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Oral Mucosa Langerhans Cell Histiocytosis

MedGen UID:
1743186
•Concept ID:
C5420233
•
Neoplastic Process
Synonym: Oral Cavity Langerhans Cell Histiocytosis

Definition

Langerhans cell histiocytosis involving the oral mucosa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral Mucosa Langerhans Cell Histiocytosis

Professional guidelines

PubMed

Osteonecrosis of the jaws and bisphosphonate treatment in cancer patients.
Wutzl A, Eisenmenger G, Hoffmann M, Czerny C, Moser D, Pietschmann P, Ewers R, Baumann A
Wien Klin Wochenschr 2006 Aug;118(15-16):473-8. doi: 10.1007/s00508-006-0644-8. PMID: 16957978

Recent clinical studies

Etiology

Langerhans cell histiocytosis oral lesions in pediatric patients.
Pavan VH, Fernández de Preliasco V, Ienco M, Benchuya C
Acta Odontol Latinoam 2023 Dec 31;36(3):156-162. doi: 10.54589/aol.36/3/156. PMID: 38345277Free PMC Article
Clinical outcomes and prognostic risk factors of Langerhans cell histiocytosis in children: Results from the BCH-LCH 2014 protocol study.
Cui L, Wang CJ, Lian HY, Zhang L, Ma HH, Wang D, Chen FF, Zhang Q, Yang Y, Wei A, Huang XT, Zhu T, Wang TY, Li ZG, Zhang R
Am J Hematol 2023 Apr;98(4):598-607. Epub 2023 Jan 9 doi: 10.1002/ajh.26829. PMID: 36594188
Bilateral Maxillary Langerhans Cell Histiocytosis in a Six-Month-Old Infant.
Mangar J, Heifetz-Li JJ, Kuklani R, Deitrick P, Bahn PA
J Dent Child (Chic) 2022 Sep 15;89(3):203-207. PMID: 37149882
Langerhans cell histiocytosis in childhood - review, symptoms in the oral cavity, differential diagnosis and report of two cases.
Merglová V, Hrušák D, Boudová L, Mukenšnabl P, Valentová E, Hostička L
J Craniomaxillofac Surg 2014 Mar;42(2):93-100. Epub 2013 Jun 7 doi: 10.1016/j.jcms.2013.03.005. PMID: 23751977
Oral manifestations of langerhans cell histiocytosis in a pediatric population: a clinical and histological study of 8 patients.
Mortellaro C, Pucci A, Palmeri A, Lucchina AG, Berta M, Celeste A, Costantino S, Del Prever AB, Forni M
J Craniofac Surg 2006 May;17(3):552-6. doi: 10.1097/00001665-200605000-00028. PMID: 16770197

Diagnosis

Langerhans cell histiocytosis oral lesions in pediatric patients.
Pavan VH, Fernández de Preliasco V, Ienco M, Benchuya C
Acta Odontol Latinoam 2023 Dec 31;36(3):156-162. doi: 10.54589/aol.36/3/156. PMID: 38345277Free PMC Article
Bilateral Maxillary Langerhans Cell Histiocytosis in a Six-Month-Old Infant.
Mangar J, Heifetz-Li JJ, Kuklani R, Deitrick P, Bahn PA
J Dent Child (Chic) 2022 Sep 15;89(3):203-207. PMID: 37149882
Molecular and oral manifestations of langerhans cell histiocytosis preceding acute myeloid leukemia.
Zhang Q, Wu X, Wang X, Pan E, Ying L
BMC Oral Health 2022 Sep 5;22(1):386. doi: 10.1186/s12903-022-02410-z. PMID: 36064398Free PMC Article
Oral manifestations of Langerhans cell histiocytosis: A case series.
Neves-Silva R, Fernandes DT, Fonseca FP, Rebelo Pontes HA, Brasileiro BF, Santos-Silva AR, Vargas PA, Lopes MA
Spec Care Dentist 2018 Nov;38(6):426-433. Epub 2018 Sep 12 doi: 10.1111/scd.12330. PMID: 30207399
Xanthoma disseminatum: case report.
Celić D, Rados J, Lipozencić J, Dobrić I
Acta Dermatovenerol Croat 2004;12(4):282-8. PMID: 15588563

Therapy

Clinical outcomes and prognostic risk factors of Langerhans cell histiocytosis in children: Results from the BCH-LCH 2014 protocol study.
Cui L, Wang CJ, Lian HY, Zhang L, Ma HH, Wang D, Chen FF, Zhang Q, Yang Y, Wei A, Huang XT, Zhu T, Wang TY, Li ZG, Zhang R
Am J Hematol 2023 Apr;98(4):598-607. Epub 2023 Jan 9 doi: 10.1002/ajh.26829. PMID: 36594188
Extensive eye-oral-bronchial mucosal nodules with eosinopgillia: a rare case report and literature review.
Wu L, Leng Q, Wang Y, Wang D, Yang D
BMC Pulm Med 2020 Nov 12;20(1):296. doi: 10.1186/s12890-020-01340-2. PMID: 33183266Free PMC Article
Revealing a rare inflammatory oral manifestation in a 6-year-old child.
Routray S, Adhya AK, John J, Dikhit P
BMJ Case Rep 2019 Jul 23;12(7) doi: 10.1136/bcr-2019-229483. PMID: 31340944Free PMC Article
Multifocal oral Langerhans cell histiocytosis.
Murray M, Dean J, Slater L
J Oral Maxillofac Surg 2011 Oct;69(10):2585-91. Epub 2011 Apr 5 doi: 10.1016/j.joms.2011.01.008. PMID: 21470739
Oral eosinophilic ulcer, an Epstein-Barr virus-associated CD30+ lymphoproliferation?
Abdel-Naser MB, Tsatsou F, Hippe S, Knolle J, Anagnostopoulos I, Stein H, Zouboulis CC
Dermatology 2011;222(2):113-8. Epub 2011 Apr 5 doi: 10.1159/000325460. PMID: 21464557

Prognosis

Clinical outcomes and prognostic risk factors of Langerhans cell histiocytosis in children: Results from the BCH-LCH 2014 protocol study.
Cui L, Wang CJ, Lian HY, Zhang L, Ma HH, Wang D, Chen FF, Zhang Q, Yang Y, Wei A, Huang XT, Zhu T, Wang TY, Li ZG, Zhang R
Am J Hematol 2023 Apr;98(4):598-607. Epub 2023 Jan 9 doi: 10.1002/ajh.26829. PMID: 36594188
Congenital self-healing reticulohistiocytosis in a newborn: unusual oral and cutaneous manifestations.
Rizzoli A, Giancristoforo S, Haass C, De Vito R, Gaspari S, Scapillati E, Diociaiuti A, El Hachem M
Ital J Pediatr 2021 Jun 10;47(1):135. doi: 10.1186/s13052-021-01082-9. PMID: 34112212Free PMC Article
Langerhans cell histiocytosis in childhood - review, symptoms in the oral cavity, differential diagnosis and report of two cases.
Merglová V, Hrušák D, Boudová L, Mukenšnabl P, Valentová E, Hostička L
J Craniomaxillofac Surg 2014 Mar;42(2):93-100. Epub 2013 Jun 7 doi: 10.1016/j.jcms.2013.03.005. PMID: 23751977
Unifocal Langerhans cell histiocytosis of the oral mucosa.
Fistarol S, Itin P, Häusermann P, Oberholzer M, Raineri I, Lambrecht T, Lindenmüller IH
J Dtsch Dermatol Ges 2009 Jul;7(7):620-2. Epub 2009 Feb 17 doi: 10.1111/j.1610-0387.2009.07042.x. PMID: 19228294
Histiocytosis X.
Fitzpatrick R, Rapaport MJ, Silva DG
Arch Dermatol 1981 May;117(5):253-7. PMID: 6971625

Clinical prediction guides

Langerhans cell histiocytosis oral lesions in pediatric patients.
Pavan VH, Fernández de Preliasco V, Ienco M, Benchuya C
Acta Odontol Latinoam 2023 Dec 31;36(3):156-162. doi: 10.54589/aol.36/3/156. PMID: 38345277Free PMC Article
Eosinophilic ulcer of the oral mucosa: a distinct entity or a non-specific reactive pattern?
Segura S, Pujol RM
Oral Dis 2008 May;14(4):287-95. doi: 10.1111/j.1601-0825.2008.01444.x. PMID: 18410573
Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa.
Hirshberg A, Amariglio N, Akrish S, Yahalom R, Rosenbaum H, Okon E, Kaplan I
Am J Clin Pathol 2006 Oct;126(4):522-9. doi: 10.1309/AFHA406GBT0N2Y64. PMID: 16938660
Eosinophilic ulcer of the oral mucosa.
Mezei MM, Tron VA, Stewart WD, Rivers JK
J Am Acad Dermatol 1995 Nov;33(5 Pt 1):734-40. doi: 10.1016/0190-9622(95)91810-8. PMID: 7593771
Eosinophilic ulcer of the oral mucosa. Report of 38 new cases with immunohistochemical observations.
el-Mofty SK, Swanson PE, Wick MR, Miller AS
Oral Surg Oral Med Oral Pathol 1993 Jun;75(6):716-22. doi: 10.1016/0030-4220(93)90429-8. PMID: 8515985

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