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Decreased circulating selenium concentration

MedGen UID:
1756605
•Concept ID:
C5421674
•
Finding
HPO: HP:0033192

Definition

An abnormally reduced concentration of selenium in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating selenium concentration

Conditions with this feature

Thyroid hormone metabolism, abnormal, 3
MedGen UID:
1824065
•Concept ID:
C5774292
•
Disease or Syndrome
Abnormal thyroid hormone metabolism-3 (THMA3) is characterized by euthyroid hyperthyroxinemia, with elevated free T4 and reverse T3 levels, and normal TSH (see 188540) and free T3 levels. Patients also show low plasma selenium levels and reduced levels of stress-related selenoproteins (Schoenmakers et al., 2016; Geslot et al., 2021). For a discussion of genetic heterogeneity of abnormal thyroid hormone metabolism, see THMA1 (609698).
See: Condition Record
Thyroid hormone metabolism, abnormal, 3

Professional guidelines

PubMed

Selenocompounds and Sepsis-Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis.
Forceville X, Van Antwerpen P, Annane D, Vincent JL
Antioxid Redox Signal 2022 Nov;37(13-15):998-1029. Epub 2022 Jul 1 doi: 10.1089/ars.2020.8062. PMID: 35287478
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, Wu X, Meng H, Feng Y, Liu Y, Li G, Wang S, Wang K, Dai J, Li H, Li M, Huang J, Li Y, Wei S, Yuan J, Yao P, Miao X, He M, Zhang X, Yang H, Wu T, Guo H
Environ Int 2019 Jun;127:685-693. Epub 2019 Apr 13 doi: 10.1016/j.envint.2019.04.021. PMID: 30991224
Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.
McMillan DC, Sattar N, Talwar D, O'Reilly DS, McArdle CS
Nutrition 2000 Jun;16(6):425-8. doi: 10.1016/s0899-9007(00)00270-7. PMID: 10869897

Recent clinical studies

Etiology

Blood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adults.
García-Esquinas E, Carballo-Casla A, Ortolá R, Sotos-Prieto M, Olmedo P, Gil F, Plans-Beriso E, Fernández-Navarro P, Pastor-Barriuso R, Rodríguez-Artalejo F
Nutrients 2023 Nov 10;15(22) doi: 10.3390/nu15224750. PMID: 38004143Free PMC Article
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, Wu X, Meng H, Feng Y, Liu Y, Li G, Wang S, Wang K, Dai J, Li H, Li M, Huang J, Li Y, Wei S, Yuan J, Yao P, Miao X, He M, Zhang X, Yang H, Wu T, Guo H
Environ Int 2019 Jun;127:685-693. Epub 2019 Apr 13 doi: 10.1016/j.envint.2019.04.021. PMID: 30991224
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen U, Johansson P, Aaseth J, Alexander J, Wågsäter D
PLoS One 2017;12(4):e0174880. Epub 2017 Apr 27 doi: 10.1371/journal.pone.0174880. PMID: 28448590Free PMC Article

Diagnosis

Blood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adults.
García-Esquinas E, Carballo-Casla A, Ortolá R, Sotos-Prieto M, Olmedo P, Gil F, Plans-Beriso E, Fernández-Navarro P, Pastor-Barriuso R, Rodríguez-Artalejo F
Nutrients 2023 Nov 10;15(22) doi: 10.3390/nu15224750. PMID: 38004143Free PMC Article
Pitfalls in the interpretation of blood tests used to assess and monitor micronutrient nutrition status.
Berger MM, Talwar D, Shenkin A
Nutr Clin Pract 2023 Feb;38(1):56-69. Epub 2022 Nov 5 doi: 10.1002/ncp.10924. PMID: 36335431
Circulating Selenium Concentration Is Inversely Associated With the Prevalence of Stroke: Results From the Canadian Health Measures Survey and the National Health and Nutrition Examination Survey.
Hu XF, Stranges S, Chan LHM
J Am Heart Assoc 2019 May 21;8(10):e012290. doi: 10.1161/JAHA.119.012290. PMID: 31084244Free PMC Article
The importance of intraoperative selenium blood levels on organ dysfunction in patients undergoing off-pump cardiac surgery: a randomised controlled trial.
Stevanovic A, Coburn M, Menon A, Rossaint R, Heyland D, Schälte G, Werker T, Wonisch W, Kiehntopf M, Goetzenich A, Rex S, Stoppe C
PLoS One 2014;9(8):e104222. Epub 2014 Aug 13 doi: 10.1371/journal.pone.0104222. PMID: 25118980Free PMC Article
New assay for the measurement of selenoprotein P as a sepsis biomarker from serum.
Hollenbach B, Morgenthaler NG, Struck J, Alonso C, Bergmann A, Köhrle J, Schomburg L
J Trace Elem Med Biol 2008;22(1):24-32. Epub 2008 Jan 29 doi: 10.1016/j.jtemb.2007.11.003. PMID: 18319137

Therapy

Pitfalls in the interpretation of blood tests used to assess and monitor micronutrient nutrition status.
Berger MM, Talwar D, Shenkin A
Nutr Clin Pract 2023 Feb;38(1):56-69. Epub 2022 Nov 5 doi: 10.1002/ncp.10924. PMID: 36335431
Selenocompounds and Sepsis-Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis.
Forceville X, Van Antwerpen P, Annane D, Vincent JL
Antioxid Redox Signal 2022 Nov;37(13-15):998-1029. Epub 2022 Jul 1 doi: 10.1089/ars.2020.8062. PMID: 35287478
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800
A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I).
Reddy VS, Bukke S, Dutt N, Rana P, Pandey AK
J Trace Elem Med Biol 2017 Jul;42:68-75. Epub 2017 Apr 23 doi: 10.1016/j.jtemb.2017.04.005. PMID: 28595794

Prognosis

Appraising the role of circulating concentrations of micro-nutrients in epithelial ovarian cancer risk: A Mendelian randomization analysis.
Guo Y, Lu Y, Jin H
Sci Rep 2020 Apr 30;10(1):7356. doi: 10.1038/s41598-020-63909-5. PMID: 32355161Free PMC Article
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, Wu X, Meng H, Feng Y, Liu Y, Li G, Wang S, Wang K, Dai J, Li H, Li M, Huang J, Li Y, Wei S, Yuan J, Yao P, Miao X, He M, Zhang X, Yang H, Wu T, Guo H
Environ Int 2019 Jun;127:685-693. Epub 2019 Apr 13 doi: 10.1016/j.envint.2019.04.021. PMID: 30991224
The importance of intraoperative selenium blood levels on organ dysfunction in patients undergoing off-pump cardiac surgery: a randomised controlled trial.
Stevanovic A, Coburn M, Menon A, Rossaint R, Heyland D, Schälte G, Werker T, Wonisch W, Kiehntopf M, Goetzenich A, Rex S, Stoppe C
PLoS One 2014;9(8):e104222. Epub 2014 Aug 13 doi: 10.1371/journal.pone.0104222. PMID: 25118980Free PMC Article
The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients.
Stoppe C, Schälte G, Rossaint R, Coburn M, Graf B, Spillner J, Marx G, Rex S
Crit Care Med 2011 Aug;39(8):1879-85. doi: 10.1097/CCM.0b013e3182190d48. PMID: 21460705

Clinical prediction guides

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I).
Reddy VS, Bukke S, Dutt N, Rana P, Pandey AK
J Trace Elem Med Biol 2017 Jul;42:68-75. Epub 2017 Apr 23 doi: 10.1016/j.jtemb.2017.04.005. PMID: 28595794
Gene-specific regulation of hepatic selenoprotein expression by interleukin-6.
Martitz J, Becker NP, Renko K, Stoedter M, Hybsier S, Schomburg L
Metallomics 2015 Nov;7(11):1515-21. Epub 2015 Sep 23 doi: 10.1039/c5mt00211g. PMID: 26399395
Vitamin D supplementation and serum levels of magnesium and selenium in type 2 diabetes mellitus patients: gender dimorphic changes.
Al-Daghri NM, Alkharfy KM, Khan N, Alfawaz HA, Al-Ajlan AS, Yakout SM, Alokail MS
Int J Vitam Nutr Res 2014;84(1-2):27-34. doi: 10.1024/0300-9831/a000190. PMID: 25835233
The time-trend and the relation between smoking and circulating selenium concentrations in Norway.
Ellingsen DG, Thomassen Y, Rustad P, Molander P, Aaseth J
J Trace Elem Med Biol 2009;23(2):107-15. Epub 2009 Mar 13 doi: 10.1016/j.jtemb.2009.01.004. PMID: 19398058

Recent systematic reviews

Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800
A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I).
Reddy VS, Bukke S, Dutt N, Rana P, Pandey AK
J Trace Elem Med Biol 2017 Jul;42:68-75. Epub 2017 Apr 23 doi: 10.1016/j.jtemb.2017.04.005. PMID: 28595794

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