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Decreased circulating selenium concentration

MedGen UID:
1756605
Concept ID:
C5421674
Finding
HPO: HP:0033192

Definition

An abnormally reduced concentration of selenium in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating selenium concentration

Conditions with this feature

Thyroid hormone metabolism, abnormal, 3
MedGen UID:
1824065
Concept ID:
C5774292
Disease or Syndrome
Abnormal thyroid hormone metabolism-3 (THMA3) is characterized by euthyroid hyperthyroxinemia, with elevated free T4 and reverse T3 levels, and normal TSH (see 188540) and free T3 levels. Patients also show low plasma selenium levels and reduced levels of stress-related selenoproteins (Schoenmakers et al., 2016; Geslot et al., 2021). For a discussion of genetic heterogeneity of abnormal thyroid hormone metabolism, see THMA1 (609698).

Professional guidelines

PubMed

Forceville X, Van Antwerpen P, Annane D, Vincent JL
Antioxid Redox Signal 2022 Nov;37(13-15):998-1029. Epub 2022 Jul 1 doi: 10.1089/ars.2020.8062. PMID: 35287478
Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, Wu X, Meng H, Feng Y, Liu Y, Li G, Wang S, Wang K, Dai J, Li H, Li M, Huang J, Li Y, Wei S, Yuan J, Yao P, Miao X, He M, Zhang X, Yang H, Wu T, Guo H
Environ Int 2019 Jun;127:685-693. Epub 2019 Apr 13 doi: 10.1016/j.envint.2019.04.021. PMID: 30991224
McMillan DC, Sattar N, Talwar D, O'Reilly DS, McArdle CS
Nutrition 2000 Jun;16(6):425-8. doi: 10.1016/s0899-9007(00)00270-7. PMID: 10869897

Recent clinical studies

Etiology

García-Esquinas E, Carballo-Casla A, Ortolá R, Sotos-Prieto M, Olmedo P, Gil F, Plans-Beriso E, Fernández-Navarro P, Pastor-Barriuso R, Rodríguez-Artalejo F
Nutrients 2023 Nov 10;15(22) doi: 10.3390/nu15224750. PMID: 38004143Free PMC Article
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800
Hu XF, Stranges S, Chan LHM
J Am Heart Assoc 2019 May 21;8(10):e012290. doi: 10.1161/JAHA.119.012290. PMID: 31084244Free PMC Article
Tariba B, Živković T, Gajski G, Gerić M, Gluščić V, Garaj-Vrhovac V, Peraica M, Pizent A
Drug Chem Toxicol 2017 Apr;40(2):228-234. Epub 2016 Jul 7 doi: 10.1080/01480545.2016.1199564. PMID: 27387363

Diagnosis

García-Esquinas E, Carballo-Casla A, Ortolá R, Sotos-Prieto M, Olmedo P, Gil F, Plans-Beriso E, Fernández-Navarro P, Pastor-Barriuso R, Rodríguez-Artalejo F
Nutrients 2023 Nov 10;15(22) doi: 10.3390/nu15224750. PMID: 38004143Free PMC Article
Berger MM, Talwar D, Shenkin A
Nutr Clin Pract 2023 Feb;38(1):56-69. Epub 2022 Nov 5 doi: 10.1002/ncp.10924. PMID: 36335431
Hu XF, Stranges S, Chan LHM
J Am Heart Assoc 2019 May 21;8(10):e012290. doi: 10.1161/JAHA.119.012290. PMID: 31084244Free PMC Article
Meyer HA, Hollenbach B, Stephan C, Endermann T, Morgenthaler NG, Cammann H, Köhrle J, Jung K, Schomburg L
Cancer Epidemiol Biomarkers Prev 2009 Sep;18(9):2386-90. Epub 2009 Aug 18 doi: 10.1158/1055-9965.EPI-09-0262. PMID: 19690186
Hollenbach B, Morgenthaler NG, Struck J, Alonso C, Bergmann A, Köhrle J, Schomburg L
J Trace Elem Med Biol 2008;22(1):24-32. Epub 2008 Jan 29 doi: 10.1016/j.jtemb.2007.11.003. PMID: 18319137

Therapy

Berger MM, Talwar D, Shenkin A
Nutr Clin Pract 2023 Feb;38(1):56-69. Epub 2022 Nov 5 doi: 10.1002/ncp.10924. PMID: 36335431
Forceville X, Van Antwerpen P, Annane D, Vincent JL
Antioxid Redox Signal 2022 Nov;37(13-15):998-1029. Epub 2022 Jul 1 doi: 10.1089/ars.2020.8062. PMID: 35287478
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Wolk A
Acta Oncol 2005;44(3):277-81. doi: 10.1080/02841860510029572. PMID: 16076700
McMillan DC, Sattar N, Talwar D, O'Reilly DS, McArdle CS
Nutrition 2000 Jun;16(6):425-8. doi: 10.1016/s0899-9007(00)00270-7. PMID: 10869897

Prognosis

Guo Y, Lu Y, Jin H
Sci Rep 2020 Apr 30;10(1):7356. doi: 10.1038/s41598-020-63909-5. PMID: 32355161Free PMC Article
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, Wu X, Meng H, Feng Y, Liu Y, Li G, Wang S, Wang K, Dai J, Li H, Li M, Huang J, Li Y, Wei S, Yuan J, Yao P, Miao X, He M, Zhang X, Yang H, Wu T, Guo H
Environ Int 2019 Jun;127:685-693. Epub 2019 Apr 13 doi: 10.1016/j.envint.2019.04.021. PMID: 30991224
Stevanovic A, Coburn M, Menon A, Rossaint R, Heyland D, Schälte G, Werker T, Wonisch W, Kiehntopf M, Goetzenich A, Rex S, Stoppe C
PLoS One 2014;9(8):e104222. Epub 2014 Aug 13 doi: 10.1371/journal.pone.0104222. PMID: 25118980Free PMC Article
Hollenbach B, Morgenthaler NG, Struck J, Alonso C, Bergmann A, Köhrle J, Schomburg L
J Trace Elem Med Biol 2008;22(1):24-32. Epub 2008 Jan 29 doi: 10.1016/j.jtemb.2007.11.003. PMID: 18319137

Clinical prediction guides

Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Hu XF, Stranges S, Chan LHM
J Am Heart Assoc 2019 May 21;8(10):e012290. doi: 10.1161/JAHA.119.012290. PMID: 31084244Free PMC Article
Tariba B, Živković T, Gajski G, Gerić M, Gluščić V, Garaj-Vrhovac V, Peraica M, Pizent A
Drug Chem Toxicol 2017 Apr;40(2):228-234. Epub 2016 Jul 7 doi: 10.1080/01480545.2016.1199564. PMID: 27387363
Martitz J, Becker NP, Renko K, Stoedter M, Hybsier S, Schomburg L
Metallomics 2015 Nov;7(11):1515-21. Epub 2015 Sep 23 doi: 10.1039/c5mt00211g. PMID: 26399395
Ellingsen DG, Thomassen Y, Rustad P, Molander P, Aaseth J
J Trace Elem Med Biol 2009;23(2):107-15. Epub 2009 Mar 13 doi: 10.1016/j.jtemb.2009.01.004. PMID: 19398058

Recent systematic reviews

Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800
Reddy VS, Bukke S, Dutt N, Rana P, Pandey AK
J Trace Elem Med Biol 2017 Jul;42:68-75. Epub 2017 Apr 23 doi: 10.1016/j.jtemb.2017.04.005. PMID: 28595794

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