023 Jun 7 doi: 10.1371/journal.pntd.0011364. PMID: 37285374Free PMC Article
Novel biomarkers for the management of chronic hepatitis B.
Inoue T, Tanaka Y
Clin Mol Hepatol 2020 Jul;26(3):261-279. Epub 2020 Jun 15 doi: 10.3350/cmh.2020.0032. PMID: 32536045Free PMC Article
Evidence for the association between IgG-antimitochondrial antibody and biochemical response to ursodeoxycholic acid treatment in primary biliary cholangitis.
Tang L, Zhong R, He X, Wang W, Liu J, Zhu Y, Li Y, Hou J
J Gastroenterol Hepatol 2017 Mar;32(3):659-666. doi: 10.1111/jgh.13534. PMID: 27529417

Recent clinical studies

Etiology

Evaluation of RNase therapy in systemic lupus erythematosus: a randomised phase 2a clinical trial of RSLV-132.
Burge DJ, Werth VP, Boackle SA, Posada J
Lupus Sci Med 2024 Feb 7;11(1) doi: 10.1136/lupus-2023-001113. PMID: 38325898Free PMC Article
New insight of human-IgH 3'regulatory regions in immunoglobulins switch.
Cianci R, Mancino G, Galli E, Serone E, Massoud R, D'Addabbo P, Poscia A, Borghetti A, Porzio O, Marmo R, Gambassi G, Frezza D
Gene 2023 Apr 30;862:147254. Epub 2023 Feb 9 doi: 10.1016/j.gene.2023.147254. PMID: 36764340
High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?
Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530
Luciferase Immunosorbent Assay Based on Multiple E Antigens for the Detection of Chikungunya Virus-Specific IgG Antibodies.
Li X, Wan X, Liu J, Wang H, Li A, Ke C, Tang S, Zhao W, Cai S, Wan C
Microbiol Spectr 2022 Apr 27;10(2):e0149621. Epub 2022 Mar 21 doi: 10.1128/spectrum.01496-21. PMID: 35311573Free PMC Article
Novel biomarkers for the management of chronic hepatitis B.
Inoue T, Tanaka Y
Clin Mol Hepatol 2020 Jul;26(3):261-279. Epub 2020 Jun 15 doi: 10.3350/cmh.2020.0032. PMID: 32536045Free PMC Article

Diagnosis

IgG4 antibodies to the recombinant filarial antigen Wb-Bhp-1 decrease dramatically following treatment of lymphatic filariasis.
Greene SE, Huang Y, Curtis KC, King CL, Fischer PU, Weil GJ
PLoS Negl Trop Dis 2023 Jun;17(6):e0011364. Epub 2023 Jun 7 doi: 10.1371/journal.pntd.0011364. PMID: 37285374Free PMC Article
Luciferase Immunosorbent Assay Based on Multiple E Antigens for the Detection of Chikungunya Virus-Specific IgG Antibodies.
Li X, Wan X, Liu J, Wang H, Li A, Ke C, Tang S, Zhao W, Cai S, Wan C
Microbiol Spectr 2022 Apr 27;10(2):e0149621. Epub 2022 Mar 21 doi: 10.1128/spectrum.01496-21. PMID: 35311573Free PMC Article
Health-Related Quality of Life in 91 Patients with X-Linked Agammaglobulinemia.
Altman K, Zhou C, Hernandez-Trujillo V, Scalchunes C, Rawlings DJ, de la Morena MT
J Clin Immunol 2022 May;42(4):811-818. Epub 2022 Mar 14 doi: 10.1007/s10875-022-01222-8. PMID: 35284987
T-follicular helper cell expansion and chronic T-cell activation are characteristic immune anomalies in Evans syndrome.
Kumar D, Prince C, Bennett CM, Briones M, Lucas L, Russell A, Patel K, Chonat S, Graciaa S, Edington H, White MH, Kobrynski L, Abdalgani M, Parikh S, Chandra S, Bleesing J, Marsh R, Park S, Waller EK, Prahalad S, Chandrakasan S
Blood 2022 Jan 20;139(3):369-383. doi: 10.1182/blood.2021012924. PMID: 34424963Free PMC Article
Novel biomarkers for the management of chronic hepatitis B.
Inoue T, Tanaka Y
Clin Mol Hepatol 2020 Jul;26(3):261-279. Epub 2020 Jun 15 doi: 10.3350/cmh.2020.0032. PMID: 32536045Free PMC Article

Therapy

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.
Canales-Herrerias P, Uzzan M, Seki A, Czepielewski RS, Verstockt B, Livanos AE, Raso F, Dunn A, Dai D, Wang A, Al-Taie Z, Martin J, Laurent T, Ko HM, Tokuyama M, Tankelevich M, Meringer H, Cossarini F, Jha D, Krek A, Paulsen JD, Taylor MD, Nakadar MZ, Wong J, Erlich EC, Mintz RL, Onufer EJ, Helmink BA, Sharma K, Rosenstein A, Ganjian D, Chung G, Dawson T, Juarez J, Yajnik V, Cerutti A, Faith JJ, Suarez-Farinas M, Argmann C, Petralia F, Randolph GJ, Polydorides AD, Reboldi A, Colombel JF, Mehandru S
Sci Immunol 2024 Apr 19;9(94):eadg7549. doi: 10.1126/sciimmunol.adg7549. PMID: 38640252Free PMC Article
Evaluation of RNase therapy in systemic lupus erythematosus: a randomised phase 2a clinical trial of RSLV-132.
Burge DJ, Werth VP, Boackle SA, Posada J
Lupus Sci Med 2024 Feb 7;11(1) doi: 10.1136/lupus-2023-001113. PMID: 38325898Free PMC Article
IgG4 antibodies to the recombinant filarial antigen Wb-Bhp-1 decrease dramatically following treatment of lymphatic filariasis.
Greene SE, Huang Y, Curtis KC, King CL, Fischer PU, Weil GJ
PLoS Negl Trop Dis 2023 Jun;17(6):e0011364. Epub 2023 Jun 7 doi: 10.1371/journal.pntd.0011364. PMID: 37285374Free PMC Article
Health-Related Quality of Life in 91 Patients with X-Linked Agammaglobulinemia.
Altman K, Zhou C, Hernandez-Trujillo V, Scalchunes C, Rawlings DJ, de la Morena MT
J Clin Immunol 2022 May;42(4):811-818. Epub 2022 Mar 14 doi: 10.1007/s10875-022-01222-8. PMID: 35284987
Novel biomarkers for the management of chronic hepatitis B.
Inoue T, Tanaka Y
Clin Mol Hepatol 2020 Jul;26(3):261-279. Epub 2020 Jun 15 doi: 10.3350/cmh.2020.0032. PMID: 32536045Free PMC Article

Prognosis

High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?
Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530
Novel biomarkers for the management of chronic hepatitis B.
Inoue T, Tanaka Y
Clin Mol Hepatol 2020 Jul;26(3):261-279. Epub 2020 Jun 15 doi: 10.3350/cmh.2020.0032. PMID: 32536045Free PMC Article
Monoclonal IgG1κ anti-glomerular basement membrane disease: a case report.
Coley SM, Shirazian S, Radhakrishnan J, D'Agati VD
Am J Kidney Dis 2015 Feb;65(2):322-6. Epub 2014 Oct 22 doi: 10.1053/j.ajkd.2014.08.022. PMID: 25446021
De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease.
Mattoo H, Mahajan VS, Della-Torre E, Sekigami Y, Carruthers M, Wallace ZS, Deshpande V, Stone JH, Pillai S
J Allergy Clin Immunol 2014 Sep;134(3):679-87. Epub 2014 May 6 doi: 10.1016/j.jaci.2014.03.034. PMID: 24815737Free PMC Article
Role of intravenous immunoglobulin G in autoimmune hematologic disorders.
Blanchette VS, Kirby MA, Turner C
Semin Hematol 1992 Jul;29(3 Suppl 2):72-82. PMID: 1509297

Clinical prediction guides

Autoantibodies against laminin-521 are pathogenic in anti-glomerular basement membrane disease.
Kuang H, Shen CR, Jia XY, Tan M, Yang XF, Cui Z, Borza DB, Zhao MH
Kidney Int 2023 Dec;104(6):1124-1134. Epub 2023 Aug 19 doi: 10.1016/j.kint.2023.07.023. PMID: 37598856Free PMC Article
High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?
Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530
Health-Related Quality of Life in 91 Patients with X-Linked Agammaglobulinemia.
Altman K, Zhou C, Hernandez-Trujillo V, Scalchunes C, Rawlings DJ, de la Morena MT
J Clin Immunol 2022 May;42(4):811-818. Epub 2022 Mar 14 doi: 10.1007/s10875-022-01222-8. PMID: 35284987
Novel biomarkers for the management of chronic hepatitis B.
Inoue T, Tanaka Y
Clin Mol Hepatol 2020 Jul;26(3):261-279. Epub 2020 Jun 15 doi: 10.3350/cmh.2020.0032. PMID: 32536045Free PMC Article
Kinetics of circulating antibody response to Trichomonas vaginalis: clinical and diagnostic implications.
Ton Nu PA, Rappelli P, Dessì D, Nguyen VQ, Fiori PL
Sex Transm Infect 2015 Dec;91(8):561-3. Epub 2015 Apr 17 doi: 10.1136/sextrans-2014-051839. PMID: 25887282

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