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Refractory Esophageal Carcinoma

MedGen UID:
1755850
•Concept ID:
C5419203
•
Neoplastic Process

Definition

Esophageal carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Esophageal Carcinoma

Professional guidelines

PubMed

Research Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib.
Li S, Wang H
Drug Des Devel Ther 2023;17:3429-3437. Epub 2023 Nov 15 doi: 10.2147/DDDT.S426898. PMID: 38024530Free PMC Article
Camrelizumab and metronomic capecitabine for patients with treatment-refractory solid tumors (McCREST trial).
Zhou C, Shangguan C, Shi M, Xi W, Wu J, Yang H, Guo L, Cai Q, Shi Y, Liu J, Zhang J
Future Oncol 2022 Jul;18(23):2495-2503. Epub 2022 Jun 15 doi: 10.2217/fon-2021-1579. PMID: 35703115
Cryotherapy in the management of premalignant and malignant conditions of the esophagus.
Lal P, Thota PN
World J Gastroenterol 2018 Nov 21;24(43):4862-4869. doi: 10.3748/wjg.v24.i43.4862. PMID: 30487696Free PMC Article

Recent clinical studies

Etiology

Liver Cirrhosis and Portal Hypertension: How to Deal with Esophageal Varices?
Jothimani D, Rela M, Kamath PS
Med Clin North Am 2023 May;107(3):491-504. Epub 2023 Feb 20 doi: 10.1016/j.mcna.2023.01.002. PMID: 37001949
Liver resection after Transjugular Portosystemic Stent Shunt (TIPSS).
Sliwinski S, Trojan J, Mader C, Vogl T, Bechstein W
Z Gastroenterol 2023 Apr;61(4):390-393. Epub 2022 Jun 13 doi: 10.1055/a-1791-2192. PMID: 35697061
Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer.
Zhou H, Hu Y, Luo R, Zhao Y, Pan H, Ji L, Zhou T, Zhang L, Long H, Fu J, Wen Z, Wang S, Wang X, Lin P, Yang H, Wang J, Song M, Yi X, Yang L, Xia X, Guan Y, Fang W, Yang Y, Hong S, Huang Y, Li P, Zhang Y, Zhou N
Nat Commun 2021 Sep 14;12(1):5431. doi: 10.1038/s41467-021-25787-x. PMID: 34521849Free PMC Article
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877
Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, Wang Z, Wang Q, Ouyang X, Yang Y, Ba Y, Liang J, Lin X, Luo D, Zheng R, Wang X, Sun G, Wang L, Zheng L, Guo H, Wu J, Xu N, Yang J, Zhang H, Cheng Y, Wang N, Chen L, Fan Z, Sun P, Yu H
J Clin Oncol 2016 May 1;34(13):1448-54. Epub 2016 Feb 16 doi: 10.1200/JCO.2015.63.5995. PMID: 26884585

Diagnosis

NCI10066: a Phase 1/2 study of olaparib in combination with ramucirumab in previously treated metastatic gastric and gastroesophageal junction adenocarcinoma.
Cecchini M, Cleary JM, Shyr Y, Chao J, Uboha N, Cho M, Shields A, Pant S, Goff L, Spencer K, Kim E, Stein S, Kortmansky JS, Canosa S, Sklar J, Swisher EM, Radke M, Ivy P, Boerner S, Durecki DE, Hsu CY, LoRusso P, Lacy J
Br J Cancer 2024 Feb;130(3):476-482. Epub 2023 Dec 22 doi: 10.1038/s41416-023-02534-1. PMID: 38135713Free PMC Article
Liver Cirrhosis and Portal Hypertension: How to Deal with Esophageal Varices?
Jothimani D, Rela M, Kamath PS
Med Clin North Am 2023 May;107(3):491-504. Epub 2023 Feb 20 doi: 10.1016/j.mcna.2023.01.002. PMID: 37001949
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877
Minimally invasive esophagectomy for dysplastic Barrett's esophagus.
Markar SR, Hanna G
World J Surg 2015 Mar;39(3):608-14. doi: 10.1007/s00268-014-2746-1. PMID: 25145822
Barrett's esophagus: a review.
Sjogren RW Jr, Johnson LF
Am J Med 1983 Feb;74(2):313-21. doi: 10.1016/0002-9343(83)90635-6. PMID: 6337489

Therapy

Treatment of refractory esophageal stenosis after endoscopic submucosal dissection with magnetic compression anastomosis.
Zhang M, Sha H, Lu G, Xue H, Lv Y, Yan X
Endoscopy 2024 Dec;56(S 01):E280-E282. Epub 2024 Mar 20 doi: 10.1055/a-2279-6910. PMID: 38508574Free PMC Article
Camrelizumab: First Global Approval.
Markham A, Keam SJ
Drugs 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0. PMID: 31313098
A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study.
Türeci O, Sahin U, Schulze-Bergkamen H, Zvirbule Z, Lordick F, Koeberle D, Thuss-Patience P, Ettrich T, Arnold D, Bassermann F, Al-Batran SE, Wiechen K, Dhaene K, Maurus D, Gold M, Huber C, Krivoshik A, Arozullah A, Park JW, Schuler M
Ann Oncol 2019 Sep 1;30(9):1487-1495. doi: 10.1093/annonc/mdz199. PMID: 31240302Free PMC Article
Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, Wang Z, Wang Q, Ouyang X, Yang Y, Ba Y, Liang J, Lin X, Luo D, Zheng R, Wang X, Sun G, Wang L, Zheng L, Guo H, Wu J, Xu N, Yang J, Zhang H, Cheng Y, Wang N, Chen L, Fan Z, Sun P, Yu H
J Clin Oncol 2016 May 1;34(13):1448-54. Epub 2016 Feb 16 doi: 10.1200/JCO.2015.63.5995. PMID: 26884585
Minimally invasive esophagectomy for dysplastic Barrett's esophagus.
Markar SR, Hanna G
World J Surg 2015 Mar;39(3):608-14. doi: 10.1007/s00268-014-2746-1. PMID: 25145822

Prognosis

Liver Cirrhosis and Portal Hypertension: How to Deal with Esophageal Varices?
Jothimani D, Rela M, Kamath PS
Med Clin North Am 2023 May;107(3):491-504. Epub 2023 Feb 20 doi: 10.1016/j.mcna.2023.01.002. PMID: 37001949
Liver resection after Transjugular Portosystemic Stent Shunt (TIPSS).
Sliwinski S, Trojan J, Mader C, Vogl T, Bechstein W
Z Gastroenterol 2023 Apr;61(4):390-393. Epub 2022 Jun 13 doi: 10.1055/a-1791-2192. PMID: 35697061
Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer.
Zhou H, Hu Y, Luo R, Zhao Y, Pan H, Ji L, Zhou T, Zhang L, Long H, Fu J, Wen Z, Wang S, Wang X, Lin P, Yang H, Wang J, Song M, Yi X, Yang L, Xia X, Guan Y, Fang W, Yang Y, Hong S, Huang Y, Li P, Zhang Y, Zhou N
Nat Commun 2021 Sep 14;12(1):5431. doi: 10.1038/s41467-021-25787-x. PMID: 34521849Free PMC Article
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study.
Doi T, Shitara K, Naito Y, Shimomura A, Fujiwara Y, Yonemori K, Shimizu C, Shimoi T, Kuboki Y, Matsubara N, Kitano A, Jikoh T, Lee C, Fujisaki Y, Ogitani Y, Yver A, Tamura K
Lancet Oncol 2017 Nov;18(11):1512-1522. Epub 2017 Oct 13 doi: 10.1016/S1470-2045(17)30604-6. PMID: 29037983
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877

Clinical prediction guides

NCI10066: a Phase 1/2 study of olaparib in combination with ramucirumab in previously treated metastatic gastric and gastroesophageal junction adenocarcinoma.
Cecchini M, Cleary JM, Shyr Y, Chao J, Uboha N, Cho M, Shields A, Pant S, Goff L, Spencer K, Kim E, Stein S, Kortmansky JS, Canosa S, Sklar J, Swisher EM, Radke M, Ivy P, Boerner S, Durecki DE, Hsu CY, LoRusso P, Lacy J
Br J Cancer 2024 Feb;130(3):476-482. Epub 2023 Dec 22 doi: 10.1038/s41416-023-02534-1. PMID: 38135713Free PMC Article
Liver Cirrhosis and Portal Hypertension: How to Deal with Esophageal Varices?
Jothimani D, Rela M, Kamath PS
Med Clin North Am 2023 May;107(3):491-504. Epub 2023 Feb 20 doi: 10.1016/j.mcna.2023.01.002. PMID: 37001949
Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer.
Zhou H, Hu Y, Luo R, Zhao Y, Pan H, Ji L, Zhou T, Zhang L, Long H, Fu J, Wen Z, Wang S, Wang X, Lin P, Yang H, Wang J, Song M, Yi X, Yang L, Xia X, Guan Y, Fang W, Yang Y, Hong S, Huang Y, Li P, Zhang Y, Zhou N
Nat Commun 2021 Sep 14;12(1):5431. doi: 10.1038/s41467-021-25787-x. PMID: 34521849Free PMC Article
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877
Minimally invasive esophagectomy for dysplastic Barrett's esophagus.
Markar SR, Hanna G
World J Surg 2015 Mar;39(3):608-14. doi: 10.1007/s00268-014-2746-1. PMID: 25145822

Recent systematic reviews

Comparative efficacy and safety of immunotherapy for patients with advanced or metastatic esophageal squamous cell carcinoma: a systematic review and network Meta-analysis.
Gao TT, Shan JH, Yang YX, Zhang ZW, Liu SL, Xi M, Liu MZ, Zhao L
BMC Cancer 2022 Sep 17;22(1):992. doi: 10.1186/s12885-022-10086-5. PMID: 36115960Free PMC Article
Toward a Treatment Sequencing Strategy: A Systematic Review of Treatment Regimens in Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma.
Catenacci DV, Chao J, Muro K, Al-Batran SE, Klempner SJ, Wainberg ZA, Shah MA, Rha SY, Ohtsu A, Liepa AM, Knoderer H, Chatterjee A, Van Cutsem E
Oncologist 2021 Oct;26(10):e1704-e1729. Epub 2021 Sep 3 doi: 10.1002/onco.13907. PMID: 34288262Free PMC Article
The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials.
Saeed A, Park R, Sun W
J Hematol Oncol 2021 Jan 12;14(1):13. doi: 10.1186/s13045-021-01034-0. PMID: 33436042Free PMC Article
Salvage systemic therapy for advanced gastric and oesophago-gastric junction adenocarcinoma.
Tomita Y, Moldovan M, Chang Lee R, Hsieh AH, Townsend A, Price T
Cochrane Database Syst Rev 2020 Nov 19;11(11):CD012078. doi: 10.1002/14651858.CD012078.pub2. PMID: 33210731Free PMC Article

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