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Decreased circulating complement C7 concentration

MedGen UID:
1762662
•Concept ID:
C5421782
•
Finding
Synonym: Decreased serum complement C7
 
HPO: HP:0033058

Definition

Concentration of the complement component C7 in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating complement C7 concentration

Conditions with this feature

Complement component 7 deficiency
MedGen UID:
355270
•Concept ID:
C1864694
•
Disease or Syndrome
Patients with C7 deficiency have an increased susceptibility to recurrent bacterial infections, especially meningitis caused by Neisseria meningitidis (Nishizaka et al., 1996).
See: Condition Record
Complement component 7 deficiency

Recent clinical studies

Etiology

Immunological evaluation of late complement component-deficient individuals.
Platonov AE, Beloborodov VB, Gabrilovitch DI, Khabarova VV, Serebrovskaya LV
Clin Immunol Immunopathol 1992 Aug;64(2):98-105. doi: 10.1016/0090-1229(92)90186-r. PMID: 1643749

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