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Milky appearance of bronchoalveolar lavage fluid

MedGen UID:
1751230
•Concept ID:
C5421661
•
Finding
HPO: HP:0033173

Definition

Return of lavage fluid with a milky appearance due to the accumulation of a mixture of pulmonary surfactant, which is a lipoprotein complex, in the alveolar space. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMilky appearance of bronchoalveolar lavage fluid

Professional guidelines

PubMed

Autoimmune pulmonary alveolar proteinosis: clinical course and diagnostic criteria.
Ben-Dov I, Segel MJ
Autoimmun Rev 2014 Apr-May;13(4-5):513-7. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.046. PMID: 24424195

Recent clinical studies

Diagnosis

Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant: A Case Report.
Sakurai M, Kato J, Toyama T, Hashida R, Yamane Y, Abe R, Koda Y, Kohashi S, Kikuchi T, Hayashi Y, Nukaga S, Ueda S, Fukunaga K, Okamoto S, Mori T
Transplant Proc 2018 Dec;50(10):4096-4098. Epub 2018 Sep 8 doi: 10.1016/j.transproceed.2018.09.004. PMID: 30577323
Pulmonary Alveolar Proteinosis with Ulcerative Colitis.
Sakamoto N, Nakashima S, Ishimoto H, Kakugawa T, Hara A, Yura H, Miyamura T, Nakamichi S, Obase Y, Ishimatsu Y, Mukae H
Intern Med 2018 Sep 15;57(18):2705-2708. Epub 2018 Apr 27 doi: 10.2169/internalmedicine.0555-17. PMID: 29709938Free PMC Article
Alveolar proteinosis associated with aluminium dust inhalation.
Chew R, Nigam S, Sivakumaran P
Occup Med (Lond) 2016 Aug;66(6):492-4. Epub 2016 Apr 19 doi: 10.1093/occmed/kqw049. PMID: 27099254
Autoimmune pulmonary alveolar proteinosis: clinical course and diagnostic criteria.
Ben-Dov I, Segel MJ
Autoimmun Rev 2014 Apr-May;13(4-5):513-7. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.046. PMID: 24424195
Pulmonary alveolar proteinosis in children.
de Blic J
Paediatr Respir Rev 2004 Dec;5(4):316-22. doi: 10.1016/j.prrv.2004.07.001. PMID: 15531257

Therapy

Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant: A Case Report.
Sakurai M, Kato J, Toyama T, Hashida R, Yamane Y, Abe R, Koda Y, Kohashi S, Kikuchi T, Hayashi Y, Nukaga S, Ueda S, Fukunaga K, Okamoto S, Mori T
Transplant Proc 2018 Dec;50(10):4096-4098. Epub 2018 Sep 8 doi: 10.1016/j.transproceed.2018.09.004. PMID: 30577323
Alveolar proteinosis associated with aluminium dust inhalation.
Chew R, Nigam S, Sivakumaran P
Occup Med (Lond) 2016 Aug;66(6):492-4. Epub 2016 Apr 19 doi: 10.1093/occmed/kqw049. PMID: 27099254
Autoimmune pulmonary alveolar proteinosis: clinical course and diagnostic criteria.
Ben-Dov I, Segel MJ
Autoimmun Rev 2014 Apr-May;13(4-5):513-7. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.046. PMID: 24424195
Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates.
Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC
Am J Respir Crit Care Med 2010 Jul 1;182(1):49-61. Epub 2010 Mar 11 doi: 10.1164/rccm.201001-0008OC. PMID: 20224064Free PMC Article
Pulmonary alveolar proteinosis successfully treated with ambroxol.
Hashizume T
Intern Med 2002 Dec;41(12):1175-8. doi: 10.2169/internalmedicine.41.1175. PMID: 12521210

Prognosis

Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant: A Case Report.
Sakurai M, Kato J, Toyama T, Hashida R, Yamane Y, Abe R, Koda Y, Kohashi S, Kikuchi T, Hayashi Y, Nukaga S, Ueda S, Fukunaga K, Okamoto S, Mori T
Transplant Proc 2018 Dec;50(10):4096-4098. Epub 2018 Sep 8 doi: 10.1016/j.transproceed.2018.09.004. PMID: 30577323
Development of microscopic polyangiitis-related pulmonary fibrosis in a patient with autoimmune pulmonary alveolar proteinosis.
Kinehara Y, Kida H, Inoue Y, Hirose M, Nakabayashi A, Takeuchi Y, Hayama Y, Fukushima K, Hirata H, Inoue K, Minami T, Nagatomo I, Takeda Y, Funakoshi T, Kijima T, Kumanogoh A
BMC Pulm Med 2014 Nov 4;14:172. doi: 10.1186/1471-2466-14-172. PMID: 25366193Free PMC Article
Autoimmune pulmonary alveolar proteinosis: clinical course and diagnostic criteria.
Ben-Dov I, Segel MJ
Autoimmun Rev 2014 Apr-May;13(4-5):513-7. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.046. PMID: 24424195

Clinical prediction guides

Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates.
Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC
Am J Respir Crit Care Med 2010 Jul 1;182(1):49-61. Epub 2010 Mar 11 doi: 10.1164/rccm.201001-0008OC. PMID: 20224064Free PMC Article

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