U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Endogenous Cushing syndrome

MedGen UID:
1727013
•Concept ID:
C5419158
•
Disease or Syndrome
Synonyms: Endogenous Cushing Syndrome; endogenous Cushing syndrome
 
Monarch Initiative: MONDO:0957431

Definition

Cushing syndrome that is caused by excessive production of cortisol by the adrenal gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndogenous Cushing syndrome

Professional guidelines

PubMed

Glucocorticoid Withdrawal Syndrome following treatment of endogenous Cushing Syndrome.
He X, Findling JW, Auchus RJ
Pituitary 2022 Jun;25(3):393-403. Epub 2022 Apr 26 doi: 10.1007/s11102-022-01218-y. PMID: 35471718Free PMC Article
Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal hyperplasia.
Raff H, Sharma ST, Nieman LK
Compr Physiol 2014 Apr;4(2):739-69. doi: 10.1002/cphy.c130035. PMID: 24715566Free PMC Article
Cyclic Cushing syndrome: definitions and treatment implications.
Velez DA, Mayberg MR, Ludlam WH
Neurosurg Focus 2007;23(3):E4; discussion E4a. doi: 10.3171/foc.2007.23.3.5. PMID: 17961029

Recent clinical studies

Etiology

Paediatric Cushing syndrome: a prospective, multisite, observational cohort study.
Tatsi C, Kamilaris C, Keil M, Saidkhodjaeva L, Faucz FR, Chittiboina P, Stratakis CA
Lancet Child Adolesc Health 2024 Jan;8(1):51-62. doi: 10.1016/S2352-4642(23)00264-X. PMID: 38097317
Inflammatory biomarkers in the evaluation of pediatric endogenous Cushing syndrome.
Wurth R, Rescigno M, Flippo C, Stratakis CA, Tatsi C
Eur J Endocrinol 2022 Mar 5;186(4):503-510. doi: 10.1530/EJE-21-1199. PMID: 35171827Free PMC Article
CHOROIDAL THICKENING AND PACHYCHOROID IN CUSHING SYNDROME: Correlation With Endogenous Cortisol Level.
Wang E, Chen S, Yang H, Yang J, Li Y, Chen Y
Retina 2019 Feb;39(2):408-414. doi: 10.1097/IAE.0000000000001956. PMID: 29266048
Incidence of Autoimmune and Related Disorders After Resolution of Endogenous Cushing Syndrome in Children.
Tatsi C, Keil M, Lyssikatos C, Belyavskaya E, Stratakis CA, Lodish MB
Horm Metab Res 2018 Apr;50(4):290-295. Epub 2018 Feb 19 doi: 10.1055/s-0044-101144. PMID: 29458220Free PMC Article
ASSOCIATION BETWEEN MIFEPRISTONE DOSE, EFFICACY, AND TOLERABILITY IN PATIENTS WITH CUSHING SYNDROME.
Yuen KC, Williams G, Kushner H, Nguyen D
Endocr Pract 2015 Oct;21(10):1087-92. Epub 2015 Jun 29 doi: 10.4158/EP15760.OR. PMID: 26121447

Diagnosis

Approach to the Patient: Diagnosis of Cushing Syndrome.
Savas M, Mehta S, Agrawal N, van Rossum EFC, Feelders RA
J Clin Endocrinol Metab 2022 Nov 23;107(11):3162-3174. doi: 10.1210/clinem/dgac492. PMID: 36036941Free PMC Article
Glucocorticoid Withdrawal Syndrome following treatment of endogenous Cushing Syndrome.
He X, Findling JW, Auchus RJ
Pituitary 2022 Jun;25(3):393-403. Epub 2022 Apr 26 doi: 10.1007/s11102-022-01218-y. PMID: 35471718Free PMC Article
Pediatric Cushing Syndrome; an Overview.
Tatsi C, Stratakis CA
Pediatr Endocrinol Rev 2019 Dec;17(2):100-109. doi: 10.17458/per.vol17.2019.ts.pediatriccushingsyndrome. PMID: 31763802
Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.
Stratakis CA
Endocrinol Metab Clin North Am 2016 Jun;45(2):311-28. doi: 10.1016/j.ecl.2016.01.006. PMID: 27241967Free PMC Article
Cushing syndrome in pediatrics.
Stratakis CA
Endocrinol Metab Clin North Am 2012 Dec;41(4):793-803. Epub 2012 Sep 27 doi: 10.1016/j.ecl.2012.08.002. PMID: 23099271Free PMC Article

Therapy

Approach to the Patient: Diagnosis of Cushing Syndrome.
Savas M, Mehta S, Agrawal N, van Rossum EFC, Feelders RA
J Clin Endocrinol Metab 2022 Nov 23;107(11):3162-3174. doi: 10.1210/clinem/dgac492. PMID: 36036941Free PMC Article
Glucocorticoid Withdrawal Syndrome following treatment of endogenous Cushing Syndrome.
He X, Findling JW, Auchus RJ
Pituitary 2022 Jun;25(3):393-403. Epub 2022 Apr 26 doi: 10.1007/s11102-022-01218-y. PMID: 35471718Free PMC Article
Cushing Syndrome Associated Myopathy: It Is Time for a Change.
Reincke M
Endocrinol Metab (Seoul) 2021 Jun;36(3):564-571. Epub 2021 Jun 18 doi: 10.3803/EnM.2021.1069. PMID: 34139801Free PMC Article
Adrenally Directed Medical Therapies for Cushing Syndrome.
Tritos NA
J Clin Endocrinol Metab 2021 Jan 1;106(1):16-25. doi: 10.1210/clinem/dgaa778. PMID: 33118025
Cushing syndrome in pediatrics.
Stratakis CA
Endocrinol Metab Clin North Am 2012 Dec;41(4):793-803. Epub 2012 Sep 27 doi: 10.1016/j.ecl.2012.08.002. PMID: 23099271Free PMC Article

Prognosis

The Effect of Endogenous Cushing Syndrome on All-cause and Cause-specific Mortality.
Limumpornpetch P, Morgan AW, Tiganescu A, Baxter PD, Nyawira Nyaga V, Pujades-Rodriguez M, Stewart PM
J Clin Endocrinol Metab 2022 Jul 14;107(8):2377-2388. doi: 10.1210/clinem/dgac265. PMID: 35486378Free PMC Article
Glucocorticoid Withdrawal Syndrome following treatment of endogenous Cushing Syndrome.
He X, Findling JW, Auchus RJ
Pituitary 2022 Jun;25(3):393-403. Epub 2022 Apr 26 doi: 10.1007/s11102-022-01218-y. PMID: 35471718Free PMC Article
Adrenally Directed Medical Therapies for Cushing Syndrome.
Tritos NA
J Clin Endocrinol Metab 2021 Jan 1;106(1):16-25. doi: 10.1210/clinem/dgaa778. PMID: 33118025
CHOROIDAL THICKENING AND PACHYCHOROID IN CUSHING SYNDROME: Correlation With Endogenous Cortisol Level.
Wang E, Chen S, Yang H, Yang J, Li Y, Chen Y
Retina 2019 Feb;39(2):408-414. doi: 10.1097/IAE.0000000000001956. PMID: 29266048
Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.
Stratakis CA
Endocrinol Metab Clin North Am 2016 Jun;45(2):311-28. doi: 10.1016/j.ecl.2016.01.006. PMID: 27241967Free PMC Article

Clinical prediction guides

Paediatric Cushing syndrome: a prospective, multisite, observational cohort study.
Tatsi C, Kamilaris C, Keil M, Saidkhodjaeva L, Faucz FR, Chittiboina P, Stratakis CA
Lancet Child Adolesc Health 2024 Jan;8(1):51-62. doi: 10.1016/S2352-4642(23)00264-X. PMID: 38097317
ARMC5-negative primary bilateral macronodular adrenal hyperplasia.
Sol B, Carprieaux M, De Leu N
BMJ Case Rep 2023 Jul 6;16(7) doi: 10.1136/bcr-2022-254099. PMID: 37419498Free PMC Article
Approach to the Patient: Diagnosis of Cushing Syndrome.
Savas M, Mehta S, Agrawal N, van Rossum EFC, Feelders RA
J Clin Endocrinol Metab 2022 Nov 23;107(11):3162-3174. doi: 10.1210/clinem/dgac492. PMID: 36036941Free PMC Article
Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, Open-Label Phase 2 Study.
Pivonello R, Bancos I, Feelders RA, Kargi AY, Kerr JM, Gordon MB, Mariash CN, Terzolo M, Ellison N, Moraitis AG
Front Endocrinol (Lausanne) 2021;12:662865. Epub 2021 Jul 14 doi: 10.3389/fendo.2021.662865. PMID: 34335465Free PMC Article
Diurnal Plasma Cortisol Measurements Utility in Differentiating Various Etiologies of Endogenous Cushing Syndrome.
Tirosh A, Lodish MB, Papadakis GZ, Lyssikatos C, Belyavskaya E, Stratakis CA
Horm Metab Res 2016 Sep;48(10):677-681. Epub 2016 Sep 19 doi: 10.1055/s-0042-115644. PMID: 27643448Free PMC Article

Recent systematic reviews

The Effect of Endogenous Cushing Syndrome on All-cause and Cause-specific Mortality.
Limumpornpetch P, Morgan AW, Tiganescu A, Baxter PD, Nyawira Nyaga V, Pujades-Rodriguez M, Stewart PM
J Clin Endocrinol Metab 2022 Jul 14;107(8):2377-2388. doi: 10.1210/clinem/dgac265. PMID: 35486378Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...