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Increased circulating selenium concentration

MedGen UID:
1758130
•Concept ID:
C5421673
•
Finding
HPO: HP:0033191

Definition

An increased concentration of selenium in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating selenium concentration

Professional guidelines

PubMed

Selenocompounds and Sepsis-Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis.
Forceville X, Van Antwerpen P, Annane D, Vincent JL
Antioxid Redox Signal 2022 Nov;37(13-15):998-1029. Epub 2022 Jul 1 doi: 10.1089/ars.2020.8062. PMID: 35287478
Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.
McMillan DC, Sattar N, Talwar D, O'Reilly DS, McArdle CS
Nutrition 2000 Jun;16(6):425-8. doi: 10.1016/s0899-9007(00)00270-7. PMID: 10869897

Recent clinical studies

Etiology

Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study.
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Selenoprotein P - Selenium transport protein, enzyme and biomarker of selenium status.
Schomburg L
Free Radic Biol Med 2022 Oct;191:150-163. Epub 2022 Sep 5 doi: 10.1016/j.freeradbiomed.2022.08.022. PMID: 36067902
Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review.
Vescini F, Chiodini I, Palermo A, Cesareo R, De Geronimo V, Scillitani A, Gennari L, Falchetti A
Endocr Metab Immune Disord Drug Targets 2021;21(4):577-585. doi: 10.2174/1871530320666200628030913. PMID: 32600242
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.
Brodin O, Hackler J, Misra S, Wendt S, Sun Q, Laaf E, Stoppe C, Björnstedt M, Schomburg L
Nutrients 2020 Apr 12;12(4) doi: 10.3390/nu12041067. PMID: 32290626Free PMC Article
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article

Diagnosis

Blood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adults.
García-Esquinas E, Carballo-Casla A, Ortolá R, Sotos-Prieto M, Olmedo P, Gil F, Plans-Beriso E, Fernández-Navarro P, Pastor-Barriuso R, Rodríguez-Artalejo F
Nutrients 2023 Nov 10;15(22) doi: 10.3390/nu15224750. PMID: 38004143Free PMC Article
Pitfalls in the interpretation of blood tests used to assess and monitor micronutrient nutrition status.
Berger MM, Talwar D, Shenkin A
Nutr Clin Pract 2023 Feb;38(1):56-69. Epub 2022 Nov 5 doi: 10.1002/ncp.10924. PMID: 36335431
Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study.
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Association between Circulating Antioxidants and Longevity: Insight from Mendelian Randomization Study.
Yu Z, Zhang F, Xu C, Wang Y
Biomed Res Int 2022;2022:4012603. Epub 2022 Jan 29 doi: 10.1155/2022/4012603. PMID: 35132376Free PMC Article
Adiposity and Serum Selenium in U.S. Adults.
Zhong Q, Lin R, Nong Q
Nutrients 2018 Jun 5;10(6) doi: 10.3390/nu10060727. PMID: 29874857Free PMC Article

Therapy

Pitfalls in the interpretation of blood tests used to assess and monitor micronutrient nutrition status.
Berger MM, Talwar D, Shenkin A
Nutr Clin Pract 2023 Feb;38(1):56-69. Epub 2022 Nov 5 doi: 10.1002/ncp.10924. PMID: 36335431
Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study.
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review.
Vescini F, Chiodini I, Palermo A, Cesareo R, De Geronimo V, Scillitani A, Gennari L, Falchetti A
Endocr Metab Immune Disord Drug Targets 2021;21(4):577-585. doi: 10.2174/1871530320666200628030913. PMID: 32600242
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.
Brodin O, Hackler J, Misra S, Wendt S, Sun Q, Laaf E, Stoppe C, Björnstedt M, Schomburg L
Nutrients 2020 Apr 12;12(4) doi: 10.3390/nu12041067. PMID: 32290626Free PMC Article
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article

Prognosis

Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study.
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Selenoprotein P - Selenium transport protein, enzyme and biomarker of selenium status.
Schomburg L
Free Radic Biol Med 2022 Oct;191:150-163. Epub 2022 Sep 5 doi: 10.1016/j.freeradbiomed.2022.08.022. PMID: 36067902
Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L
Nutrients 2021 May 31;13(6) doi: 10.3390/nu13061898. PMID: 34072977Free PMC Article
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article
Circulating Multiple Metals and Incident Stroke in Chinese Adults.
Xiao Y, Yuan Y, Liu Y, Yu Y, Jia N, Zhou L, Wang H, Huang S, Zhang Y, Yang H, Li X, Hu FB, Liang L, Pan A, Zhang X, He M, Cheng J, Wu T
Stroke 2019 Jul;50(7):1661-1668. Epub 2019 Jun 6 doi: 10.1161/STROKEAHA.119.025060. PMID: 31167624Free PMC Article

Clinical prediction guides

Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study.
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Selenoprotein P - Selenium transport protein, enzyme and biomarker of selenium status.
Schomburg L
Free Radic Biol Med 2022 Oct;191:150-163. Epub 2022 Sep 5 doi: 10.1016/j.freeradbiomed.2022.08.022. PMID: 36067902
Clinical Relevance of Serum Selenium Levels and Abdominal Aortic Calcification.
Lu YY, Chen WL
Biol Trace Elem Res 2021 Aug;199(8):2803-2810. Epub 2020 Sep 24 doi: 10.1007/s12011-020-02405-3. PMID: 32974845
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.
Brodin O, Hackler J, Misra S, Wendt S, Sun Q, Laaf E, Stoppe C, Björnstedt M, Schomburg L
Nutrients 2020 Apr 12;12(4) doi: 10.3390/nu12041067. PMID: 32290626Free PMC Article
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS
Lancet Gastroenterol Hepatol 2020 Jan;5(1):55-62. Epub 2019 Oct 24 doi: 10.1016/S2468-1253(19)30294-8. PMID: 31668584Free PMC Article

Recent systematic reviews

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis.
Janjuha R, Bunn D, Hayhoe R, Hooper L, Abdelhamid A, Mahmood S, Hayden-Case J, Appleyard W, Morris S, Welch A
Nutrients 2020 May 18;12(5) doi: 10.3390/nu12051457. PMID: 32443563Free PMC Article
Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800
A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I).
Reddy VS, Bukke S, Dutt N, Rana P, Pandey AK
J Trace Elem Med Biol 2017 Jul;42:68-75. Epub 2017 Apr 23 doi: 10.1016/j.jtemb.2017.04.005. PMID: 28595794

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