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Resectable Carcinoma of Unknown Primary

MedGen UID:
1733330
Concept ID:
C5418906
Neoplastic Process

Definition

A carcinoma of unknown primary that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Carcinoma of Unknown Primary

Professional guidelines

PubMed

Ye W, Arnaud EH, Langerman A, Mannion K, Topf MC
Eur J Cancer Care (Engl) 2021 Nov;30(6):e13459. Epub 2021 May 1 doi: 10.1111/ecc.13459. PMID: 33932056
Qian XH, Yan YC, Gao BQ, Wang WL
World J Gastroenterol 2020 Oct 28;26(40):6195-6206. doi: 10.3748/wjg.v26.i40.6195. PMID: 33177793Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718

Recent clinical studies

Etiology

Lu S, Zhang W, Wu L, Wang W, Zhang P; Neotorch Investigators, Fang W, Xing W, Chen Q, Yang L, Mei J, Tan L, Sun X, Xu S, Hu X, Yu G, Yu D, Yang N, Chen Y, Shan J, Xing L, Tian H, Zhang X, Zhou M, Fang H, Wu G, Liu Y, Ye M, Cao L, Jiang J, Li X, Zhu L, Li D, Kang M, Zhong A, Chen K, Wu N, Sun Q, Ma H, Cai K, Wang C, Lin G, Zhu K, Zhang Y, Zhang X, Hu H, Zhang W, Chen J, Yang Z, Hang X, Hu J, Huang Y, Zhang Z, Zhang L, Zhang L, Liu L, Lin D, Zhang J, Chen G, Li Y, Zhu L, Wang W, Yu W, Cao D, Keegan P, Yao S
JAMA 2024 Jan 16;331(3):201-211. doi: 10.1001/jama.2023.24735. PMID: 38227033Free PMC Article
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177
Bex A, Mulders P, Jewett M, Wagstaff J, van Thienen JV, Blank CU, van Velthoven R, Del Pilar Laguna M, Wood L, van Melick HHE, Aarts MJ, Lattouf JB, Powles T, de Jong Md PhD IJ, Rottey S, Tombal B, Marreaud S, Collette S, Collette L, Haanen J
JAMA Oncol 2019 Feb 1;5(2):164-170. doi: 10.1001/jamaoncol.2018.5543. PMID: 30543350Free PMC Article
Gomez DR, Blumenschein GR Jr, Lee JJ, Hernandez M, Ye R, Camidge DR, Doebele RC, Skoulidis F, Gaspar LE, Gibbons DL, Karam JA, Kavanagh BD, Tang C, Komaki R, Louie AV, Palma DA, Tsao AS, Sepesi B, William WN, Zhang J, Shi Q, Wang XS, Swisher SG, Heymach JV
Lancet Oncol 2016 Dec;17(12):1672-1682. Epub 2016 Oct 24 doi: 10.1016/S1470-2045(16)30532-0. PMID: 27789196Free PMC Article

Diagnosis

Ye W, Arnaud EH, Langerman A, Mannion K, Topf MC
Eur J Cancer Care (Engl) 2021 Nov;30(6):e13459. Epub 2021 May 1 doi: 10.1111/ecc.13459. PMID: 33932056
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Fang SH, Lal G
Endocr Pract 2011 Mar-Apr;17 Suppl 1:36-43. doi: 10.4158/EP10310.RA. PMID: 21454239
Givi B, Shah JP
Clin Oncol (R Coll Radiol) 2010 Aug;22(6):498-507. Epub 2010 May 26 doi: 10.1016/j.clon.2010.04.007. PMID: 20510594Free PMC Article
Rodgers SE, Perrier ND
Curr Opin Oncol 2006 Jan;18(1):16-22. doi: 10.1097/01.cco.0000198019.53606.2b. PMID: 16357559

Therapy

Lu S, Zhang W, Wu L, Wang W, Zhang P; Neotorch Investigators, Fang W, Xing W, Chen Q, Yang L, Mei J, Tan L, Sun X, Xu S, Hu X, Yu G, Yu D, Yang N, Chen Y, Shan J, Xing L, Tian H, Zhang X, Zhou M, Fang H, Wu G, Liu Y, Ye M, Cao L, Jiang J, Li X, Zhu L, Li D, Kang M, Zhong A, Chen K, Wu N, Sun Q, Ma H, Cai K, Wang C, Lin G, Zhu K, Zhang Y, Zhang X, Hu H, Zhang W, Chen J, Yang Z, Hang X, Hu J, Huang Y, Zhang Z, Zhang L, Zhang L, Liu L, Lin D, Zhang J, Chen G, Li Y, Zhu L, Wang W, Yu W, Cao D, Keegan P, Yao S
JAMA 2024 Jan 16;331(3):201-211. doi: 10.1001/jama.2023.24735. PMID: 38227033Free PMC Article
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177
Bex A, Mulders P, Jewett M, Wagstaff J, van Thienen JV, Blank CU, van Velthoven R, Del Pilar Laguna M, Wood L, van Melick HHE, Aarts MJ, Lattouf JB, Powles T, de Jong Md PhD IJ, Rottey S, Tombal B, Marreaud S, Collette S, Collette L, Haanen J
JAMA Oncol 2019 Feb 1;5(2):164-170. doi: 10.1001/jamaoncol.2018.5543. PMID: 30543350Free PMC Article
Gomez DR, Blumenschein GR Jr, Lee JJ, Hernandez M, Ye R, Camidge DR, Doebele RC, Skoulidis F, Gaspar LE, Gibbons DL, Karam JA, Kavanagh BD, Tang C, Komaki R, Louie AV, Palma DA, Tsao AS, Sepesi B, William WN, Zhang J, Shi Q, Wang XS, Swisher SG, Heymach JV
Lancet Oncol 2016 Dec;17(12):1672-1682. Epub 2016 Oct 24 doi: 10.1016/S1470-2045(16)30532-0. PMID: 27789196Free PMC Article

Prognosis

Zhang G, Yuan J, Pan C, Xu Q, Cui X, Zhang J, Liu M, Song Z, Wu L, Wu D, Luo H, Hu Y, Jiao S, Yang B
EBioMedicine 2023 Apr;90:104515. Epub 2023 Mar 13 doi: 10.1016/j.ebiom.2023.104515. PMID: 36921563Free PMC Article
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718
Givi B, Shah JP
Clin Oncol (R Coll Radiol) 2010 Aug;22(6):498-507. Epub 2010 May 26 doi: 10.1016/j.clon.2010.04.007. PMID: 20510594Free PMC Article

Clinical prediction guides

Zhang G, Yuan J, Pan C, Xu Q, Cui X, Zhang J, Liu M, Song Z, Wu L, Wu D, Luo H, Hu Y, Jiao S, Yang B
EBioMedicine 2023 Apr;90:104515. Epub 2023 Mar 13 doi: 10.1016/j.ebiom.2023.104515. PMID: 36921563Free PMC Article
Boerner T, Drill E, Pak LM, Nguyen B, Sigel CS, Doussot A, Shin P, Goldman DA, Gonen M, Allen PJ, Balachandran VP, Cercek A, Harding J, Solit DB, Schultz N, Kundra R, Walch H, D'Angelica MI, DeMatteo RP, Drebin J, Kemeny NE, Kingham TP, Simpson AL, Hechtman JF, Vakiani E, Lowery MA, Ijzermans JNM, Buettner S, Koerkamp BG, Doukas M, Chandwani R, Jarnagin WR
Hepatology 2021 Sep;74(3):1429-1444. doi: 10.1002/hep.31829. PMID: 33765338Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718
Gomez DR, Blumenschein GR Jr, Lee JJ, Hernandez M, Ye R, Camidge DR, Doebele RC, Skoulidis F, Gaspar LE, Gibbons DL, Karam JA, Kavanagh BD, Tang C, Komaki R, Louie AV, Palma DA, Tsao AS, Sepesi B, William WN, Zhang J, Shi Q, Wang XS, Swisher SG, Heymach JV
Lancet Oncol 2016 Dec;17(12):1672-1682. Epub 2016 Oct 24 doi: 10.1016/S1470-2045(16)30532-0. PMID: 27789196Free PMC Article

Recent systematic reviews

Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609
Lim KC, Chow PK, Allen JC, Siddiqui FJ, Chan ES, Tan SB
Br J Surg 2012 Dec;99(12):1622-9. Epub 2012 Sep 28 doi: 10.1002/bjs.8915. PMID: 23023956
Capurso G, Rinzivillo M, Bettini R, Boninsegna L, Delle Fave G, Falconi M
Br J Surg 2012 Nov;99(11):1480-6. Epub 2012 Sep 13 doi: 10.1002/bjs.8842. PMID: 22972490
Pentheroudakis G, Lazaridis G, Pavlidis N
Breast Cancer Res Treat 2010 Jan;119(1):1-11. doi: 10.1007/s10549-009-0554-3. PMID: 19771506

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