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Increased immunoglobulin level in body fluid

MedGen UID:
1774075
•Concept ID:
C5421707
•
Finding
HPO: HP:0041077

Definition

An elevation from normal levels of immunoglobulins in body fluids, such as mucous. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased immunoglobulin level in body fluid

Professional guidelines

PubMed

Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders.
Ward ES, Gelinas D, Dreesen E, Van Santbergen J, Andersen JT, Silvestri NJ, Kiss JE, Sleep D, Rader DJ, Kastelein JJP, Louagie E, Vidarsson G, Spriet I
Front Immunol 2022;13:892534. Epub 2022 Jun 1 doi: 10.3389/fimmu.2022.892534. PMID: 35757719Free PMC Article
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria.
Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC
Brain 2014 Jan;137(Pt 1):33-43. Epub 2013 Oct 26 doi: 10.1093/brain/awt285. PMID: 24163275

Recent clinical studies

Etiology

Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders.
Ward ES, Gelinas D, Dreesen E, Van Santbergen J, Andersen JT, Silvestri NJ, Kiss JE, Sleep D, Rader DJ, Kastelein JJP, Louagie E, Vidarsson G, Spriet I
Front Immunol 2022;13:892534. Epub 2022 Jun 1 doi: 10.3389/fimmu.2022.892534. PMID: 35757719Free PMC Article
A single-center analysis of early readmission after renal transplantation.
Kim SH, Baird GL, Bayliss G, Merhi B, Osband A, Gohh R, Morrissey PE
Clin Transplant 2019 May;33(5):e13520. Epub 2019 Mar 27 doi: 10.1111/ctr.13520. PMID: 30861203
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria.
Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC
Brain 2014 Jan;137(Pt 1):33-43. Epub 2013 Oct 26 doi: 10.1093/brain/awt285. PMID: 24163275
Asthma and wheezing in the first six years of life. The Group Health Medical Associates.
Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ
N Engl J Med 1995 Jan 19;332(3):133-8. doi: 10.1056/NEJM199501193320301. PMID: 7800004

Diagnosis

Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial.
Pontecorvo MJ, Lu M, Burnham SC, Schade AE, Dage JL, Shcherbinin S, Collins EC, Sims JR, Mintun MA
JAMA Neurol 2022 Dec 1;79(12):1250-1259. doi: 10.1001/jamaneurol.2022.3392. PMID: 36251300Free PMC Article
Exponential increase in neutralizing and spike specific antibodies following vaccination of COVID-19 convalescent plasma donors.
Vickers MA, Sariol A, Leon J, Ehlers A, Locher AV, Dubay KA, Collins L, Voss D, Odle AE, Holida M, Merrill AE, Perlman S, Knudson CM
Transfusion 2021 Jul;61(7):2099-2106. Epub 2021 Apr 15 doi: 10.1111/trf.16401. PMID: 33829513Free PMC Article
Posttransplant Lymphoproliferative Disorder Following Kidney Transplantation: A Review.
Sprangers B, Riella LV, Dierickx D
Am J Kidney Dis 2021 Aug;78(2):272-281. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2021.01.015. PMID: 33774079
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria.
Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC
Brain 2014 Jan;137(Pt 1):33-43. Epub 2013 Oct 26 doi: 10.1093/brain/awt285. PMID: 24163275

Therapy

Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial.
Pontecorvo MJ, Lu M, Burnham SC, Schade AE, Dage JL, Shcherbinin S, Collins EC, Sims JR, Mintun MA
JAMA Neurol 2022 Dec 1;79(12):1250-1259. doi: 10.1001/jamaneurol.2022.3392. PMID: 36251300Free PMC Article
Posttransplant Lymphoproliferative Disorder Following Kidney Transplantation: A Review.
Sprangers B, Riella LV, Dierickx D
Am J Kidney Dis 2021 Aug;78(2):272-281. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2021.01.015. PMID: 33774079
A single-center analysis of early readmission after renal transplantation.
Kim SH, Baird GL, Bayliss G, Merhi B, Osband A, Gohh R, Morrissey PE
Clin Transplant 2019 May;33(5):e13520. Epub 2019 Mar 27 doi: 10.1111/ctr.13520. PMID: 30861203
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria.
Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC
Brain 2014 Jan;137(Pt 1):33-43. Epub 2013 Oct 26 doi: 10.1093/brain/awt285. PMID: 24163275

Prognosis

A single-center analysis of early readmission after renal transplantation.
Kim SH, Baird GL, Bayliss G, Merhi B, Osband A, Gohh R, Morrissey PE
Clin Transplant 2019 May;33(5):e13520. Epub 2019 Mar 27 doi: 10.1111/ctr.13520. PMID: 30861203
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria.
Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC
Brain 2014 Jan;137(Pt 1):33-43. Epub 2013 Oct 26 doi: 10.1093/brain/awt285. PMID: 24163275
The chemokine CXCL13 (BLC): a putative diagnostic marker for neuroborreliosis.
Rupprecht TA, Pfister HW, Angele B, Kastenbauer S, Wilske B, Koedel U
Neurology 2005 Aug 9;65(3):448-50. doi: 10.1212/01.wnl.0000171349.06645.79. PMID: 16087912
The yeast homologue of U3 snRNA.
Hughes JM, Konings DA, Cesareni G
EMBO J 1987 Jul;6(7):2145-55. doi: 10.1002/j.1460-2075.1987.tb02482.x. PMID: 3308452Free PMC Article

Clinical prediction guides

Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial.
Pontecorvo MJ, Lu M, Burnham SC, Schade AE, Dage JL, Shcherbinin S, Collins EC, Sims JR, Mintun MA
JAMA Neurol 2022 Dec 1;79(12):1250-1259. doi: 10.1001/jamaneurol.2022.3392. PMID: 36251300Free PMC Article
A single-center analysis of early readmission after renal transplantation.
Kim SH, Baird GL, Bayliss G, Merhi B, Osband A, Gohh R, Morrissey PE
Clin Transplant 2019 May;33(5):e13520. Epub 2019 Mar 27 doi: 10.1111/ctr.13520. PMID: 30861203
Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria.
Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC
Brain 2014 Jan;137(Pt 1):33-43. Epub 2013 Oct 26 doi: 10.1093/brain/awt285. PMID: 24163275
Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis.
Fivush BA, Case B, May MW, Lederman HM
Pediatr Nephrol 1989 Apr;3(2):186-8. doi: 10.1007/BF00852907. PMID: 2484452
The yeast homologue of U3 snRNA.
Hughes JM, Konings DA, Cesareni G
EMBO J 1987 Jul;6(7):2145-55. doi: 10.1002/j.1460-2075.1987.tb02482.x. PMID: 3308452Free PMC Article

Recent systematic reviews

Donor-Specific Antibodies and Primary Graft Failure in Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.
Xie Y, Parekh J, Tang Z, Wu D, Wu X
Transplant Cell Ther 2021 Aug;27(8):687.e1-687.e7. Epub 2021 May 12 doi: 10.1016/j.jtct.2021.04.030. PMID: 33989833
The association between systemic vascular endothelial growth factor and retinopathy of prematurity in premature infants: a systematic review.
Kandasamy Y, Hartley L, Rudd D, Smith R
Br J Ophthalmol 2017 Jan;101(1):21-24. Epub 2016 Jul 7 doi: 10.1136/bjophthalmol-2016-308828. PMID: 27388246
Health effects of passive smoking .5. Parental smoking and allergic sensitisation in children.
Strachan DP, Cook DG
Thorax 1998 Feb;53(2):117-23. doi: 10.1136/thx.53.2.117. PMID: 9624297Free PMC Article

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