U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Transient decreased circulating IgG4

MedGen UID:
1729050
•Concept ID:
C5421690
•
Finding
Synonym: Transient decreased IgG4 in blood
 
HPO: HP:0041057

Definition

A temporary reduction beneath the normal level of total immunoglobulin G4 (IgG4) in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS project.
Mageau A, Tchen J, Ferré VM, Nicaise-Roland P, Descamps D, Delory N, François C, Mendes C, Papo T, Goulenok T, Charles N, Sacré K
J Autoimmun 2023 Jan;134:102987. Epub 2022 Dec 19 doi: 10.1016/j.jaut.2022.102987. PMID: 36563528Free PMC Article
High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life.
Tomicić S, Norrman G, Fälth-Magnusson K, Jenmalm MC, Devenney I, Böttcher MF
Pediatr Allergy Immunol 2009 Feb;20(1):35-41. Epub 2008 Mar 12 doi: 10.1111/j.1399-3038.2008.00738.x. PMID: 18346097
Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome.
Li J, Ha YM, Kü NY, Choi SY, Lee SJ, Oh SB, Kim JS, Lee JH, Lee EB, Song YW, Park K
Lab Invest 2004 Nov;84(11):1430-8. doi: 10.1038/labinvest.3700173. PMID: 15448705
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency.
Kowalczyk D, Mytar B, Zembala M
J Allergy Clin Immunol 1997 Oct;100(4):556-62. doi: 10.1016/s0091-6749(97)70150-7. PMID: 9338552
Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment.
Berchtold P, Wenger M
Blood 1993 Mar 1;81(5):1246-50. PMID: 8443385

Diagnosis

Immune-mediated etiology of acquired von Willebrand syndrome in systemic lupus erythematosus and in benign monoclonal gammopathy: therapeutic implications.
Michiels JJ, Berneman Z, Gadisseur A, van der Planken M, Schroyens W, Budde U, van Vliet HH
Semin Thromb Hemost 2006 Sep;32(6):577-88. doi: 10.1055/s-2006-949663. PMID: 16977568
Mild endotoxaemia and the inflammatory response induced by a marathon race.
Camus G, Poortmans J, Nys M, Deby-Dupont G, Duchateau J, Deby C, Lamy M
Clin Sci (Lond) 1997 Apr;92(4):415-22. doi: 10.1042/cs0920415. PMID: 9176042
Sequential anti-core glycolipid immunoglobulin antibody activities in patients with and without septic shock and their relation to outcome.
Nys M, Damas P, Joassin L, Lamy M
Ann Surg 1993 Mar;217(3):300-6. doi: 10.1097/00000658-199303000-00013. PMID: 8452409Free PMC Article

Therapy

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors.
Strauss J, Heery CR, Kim JW, Jochems C, Donahue RN, Montgomery AS, McMahon S, Lamping E, Marté JL, Madan RA, Bilusic M, Silver MR, Bertotti E, Schlom J, Gulley JL
Clin Cancer Res 2019 Jan 1;25(1):99-109. Epub 2018 Aug 21 doi: 10.1158/1078-0432.CCR-18-1512. PMID: 30131389Free PMC Article
Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component.
Richards DB, Cookson LM, Berges AC, Barton SV, Lane T, Ritter JM, Fontana M, Moon JC, Pinzani M, Gillmore JD, Hawkins PN, Pepys MB
N Engl J Med 2015 Sep 17;373(12):1106-14. Epub 2015 Jul 15 doi: 10.1056/NEJMoa1504942. PMID: 26176329
High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life.
Tomicić S, Norrman G, Fälth-Magnusson K, Jenmalm MC, Devenney I, Böttcher MF
Pediatr Allergy Immunol 2009 Feb;20(1):35-41. Epub 2008 Mar 12 doi: 10.1111/j.1399-3038.2008.00738.x. PMID: 18346097
Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment.
Berchtold P, Wenger M
Blood 1993 Mar 1;81(5):1246-50. PMID: 8443385
The effect of immunoadsorption therapy by a protein A column on patients with thrombocytopenia.
Muroi K, Sasaki R, Miura Y
Semin Hematol 1989 Apr;26(2 Suppl 1):10-4. PMID: 2658094

Prognosis

Humoral immune response against tumoral mucin 1 (MUC1) in breast cancer patients.
Isla Larrain MT, Colussi AG, Demichelis SO, Barbera A, Cretón A, Segal-Eiras A, Croce MV
Int J Biol Markers 2013 Sep 27;28(3):318-25. doi: 10.5301/jbm.5000036. PMID: 23828406
Experience with protein A-immunoadsorption in treatment-resistant adult immune thrombocytopenic purpura.
Snyder HW Jr, Cochran SK, Balint JP Jr, Bertram JH, Mittelman A, Guthrie TH Jr, Jones FR
Blood 1992 May 1;79(9):2237-45. PMID: 1571540
Recurrent nephrotic syndrome following renal transplantation in patients with focal glomerulosclerosis. A one-center study of plasma exchange effects.
Dantal J, Baatard R, Hourmant M, Cantarovich D, Buzelin F, Soulillou JP
Transplantation 1991 Nov;52(5):827-31. doi: 10.1097/00007890-199111000-00014. PMID: 1949168
Studies on circulating immune complexes. III: Kinetics of the immunoglobulin class of circulating immune complexes in systemic lupus erythematosus.
Miura Y
Nihon Jinzo Gakkai Shi 1989 Feb;31(2):201-9. PMID: 2739119
Characterization of antihuman chorionic gonadotropin serum antibody appearing after ovulation induction.
Braunstein GD, Bloch SK, Rasor JL, Winikoff J
J Clin Endocrinol Metab 1983 Dec;57(6):1164-72. doi: 10.1210/jcem-57-6-1164. PMID: 6630412

Clinical prediction guides

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors.
Strauss J, Heery CR, Kim JW, Jochems C, Donahue RN, Montgomery AS, McMahon S, Lamping E, Marté JL, Madan RA, Bilusic M, Silver MR, Bertotti E, Schlom J, Gulley JL
Clin Cancer Res 2019 Jan 1;25(1):99-109. Epub 2018 Aug 21 doi: 10.1158/1078-0432.CCR-18-1512. PMID: 30131389Free PMC Article
Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component.
Richards DB, Cookson LM, Berges AC, Barton SV, Lane T, Ritter JM, Fontana M, Moon JC, Pinzani M, Gillmore JD, Hawkins PN, Pepys MB
N Engl J Med 2015 Sep 17;373(12):1106-14. Epub 2015 Jul 15 doi: 10.1056/NEJMoa1504942. PMID: 26176329
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency.
Kowalczyk D, Mytar B, Zembala M
J Allergy Clin Immunol 1997 Oct;100(4):556-62. doi: 10.1016/s0091-6749(97)70150-7. PMID: 9338552
Mild endotoxaemia and the inflammatory response induced by a marathon race.
Camus G, Poortmans J, Nys M, Deby-Dupont G, Duchateau J, Deby C, Lamy M
Clin Sci (Lond) 1997 Apr;92(4):415-22. doi: 10.1042/cs0920415. PMID: 9176042
Corticosteroid inhibition of the OKT3-induced cytokine-related syndrome--dosage and kinetics prerequisites.
Chatenoud L, Legendre C, Ferran C, Bach JF, Kreis H
Transplantation 1991 Feb;51(2):334-8. doi: 10.1097/00007890-199102000-00012. PMID: 1899732

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...