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Decreased circulating terminal complement component concentration

MedGen UID:
1741072
•Concept ID:
C5421575
•
Finding
Synonym: Decreased serum terminal complement component
 
HPO: HP:0033057

Definition

Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components [from HPO]

Recent clinical studies

Etiology

Microparticles Expressing Myeloperoxidase and Complement C3a and C5a as Markers of Renal Involvement in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
Antovic A, Mobarrez F, Manojlovic M, Soutari N, De Porta Baggemar V, Nordin A, Bruchfeld A, Vojinovic J, Gunnarsson I
J Rheumatol 2020 May 1;47(5):714-721. Epub 2019 Aug 1 doi: 10.3899/jrheum.181347. PMID: 31371653
The inflammatory response to recycled pericardial suction blood and the influence of cell-saving.
Svenmarker S, Engström KG
Scand Cardiovasc J 2003 Jun;37(3):158-64. doi: 10.1080/14017430310001465. PMID: 12881158
Immunological evaluation of late complement component-deficient individuals.
Platonov AE, Beloborodov VB, Gabrilovitch DI, Khabarova VV, Serebrovskaya LV
Clin Immunol Immunopathol 1992 Aug;64(2):98-105. doi: 10.1016/0090-1229(92)90186-r. PMID: 1643749

Diagnosis

Microparticles Expressing Myeloperoxidase and Complement C3a and C5a as Markers of Renal Involvement in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
Antovic A, Mobarrez F, Manojlovic M, Soutari N, De Porta Baggemar V, Nordin A, Bruchfeld A, Vojinovic J, Gunnarsson I
J Rheumatol 2020 May 1;47(5):714-721. Epub 2019 Aug 1 doi: 10.3899/jrheum.181347. PMID: 31371653
Complement component C1q as potential diagnostic but not predictive marker of preeclampsia.
Agostinis C, Stampalija T, Tannetta D, Loganes C, Vecchi Brumatti L, De Seta F, Celeghini C, Radillo O, Sargent I, Tedesco F, Bulla R
Am J Reprod Immunol 2016 Dec;76(6):475-481. Epub 2016 Sep 26 doi: 10.1111/aji.12586. PMID: 27666323
The inflammatory response to recycled pericardial suction blood and the influence of cell-saving.
Svenmarker S, Engström KG
Scand Cardiovasc J 2003 Jun;37(3):158-64. doi: 10.1080/14017430310001465. PMID: 12881158

Therapy

The inflammatory response to recycled pericardial suction blood and the influence of cell-saving.
Svenmarker S, Engström KG
Scand Cardiovasc J 2003 Jun;37(3):158-64. doi: 10.1080/14017430310001465. PMID: 12881158

Prognosis

Complement component C1q as potential diagnostic but not predictive marker of preeclampsia.
Agostinis C, Stampalija T, Tannetta D, Loganes C, Vecchi Brumatti L, De Seta F, Celeghini C, Radillo O, Sargent I, Tedesco F, Bulla R
Am J Reprod Immunol 2016 Dec;76(6):475-481. Epub 2016 Sep 26 doi: 10.1111/aji.12586. PMID: 27666323
The inflammatory response to recycled pericardial suction blood and the influence of cell-saving.
Svenmarker S, Engström KG
Scand Cardiovasc J 2003 Jun;37(3):158-64. doi: 10.1080/14017430310001465. PMID: 12881158

Clinical prediction guides

Microparticles Expressing Myeloperoxidase and Complement C3a and C5a as Markers of Renal Involvement in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
Antovic A, Mobarrez F, Manojlovic M, Soutari N, De Porta Baggemar V, Nordin A, Bruchfeld A, Vojinovic J, Gunnarsson I
J Rheumatol 2020 May 1;47(5):714-721. Epub 2019 Aug 1 doi: 10.3899/jrheum.181347. PMID: 31371653
Complement component C1q as potential diagnostic but not predictive marker of preeclampsia.
Agostinis C, Stampalija T, Tannetta D, Loganes C, Vecchi Brumatti L, De Seta F, Celeghini C, Radillo O, Sargent I, Tedesco F, Bulla R
Am J Reprod Immunol 2016 Dec;76(6):475-481. Epub 2016 Sep 26 doi: 10.1111/aji.12586. PMID: 27666323
Selective removal of human serum amyloid P component from rat blood by use of an immunoaffinity membrane in an extracorporeal circulation system.
Adachi T, Mogi M, Harada M, Kojima K
J Chromatogr B Biomed Appl 1996 Jun 28;682(1):47-54. doi: 10.1016/0378-4347(96)00059-x. PMID: 8832424
Altered concentrations of terminal complement complexes, anaphylatoxins, and leukotrienes in the coronary sinus during cardiopulmonary bypass.
Bengtson A, Millocco I, Heideman M, Berggren H
J Cardiothorac Anesth 1989 Jun;3(3):305-10. doi: 10.1016/0888-6296(89)90113-0. PMID: 2520655

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