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Abnormal immunoglobulin level in body fluid

MedGen UID:
1756838
•Concept ID:
C5421706
•
Finding
HPO: HP:0041076

Definition

An abnormal deviation from normal levels of immunoglobulins in body fluids, such as mucous. [from HPO]

Professional guidelines

PubMed

No evidence of HEV genotype 1 infections harming the male reproductive system.
El-Mokhtar MA, Seddik MI, Osman AOB, Mahmoud AA, Mandour SA, Radwan E, Ali M, Ismael AE, Twisy HO, Karam-Allah Ramadan H, Shehata RR, Sayed IM
Virology 2021 Feb;554:37-41. Epub 2020 Dec 10 doi: 10.1016/j.virol.2020.12.002. PMID: 33360325
Graves' disease in pregnancy: prospective evaluation of a selective invasive treatment protocol.
Nachum Z, Rakover Y, Weiner E, Shalev E
Am J Obstet Gynecol 2003 Jul;189(1):159-65. doi: 10.1067/mob.2003.321. PMID: 12861156
Analysis of polyunsaturated fatty acids in newborn sera: a screening tool for atopic disease?
Galli E, Picardo M, Chini L, Passi S, Moschese V, Terminali O, Paone F, Fraioli G, Rossi P
Br J Dermatol 1994 Jun;130(6):752-6. doi: 10.1111/j.1365-2133.1994.tb03413.x. PMID: 8011501

Recent clinical studies

Etiology

Prevalence of and risk factors for nutritional deficiency and food allergy in a cohort of 21 patients with Netherton syndrome.
Prodinger C, Yerlett N, MacDonald C, Chottianchaiwat S, Goh L, Du Toit G, Mellerio JE, Petrof G, Martinez AE
Pediatr Allergy Immunol 2023 Jan;34(1):e13914. doi: 10.1111/pai.13914. PMID: 36705039
Placental deficiency during maternal SARS-CoV-2 infection.
Celik E, Vatansever C, Ozcan G, Kapucuoglu N, Alatas C, Besli Y, Palaoglu E, Gursoy T, Manici M, Turgal M, Dogan O, Cekic SG, Duru B, Ata B, Ergonul O, Can F
Placenta 2022 Jan;117:47-56. Epub 2021 Oct 23 doi: 10.1016/j.placenta.2021.10.012. PMID: 34768168Free PMC Article
No evidence of HEV genotype 1 infections harming the male reproductive system.
El-Mokhtar MA, Seddik MI, Osman AOB, Mahmoud AA, Mandour SA, Radwan E, Ali M, Ismael AE, Twisy HO, Karam-Allah Ramadan H, Shehata RR, Sayed IM
Virology 2021 Feb;554:37-41. Epub 2020 Dec 10 doi: 10.1016/j.virol.2020.12.002. PMID: 33360325
Transplacental total IgG transfer in twin pregnancies.
Stach SC, Brizot Mde L, Liao AW, Francisco RP, Palmeira P, Carneiro-Sampaio M, Zugaib M
Am J Reprod Immunol 2014 Dec;72(6):555-60. Epub 2014 Aug 2 doi: 10.1111/aji.12305. PMID: 25087927
B- and T-cells in the follicular fluid and peripheral blood of patients undergoing IVF/ET procedures.
Vujisić S, Lepej SZ, Aksamija A, Jerković L, Sokolić B, Kupesić S, Vince A
Am J Reprod Immunol 2004 Dec;52(6):379-85. doi: 10.1111/j.1600-0897.2004.00238.x. PMID: 15663603

Diagnosis

Intestinal Lymphangiectasia: Insights on Management and Literature Review.
Alshikho MJ, Talas JM, Noureldine SI, Zazou S, Addas A, Kurabi H, Nasser M
Am J Case Rep 2016 Jul 21;17:512-22. doi: 10.12659/ajcr.899636. PMID: 27440277Free PMC Article
Hematologic effects and complications of snake envenoming.
Berling I, Isbister GK
Transfus Med Rev 2015 Apr;29(2):82-9. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.005. PMID: 25556574
Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab.
Sebejova L, Borsky M, Jaskova Z, Potesil D, Navrkalova V, Malcikova J, Sramek M, Doubek M, Loja T, Pospisilova S, Mayer J, Trbusek M
Exp Hematol 2014 Oct;42(10):867-74.e1. Epub 2014 Jun 23 doi: 10.1016/j.exphem.2014.06.003. PMID: 24970561
Asymptomatic neurosyphilis.
Dijkstra JW
Int J Dermatol 1983 Dec;22(10):581-9. doi: 10.1111/j.1365-4362.1983.tb02130.x. PMID: 6363314
Neurosyphilis.
Kolar OJ, Burkhart JE
Br J Vener Dis 1977 Aug;53(4):221-5. doi: 10.1136/sti.53.4.221. PMID: 336144Free PMC Article

Therapy

Platelet/Lymphocyte ratio independently predicts the outcome of severe aplastic anemia patients treated with antithymocyte globulin.
Dong P, Ge M, Wu H, Ren X, Huo J, Li X, Zheng Y
Rev Assoc Med Bras (1992) 2021 Mar;67(3):378-384. doi: 10.1590/1806-9282.20200767. PMID: 34468601
IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis.
Jo S, Wang SE, Lee YL, Kang S, Lee B, Han J, Sung IH, Park YS, Bae SC, Kim TH
Arthritis Res Ther 2018 Jun 7;20(1):115. doi: 10.1186/s13075-018-1582-3. PMID: 29880011Free PMC Article
Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC
J Immunol 2016 Jun 15;196(12):4957-66. Epub 2016 May 13 doi: 10.4049/jimmunol.1502587. PMID: 27183609Free PMC Article
Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.
Kragstrup TW, Jalilian B, Keller KK, Zhang X, Laustsen JK, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hauge EM, Hvid M, Vorup-Jensen T, Deleuran B
PLoS One 2016;11(2):e0148486. Epub 2016 Feb 5 doi: 10.1371/journal.pone.0148486. PMID: 26849368Free PMC Article
Hematologic effects and complications of snake envenoming.
Berling I, Isbister GK
Transfus Med Rev 2015 Apr;29(2):82-9. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.005. PMID: 25556574

Prognosis

Platelet/Lymphocyte ratio independently predicts the outcome of severe aplastic anemia patients treated with antithymocyte globulin.
Dong P, Ge M, Wu H, Ren X, Huo J, Li X, Zheng Y
Rev Assoc Med Bras (1992) 2021 Mar;67(3):378-384. doi: 10.1590/1806-9282.20200767. PMID: 34468601
Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.
Kragstrup TW, Jalilian B, Keller KK, Zhang X, Laustsen JK, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hauge EM, Hvid M, Vorup-Jensen T, Deleuran B
PLoS One 2016;11(2):e0148486. Epub 2016 Feb 5 doi: 10.1371/journal.pone.0148486. PMID: 26849368Free PMC Article
Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab.
Sebejova L, Borsky M, Jaskova Z, Potesil D, Navrkalova V, Malcikova J, Sramek M, Doubek M, Loja T, Pospisilova S, Mayer J, Trbusek M
Exp Hematol 2014 Oct;42(10):867-74.e1. Epub 2014 Jun 23 doi: 10.1016/j.exphem.2014.06.003. PMID: 24970561
Carbohydrate antigens in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy.
Deutscher SL, Dickerson M, Gui G, Newton J, Holm JE, Vogeltanz-Holm N, Kliethermes B, Hewett JE, Kumar SR, Quinn TP, Sauter ER
BMC Cancer 2010 Oct 1;10:519. doi: 10.1186/1471-2407-10-519. PMID: 20920311Free PMC Article
Immune complexes in pregnancy. III. Immune complexes in immune complex-associated conditions.
Gleicher N, Adelsberg BR, Liu TL, Cederqvist LL, Phillips RN, Siegel I
Am J Obstet Gynecol 1982 Apr 15;142(8):1011-5. PMID: 6462061

Clinical prediction guides

IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis.
Jo S, Wang SE, Lee YL, Kang S, Lee B, Han J, Sung IH, Park YS, Bae SC, Kim TH
Arthritis Res Ther 2018 Jun 7;20(1):115. doi: 10.1186/s13075-018-1582-3. PMID: 29880011Free PMC Article
Intestinal Lymphangiectasia: Insights on Management and Literature Review.
Alshikho MJ, Talas JM, Noureldine SI, Zazou S, Addas A, Kurabi H, Nasser M
Am J Case Rep 2016 Jul 21;17:512-22. doi: 10.12659/ajcr.899636. PMID: 27440277Free PMC Article
Hematologic effects and complications of snake envenoming.
Berling I, Isbister GK
Transfus Med Rev 2015 Apr;29(2):82-9. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.005. PMID: 25556574
Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab.
Sebejova L, Borsky M, Jaskova Z, Potesil D, Navrkalova V, Malcikova J, Sramek M, Doubek M, Loja T, Pospisilova S, Mayer J, Trbusek M
Exp Hematol 2014 Oct;42(10):867-74.e1. Epub 2014 Jun 23 doi: 10.1016/j.exphem.2014.06.003. PMID: 24970561
Anti-TPO antibodies diffusion through the placental barrier during pregnancy.
Seror J, Amand G, Guibourdenche J, Ceccaldi PF, Luton D
PLoS One 2014;9(1):e84647. Epub 2014 Jan 31 doi: 10.1371/journal.pone.0084647. PMID: 24497920Free PMC Article

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